Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA polymerase subunit gamma-1, mitochondrial


DESCRIPTION:
Involved in the replication of mitochondrial DNA. Has both 5'->3' DNA polymerase and 3'->5' exonuclease activity.

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-A family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MQFHLIRKYA SKVSREHYAS SSVKIFRRVK PPQKVNKPKK PENVENGPTE YAENLVKVQM
        70         80         90        100        110        120
ISRNLHAQLF PQAPRSISEQ QVASAKVYKD ELRRHGVDIE SSAPVSDVQL KLPALRGANI
       130        140        150        160        170        180
EEHFHNIAKE QVQPYEELLL PLVQCEQLPK RPKRWAFHTG WTAYDPEDGT ATPVDHPLEK
       190        200        210        220        230        240
GLVFDVEVCV SEGQAPVLAT AVSTKRWYSW VSSKLTKHRL SVEKLEPLDV DTDSERPHYT
       250        260        270        280        290        300
TDELIPLGTT GPGLVVGHNV SYDRARLKEQ YLTEDTGTRF VDTMSLHMCV SGVTSYQRAM
       310        320        330        340        350        360
LKSKKEPAAE DLGWLEQSSL NSLVEVHRLY CGGDTLSKEP RNIFVEGTLE QVRQSFQSLT
       370        380        390        400        410        420
NYCASDVEAT HRILRVLYPL YAERFPHPAS LAGMLEMGSA YLPVNSNWER YIREAQLTYE
       430        440        450        460        470        480
DLSIEAKYHL GRRAEEACSL LLDDQYRQNL WLWDEDWSVQ ELKLKQPPKR KPLPTVELKD
       490        500        510        520        530        540
SGNTPEERRL QAKFQHLYDQ QALLPARRPL LPGYPLWYRK LCRKPPAKRA DEILEDDEEP
       550        560        570        580        590        600
WSPGASEIST GMQIAPKLLS LCWEGYPLHY EREQGWGFLV PFRSDSEGVD RLPMEQLLAH
       610        620        630        640        650        660
CPVPEFARLS ASKAESDMAF DMLPGQVEQH LGKREHYKKL SQKQQRLETQ YQGSGVWCNK
       670        680        690        700        710        720
VLDDCCFFLK LPHKNGPSFR VGNPLSKDFL NKFAENVLSS GDPSCQAAAR VIDIARMMSY
       730        740        750        760        770        780
WRNNRDRIMG QMVVWLDSQQ LPNEFTGEKC QPIAYGAICP QVVACGTLTR RAMEPTWMTA
       790        800        810        820        830        840
SNSRPDRLGS ELRSMVQAPP GYRLVGADVD SQELWIASVL GDAYACGEHG ATPLGWMTLS
       850        860        870        880        890        900
GSKSNGSDMH SITAKAVGIS RDHAKVINYA RIYGAGQLFA ETLLRQFNPT FSASEAKAKA
       910        920        930        940        950        960
MKMFSITKGK RVYRLREEFH DELEDRAYSS YEASRLAIQR NRTLAEVFHR PNWQGGTESA
       970        980        990       1000       1010       1020
MFNRLEEIAT GSQPRTPFLG GRLSRALEAD TGPEQEQRFL PTRINWVVQS GAVDFLHLML
      1030       1040       1050       1060       1070       1080
VSMRWLMGSH VRFCLSFHDE LRYLVKEELS PKAALAMHIT NLMTRSFCVS RIGLQDLPMS
      1090       1100       1110       1120       1130       1140
VAFFSSVEVD TVLRKECTMD CKTPSNPHGL RIGYGIQPGQ SLSVAEAIEK AGGNDVSQWD

WIKKS     

Encoded by tam gene

FULL NAME: tamas


OTHER NAME(S):
34Dc
AAC47658
anon-34Dc
BG:DS00941.6
br5
cDNA 2
CG8987
D-pol gamma-alpha
Dmel\CG8987
DNApol-gamma
DNApol-gamma125
l(2)34Dc
l(2)br14
l(2)br5
l(2)brS
mtDNA pol
mtPolA
MtPolA
pol gamma
pol gamma-alpha
polgamma
Polgamma
polgamma-alpha
Tam


