Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA replication licensing factor Mcm3


DESCRIPTION:
Acts as component of the Mcm2-7 complex (Mcm complex) (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MAHEGEQFIK DIQREYVDFL DDEEDQGIYA GHVKDMIAEK SKRLIVNVND LKRKNPQRAL
        70         80         90        100        110        120
GLLSNAADEQ LAFGRALKEY ASTVDPGYAK MHEDLFVGFE GCFGNRHVTP RSLTSIYLGN
       130        140        150        160        170        180
MVCVEGIVTK VSLIRPKVVR SVHYCPNTRK VMERKYTDLT SFEAVPSGAA YPTKDEDGNL
       190        200        210        220        230        240
LETEYGLSVY KDHQTLTIQE MPEKAPAGQL PRSVDIVCDD DLVDRCKPGD RVQIVGSYRC
       250        260        270        280        290        300
LPGKRGGYTS GTFRTVLLAN NISLLSKESN LDISREDIML CKKLAKNNDI FELLSKSLAP
       310        320        330        340        350        360
SIHGHAYVKQ AILCLLLGGV EKILPNGTRL RGDINVLLIG DPSVAKSQLL RYVLNTAPRA
       370        380        390        400        410        420
IPTTGRGSSG VGLTAAVTTD QETGERRLEA GAMVLADRGV VCIDEFDKMS DIDRTAIHEV
       430        440        450        460        470        480
MEQGRVTISK AGIHASLNAR CSVLAAANPV YGRYDQYKTP MENIGLQDSL LSRFDLLFVM
       490        500        510        520        530        540
LDVIDSDVDQ MISDHVVRMH RYRNPKEADG EPLSMGSSYA DSLSFVSSSE EKKDTEVYEK
       550        560        570        580        590        600
YDALLHGKSR QRHEKILSVE FMRKYIHIAK CMKPKLGEQA CEAIANEYSR LRSQEAVETD
       610        620        630        640        650        660
VARTQPITAR TLETLIRLST AHARARMSKS VTIDDAHAAI ELVQFAYFKK VLDKDRPSKR
       670        680        690        700        710        720
RRNSGSDAED DNGEASSQRS PSRRSKRTRT ATVGADSDEE DIEPPQPDAG DLTRRETRRS
       730        740        750        760        770        780
LPARSVAMLM ASPSSEEQSV ATSTTEPAII SDARLGEFKN NLQRLFREAR EQSLALARIT
       790        800        810
TAINVGSQEP FTAGEIEAAV HRMTEDNQIM VADDIVFLI  

Encoded by Mcm3 gene

FULL NAME: Minichromosome maintenance 3


OTHER NAME(S):
CG4206
dMCM3
Dmel\CG4206
DmeMCM3
DmMcm3
DmMCM3
McM3
MCM3
Mcp-PCR2
PCR2


