Homo sapiens L. (human) [HSA]


STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP
        70         80         90        100        110        120
ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR
       130        140        150        160        170        180
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA
       190        200        210        220        230        240
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH
       250        260        270        280        290        300
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA
       310        320        330        340        350        360
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG
       370        380        390        400        410        420
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR
       430        440        450        460        470        480
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA
       490        500        510        520        530        540
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV
       550        560        570        580        590        600
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY
       610        620        630        640        650        660
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV
       670        680        690        700        710
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV

Encoded by MCM7 gene

FULL NAME: minichromosome maintenance complex component 7


OTHER NAME(S):
CDC47
MCM2
P1.1-MCM3
P1CDC47
P85MCM
PNAS146


DESCRIPTION:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcactga aggactacgc gctagagaag gaaaaggtta agaagttctt acaagagttc
        70         80         90        100        110        120
taccaggatg atgaactcgg gaagaagcag ttcaagtatg ggaaccagtt ggttcggctg
       130        140        150        160        170        180
gctcatcggg aacaggtggc tctgtatgtg gacctggacg acgtagccga ggatgacccc
       190        200        210        220        230        240
gagttggtgg actcaatttg tgagaatgcc aggcgctacg cgaagctctt tgctgatgcc
       250        260        270        280        290        300
gtacaagagc tgctgcctca gtacaaggag agggaagtgg taaataaaga tgtcctggac
       310        320        330        340        350        360
gtttacattg agcatcggct aatgatggag cagcggagtc gggaccctgg gatggtccga
       370        380        390        400        410        420
agcccccaga accagtaccc tgctgaactc atgcgcagat ttgagctgta ttttcaaggc
       430        440        450        460        470        480
cctagcagca acaagcctcg tgtgatccgg gaagtgcggg ctgactctgt ggggaagttg
       490        500        510        520        530        540
gtaactgtgc gtggaatcgt cactcgtgtc tctgaagtca aacccaagat ggtggtggcc
       550        560        570        580        590        600
acttacactt gtgaccagtg tggggcagag acctaccagc cgatccagtc tcccactttc
       610        620        630        640        650        660
atgcctctga tcatgtgccc aagccaggag tgccaaacca accgctcagg agggcggctg
       670        680        690        700        710        720
tatctgcaga cacggggctc cagattcatc aaattccagg agatgaagat gcaagaacat
       730        740        750        760        770        780
agtgatcagg tgcctgtggg aaatatccct cgtagtatca cggtgctggt agaaggagag
       790        800        810        820        830        840
aacacaagga ttgcccagcc tggagaccac gtcagcgtca ctggtatttt cttgccaatc
       850        860        870        880        890        900
ctgcgcactg ggttccgaca ggtggtacag ggtttactct cagaaaccta cctggaagcc
       910        920        930        940        950        960
catcggattg tgaagatgaa caagagtgag gatgatgagt ctggggctgg agagctcacc
       970        980        990       1000       1010       1020
agggaggagc tgaggcaaat tgcagaggag gatttctacg aaaagctggc agcttcaatc
      1030       1040       1050       1060       1070       1080
gccccagaaa tatacgggca tgaagatgtg aagaaggcac tgctgctcct gctagtcggg
      1090       1100       1110       1120       1130       1140
ggtgtggacc agtctcctcg aggcatgaaa atccggggca acatcaacat ctgtctgatg
      1150       1160       1170       1180       1190       1200
ggggatcctg gtgtggccaa gtctcagctc ctgtcataca ttgatcgact ggcgcctcgc
      1210       1220       1230       1240       1250       1260
agccagtaca caacaggccg gggctcctca ggagtggggc ttacggcagc tgtgctgaga
      1270       1280       1290       1300       1310       1320
gactccgtga gtggagaact gaccttagag ggtggggccc tggtgctggc tgaccagggt
      1330       1340       1350       1360       1370       1380
gtgtgctgca ttgatgagtt cgacaagatg gctgaggccg accgcacagc catccacgag
      1390       1400       1410       1420       1430       1440
gtcatggagc agcagaccat ctccattgcc aaggccggca ttctcaccac actcaatgcc
      1450       1460       1470       1480       1490       1500
cgctgctcca tcctggctgc cgccaaccct gcctacgggc gctacaaccc tcgccgcagc
      1510       1520       1530       1540       1550       1560
ctggagcaga acatacagct acctgctgca ctgctctccc ggtttgacct cctctggctg
      1570       1580       1590       1600       1610       1620
attcaggacc ggcccgaccg agacaatgac ctacggttgg cccagcacat cacctatgtg
      1630       1640       1650       1660       1670       1680
caccagcaca gccggcagcc cccctcccag tttgaacctc tggacatgaa gctcatgagg
      1690       1700       1710       1720       1730       1740
cgttacatag ccatgtgccg cgagaagcag cccatggtgc cagagtctct ggctgactac
      1750       1760       1770       1780       1790       1800
atcacagcag catacgtgga gatgaggcga gaggcttggg ctagtaagga tgccacctat
      1810       1820       1830       1840       1850       1860
acttctgccc ggaccctgct ggctatcctg cgcctttcca ctgctctggc acgtctgaga
      1870       1880       1890       1900       1910       1920
atggtggatg tggtggagaa agaagatgtg aatgaagcca tcaggctaat ggagatgtca
      1930       1940       1950       1960       1970       1980
aaggactctc ttctaggaga caaggggcag acagctagga ctcagagacc agcagatgtg
      1990       2000       2010       2020       2030       2040
atatttgcca ccgtccgtga actggtctca gggggccgaa gtgtccggtt ctctgaggca
      2050       2060       2070       2080       2090       2100
gagcagcgct gtgtatctcg tggcttcaca cccgcccagt tccaggcggc tctggatgaa
      2110       2120       2130       2140       2150       2160
tatgaggagc tcaatgtctg gcaggtcaat gcttcccgga cacggatcac ttttgtctga

Last modification date: Oct. 2, 2011