Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: Replication factor C subunit 1


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds to the primer-template junction (By similarity).

STRUCTURE SIMILARITY:
Belongs to the activator 1 large subunit family.
Contains 1 BRCT domain.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MQRGIDSFFK RLPAKAKSAE AENGETPSKA PKRRKAVIIS SDEDEVVSPP ETKKRKASKT
        70         80         90        100        110        120
ASSEDDVVAA TPEPIAKKAR NGQKPALSKL KRHVDPTELF GGETKRVIVP KPKTKAVLEF
       130        140        150        160        170        180
ENEDIDRSLM EVDLDESIKE AAPEKKVHSI TRSSPSPKRA KNSSPEPPKP KSTKSKATTP
       190        200        210        220        230        240
RVKKEKPAAD LESSVLTDEE RHERKRASAV LYQKYKNRSS CLNPGSKEIP KGSPDCLSGL
       250        260        270        280        290        300
TFVVTGVLES MEREEAESVI KEYGGKVMTV VGKKLKYLVV GEEAGPKKLA VAEELNIPIL
       310        320        330        340        350        360
SEDGLFDLIR EKSGIAKQVK EEKKSPKKEH SSEEKGKKEV KTSRRSSDKK EKEATKLKYG
       370        380        390        400        410        420
EKHDIAKHKV KEEHTSPKET KDKLNDVPAV TLKVKKEPSS QKEHPPSPRT ADLKTLDVVG
       430        440        450        460        470        480
MAWVDKHKPT SIKEIVGQAG AASNVTNHNL KLKAKQERVK VLHYFNFPRL MNWLSKWYVN
       490        500        510        520        530        540
HDGNKKPQRP NPWAKNDDGS FYKAALLSGP PGIGKTTTAT LVVKELGFDA VEFNASDTRS
       550        560        570        580        590        600
KRLLKDEVST LLSNKSLSGY FTGQGQAVSR KHVLIMDEVD GMAGNEDRGG MQELIALIKD
       610        620        630        640        650        660
SSIPIICMCN DRNHPKIRSL VNYCYDLRFQ RPRLEQIKGK IMSICFKEKV KISPAKVEEI
       670        680        690        700        710        720
IAATNNDIRQ SINHIALLSA KEDASQKSGQ QVATKDLKLG PWEVVRKVFT ADEHKHMSFA
       730        740        750        760        770        780
DKSDLFFHDY SLAPLFVQQN YLQVLPQGNK KDVLAKVAAT ADALSLGDLV EKRIRANSAW
       790        800        810        820        830        840
SLLPTQAFFS SVLPGEHMCG HFTGQINFPG WLGKNSKSGK RARLAQELHD HTRVCTSGSR
       850        860        870        880        890        900
LSVRLDYAPF LLDNIVRPLA KDGQEGVPAA LDVMKDYHLL REDLDSLVEL TSWPGKKSPL
       910        920        930        940        950        960
DAVDGRVKAA LTRSYNKEVM AYSYSAQAGI KKKKSEAAGA DDDYLDEGPG EEDGAGGHLS
       970        980        990       1000
SEEDEDKDNL ELDSLIKAKK RTTTSKASGG SKKATSSTAS KSKAKAKK 

Encoded by Gnf1 gene

FULL NAME: Germ line transcription factor 1


OTHER NAME(S):
CG1119
Dmel\CG1119
DmRFC1
dRF-Cp140
Gnf-1
gnf1
GTF-1
gtf1
Gtf1
ONF-CAACAA
RF-C 140
RfC
RFC
RFC1
RfC140


