Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSDSSKGKVL QNTGKFVSEN RTEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY
        70         80         90        100        110        120
LINMHSNEVL DEDRRLIAAL DLFFIQMDGS RFKCTVAYQP YLLIRPEDNM HLEVARFLGR
       130        140        150        160        170        180
KYSGQISGLE HITKEDLDLP NHLSGLQQQY IKLSFLNQTA MTKVRRELMS AVKRNQERQK
       190        200        210        220        230        240
SNTYYMQMLA TSLAQSSAGS EDATLGKRQQ DYMDCIVDIR EHDVPYHVRV SIDLRIFCGQ
       250        260        270        280        290        300
WYNIRCRSGV ELPTITCRPD ILDRPEPVVL AFDIETTKLP LKFPDAQTDQ VMMISYMIDG
       310        320        330        340        350        360
QGYLITNREI ISSNVDDFEY TPKPEFEGNF IVFNEENEMQ LLQRFFDHIM EVRPHIIVTY
       370        380        390        400        410        420
NGDFFDWPFV ETRAAVYDLD MKQEIGFSKL RDGNYLSRPA IHMDCLCWVK RDSYLPVGSQ
       430        440        450        460        470        480
GLKAVAKAKL RYDPVELDPE DMCRMAVEQP QVLANYSVSD AVATYYLYMK YVHPFIFALN
       490        500        510        520        530        540
TIIPMEPDEI LRKGSGTLCE TLLMVEAYHA QIVYPNKHQS ELNKLSNEGH VLDSETYVGG
       550        560        570        580        590        600
HVEALESGVF RADIPCRFRL DPAMVKQLQE QVDAVLRHAI EVEEGIPLEK VLNLDEVRQE
       610        620        630        640        650        660
IVQGLQGLHD IPNRLEQPVI YHLDVGAMYP NIILTNRLQP SAMVSDLDCA ACDFNKPGVR
       670        680        690        700        710        720
CKRSMDWLWR GEMLPASRNE FQRIQQQLET EKFPPLFPGG PQRAFHELSK EDQAAYEKKR
       730        740        750        760        770        780
LTDYCRKAYK KTKLTKLETR TSTICQKENS FYVDTVRAFR DRRYEYKGLT KVAKASVNAA
       790        800        810        820        830        840
VASGDAAEIK AAKGREVLYD SLQLAHKCIL NSFYGYVMRR GARWHSMPMA GIVCLTGSNI
       850        860        870        880        890        900
ITKAREIIER VGRPLELDTD GIWCILPGSF PQEFTIHTSH EKKKKINISY PNAVLNTMVK
       910        920        930        940        950        960
DHFTNDQYHE LRKDKENNLP KYDIRDENSI FFEVDGPYLA MVLPAAKEEG KKLKKRYAVF
       970        980        990       1000       1010       1020
NFDGTLAELK GFEVKRRGEL QLIKNFQSSV FEAFLAGSTL EECYASVAKV ADYWLDVLYS
      1030       1040       1050       1060       1070       1080
RGSNLPDSEL FELISENKSM SKKLEEYGAQ KSTSISTAKR LAEFLGEQMV KDAGLACKYI
      1090       1100       1110       1120       1130       1140
ISKKPEGAPV TERAIPLAIF QSEPSVRRHH LRRWLKDNTM GDADIRDVLD WNYYIERLGG
      1150       1160       1170       1180       1190       1200
TIQKIITIPA ALQGLANPVP RVQHPDWLHK KMLEKNDVLK QRRINEMFTS RPKPKPLATE
      1210       1220       1230       1240       1250       1260
EDKLADMEDL AGKDGGEGAA GCPIVTKRKR IQLEEHDDEE AQPQATTWRQ ALGAPPPIGE
      1270       1280       1290       1300       1310       1320
TRKTIVEWVR FQKKKWKWQQ DQRQRNRQAS KRTRGEDPPV VRATGSTATL GGFLRRAQRT
      1330       1340       1350       1360       1370       1380
LLDQPWQIVQ LVPVDDLGHF TVWALIGEEL HKIKLTVPRI FYVNQRSAAP PEEGQLWRKV
      1390       1400       1410       1420       1430       1440
NRVLPRSRPV FNLYRYSVPE QLFRDNSLGM LADLATPDIE GIYETQMTLE FRALMDMGCI
      1450       1460       1470       1480       1490       1500
CGVQREEARR LAQLATKDLE TFSIEQLEQR PQTQVKYLAS ANNRLRKIYL YQHNTPTAKK
      1510       1520       1530       1540       1550       1560
EIWSLILMPS KKAFVFALDT VRANQMPNMR QLYTAERLAL LKNLTAEEQD KIPVEDYTFE
      1570       1580       1590       1600       1610       1620
