Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA replication licensing factor Mcm5


DESCRIPTION:
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MEGFDDAGVF FSDNFGGDNQ QDAQINLQAV KKKYKEFIRT FNEENFFYKY RDTLKRNYLN
        70         80         90        100        110        120
GRYFLEIEME DLVGFDETLA DKLNKQPTEH LEIFEEAARE VADEITAPRP EHEEHMHDIQ
       130        140        150        160        170        180
ILLSSNANPT NIRQLKSDCV SKLVKIAGII VAASGISAKA TRMSIQCLSC STVIPNLKVN
       190        200        210        220        230        240
PGLEGYALPR KCNTEQAGRP KCPLDPFFIM PDKCKCVDFQ TLKLQELPDF VPQGEIPRHL
       250        260        270        280        290        300
QLFCDRSLCE RVVPGNRVLI QGIYSIRKVG KPSRRDGREK AVVGVRAPYM RVVGITVDSE
       310        320        330        340        350        360
GAGAISRYSN ITSDEEEHFR RMAASGDIYE RLSQSLAPSI FGSRDIKKAI TCMLFGGSRK
       370        380        390        400        410        420
RLPDGLCRRG DINVLLLGDP GTAKSQLLKF VEKVAPIAVY TSGKGSSAAG LTASVMKDPQ
       430        440        450        460        470        480
TRNFVMEGGA MVLADGGVVC IDEFDKMRED DRVAIHEAME QQTISIAKAG ITTTLNSRCS
       490        500        510        520        530        540
VLAAANSIFG RWDDTKGEEN IDFMPTILSR FDMIFIVKDI HDESRDITLA KHIINVHLSS
       550        560        570        580        590        600
NKSAPSEPAE GEISLSTFKK YIHYCRTHCG PRLSEAAGEK LKSRYVLMRS GAGQQEKASD
       610        620        630        640        650        660
KRLSIPITVR QLEAVIRISE SLAKIRLQPF ATDEHVNEAL RLFQVSTLDA AMTGSLAGAE
       670        680        690        700        710        720
GFTTEEDQET LNRIEKQLKR RFAIGSQVSE QNILQDFLRQ KYEERTVMKV IHTMIRRGEL
       730
QHRMQRKMLY RIC    

Encoded by Mcm5 gene

FULL NAME: Minichromosome maintenance 5


OTHER NAME(S):
CG4082
DmCDC46
DmCDC465
Dmel\CG4082
DmeMCM5
DmMcm5
DmMCM5
mcm5
McM5
MCM5
PCR4