Nucleic acid sequence

        10         20         30         40         50         60
atgcagttcc acctgatcag aaagtacgcc agcaaagtta gccgggagca ctacgccagc
        70         80         90        100        110        120
agtagcgtga agatctttcg gcgggtcaag cctccgcaaa aggtaaacaa accaaagaag
       130        140        150        160        170        180
ccggagaatg tggagaatgg cccaacggaa tatgcggaaa atctggtcaa ggtgcagatg
       190        200        210        220        230        240
atctcgcgga atttgcacgc ccaactgttc ccacaagcgc cgcgaagcat ttcggagcag
       250        260        270        280        290        300
caggtggcct ccgctaaggt ttacaaagac gagttgcgcc ggcacggagt cgatatcgaa
       310        320        330        340        350        360
agttctgctc ctgtttcgga tgtccagttg aaattgcccg cgcttagggg cgccaatatt
       370        380        390        400        410        420
gaagagcact tccacaacat tgccaaggag caagtgcagc catacgagga gttactactt
       430        440        450        460        470        480
cccctggtcc aatgcgagca gctgccgaag cgtccgaagc gatgggcttt ccataccggc
       490        500        510        520        530        540
tggacagctt atgatccaga ggatggaaca gccacgccgg tggatcaccc actggagaag
       550        560        570        580        590        600
ggacttgtct tcgatgtgga ggtgtgcgtc agcgaggggc aggctccagt tttggccacc
       610        620        630        640        650        660
gccgtcagca ccaagagatg gtattcgtgg gtgagctcaa agctgacgaa acatcgccta
       670        680        690        700        710        720
agcgtggaga aattagagcc attagatgtg gacacggact cagagcgacc gcactacact
       730        740        750        760        770        780
acggacgaac tcataccact gggcaccact ggacctggcc tggtggtggg tcacaatgtc
       790        800        810        820        830        840
tcctacgaca gggcgcgact gaaggagcag tatttgaccg aggacacggg cactcggttc
       850        860        870        880        890        900
gtggacacaa tgtcgctgca catgtgtgtc agtggagtga ccagctacca gcgggccatg
       910        920        930        940        950        960
ctcaaatcca agaaggaacc ggctgccgag gatctgggct ggctggagca gagctctctt
       970        980        990       1000       1010       1020
aacagtctgg tggaggtgca tcgcctctac tgcggtgggg atacgctatc caaggagccg
      1030       1040       1050       1060       1070       1080
aggaacattt tcgtcgaggg aactctggag caagtacgtc agagctttca gtcgttaacc
      1090       1100       1110       1120       1130       1140
aactactgcg ccagcgatgt ggaggctaca catcggatac tccgagtcct gtatcccttg
      1150       1160       1170       1180       1190       1200
tacgcagaac gatttccgca tcctgcctcc ttggctggca tgttggagat gggatccgcc
      1210       1220       1230       1240       1250       1260
tatttgccag tcaattccaa ctgggagcgc tacatacgtg aggcgcagct cacctacgag
      1270       1280       1290       1300       1310       1320
gacctcagca tcgaggccaa gtaccatttg ggccgcagag ctgaggaagc gtgctccttg
      1330       1340       1350       1360       1370       1380
ctgctcgacg atcagtaccg ccagaatttg tggctctggg acgaggattg gagtgtgcag
      1390       1400       1410       1420       1430       1440
gaactgaaac taaagcagcc gccgaagcgc aagcctctgc ctactgtgga gcttaaggat
      1450       1460       1470       1480       1490       1500
tctggaaaca caccggagga gcgacgtctg caggccaagt ttcagcacct ctatgatcaa
      1510       1520       1530       1540       1550       1560
caggcgctac tgccagctcg acggccattg ctacccggtt atcctctgtg gtatcgcaaa
      1570       1580       1590       1600       1610       1620
ctgtgccgca aaccaccagc caaaagggca gatgaaattc tagaggatga cgaagagccg
      1630       1640       1650       1660       1670       1680
tggtccccgg gagccagcga gattagcacc ggcatgcaga ttgcccccaa gctgctttcc
      1690       1700       1710       1720       1730       1740
