Mus musculus L. (mouse) [MMU]

FULL NAME: DNA replication complex GINS protein PSF2


DESCRIPTION:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).

STRUCTURE SIMILARITY:
Belongs to the GINS2/PSF2 family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVDVPLWLAI NLKQRQKCRL
        70         80         90        100        110        120
LPPEWMDVEK LEQMRDEERK EETFTPVPSP HYMEITKLLL NHASDNIPKA DTIRTLIKDL
       130        140        150        160        170        180
WDTRMAKLRV SADSFVRQQE AHAKLDNLTL MEISSSGAFL TQALNHMYKL RTNLQPSEST

QSQDF     

Encoded by Gins2 gene

FULL NAME: GINS complex subunit 2 (Psf2 homolog)


OTHER NAME(S):
2210013I18Rik
4833427B12Rik
AI323585
Pfs2


Nucleic acid sequence

        10         20         30         40         50         60
atggatgcgg ccgaggtgga gtttttggcc gaaaaggagt tggtgactat catcccgaac
        70         80         90        100        110        120
ttcagtctgg acaagatcta cctgatcggg ggggacctgg ggcccttcaa ccccggctta
       130        140        150        160        170        180
cccgtggacg tgcccctgtg gctggccatt aacctgaaac agagacagaa gtgccgcctg
       190        200        210        220        230        240
ttacctccgg aatggatgga tgtggagaaa ctggaacaga tgcgtgatga ggagcggaag
       250        260        270        280        290        300
gaggagacat tcaccccagt gcccagcccg cactacatgg agatcacgaa gctcctgctg
       310        320        330        340        350        360
aatcatgctt ctgacaacat ccccaaagca gacaccatcc ggacactgat caaagacctg
       370        380        390        400        410        420
tgggacacac gcatggccaa gcttcgagtg tctgctgaca gttttgtgcg gcagcaagag
       430        440        450        460        470        480
gcacatgcca agctggacaa cctgaccttg atggagatca gcagcagcgg ggccttcctc
       490        500        510        520        530        540
acccaggccc tcaaccacat gtacaagctc cgcacaaacc tccagccctc cgagagcacc
       550
cagtcgcagg acttctag    

Last modification date: Oct. 2, 2011