Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA replication licensing factor MCM4


DESCRIPTION:
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Essential role in mitotic DNA replication but not in endoreplication.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSSPARSPSV GGATPKQGAR TPTRGIASQD VETPMRMGPG RAVRPSDNIS LPPTSPGNIS
        70         80         90        100        110        120
LPATSPARGL GANMSEIDLS SPLNYGTPSS MGSIRTPRSG IRGTPLRARP DIRTDKRIRQ
       130        140        150        160        170        180
VAIGGGSGLE PIPEKGSETT DPVSESSQAP QLVVWGTNVV VSQCKSKFKS FIMRFIDPSA
       190        200        210        220        230        240
EQDEISENID VNQPLYLQKL EEIHTLEEPY LNLNCAHLKT FDQDLYRQLI CYPQEVIPGF
       250        260        270        280        290        300
DMAINEMFFE RYPAALLEHQ IQVRPFNADK TRNMRSLNPE DMDQLISISG MVIRSSNVIP
       310        320        330        340        350        360
EMREAFFSCN ICSFSTTVEV DRGRINQPTL CTNCNTNHCF RLIHNRSEFT DKQLVKLQES
       370        380        390        400        410        420
PDDMAAGQTP HNVLLYAHND LVDKVQPGDR VTVTGIYRAT PLKTGGLSSS VKSVYKTHVD
       430        440        450        460        470        480
VVHFRKVDNK RLYEDEEGKD HIFPPERVEL LQLLAKKPDI YDRLARAIAP SIYENDDIKK
       490        500        510        520        530        540
GILLQLFGGT KKKHATLGRQ NFRSEIHLLL CGDPGTSKSQ MLQYVFNLVP RSQYTSGRGS
       550        560        570        580        590        600
SAVGLTAYVT KDPETRQLVL QTGALVLADN GVCCIDEFDK MNDSTRSVLH EVMEQQTLSI
       610        620        630        640        650        660
AKAGIICQLN ARTSILAAAN PAESQWNKRK NIIDNVQLPH TLLSRFDLIF LVLDPQDEIF
       670        680        690        700        710        720
DKRLASHLVS LYYVTRHEEE DTMFDMSVLR DYIAYAREHL SPTLSDEAQQ RLIQAYVDMR
       730        740        750        760        770        780
KVGAGRGQIS AYPRQLESLI RLSEAHAKVR LSNQVELLDV EEAWRLHREA LKQSATDPLS
       790        800        810        820        830        840
GKIDVGILTT GLSTAARKKR ADLVAAIKEN LKKKGKVLTV PYQKLFSDIK EGSQIMITRE
       850        860
QFEDALKEVQ DEGAIVVMGK NTIRIC   

Encoded by dpa gene

FULL NAME: disc proliferation abnormal


OTHER NAME(S):
43Ca
CG1616
Dmel\CG1616
DmeMCM4
DmMcm4
DmMCM4
Dpa
l(2)43Ca
mcm4
Mcm4
MCM4
MCM4_DROME