Nucleic acid sequence

        10         20         30         40         50         60
atggaaggct tcgacgatgc gggtgtgttc ttttcggaca atttcggcgg agataaccag
        70         80         90        100        110        120
caggatgcgc aaatcaactt gcaggcggta aagaagaagt acaaggagtt catccggaca
       130        140        150        160        170        180
tttaacgagg agaacttttt ctacaaatac cgtgacaccc tgaagaggaa ctatcttaat
       190        200        210        220        230        240
ggtcgctact tcttggagat tgagatggag gatttggtgg gcttcgatga gaccttggct
       250        260        270        280        290        300
gacaagctga acaagcagcc gacggagcat ttggaaatct tcgaggaggc tgcccgggag
       310        320        330        340        350        360
gtagccgacg agatcacagc tccccggccg gagcacgagg aacatatgca cgacatccag
       370        380        390        400        410        420
attcttctga gctccaatgc gaatcccacc aacatacgac agttgaagtc ggactgcgta
       430        440        450        460        470        480
tccaagctgg ttaagatcgc cggaatcatt gtcgcagcct caggaataag tgccaaggct
       490        500        510        520        530        540
acgcggatgt ctatccaatg cctgtcctgc agcacggtca taccgaatct caaagtgaat
       550        560        570        580        590        600
ccaggtttgg agggctacgc cctacccagg aagtgcaaca cggagcaggc gggcagaccc
       610        620        630        640        650        660
aagtgcccgc tggacccctt cttcatcatg ccggacaagt gcaagtgcgt cgatttccag
       670        680        690        700        710        720
acccttaagt tgcaagagct ccccgacttt gtgccacagg gtgagattcc ccgccacttg
       730        740        750        760        770        780
cagctcttct gcgatcgctc gctctgtgaa cgcgtggtgc ccggcaatcg cgtgcttatc
       790        800        810        820        830        840
cagggcatat actccattcg caaggtgggc aaaccctcgc gtcgggatgg tcgcgagaaa
       850        860        870        880        890        900
gccgtcgttg gagtccgtgc tccttacatg agggtggtgg gcatcaccgt cgactcagag
       910        920        930        940        950        960
ggtgcgggtg ccatctcccg atacagcaac atcacatccg atgaggagga gcacttccgg
       970        980        990       1000       1010       1020
cgaatggccg cctctgggga catctacgaa cgtctctcac agtcactggc gcccagcatc
      1030       1040       1050       1060       1070       1080
ttcggctctc gggatatcaa gaaagctata acttgtatgc tttttggcgg gtctcgtaag
      1090       1100       1110       1120       1130       1140
cgtttaccgg atggtctgtg ccgtcgaggc gacattaacg tcttactgct gggagatcct
      1150       1160       1170       1180       1190       1200
ggtactgcca agtcacagtt gttaaagttt gtggagaagg tggcacccat agcagtctac
      1210       1220       1230       1240       1250       1260
acttcgggca aaggctccag tgcggctggt ctcacggctt cggttatgaa ggatcctcaa
      1270       1280       1290       1300       1310       1320
acgcgtaact ttgtcatgga gggtggagcc atggtgctgg ccgatggagg cgtggtttgt
      1330       1340       1350       1360       1370       1380
attgatgagt tcgacaaaat gcgagaggat gatcgtgtgg ccattcacga ggccatggaa
      1390       1400       1410       1420       1430       1440
cagcagacaa tatccattgc caaagccggc atcacgacca ccttgaactc acgctgttcg
      1450       1460       1470       1480       1490       1500
gtcttggcag ctgccaactc cattttcggt cgatgggacg acaccaaggg cgaggagaac
      1510       1520       1530       1540       1550       1560
attgacttta tgcccacaat tctctcccgt ttcgacatga ttttcattgt aaaggatatt
      1570       1580       1590       1600       1610       1620
cacgatgagt cgcgggacat tacgctggcc aagcacatca tcaacgtgca tctgagctct
      1630       1640       1650       1660       1670       1680
aacaagtcag cgccttcaga gccggctgag ggtgagatat cgctgtcgac gttcaagaag
      1690       1700       1710       1720       1730       1740
tatattcact actgccgaac tcattgcggt ccgcgcctga gcgaagctgc cggcgagaag
      1750       1760       1770       1780       1790       1800
ctaaagagcc gctacgtgct tatgcgcagt ggagccggcc agcaggagaa ggcatctgac
      1810       1820       1830       1840       1850       1860
aagcggctaa gcattcccat cactgtgcgt cagttggagg ctgtcatccg catttcggag
      1870       1880       1890       1900       1910       1920
tcgctggcaa agattcgttt gcaaccgttc gccacagatg agcacgtgaa cgaagcactt
      1930       1940       1950       1960       1970       1980
cgacttttcc aagtgtctac ccttgatgct gcgatgactg gcagcttggc tggagccgaa
      1990       2000       2010       2020       2030       2040
ggattcacga ccgaggagga ccaggaaaca ctcaaccgca tcgaaaagca attgaaacgt
      2050       2060       2070       2080       2090       2100
cgctttgcaa ttggatctca agtatcggag cagaatatct tacaggactt tttgcgtcag
      2110       2120       2130       2140       2150       2160
aaatacgaag aacgcacggt aatgaaggta attcatacca tgatccgacg tggagagctg
      2170       2180       2190       2200
cagcaccgga tgcaacggaa gatgctctat cgaatttgct aa 

Last modification date: Oct. 2, 2011