VLIEVDVKQI YRHIQRALTT YKQEHQGPTI LCLQTALSAR KLSLAMPILL EFPQAEIHIS
      1630       1640       1650       1660       1670       1680
DDASLLSGLD WQRQGSRAVI RHFLNLNNVL DLMLDQCRYF HVPIGNMPPD TVLFGADLFF
      1690       1700       1710       1720       1730       1740
ARLLQRHNFV LWWSASTRPD LGGREADDSR LLAEFEESIS VVQNKAGFYP DVCVELALDS
      1750       1760       1770       1780       1790       1800
LAVSALLQST RIQEMEGASS AITFDVMPQV SLEEMIGTVP AATLPSYDET ALCSAAFRVM
      1810       1820       1830       1840       1850       1860
RSMVNGWLRE VSINRNIFSD FQIVHFYRWV RSSNALLYDP ALRRSLNNLM RKMFLRIIAE
      1870       1880       1890       1900       1910       1920
FKRLGATIIY ADFNRIILSS GKKTVSDALG YVDYIVQSLR NKEMFHSIQL SFEQCWNFML
      1930       1940       1950       1960       1970       1980
WMDQANFSGI RGKLPKGIDE TVSSIVSTTM IRDSERNQDD DEDEEEDSEN RDPVESNEAE
      1990       2000       2010       2020       2030       2040
QDQEDELSLE LNWTIGEHLP DENECREKFE SLLTLFMQSL AEKKTTEQAI KDISHCAFDF
      2050       2060       2070       2080       2090       2100
ILKLHKNYGK GKPSPGLELI RTLIKALSVD KTLAEQINEL RRNMLRLVGI GEFSDLAEWE
      2110       2120       2130       2140       2150       2160
DPCDSHIINE VICKACNHCR DLDLCKDKHR AMKDGVPVWL CAQCYVAYDN EEIEMRMLDA
      2170       2180       2190       2200       2210       2220
LQRKMMSYVL QDLRCSRCSE IKRENLAEFC TCAGNFVPLI SGKDIQTLLG TFNKVAANHK
      2230
MQLLQQTVHQ ALTTPR    

Encoded by DNApol-epsilon gene

FULL NAME: DNA polymerase epsilon


OTHER NAME(S):
6768
BAB17608
CG6768
Dmel\CG6768
pol-epsilon


Nucleic acid sequence

        10         20         30         40         50         60
atgtccgact ccagcaaagg caaagtgctg caaaatacgg gtaaattcgt cagcgagaat
        70         80         90        100        110        120
cgcacagaag gcgacgactt cttcaatgag gcgggctatc gtcaatcccg ggagaacgat
       130        140        150        160        170        180
aaaatcgact cgaaatatgg cttcgatcgg gttaaggaca gccaggagcg gacgggctac
       190        200        210        220        230        240
ctcatcaaca tgcattcgaa cgaagttttg gatgaggaca gaagattgat tgctgccttg
       250        260        270        280        290        300
gacctgttct tcatccaaat ggatggttcc cgcttcaaat gcacggtggc ctatcagcca
       310        320        330        340        350        360
tatttactca tccgaccaga ggataatatg catctggaag tggcgcgatt tctgggtcgc
       370        380        390        400        410        420
aagtattccg gccagatttc tggactggag cacataacca aagaagattt ggatctgccc
       430        440        450        460        470        480
aatcatctat ccggtttgca gcagcagtac ataaaacttt cgtttctcaa tcagacagcc
       490        500        510        520        530        540
atgaccaagg ttagaaggga actcatgtcc gcggtgaaga gaaatcagga gcgacagaaa
       550        560        570        580        590        600
tccaacacat actacatgca aatgctggcc acctcgctgg cccaatcctc cgcaggttcc
       610        620        630        640        650        660
gaggatgcca cattgggtaa gaggcagcag gattacatgg attgtattgt ggacataagg
       670        680        690        700        710        720
gagcatgatg tgccttacca cgtcagagtg tccatcgatt tgcgcatctt ttgtggacag
       730        740        750        760        770        780
tggtacaata tcaggtgcag aagtggcgtg gaattgccta cgatcacctg ccgaccggat
       790        800        810        820        830        840
attctggaca gacccgagcc cgtggtcctg gcctttgata tagaaaccac taagctgccc
       850        860        870        880        890        900
