Homo sapiens L. (human) [HSA]

FULL NAME: DNA replication complex GINS protein PSF1


DESCRIPTION:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.

STRUCTURE SIMILARITY:
Belongs to the GINS1/PSF1 family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSGGRSDLIP
        70         80         90        100        110        120
TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN ALRFHMAAEE MEWFNNYKRS
       130        140        150        160        170        180
LATYMRSLGG DEGLDITQDM KPPKSLYIEV RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW
       190
KCEQLIRQGV LEHILS    

Encoded by GINS1 gene

FULL NAME: GINS complex subunit 1 (Psf1 homolog)


OTHER NAME(S):
KIAA0186
PSF1
RP4-691N24.2


DESCRIPTION:
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgttctgcg aaaaagccat ggaactgatc cgcgagctgc atcgcgcgcc cgaagggcaa
        70         80         90        100        110        120
ctgcctgcct tcaacgagga tggactcaga caagttctgg aggagatgaa agctttgtat
       130        140        150        160        170        180
gaacaaaacc agtctgatgt gaatgaagca aagtcaggtg gacgaagtga tttgatacca
       190        200        210        220        230        240
actatcaaat ttcgacactg ttctctgtta agaaatcgac gctgcactgt agcatacctg
       250        260        270        280        290        300
tatgaccgct tgcttcggat cagagcactc agatgggaat atggtagcgt cttgccaaat
       310        320        330        340        350        360
gcattacgat ttcacatggc tgctgaagaa atggagtggt ttaataatta taaaagatct
       370        380        390        400        410        420
cttgctactt atatgaggtc actgggagga gatgaaggtt tggacattac acaggatatg
       430        440        450        460        470        480
aaaccaccaa aaagcctata tattgaagtc cggtgtctaa aagactatgg agaatttgaa
       490        500        510        520        530        540
gttgatgatg gcacttcagt cctattaaaa aaaaatagcc agcacttttt acctcgatgg
       550        560        570        580        590
aaatgtgagc agctgatcag acaaggagtc ctggagcaca tcctgtcatg a

Last modification date: Oct. 2, 2011