Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA replication licensing factor Mcm2


DESCRIPTION:
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDNPSSPPPN TPSDAAERRD LRAAMTSPVG DFEPFENEDE ILGDQTVRDE AEEEDGEELF
        70         80         90        100        110        120
GDNMENDYRP MPELDHYDPA LLDDEDDFSE MSQGDRFAAE SEMRRRDRAA GIHRDDRDLG
       130        140        150        160        170        180
FGQSDDEDDV GPRAKRRAGE KAAVGEVEDT EMVESIENLE DTKGHSTKEW VSMLGPRTEI
       190        200        210        220        230        240
ANRFQSFLRT FVDERGAYTY RDRIRRMCEQ NMSSFVVSYT DLANKEHVLA YFLPEAPFQM
       250        260        270        280        290        300
LEIFDKVAKD MVLSIFPTYE RVTTEIHVRI SELPLIEELR TFRKLHLNQL VRTLGVVTAT
       310        320        330        340        350        360
TGVLPQLSVI KYDCVKCGYV LGPFVQSQNT EIKPGSCPEC QSTGPFSINM EQTLYRNYQK
       370        380        390        400        410        420
ITLQESPGRI PAGRIPRSKD VILLADLCDQ CKPGDELEVT GIYTNNYDGS LNTDQGFPVF
       430        440        450        460        470        480
ATVIIANHVV VKDSKQVVQS LTDEDIATIQ KLSKDPRIVE RVVASMAPSI YGHDYIKRAL
       490        500        510        520        530        540
ALALFGGESK NPGEKHKVRG DINLLICGDP GTAKSQFLKY TEKVAPRAVF TTGQGASAVG
       550        560        570        580        590        600
LTAYVRRNPV SREWTLEAGA LVLADQGVCL IDEFDKMNDQ DRTSIHEAME QQSISISKAG
       610        620        630        640        650        660
IVTSLQARCT VIAAANPIGG RYDPSMTFSE NVNLSEPILS RFDVLCVVKD EFDPMQDQQL
       670        680        690        700        710        720
AKFVVHSHMK HHPSEEEQPE LEEPQLKTVD EIPQDLLRQY IVYAKENIRP KLTNIDEDKI
       730        740        750        760        770        780
AKMYAQLRQE SFATGSLPIT VRHIESVIRM SEAHARMHLR ENVMEADVSM AIRMMLESFI
       790        800        810        820        830        840
EAQKFSVMKK MRSTFQKYLS FQKDHSELLF FILRQLTLDQ LAYIRCKDGP GATHVEIMER
       850        860        870        880
DLIERAKQLD IVNLKPFYES DLFRTNGFSY DPKRRIILQI VVDGNTA 

Encoded by Mcm2 gene

FULL NAME: Minichromosome maintenance 2


OTHER NAME(S):
CG7538
dMCM2
Dmel\CG7538
DmeMCM2
DmMcm2
DmMCM2
l(3)rL074
McM2
MCM2
MCM2-7
MCM2_DROME
PCR3