cttaagtttc ccgatgccca gacggatcag gttatgatga tctcgtacat gatcgatggt
       910        920        930        940        950        960
cagggttatc tgataaccaa tcgtgagatt atatcatcca atgtggacga ttttgagtac
       970        980        990       1000       1010       1020
actcccaagc cggaattcga gggtaacttt atagtattca acgaagagaa cgagatgcag
      1030       1040       1050       1060       1070       1080
ctgctccagc gcttcttcga tcacatcatg gaggtgcgtc cccacatcat tgttacatac
      1090       1100       1110       1120       1130       1140
aacggcgact tcttcgattg gcccttcgtg gagacgcgtg ctgcagtgta cgatctggac
      1150       1160       1170       1180       1190       1200
atgaagcaag agattggctt ctccaagcta cgggatggca attatctaag tcgccctgcc
      1210       1220       1230       1240       1250       1260
atacacatgg attgcctatg ttgggtgaaa cgagattctt atttacctgt tggatctcaa
      1270       1280       1290       1300       1310       1320
ggcttaaagg cggtggccaa ggctaaatta cgctatgatc ctgtggaact cgatccggag
      1330       1340       1350       1360       1370       1380
gatatgtgcc gcatggccgt ggaacagccc caagtgctgg ccaattactc tgtatccgat
      1390       1400       1410       1420       1430       1440
gcggtggcca catactatct gtacatgaag tatgtgcatc catttatctt cgccctaaat
      1450       1460       1470       1480       1490       1500
acgattattc ccatggaacc cgatgagatc ctaagaaagg gttccggcac actctgtgaa
      1510       1520       1530       1540       1550       1560
acgttgctga tggtggaggc ttaccatgcc cagattgtgt atcccaacaa gcatcagagt
      1570       1580       1590       1600       1610       1620
gagctgaata agctctccaa cgagggacac gtactggatt cggaaaccta tgtgggtggt
      1630       1640       1650       1660       1670       1680
catgtggagg ctttggaatc gggtgttttc cgggcggaca taccatgccg ttttcgtcta
      1690       1700       1710       1720       1730       1740
gatcctgcta tggtcaagca actgcaggag caggttgatg cagttctgcg ccacgctatc
      1750       1760       1770       1780       1790       1800
gaagtggagg aaggcatacc gctcgagaag gtcttgaatc tggatgaagt gcggcaggag
      1810       1820       1830       1840       1850       1860
attgtgcagg ggctacaggg tctgcacgat atacccaatc gcttggagca gccggtcatc
      1870       1880       1890       1900       1910       1920
tatcacttgg atgtgggtgc catgtacccc aacattattt tgaccaatcg cctgcagccc
      1930       1940       1950       1960       1970       1980
tcggcaatgg ttagtgactt agattgtgcc gcctgtgact tcaacaagcc aggagttcgg
      1990       2000       2010       2020       2030       2040
tgcaaacgtt ccatggactg gttgtggcgc ggcgagatgt tgcccgcctc caggaacgag
      2050       2060       2070       2080       2090       2100
tttcagcgca ttcagcagca gctggagacc gagaagtttc cacccctttt ccctggcgga
      2110       2120       2130       2140       2150       2160
ccacagcgag cctttcacga gctctccaag gaggatcagg cggcgtacga gaagaaacgt
      2170       2180       2190       2200       2210       2220
ctgacggatt actgccgcaa ggcttacaag aagaccaagc taaccaaatt ggaaacgcgc
      2230       2240       2250       2260       2270       2280
acttcgacca tctgccagaa ggagaacagc ttctatgtgg acacggtgcg agcttttcgc
      2290       2300       2310       2320       2330       2340
gatcgtcgct acgagtacaa aggactaacc aaagtggcaa aagcatcggt gaatgctgcg
      2350       2360       2370       2380       2390       2400
gtggcttcgg gagacgcggc agagatcaag gcagccaagg gcagggaggt gctctacgat
      2410       2420       2430       2440       2450       2460
tccctgcagt tggcccacaa gtgcatcctg aactccttct atggctacgt gatgaggaga
