Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA replication licensing factor Mcm7


DESCRIPTION:
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MARRDYAQDR ESIKTFLSEF CKCDDDGKKE FVYGSQLVKL AHREQVLITI DLDDLAEFNE
        70         80         90        100        110        120
SLAEAVVDNC RRYTSIFSDV IAELLPSYKQ QEVHAKDALD VYIEHRLMME SRTRNPMEQR
       130        140        150        160        170        180
DERNSFPSEL MKRFEVGFKP LSTEKAHSIR EVKAQHIGKL VTVRGIVTRC TEVKPMMVVA
       190        200        210        220        230        240
TYTCDRCGSE TYQPVNSLSF TPVHDCPSDD CRVNKAGGRL YLQTRGSKFV KFQEVKMQEH
       250        260        270        280        290        300
SDQVPVGHIP RSMTIMCRGE VTRMAQPGDH IVVSGVFLPL MRTGFAQMIQ GLLSETFLQA
       310        320        330        340        350        360
HRIICINKND EISDKDAELT PEELEELAQD DFYERLATSL APEIYGHLDV KKALLLLLVG
       370        380        390        400        410        420
GVDKRPDGMK IRGNINICLM GDPGVAKSQL LGYISRLAVR SQYTTGRGSS GVGLTAAVMK
       430        440        450        460        470        480
DPLTGEMTLE GGALVLADQG VCCIDEFDKM ADQDRTAIHE VMEQQTISIA KAGIMTTLNA
       490        500        510        520        530        540
RVSILAAANP AFGRYNPRRT VEQNIQLPAA LLSRFDLLWL IQDKPDRDND LRLAKHITYV
       550        560        570        580        590        600
HSHSKQPPTR VKALDMNLMR RYINLCKRKN PTIPDELTDY IVGAYVELRR EARNQKDMTF
       610        620        630        640        650        660
TSARNLLGIL RLSTALARLR LSDSVEKDDV AEALRLLEMS KDSLNQIHEH QKGHVPNTSD
       670        680        690        700        710        720
RIFAIVRELA GSGKAVKISD IMDRCTTKGF KPDQVDKCID DYEELNVWQV NMGRTKITFM

Encoded by Mcm7 gene

FULL NAME: Minichromosome maintenance 7


OTHER NAME(S):
anon-EST:Liang-1.66
CG4978
clone 1.66
Dmel\CG4978
DmeMCM7
DmMCM7
mcm7
McM7
MCM7
Mcp-PCR1
PCR1