Nucleic acid sequence

        10         20         30         40         50         60
atggcccacg agggggagca gttcatcaag gacatacaac gcgagtatgt ggactttctg
        70         80         90        100        110        120
gacgacgagg aggatcaggg catctatgcg ggccacgtca aggatatgat cgcggagaag
       130        140        150        160        170        180
agcaagcgcc tgatcgtgaa tgtcaacgat ctaaaacgca agaatccgca acgtgcattg
       190        200        210        220        230        240
gggctactga gcaacgcggc ggatgagcag ctggcctttg gcagggcgct caaggagtat
       250        260        270        280        290        300
gcgtccacgg ttgatccggg ctatgccaaa atgcatgagg atctgtttgt cggcttcgag
       310        320        330        340        350        360
ggctgctttg gcaatcggca tgtgacgccg cgctccctca cctccatcta tctgggcaac
       370        380        390        400        410        420
atggtgtgcg tggagggcat tgttaccaag gtatcgctga ttcgtcccaa ggtggtgcgc
       430        440        450        460        470        480
agcgttcact attgccccaa tacgcgtaag gtaatggagc gcaaatacac cgatctcaca
       490        500        510        520        530        540
tcgttcgagg ctgtgccatc tggcgctgcc tatcccacaa aggacgagga tggcaatctg
       550        560        570        580        590        600
ctggagaccg aatacggttt gtccgtttac aaggatcacc agacgctgac cattcaagag
       610        620        630        640        650        660
atgcccgaga aggcgccggc tggccaattg ccgcgttcgg tggatattgt gtgcgacgac
       670        680        690        700        710        720
gatctcgtgg atcgctgcaa gcccggcgat cgtgtacaga ttgtgggcag ctatcgctgt
       730        740        750        760        770        780
ttgccgggca aacgcggtgg ctacacctcg ggcacgttcc gcaccgtgct gctggccaac
       790        800        810        820        830        840
aatatatcgc tgctcagcaa ggagagcaat ttggacatat cgcgcgaaga catcatgctg
       850        860        870        880        890        900
tgcaagaagc tagcgaagaa taacgacatc ttcgagctgc tcagcaagag tttggcgccc
       910        920        930        940        950        960
tcgattcatg gacatgccta tgtgaagcag gccattcttt gcctgctgct cggcggcgtt
       970        980        990       1000       1010       1020
gagaagatcc tgccgaatgg cacacgcctg cgtggcgata ttaatgtctt gcttatcggc
      1030       1040       1050       1060       1070       1080
gatccttcgg tggccaagtc gcagctactg cgctacgtct tgaatacggc accaagggcc
      1090       1100       1110       1120       1130       1140
ataccgacaa cgggtcgcgg atccagcggc gtcggtctga cggcggcggt taccacggat
      1150       1160       1170       1180       1190       1200
caggagaccg gtgagcggcg attggaggcg ggcgccatgg tcctggccga tcgcggtgtc
      1210       1220       1230       1240       1250       1260
gtctgcattg atgagtttga caagatgagc gacatcgatc gcacagccat tcacgaggtg
      1270       1280       1290       1300       1310       1320
atggaacagg gtcgtgttac catttccaaa gcgggcatcc atgcctcgct caatgctcgc
      1330       1340       1350       1360       1370       1380
tgctccgttt tggcagccgc taatccggtg tacggaaggt atgatcaata taagacgccg
      1390       1400       1410       1420       1430       1440
atggaaaata ttggactgca ggattcgctg ctttcgcgtt tcgatttgct cttcgttatg
      1450       1460       1470       1480       1490       1500
ctggacgtga ttgacagcga tgtggatcaa atgatttcgg accatgtggt gcgcatgcat
      1510       1520       1530       1540       1550       1560
cgctatcgca atcccaagga ggccgacggc gagcccttgt ccatgggcag ctcctatgcg
      1570       1580       1590       1600       1610       1620
gactccttgt cctttgtttc cagcagcgag gagaagaagg acaccgaggt gtacgaaaag
      1630       1640       1650       1660       1670       1680
tacgatgccc tgctgcatgg caagtcgcgt cagcgtcacg agaagatcct atccgtggag
      1690       1700       1710       1720       1730       1740
ttcatgcgca agtacataca cattgccaag tgtatgaagc ccaaattggg cgagcaggcc
      1750       1760       1770       1780       1790       1800
tgcgaggcga ttgccaatga gtattcgcgc ctgcgctccc aggaggcggt cgaaacggat
      1810       1820       1830       1840       1850       1860
gtggcacgca cgcagccaat aacggcccgt accctggaga ccctcatccg tttgtccacg
      1870       1880       1890       1900       1910       1920
gcccatgccc gggcacgcat gtccaaatcg gtgaccatcg acgatgccca tgcggccatc
      1930       1940       1950       1960       1970       1980
gaactggtac agtttgccta ctttaagaag gtgctggata aggatcgccc cagcaagcgt
      1990       2000       2010       2020       2030       2040
cgtcgcaaca gcggctccga tgcggaggat gacaacggtg aggcatctag ccagcgctca
      2050       2060       2070       2080       2090       2100
ccatcgcgac gctccaaacg cacacgcaca gcgaccgtcg gtgccgatag cgatgaggag
      2110       2120       2130       2140       2150       2160
gatattgagc caccacagcc ggatgctggc gatttgacgc gtcgcgaaac gcgtcgttct
      2170       2180       2190       2200       2210       2220
ctgcccgctc gctcggtcgc catgctgatg gccagcccct ccagtgagga gcagtcggtg
      2230       2240       2250       2260       2270       2280
gccacatcga ccacggagcc ggccatcatt agcgatgccc gcctgggcga gttcaagaac
      2290       2300       2310       2320       2330       2340
aatttgcagc gactgtttcg cgaggcacgc gaacagagct tggcgctggc caggatcacc
      2350       2360       2370       2380       2390       2400
acggccatca acgttggcag ccaggagccg ttcaccgctg gcgaaatcga ggccgccgtg
      2410       2420       2430       2440       2450       2460
catcgcatga ccgaggacaa tcagatcatg gtcgccgacg atatagtctt tctcatctga

Last modification date: Oct. 2, 2011