ctctgctggg aaggatatcc cttgcactac gagagggagc aaggctgggg cttcctggtt
      1750       1760       1770       1780       1790       1800
ccatttcgca gcgattcaga aggagtagat cgactgccca tggagcaact tctggcgcac
      1810       1820       1830       1840       1850       1860
tgtccagtgc cggagtttgc tcgcctcagc gcctcgaagg cggaaagtga tatggccttt
      1870       1880       1890       1900       1910       1920
gacatgctgc ctggtcaggt tgagcagcat ttgggaaagc gggaacacta caagaagttg
      1930       1940       1950       1960       1970       1980
tcccagaagc aacaacgtct ggaaacccag taccaaggct ctggcgtgtg gtgcaacaaa
      1990       2000       2010       2020       2030       2040
gtactggatg attgctgctt cttcctcaag ctgccccaca agaatggacc ttcctttcgg
      2050       2060       2070       2080       2090       2100
gtgggcaacc ccctatccaa ggacttcctt aacaagttcg cagaaaacgt gctgagcagt
      2110       2120       2130       2140       2150       2160
ggtgatccat cttgtcaagc tgccgcccgc gtcatcgaca ttgcccgcat gatgtcctac
      2170       2180       2190       2200       2210       2220
tggcgcaaca atagggatcg aattatgggt cagatggtgg tctggctgga ttcgcagcaa
      2230       2240       2250       2260       2270       2280
ctaccaaatg aattcactgg cgaaaagtgc cagccaatag cctacggagc catttgtcca
      2290       2300       2310       2320       2330       2340
caagttgttg cctgtggcac tttaacacgt cgcgcgatgg aacccacatg gatgacggcc
      2350       2360       2370       2380       2390       2400
tccaattcgc gacctgatcg gctgggatcg gagctgcgct cgatggtaca ggcaccaccg
      2410       2420       2430       2440       2450       2460
ggttatagac tcgttggtgc cgatgtcgat tcgcaggagc tgtggatcgc ttccgtgctg
      2470       2480       2490       2500       2510       2520
ggtgatgcct acgcctgcgg tgagcacggt gccacgccac tcggttggat gaccctcagc
      2530       2540       2550       2560       2570       2580
ggcagtaagt cgaatggcag cgatatgcac tccataacgg caaaggcggt cggcatttcc
      2590       2600       2610       2620       2630       2640
cgagatcacg ccaaagtgat caactatgcc cggatctacg gagctggtca attgtttgcc
      2650       2660       2670       2680       2690       2700
gagaccctgc tccgtcagtt taatcccaca ttcagtgcat ccgaggcgaa ggccaaggca
      2710       2720       2730       2740       2750       2760
atgaaaatgt tctccatcac aaagggcaag cgagtgtatc gattgcgaga ggagtttcat
      2770       2780       2790       2800       2810       2820
gacgaactgg aggacagggc ctacagcagc tacgaggctt cccgactggc cattcaacgc
      2830       2840       2850       2860       2870       2880
aaccgcaccc tggcagaggt atttcatcgt cccaactggc agggaggcac ggaaagcgcc
      2890       2900       2910       2920       2930       2940
atgttcaatc gcctggaaga gattgccacg ggatcgcagc cacgaacgcc gttcctgggc
      2950       2960       2970       2980       2990       3000
ggacgtctta gtcgagcatt ggaggcggat actggaccgg agcaggagca acgtttcctg
      3010       3020       3030       3040       3050       3060
ccaacgcgca tcaattgggt ggtacagagc ggtgcagtgg acttccttca tctgatgctg
      3070       3080       3090       3100       3110       3120
gtgagcatgc gatggctgat gggatcgcat gttagattct gcttgagctt ccatgatgaa
      3130       3140       3150       3160       3170       3180
ttgcgctact tggtcaagga agagctatcg cccaaagcgg cgctggccat gcacatcaca
      3190       3200       3210       3220       3230       3240
aacctaatga cgcgctcctt ttgtgtgtcc cgcatcggac tgcaggatct gcccatgtcg
      3250       3260       3270       3280       3290       3300
gtggccttct tctcgtccgt ggaggtagac actgtgctgc gcaaggagtg caccatggac
      3310       3320       3330       3340       3350       3360
tgcaagacgc cctcgaatcc gcatggcctg cgcatcggct atggtattca gcctggtcag
      3370       3380       3390       3400       3410       3420
agcttgagcg tagcggaggc aatcgagaag gctggaggca acgatgtcag tcagtgggat
      3430
tggataaaga agagttag    

Last modification date: Oct. 2, 2011