Nucleic acid sequence

        10         20         30         40         50         60
atggctcgac gagattatgc ccaagaccga gaatctatca agaccttcct ttcggaattc
        70         80         90        100        110        120
tgcaagtgcg acgatgatgg caaaaaggag ttcgtctacg gatctcagct ggtgaagttg
       130        140        150        160        170        180
gcccatcgag agcaagttct gatcaccatc gatctggatg atctggcgga attcaatgaa
       190        200        210        220        230        240
agtctcgcgg aggcggtggt cgacaattgt cggcgataca cgtccatatt cagcgatgta
       250        260        270        280        290        300
attgctgaac tcctgcccag ctacaaacag caggaggtac acgccaagga tgctctggat
       310        320        330        340        350        360
gtgtacattg agcaccgcct gatgatggag tcccgcacca ggaatcccat ggaacagcgc
       370        380        390        400        410        420
gatgagcgga actctttccc ctcggagctg atgaagcgat tcgaggtggg cttcaaacca
       430        440        450        460        470        480
ctgtccacag agaaggcgca ctctattcgc gaggttaagg cccagcacat tggtaaactg
       490        500        510        520        530        540
gtcaccgttc gcggcattgt tacacgctgc acggaggtta agcccatgat ggtggttgcc
       550        560        570        580        590        600
acctacacat gcgatcgctg tggctcggag acgtatcagc cagttaactc gctatccttc
       610        620        630        640        650        660
acgcccgtgc acgattgccc gtcggatgat tgccgagtga acaaagcggg aggtcgtctg
       670        680        690        700        710        720
tatctgcaga cccgcggctc caagttcgtc aagttccagg aggtcaaaat gcaggagcac
       730        740        750        760        770        780
agcgaccagg tgcccgtggg ccacattccg cgcagcatga ccatcatgtg caggggtgag
       790        800        810        820        830        840
gtcactcgaa tggcccagcc tggggatcac attgtggtct ctggagtgtt cttgccacta
       850        860        870        880        890        900
atgcgcacag gtttcgctca gatgattcag ggtttgctct cggagacatt ccttcaagct
       910        920        930        940        950        960
caccgcatca tctgtatcaa caagaacgac gagatttcgg acaaggatgc cgagctgact
       970        980        990       1000       1010       1020
ccagaagagc tggaggaatt ggcccaggat gacttctacg agcgcttggc caccagcttg
      1030       1040       1050       1060       1070       1080
gcacccgaaa tctatggcca tttggatgtt aagaaagcgc tgctcttgct gttggtcgga
      1090       1100       1110       1120       1130       1140
ggagttgaca agcggcccga tggcatgaag attcgtggca acattaacat ctgcctgatg
      1150       1160       1170       1180       1190       1200
ggagatcccg gtgtggccaa gtcgcagctg ctgggctaca ttagccgatt ggccgtgcga
      1210       1220       1230       1240       1250       1260
tcgcagtaca ccacagggcg aggttcttcg ggggtgggtc ttaccgctgc ggtcatgaag
      1270       1280       1290       1300       1310       1320
gaccctctca caggcgagat gacattggaa ggaggagctc ttgtgctggc tgatcaggga
      1330       1340       1350       1360       1370       1380
gtctgctgca ttgatgagtt cgacaagatg gcggatcagg atcgtacagc cattcacgag
      1390       1400       1410       1420       1430       1440
gtgatggaac agcagaccat ttcgatagcc aaagcaggca tcatgacgac cctaaacgct
      1450       1460       1470       1480       1490       1500
cgcgtttcca tcctggccgc tgctaatccc gcttttggac gctacaatcc tcgtcgtacc
      1510       1520       1530       1540       1550       1560
gtggagcaga acattcagct tcccgcagcc ctgctctcac gtttcgatct gctgtggctc
      1570       1580       1590       1600       1610       1620
atccaggata aaccggatcg cgataatgat ttgcgcttgg ccaagcacat aacctatgtg
      1630       1640       1650       1660       1670       1680
catagccaca gcaaacagcc acccactcga gtaaaggctc tggacatgaa tcttatgcgg
      1690       1700       1710       1720       1730       1740
cgctacatta acctgtgcaa gcgcaagaat ccaactattc cggatgagct caccgactac
      1750       1760       1770       1780       1790       1800
attgtgggag cttatgtgga gttgcgtcgg gaggcgcgca accagaagga catgaccttc
      1810       1820       1830       1840       1850       1860
acctcggcac gtaacttgtt gggaatcctg cggttgtcca ccgctttggc taggttgcgt
      1870       1880       1890       1900       1910       1920
ctttccgata gcgtggagaa agatgatgtg gctgaagcac tgcgtctgct ggagatgtct
      1930       1940       1950       1960       1970       1980
aaggactcgc tcaaccaaat ccacgagcac cagaagggac acgtacccaa cacttcggat
      1990       2000       2010       2020       2030       2040
cgaatctttg ccatcgttcg tgaactggct ggctctggaa aggcagtcaa aatctccgac
      2050       2060       2070       2080       2090       2100
atcatggacc gctgcacaac caaaggattc aagcccgacc aggtggacaa atgcatcgat
      2110       2120       2130       2140       2150       2160
gattacgagg agctcaatgt ctggcaggtc aacatgggac gcacgaagat cacattcatg

tag     

Last modification date: Oct. 2, 2011