Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: Proliferating cell nuclear antigen


DESCRIPTION:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

STRUCTURE SIMILARITY:
Belongs to the PCNA family.


SUBUNIT STRUCTURE:
Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Interacts with E2f.


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MFEARLGQAT ILKKILDAIK DLLNEATFDC SDSGIQLQAM DNSHVSLVSL TLRSDGFDKF
        70         80         90        100        110        120
RCDRNLSMGM NLGSMAKILK CANNEDNVTM KAQDNADTVT IMFESANQEK VSDYEMKLMN
       130        140        150        160        170        180
LDQEHLGIPE TDFSCVVRMP AMEFARICRD LAQFSESVVI CCTKEGVKFS ASGDVGTANI
       190        200        210        220        230        240
KLAQTGSVDK EEEAVIIEMQ EPVTLTFACR YLNAFTKATP LSTQVQLSMC ADVPLVVEYA
       250        260
IKDLGHIRYY LAPKIEDNET    

Encoded by mus209 gene

FULL NAME: mutagen-sensitive 209


OTHER NAME(S):
53/13
CG9193
Dmel\CG9193
DmPCNA
dPCNA
l(2)02448
l(2)56F
l(2)56Fa
l(2)s1534
Mus209
pcna
Pcna
PCNA
PCNA/mus209


Nucleic acid sequence

        10         20         30         40         50         60
atgttcgagg cacgcctggg tcaagccacc atcctgaaga agatcttgga tgccatcaag
        70         80         90        100        110        120
gatctgctca atgaggcaac cttcgattgc agcgactccg gcattcagct acaggccatg
       130        140        150        160        170        180
gacaactccc atgtgtcgct tgtctcgctg accctgcgtt ccgatggctt cgacaagttt
       190        200        210        220        230        240
cgctgcgacc gcaatctctc catgggcatg aatctgggca gcatggccaa gattctgaaa
       250        260        270        280        290        300
tgcgccaaca acgaggacaa tgtgacgatg aaggcgcagg ataacgccga cactgtcacc
       310        320        330        340        350        360
atcatgttcg aatcggctaa ccaggagaag gtatcggact acgagatgaa actgatgaac
       370        380        390        400        410        420
ctcgaccagg agcacctggg cataccggag acagacttct cgtgcgtggt ccgcatgccg
       430        440        450        460        470        480
gccatggagt tcgctcgcat ctgccgcgat ctggcgcagt tcagcgaatc cgttgtgatc
       490        500        510        520        530        540
tgctgcacca aggagggcgt caagttctcg gccagcggcg atgtgggcac cgccaacatt
       550        560        570        580        590        600
aagctagccc aaaccggctc tgtcgacaag gaggaggagg cggtgatcat cgagatgcag
       610        620        630        640        650        660
gagccggtga cgctgacatt tgcctgtcgc tacctgaacg ccttcacaaa ggcgacgcca
       670        680        690        700        710        720
ttgtccaccc aagtgcagct gtcgatgtgc gcagatgttc cgctggtagt cgagtatgcg
       730        740        750        760        770        780
atcaaggatc tgggtcacat tcgctactac ctggcaccca agatcgagga caacgagaca

taa     

Last modification date: Oct. 7, 2011