Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA polymerase gamma


DESCRIPTION:
Involved in the replication of mitochondrial DNA.

MISCELLANEOUS:
Present with 377 molecules/cell in log phase SD medium.
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-A family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MTKLMVRSEC MLRMVRRRPL RVQFCARWFS TKKNTAEAPR INPVGIQYLG ESLQRQVFGS
        70         80         90        100        110        120
CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP LPPLQGRSLD EHFQKIGRFN
       130        140        150        160        170        180
SEPYKSFCED KFTEMVARPA EWLRKPGWVK YVPGMAPVEV AYPDEELVVF DVETLYNVSD
       190        200        210        220        230        240
YPTLATALSS TAWYLWCSPF ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF
       250        260        270        280        290        300
RDSKAFFLDT QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS
       310        320        330        340        350        360
ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA TSQVFDEIFP
       370        380        390        400        410        420
VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL YQQSKVQIES KIVQIIKDIV
       430        440        450        460        470        480
LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI
       490        500        510        520        530        540
TIKSRIIPIL FKLSWENSPV IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT
       550        560        570        580        590        600
HNLGLQCTGV LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY
       610        620        630        640        650        660
WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM GTITRRAVEN
       670        680        690        700        710        720
AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW IASLVGDSIF NVHGGTAIGW
       730        740        750        760        770        780
MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI FNYGRIYGAG AKFASQLLKR FNPSLTDEET
       790        800        810        820        830        840
KKIANKLYEN TKGKTKRSKL FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM
       850        860        870        880        890        900
KKNLRANSFL PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE
       910        920        930        940        950        960
KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV NMDCITPSNK
       970        980        990       1000       1010       1020
TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY REPVFEEYNK SYTPEFLKYF
      1030       1040       1050       1060       1070       1080
LAMQVQSDKR DVNRLEDEYL RECTSKEYAR DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN
      1090       1100       1110       1120       1130       1140
FLDGTKNAKA DQRIRLPVNM PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT
      1150       1160       1170       1180       1190       1200
RKKNTTPMER KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS
      1210       1220       1230       1240       1250
NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI SREY