Nucleic acid sequence

        10         20         30         40         50         60
atggacaatc ccagttcacc accgccaaat acgcccagcg atgccgccga acgccgcgat
        70         80         90        100        110        120
ctgcgggcag caatgacgtc gccggttggc gactttgagc cgttcgagaa cgaggacgag
       130        140        150        160        170        180
atcctgggag atcagaccgt tcgcgatgag gccgaggagg aggatggcga ggagctgttc
       190        200        210        220        230        240
ggggacaaca tggagaacga ttaccggccc atgcctgagc tggatcacta cgatccggcg
       250        260        270        280        290        300
ctgctggacg acgaggatga cttctcggag atgtcccagg gcgatcgctt tgccgccgag
       310        320        330        340        350        360
tcggagatgc gtcgacgcga ccgggccgcc ggaatccacc gcgacgatcg tgatctgggt
       370        380        390        400        410        420
ttcggtcagt ccgatgatga ggacgacgtt ggaccccggg ccaagagacg agctggcgag
       430        440        450        460        470        480
aaggcagctg ttggcgaggt agaggacacc gagatggtgg agtctattga aaacctggag
       490        500        510        520        530        540
gataccaagg gacactcaac taaagagtgg gtcagtatgc taggaccacg cacggaaatc
       550        560        570        580        590        600
gccaatcgct ttcaatcctt tttgagaact tttgtggatg aaaggggcgc atacacctat
       610        620        630        640        650        660
cgtgatcgca tacgtcggat gtgcgagcag aacatgtctt cgttcgtcgt ctcctacact
       670        680        690        700        710        720
gatctggcca acaaggaaca cgtattggcc tatttcctgc ccgaggctcc ctttcaaatg
       730        740        750        760        770        780
ctcgagattt tcgataaagt ggctaaggac atggtgctct ccattttccc cacttacgaa
       790        800        810        820        830        840
cgtgtcacca cagagattca cgtgcgcatc tcggagctgc cgctgatcga ggagctgcgc
       850        860        870        880        890        900
acattcagaa aactgcatct gaaccagttg gttcgcactt tgggcgtggt aactgccacc
       910        920        930        940        950        960
accggagttc ttccccagct atccgtgatc aagtacgact gcgttaagtg cggctatgtg
       970        980        990       1000       1010       1020
ctgggtccct tcgttcagtc gcaaaatacg gagataaagc ccggttcctg cccagagtgc
      1030       1040       1050       1060       1070       1080
cagagcactg gacccttctc aatcaacatg gagcagacgt tgtatcgaaa ttatcaaaag
      1090       1100       1110       1120       1130       1140
atcacgttgc aggagtcgcc aggcaggatt ccagccggac gcattcctcg cagcaaggat
      1150       1160       1170       1180       1190       1200
gtcattttgc tcgctgattt gtgtgatcaa tgcaagcctg gagatgaact tgaggtcaca
      1210       1220       1230       1240       1250       1260
ggtatatata ccaataacta cgatggctcc ttgaacaccg accaaggatt tcccgtgttt
      1270       1280       1290       1300       1310       1320
gccaccgtga ttattgccaa tcatgtggtt gtaaaggact ccaagcaggt agtgcagtcg
      1330       1340       1350       1360       1370       1380
cttacggacg aggacattgc caccattcag aagttgagca aggatccgcg tatcgtagag
      1390       1400       1410       1420       1430       1440
cgtgtagtag catccatggc gccttctata tacggacatg attatatcaa gagggcgctg
      1450       1460       1470       1480       1490       1500
gccttagctc tctttggggg tgagtcaaag aatcccggtg agaaacacaa ggttagaggt
      1510       1520       1530       1540       1550       1560
gatataaacc tactcatctg tggagatccc ggaacggcaa agtcgcagtt cctcaagtac
      1570       1580       1590       1600       1610       1620
accgaaaagg ttgcgccacg tgcggttttc acgactgggc agggagccag tgccgtgggt
      1630       1640       1650       1660       1670       1680
ctcacggctt atgtgcgccg caatccagta tctcgggagt ggacattgga agcgggtgct
      1690       1700       1710       1720       1730       1740
ctggttctgg ctgatcaggg agtttgtcta atcgacgagt tcgacaaaat gaacgaccag
      1750       1760       1770       1780       1790       1800
gatcgtacct ctattcacga agccatggag cagcagtcta tttcgatttc caaggctggt
      1810       1820       1830       1840       1850       1860
attgtcacct ctcttcaagc tcgttgcacc gtgattgctg ctgccaatcc cattggcggt
      1870       1880       1890       1900       1910       1920
cgctatgatc cgtcgatgac cttctcggag aacgtgaatc tctcggagcc catcctgtcc
      1930       1940       1950       1960       1970       1980
cgtttcgatg tgctgtgcgt ggtgaaggac gaatttgacc ccatgcagga tcagcagctc
      1990       2000       2010       2020       2030       2040
gccaaattcg tggtacactc gcatatgaag catcacccga gtgaggagga gcagccggag
      2050       2060       2070       2080       2090       2100
ttggaggaac cacagctgaa gaccgttgat gagatcccgc aggacttgtt gcgacaatac
      2110       2120       2130       2140       2150       2160
attgtatacg ctaaggagaa cattcggccc aagctaacga acatcgacga ggacaagatc
      2170       2180       2190       2200       2210       2220
gccaagatgt acgcccagct gcgacaggag tcttttgcca cgggctcact gcccattacg
      2230       2240       2250       2260       2270       2280
gtgcgtcaca ttgagagtgt catccgaatg tccgaagcgc acgcgcggat gcatctgcgc
      2290       2300       2310       2320       2330       2340
gaaaacgtaa tggaggcaga tgtcagcatg gccatccgca tgatgttgga gagctttatc
      2350       2360       2370       2380       2390       2400
gaggcgcaga agttcagcgt tatgaagaag atgcgcagca cattccagaa gtacctgtcc
      2410       2420       2430       2440       2450       2460
ttccaaaagg accattccga gctgctgttc tttattctgc gacagctgac gctcgaccag
      2470       2480       2490       2500       2510       2520
ctcgcctaca ttcgctgcaa ggacgggcct ggcgccacac atgtggagat tatggagcgg
      2530       2540       2550       2560       2570       2580
gatttgatcg aacgggctaa gcagctggat attgtaaacc tgaagccgtt ctacgaatca
      2590       2600       2610       2620       2630       2640
gatctgtttc gcacaaatgg cttctcttac gatcccaagc gacgcatcat ccttcaaatt
      2650       2660
gtggtcgacg gcaacacagc ttaa   

Last modification date: Oct. 2, 2011