Nucleic acid sequence

        10         20         30         40         50         60
atgcaacgcg gcattgactc ctttttcaaa cggctgccgg ccaaggcgaa aagtgccgag
        70         80         90        100        110        120
gccgaaaatg gagagacgcc gtcgaaggcg ccaaaacgca ggaaagccgt gataatttcc
       130        140        150        160        170        180
agcgacgagg acgaggtggt cagtccgccg gagaccaaga aacgcaaggc ttcgaagaca
       190        200        210        220        230        240
gcatccagcg aggatgatgt ggtggccgcc acaccggaac cgattgcgaa gaaggccagg
       250        260        270        280        290        300
aacgggcaga aaccagcgct ctccaagctt aagcggcacg tagatcctac ggagcttttc
       310        320        330        340        350        360
ggtggagaaa ccaaacgggt gattgtgccc aagccgaaga ccaaagctgt tctcgagttc
       370        380        390        400        410        420
gagaacgaag acattgaccg gagtttaatg gaagttgatc tggacgagag tatcaaagag
       430        440        450        460        470        480
gctgcccccg aaaaaaaggt tcactcgata accaggagct ctccctcgcc taaaagagca
       490        500        510        520        530        540
aagaacagca gcccggaacc gccaaaaccc aagtcaacaa aatccaaagc caccactccg
       550        560        570        580        590        600
cgtgtgaaga aggagaaacc tgcggcagat ctagaatcca gtgtcctaac agacgaggaa
       610        620        630        640        650        660
cgccacgagc gtaaacgtgc ttccgccgtg ctctaccaga agtacaaaaa ccgcagttcg
       670        680        690        700        710        720
tgcctgaacc ccggcagcaa agaaattcca aagggatccc cggattgtct gagtggctta
       730        740        750        760        770        780
acctttgtcg taaccggagt cctcgagtcc atggaacgag aggaggcgga gtccgtgatc
       790        800        810        820        830        840
aaggagtatg gcggaaaggt gatgaccgtg gttggaaaga aactcaagta tctggtcgta
       850        860        870        880        890        900
ggagaagagg ctggaccaaa gaaattagct gtggctgagg aactcaatat acccattctc
       910        920        930        940        950        960
agcgaggacg ggctcttcga tctaatcagg gagaaatcag gaatcgctaa gcaggtaaag
       970        980        990       1000       1010       1020
gaagagaaga aaagcccgaa gaaggagcac agctccgagg agaaagggaa aaaggaagtc
      1030       1040       1050       1060       1070       1080
aagacttcta gaaggtccag tgataaaaag gagaaggaag ccactaaact gaaatatggc
      1090       1100       1110       1120       1130       1140
gagaagcatg atatcgccaa acataaagtc aaggaagaac acacttcccc gaaggagacg
      1150       1160       1170       1180       1190       1200
aaggataagc ttaatgatgt accagctgtt accttgaaag taaaaaaaga gcccagctcc
      1210       1220       1230       1240       1250       1260
cagaaagaac accctccgtc gccaagaact gccgatctga agactctgga tgtggtcggg
      1270       1280       1290       1300       1310       1320
atggcctggg tggacaagca caagcctacg agcataaaag aaatcgttgg ccaggcagga
      1330       1340       1350       1360       1370       1380
gccgccagca acgtgaccaa tcacaatttg aaactgaaag ccaaacagga gagggttaaa
      1390       1400       1410       1420       1430       1440
gttttacatt attttaattt tcctaggctg atgaactggt tgtccaagtg gtatgttaac
      1450       1460       1470       1480       1490       1500
catgatggaa acaagaagcc ccaacggccc aatccttggg ccaagaacga cgacggcagc
      1510       1520       1530       1540       1550       1560
ttctacaagg cggccctact ttcgggaccc cctggaatag gaaagaccac gacggcgact
      1570       1580       1590       1600       1610       1620
ctggtagtga aggagcttgg cttcgatgcg gtggagttca acgcctccga cacacgcagc
      1630       1640       1650       1660       1670       1680
aaacgcttgc tcaaggatga agtgtccacg ctgctgagca acaaatccct ctccggttac
      1690       1700       1710       1720       1730       1740
tttacagggc aaggccaagc ggtctcccgc aagcatgtgc tcataatgga cgaagttgat
      1750       1760       1770       1780       1790       1800
ggcatggccg gtaacgagga ccgtggtgga atgcaggagc tgattgcctt gatcaaggat
      1810       1820       1830       1840       1850       1860
agctctattc caattatttg catgtgtaat gatcgcaacc atccaaaaat tcgatccctg
      1870       1880       1890       1900       1910       1920
gttaactatt gctacgatct gcgatttcag aggcctcgcc tcgagcaaat caaagggaaa
      1930       1940       1950       1960       1970       1980
ataatgagca tctgctttaa ggaaaaagta aagatatcac cggccaaagt ggaagaaatc
      1990       2000       2010       2020       2030       2040
atagcggcta ccaacaacga tattcggcaa tccattaacc acattgccct gctgagcgcc
      2050       2060       2070       2080       2090       2100
aaggaagacg cttcccaaaa gtcagggcag caggttgcca ccaaggatct gaagctggga
      2110       2120       2130       2140       2150       2160
ccctgggagg tggtgcgaaa agtcttcacc gcggacgagc acaaacacat gtcttttgcc
      2170       2180       2190       2200       2210       2220
gacaagagcg accttttctt tcacgactac agcctggccc cgctctttgt gcagcaaaac
      2230       2240       2250       2260       2270       2280
tatctgcagg tcctaccaca gggaaacaaa aaggatgtcc tggcaaaggt ggcagctacg
      2290       2300       2310       2320       2330       2340
gcagatgccc taagcttggg tgaccttgtt gaaaagcgta ttcgtgcgaa ttctgcttgg
      2350       2360       2370       2380       2390       2400
agtcttctac ccactcaggc ctttttcagc tcggtccttc ctggcgagca catgtgtggc
      2410       2420       2430       2440       2450       2460
cacttcactg gacagattaa ctttcccggg tggctgggca agaattccaa gtctggaaaa
      2470       2480       2490       2500       2510       2520
cgtgccaggc tggcccagga gctgcatgat catactaggg tctgcacctc gggctcaagg
      2530       2540       2550       2560       2570       2580
ctatcagtga ggctggatta cgcccccttc cttctggata atattgtgcg acctcttgca
      2590       2600       2610       2620       2630       2640
aaggatgggc aggagggtgt gcccgctgct ttagacgtta tgaaggatta ccatctactc
      2650       2660       2670       2680       2690       2700
cgtgaggatc tggactcgct ggtcgagctt acatcctggc ccggcaagaa atccccactg
      2710       2720       2730       2740       2750       2760
gacgcagtgg atgggagagt aaaagccgct ttaacgcgat cctacaacaa ggaggttatg
      2770       2780       2790       2800       2810       2820
gcatactcct attccgctca agcaggcatc aaaaagaaga aatcagaggc tgctggagcg
      2830       2840       2850       2860       2870       2880
gatgacgatt acttggacga gggtccgggc gaagaggacg gagctggtgg ccacttatca
      2890       2900       2910       2920       2930       2940
tcagaggaag acgaggacaa ggacaaccta gagctggata gtttgatcaa agccaaaaag
      2950       2960       2970       2980       2990       3000
aggacaacta cgtcaaaagc gtctggtgga tccaaaaagg ctacatcttc cacggcttca
      3010       3020
aagtctaagg ccaaggccaa aaagtga   

Last modification date: Oct. 2, 2011