Homo sapiens L. (human) [HSA]

FULL NAME: DNA replication complex GINS protein PSF2


DESCRIPTION:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

STRUCTURE SIMILARITY:
Belongs to the GINS2/PSF2 family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVEVPLWLAI NLKQRQKCRL
        70         80         90        100        110        120
LPPEWMDVEK LEKMRDHERK EETFTPMPSP YYMELTKLLL NHASDNIPKA DEIRTLVKDM
       130        140        150        160        170        180
WDTRIAKLRV SADSFVRQQE AHAKLDNLTL MEINTSGTFL TQALNHMYKL RTNLQPLEST

QSQDF     

Encoded by GINS2 gene

FULL NAME: GINS complex subunit 2 (Psf2 homolog)


OTHER NAME(S):
HSPC037
PSF2
Pfs2


DESCRIPTION:
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggacgctg ccgaggtcga attcctcgcc gagaaggagc tggttaccat tatccccaac
        70         80         90        100        110        120
ttcagtctgg acaagatcta cctcatcggg ggggacctgg ggccttttaa ccctggttta
       130        140        150        160        170        180
cccgtggaag tgcccctgtg gctggcgatt aacctgaaac aaagacagaa atgtcgcctg
       190        200        210        220        230        240
ctccctccag agtggatgga tgtagaaaag ttggagaaga tgagggatca tgaacgaaag
       250        260        270        280        290        300
gaagaaactt ttaccccaat gcccagccct tactacatgg aacttacgaa gctcctgtta
       310        320        330        340        350        360
aatcatgctt cagacaacat cccgaaggca gacgaaatcc ggaccctggt caaggatatg
       370        380        390        400        410        420
tgggacactc gtatagccaa actccgagtg tctgctgaca gctttgtgag acagcaggag
       430        440        450        460        470        480
gcacatgcca agctggataa cttgaccttg atggagatca acaccagcgg gactttcctc
       490        500        510        520        530        540
acacaagcgc tcaaccacat gtacaaactc cgcacgaacc tccagcctct ggagagtact
       550
cagtctcagg acttctag    

Last modification date: Oct. 2, 2011