Encoded by MIP1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgacgaaat tgatggttag atctgaatgc atgctgcgaa tggtgcggcg gcggccgctg
        70         80         90        100        110        120
cgtgtgcagt tttgtgctcg atggttctcc acaaagaaga ataccgcaga agcacccagg
       130        140        150        160        170        180
attaatcctg tggggataca gtatttaggt gagtctttgc aaagacaggt atttggtagt
       190        200        210        220        230        240
tgcggtggta aagatgaggt ggagcaaagc gacaaactta tggagttatc gaaaaagtcg
       250        260        270        280        290        300
ctaaaggacc atgggttgtg ggggaagaag acgctcatca cggatccaat atcgtttcct
       310        320        330        340        350        360
ctgccgccac tacaaggcag gtcgctagat gagcatttcc agaagattgg gcgtttcaat
       370        380        390        400        410        420
tctgaaccgt acaagagttt ttgcgaggac aagttcacgg agatggtggc acgaccggcg
       430        440        450        460        470        480
gaatggctgc ggaagccagg ctgggttaaa tacgtacctg gaatggcacc cgtcgaagtg
       490        500        510        520        530        540
gcatacccag acgaagagct ggtggtgttt gatgtagaaa cactctataa cgtctctgac
       550        560        570        580        590        600
tatccgactt tggccacggc cttgtcatcg acggcgtggt acctttggtg ttcgccgttc
       610        620        630        640        650        660
atatgtggtg gtgatgatcc tgctgcactg atacccctaa acacattgaa taaagagcaa
       670        680        690        700        710        720
gtaataattg gtcacaatgt tgcgtatgat agggcacggg ttctcgaaga atacaacttc
       730        740        750        760        770        780
agggactcga aggcgttttt cctcgacact caatctctgc atattgcatc tttcgggctg
       790        800        810        820        830        840
tgttcaagac aacgtccgat gttcatgaag aataacaaga aaaaagaggc agaagtggaa
       850        860        870        880        890        900
tcggaagtac atccagaaat ttccatagaa gattatgacg acccttggtt aaatgtgtct
       910        920        930        940        950        960
gctttaaact cgctaaagga tgtagcgaaa tttcactgca agatagatct tgataagact
       970        980        990       1000       1010       1020
gatagagatt tctttgcttc cacagataaa tcaacgataa tagaaaattt ccaaaaactg
      1030       1040       1050       1060       1070       1080
gtcaactact gcgccactga cgtaacggcc acaagccaag tgtttgatga gattttccct
      1090       1100       1110       1120       1130       1140
gttttcctga aaaagtgtcc tcatccagtt tcgtttgcag gtttaaagtc cttaagcaaa
      1150       1160       1170       1180       1190       1200
tgcattctgc cgacgaagct aaacgactgg aatgattact tgaacagctc tgagtctttg
      1210       1220       1230       1240       1250       1260
taccaacagt ccaaagtcca gatagaatcc aaaattgttc aaatcataaa agatatcgtc
      1270       1280       1290       1300       1310       1320
ctgttgaagg acaaaccaga tttttatctc aaggatccct ggttatcaca attggattgg
      1330       1340       1350       1360       1370       1380
accaccaaac ctttaagatt gacaaagaaa ggtgttcctg caaagtgtca aaagctgccc
      1390       1400       1410       1420       1430       1440
ggctttccag aatggtatag acaacttttt ccctcaaagg acactgtaga acctaagatc
      1450       1460       1470       1480       1490       1500
actattaaat caagaataat tccgattttg ttcaagttat cgtgggagaa ttcccccgta
      1510       1520       1530       1540       1550       1560
atatggtcga aggagtctgg atggtgcttc aacgtgcccc atgaacaagt agaaacatac
      1570       1580       1590       1600       1610       1620
aaggctaaaa attatgtttt ggcagatagc gtatctcaag aggaagagga aataagaacg
      1630       1640       1650       1660       1670       1680
cataacctag gattgcaatg cacaggtgtt cttttcaaag tacctcatcc caatgggccg
      1690       1700       1710       1720       1730       1740
acttttaatt gcactaatct tttaaccaaa tcgtataacc atttttttga aaagggcgta
      1750       1760       1770       1780       1790       1800
ctaaaatctg agtcagaatt ggctcatcag gctttacaaa ttaactcttc agggtcttat
      1810       1820       1830       1840       1850       1860
tggatgtcag caagggaaag aatccaatcc caatttgtag tccccagttg taaattccct
      1870       1880       1890       1900       1910       1920
aatgagttcc agtctttgtc cgcaaaatcg tcgttaaata atgagaagac aaatgatctt
      1930       1940       1950       1960       1970       1980
gccataatta taccgaaaat cgtccccatg ggcacaatca ctagaagagc tgtggaaaat
      1990       2000       2010       2020       2030       2040
gcgtggttaa ccgcatccaa tgcaaaagca aataggatag gttccgaatt gaaaactcaa
      2050       2060       2070       2080       2090       2100
gtcaaagctc ctccaggtta ttgttttgtt ggggcggacg tggatagtga ggaattgtgg
      2110       2120       2130       2140       2150       2160
atagcatctt tagtcggtga ctccattttc aatgttcatg gtggtaccgc cattggttgg
      2170       2180       2190       2200       2210       2220
atgtgtttag aaggcactaa aaacgaaggt acagatttgc acacgaagac tgctcaaatt
      2230       2240       2250       2260       2270       2280
ttggggtgtt ctcgtaatga ggcgaaaatt tttaattatg gtagaattta cggcgctggt
      2290       2300       2310       2320       2330       2340
gctaaatttg cgagtcagtt acttaaaagg tttaacccat ctctaactga tgaagagaca
      2350       2360       2370       2380       2390       2400
aaaaaaattg cgaataagtt atatgaaaat acgaaaggta aaacgaaaag atcaaaatta
      2410       2420       2430       2440       2450       2460
ttcaaaaaat tttggtatgg tggatctgag tcaattctat tcaataaatt agaaagcatc
      2470       2480       2490       2500       2510       2520
gcggaacaag aaactccaaa gacaccggta ctgggatgtg gtattaccta ttcacttatg
      2530       2540       2550       2560       2570       2580
aagaaaaatc tgagggcgaa ttcctttcta ccttcaagaa tcaattgggc catccagtca
      2590       2600       2610       2620       2630       2640
tctggagtgg attatctaca tcttctttgt tgctccatgg aatatattat taagaaatat
      2650       2660       2670       2680       2690       2700
aaccttgagg caaggctttg catttccatc catgatgaga ttagattttt ggtgagcgaa
      2710       2720       2730       2740       2750       2760
aaggacaaat acagagctgc tatggctttg caaatcagca acatatggac gagagcaatg
      2770       2780       2790       2800       2810       2820
ttttgccagc aaatggggat aaatgaatta ccgcaaaact gtgccttttt ctcgcaagta
      2830       2840       2850       2860       2870       2880
gatattgatt ctgtcatacg taaagaagtc aatatggact gcataacccc ctcgaacaaa
      2890       2900       2910       2920       2930       2940
accgccattc ctcatgggga ggcgcttgat atcaatcaac tgctagacaa atccaatagt
      2950       2960       2970       2980       2990       3000
aaattgggta aaccaaatct cgatatcgac agcaaagtat cacaatatgc ctataactac
      3010       3020       3030       3040       3050       3060
agagaacctg tatttgaaga atataataaa tcttatactc cagagttctt aaaatatttt
      3070       3080       3090       3100       3110       3120
cttgcgatgc aagtccagtc agataagcgc gatgtgaatc ggctagaaga tgagtatctg
      3130       3140       3150       3160       3170       3180
cgggagtgta catccaaaga atacgctaga gatgggaaca ctgcagagta cagcctccta
      3190       3200       3210       3220       3230       3240
gactatataa aggatgtcga gaagggcaaa aggactaaag tacgtattat gggatccaat
      3250       3260       3270       3280       3290       3300
tttttagatg gtaccaaaaa tgccaaagct gatcaacgaa tcagattacc tgtcaatatg
      3310       3320       3330       3340       3350       3360
ccagattatc ccacacttca taaaattgct aacgattcag caatcccaga aaagcaattg
      3370       3380       3390       3400       3410       3420
ctggagaaca ggagaaagaa ggaaaacagg atagatgacg aaaataagaa aaaattaacc
      3430       3440       3450       3460       3470       3480
agaaaaaaga ataccacgcc tatggaaagg aagtacaaaa gagtgtatgg tggcaggaag
      3490       3500       3510       3520       3530       3540
gcatttgaag cgttctatga atgtgcaaat aaaccgttag actatacttt ggagacagaa
      3550       3560       3570       3580       3590       3600
aaacaattct ttaatattcc tatagatgga gtgattgacg acgttctgaa cgacaaatct
      3610       3620       3630       3640       3650       3660
aattataaaa agaaaccatc acaagcaaga acggcatcat catcgccaat aagaaagact
      3670       3680       3690       3700       3710       3720
gcgaaagcag tacattccaa aaaattgccg gcaaggaagt caagcactac aaatagaaat
      3730       3740       3750       3760
ttggttgagc tggaaaggga cattactatt tctagagagt actag 

Last modification date: Oct. 2, 2011