Nucleic acid sequence

        10         20         30         40         50         60
atgtcaagcc ccgctcgttc gcccagtgtt ggaggtgcga cgcccaaaca aggcgcccgc
        70         80         90        100        110        120
acacccacta gaggcattgc gtcgcaagat gtggagacac ccatgcgcat gggtcccggg
       130        140        150        160        170        180
agggctgtcc ggccctcgga caacatcagt ttgccgccca cctcgccggg aaacatcagc
       190        200        210        220        230        240
ttgccagcca ccagtccggc tcgaggattg ggtgcgaaca tgagcgagat cgatctgagt
       250        260        270        280        290        300
tcgccgctga actacggcac ccccagctcg atggggtcca ttcgaacccc tcgttccgga
       310        320        330        340        350        360
attagaggca ctccgctgcg ggcgcggccc gatataagaa cggacaagcg catccgccag
       370        380        390        400        410        420
gtggccatcg gtgggggctc tgggctcgaa ccaattcctg agaagggctc tgaaaccacc
       430        440        450        460        470        480
gatcctgtat cggaatcttc gcaagcacct cagctcgtcg tctggggaac caatgttgtt
       490        500        510        520        530        540
gtcagccagt gcaaatccaa gttcaagtcg tttattatgc gctttattga ccccagtgcc
       550        560        570        580        590        600
gagcaggacg aaatctccga gaatattgat gttaaccagc cactgtatct tcagaagctg
       610        620        630        640        650        660
gaggagattc acacattgga ggagccctat ctgaatctca actgtgccca tctcaagacc
       670        680        690        700        710        720
tttgatcagg acttgtaccg ccagttgatc tgctatccgc aggaggttat tcctggcttt
       730        740        750        760        770        780
gatatggcca taaacgagat gttctttgag cgttatcctg ccgctcttct ggaacaccag
       790        800        810        820        830        840
attcaagtgc gccccttcaa cgcggacaag acacgcaaca tgcgatccct aaatcccgag
       850        860        870        880        890        900
gatatggacc agttgatcag cattagtggc atggtcattc gctcgtcgaa cgtcattccc
       910        920        930        940        950        960
gagatgcgcg aagccttttt cagttgcaac atctgttcct tcagcacaac cgtcgaggtg
       970        980        990       1000       1010       1020
gaccgcggtc gcattaacca gcccacgctc tgcaccaact gcaacacgaa ccactgcttc
      1030       1040       1050       1060       1070       1080
cgtttaatcc acaatcgatc ggagtttacg gataagcagc ttgtcaaact tcaggagtct
      1090       1100       1110       1120       1130       1140
ccagatgaca tggcggcggg acagactccg cataatgtgc ttttgtatgc tcacaacgat
      1150       1160       1170       1180       1190       1200
ctggtggaca aggtgcagcc tggtgatcgc gtcacggtca caggcatcta tcgggcgacg
      1210       1220       1230       1240       1250       1260
ccactgaaga ctggaggcct cagttcgtcg gtaaaaagtg tgtataagac gcacgtggat
      1270       1280       1290       1300       1310       1320
gtggttcact tccggaaggt ggacaacaag cgactgtacg aggatgagga gggtaaggat
      1330       1340       1350       1360       1370       1380
cacatcttcc cgccagaacg cgttgagctg ctacaattgc tggccaagaa accggacatc
      1390       1400       1410       1420       1430       1440
tacgaccgct tggccagggc cattgcccca tctatttacg agaacgacga catcaagaaa
      1450       1460       1470       1480       1490       1500
ggcatcttgc tgcagctctt tggtggcacc aagaagaagc atgcaactct cggccgccag
      1510       1520       1530       1540       1550       1560
aatttcagat cggaaattca cctgctgtta tgcggtgatc cgggtacttc caagtcccag
      1570       1580       1590       1600       1610       1620
atgctgcagt acgtcttcaa cctcgtgcca agatcacagt acacctccgg tcgcggttct
      1630       1640       1650       1660       1670       1680
tcggccgtcg gtttgactgc ctatgtgacc aaagatccgg agactcgcca gctggttctg
      1690       1700       1710       1720       1730       1740
caaacaggtg cactggtttt ggccgataat ggagtttgct gcattgacga gtttgacaag
      1750       1760       1770       1780       1790       1800
atgaacgact cgacacgcag tgtgctgcac gaggtgatgg agcagcagac actgagtatt
      1810       1820       1830       1840       1850       1860
gccaaggcgg gaatcatctg tcagctaaac gcgaggacct cgattcttgc tgccgccaat
      1870       1880       1890       1900       1910       1920
cccgccgagt ctcagtggaa taagcgcaag aacatcattg ataacgtcca gcttccgcac
      1930       1940       1950       1960       1970       1980
accctgttgt cccgcttcga cctaatcttt ctggtcctgg atccccagga tgagatcttt
      1990       2000       2010       2020       2030       2040
gacaagcgac tggccagcca tttggtatct ttgtactatg tgacgcgtca tgaggaggag
      2050       2060       2070       2080       2090       2100
gataccatgt ttgacatgag cgtcctgcgc gactacatcg cctatgcccg cgaacatctg
      2110       2120       2130       2140       2150       2160
tcgcctacgt tgtcggatga agcgcaacaa cgactcattc aggcctacgt ggacatgcga
      2170       2180       2190       2200       2210       2220
aaggtgggcg ccggtcgtgg ccagatctct gcttacccgc gccagctgga gagtctcatc
      2230       2240       2250       2260       2270       2280
cgactgtcgg aggcgcacgc caaggtgcgt ctcagcaacc aggtggaatt gctggacgtg
      2290       2300       2310       2320       2330       2340
gaggaggctt ggcggcttca tcgcgaggct ctcaagcagt cggccacgga tcccctgtcc
      2350       2360       2370       2380       2390       2400
ggcaaaattg acgtgggcat tctcaccacc ggcttatcaa cagccgctcg caaaaagcgc
      2410       2420       2430       2440       2450       2460
gccgatctgg tggcagccat caaggaaaac ctcaagaaga agggcaaagt tctcacagtt
      2470       2480       2490       2500       2510       2520
ccctatcaga aactgtttag cgatattaag gaaggatccc aaattatgat cacacgcgag
      2530       2540       2550       2560       2570       2580
caatttgaag atgccctgaa ggaggtgcaa gatgagggcg caattgttgt catgggaaag
      2590       2600
aacaccattc gtatttgtta a   

Last modification date: Oct. 2, 2011