Homo sapiens L. (human) [HSA]

FULL NAME: DNA replication complex GINS protein SLD5


DESCRIPTION:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.

STRUCTURE SIMILARITY:
Belongs to the GINS4/SLD5 family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MTEEVDFLGQ DSDGGSEEVV LTPAELIERL EQAWMNEKFA PELLESKPEI VECVMEQLEH
        70         80         90        100        110        120
MEENLRRAKR EDLKVSIHQM EMERIRYVLS SYLRCRLMKI EKFFPHVLEK EKTRPEGEPS
       130        140        150        160        170        180
SLSPEELAFA REFMANTESY LKNVALKHMP PNLQKVDLFR AVPKPDLDSY VFLRVRERQE
       190        200        210        220
NILVEPDTDE QRDYVIDLEK GSQHLIRYKT IAPLVASGAV QLI 

Encoded by GINS4 gene

FULL NAME: GINS complex subunit 4 (Sld5 homolog)


OTHER NAME(S):
MGC14799
SLD5


DESCRIPTION:
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgaccgaag aagtggattt cctgggacag gactctgatg ggggtagtga ggaagtggtc
        70         80         90        100        110        120
ctaactcctg cagagctcat tgaaagattg gagcaggcct ggatgaatga aaagtttgcc
       130        140        150        160        170        180
cctgagctgc tggagagcaa gcctgagatt gtagaatgtg tcatggaaca gctggagcac
       190        200        210        220        230        240
atggaagaaa atctcaggag agccaaaagg gaggacctga aggtcagcat ccaccaaatg
       250        260        270        280        290        300
gagatggaga ggatccgcta cgtcctcagc agctacttgc ggtgtcgcct catgaagata
       310        320        330        340        350        360
gagaagtttt tccctcatgt ccttgagaag gaaaaaacac gtcctgaggg ggagccttcc
       370        380        390        400        410        420
agcctctcgc cggaagagtt ggcctttgcc agagagttca tggcgaacac agagtcctat
       430        440        450        460        470        480
ctgaaaaatg tcgccttgaa gcacatgccc cctaacttac agaaggtgga cctctttcgg
       490        500        510        520        530        540
gcagttccca aaccagatct agattcttac gtgtttctga gagtgagaga acgacaagaa
       550        560        570        580        590        600
aacatactgg tagaaccaga cacagatgag cagagggact acgtgattga cctggagaag
       610        620        630        640        650        660
ggctcacagc acttgatccg atacaaaacc attgcacctc tggttgcatc tggagctgtc
       670
cagctaattt aa    

Last modification date: Oct. 2, 2011