      2470       2480       2490       2500       2510       2520
ggagcccgtt ggcattccat gcctatggcc ggcattgtgt gcctcacggg ctcgaatatt
      2530       2540       2550       2560       2570       2580
atcaccaagg cgagggaaat tatcgagcga gttggtcgac cactcgaatt ggacactgat
      2590       2600       2610       2620       2630       2640
ggtatatggt gcatattgcc tggctccttt ccgcaggagt ttaccattca cacgagccat
      2650       2660       2670       2680       2690       2700
gagaagaaaa agaagattaa catatcatat ccgaatgcag tgctaaacac tatggttaaa
      2710       2720       2730       2740       2750       2760
gatcatttta ccaacgatca gtaccacgag ttgaggaagg ataaggaaaa caatctaccc
      2770       2780       2790       2800       2810       2820
aaatacgata ttcgagatga gaactctata ttcttcgagg tggatggacc ctaccttgcc
      2830       2840       2850       2860       2870       2880
atggtgttac ccgctgccaa agaggagggc aagaagctga agaaaagata tgcggtcttt
      2890       2900       2910       2920       2930       2940
aatttcgatg gcacactggc tgaactcaag ggattcgagg tgaagcgacg cggtgaactg
      2950       2960       2970       2980       2990       3000
cagctgatca aaaatttcca gagttccgtc ttcgaagctt tcctcgctgg tagcacactt
      3010       3020       3030       3040       3050       3060
gaggaatgct atgcatctgt ggccaaggtg gcggattact ggcttgatgt actctacagc
      3070       3080       3090       3100       3110       3120
agaggatcaa atctacccga ctcggagcta ttcgaactta tttcggagaa caagagcatg
      3130       3140       3150       3160       3170       3180
tccaagaagc ttgaggagta tggcgcccaa aagagtacgt ccatctccac ggccaagcga
      3190       3200       3210       3220       3230       3240
ttggctgagt tcctgggcga gcagatggta aaggatgcgg gtctggcttg taagtacatt
      3250       3260       3270       3280       3290       3300
atttcgaaga aacccgaagg agcacccgtc accgagagag ctattccctt ggccattttc
      3310       3320       3330       3340       3350       3360
caatccgaac cgagcgtgag gcgacatcac ctgcgtcgct ggcttaagga caacaccatg
      3370       3380       3390       3400       3410       3420
ggcgatgcgg atatacgcga tgtgctcgat tggaactact acatagagag attgggtggg
      3430       3440       3450       3460       3470       3480
accattcaga agatcataac cataccggcg gcactgcagg gactggccaa tccagtgccc
      3490       3500       3510       3520       3530       3540
agagttcagc atccggattg gttgcacaag aaaatgctgg agaagaacga tgtgctcaag
      3550       3560       3570       3580       3590       3600
cagcgtcgca tcaatgagat gttcaccagc agacccaaac cgaaacctct agccacagag
      3610       3620       3630       3640       3650       3660
gaggacaagc tggccgatat ggaagatttg gctggtaaag atggcggtga gggtgctgca
      3670       3680       3690       3700       3710       3720
ggctgtccga tagtcaccaa gagaaagaga atccagctgg aggagcacga tgacgaggag
      3730       3740       3750       3760       3770       3780
gcacagccgc aggccaccac ttggcgtcag gccttgggcg ctccaccgcc catcggtgaa
      3790       3800       3810       3820       3830       3840
accagaaaga ccatcgttga gtgggtgaga tttcagaaga agaaatggaa atggcagcag
      3850       3860       3870       3880       3890       3900
gatcagcgcc agcgtaatcg ccaggcgagc aagcgaactc gaggcgagga tccgccggtg
      3910       3920       3930       3940       3950       3960
gtcagagcaa caggatccac agctacactg ggcggattcc ttagacgtgc acaacgcacc
      3970       3980       3990       4000       4010       4020
ctgttggacc agccgtggca gatcgtacag ttggtgcccg tcgacgacct gggccacttc
      4030       4040       4050       4060       4070       4080
actgtgtggg ccttaatcgg cgaagagttg cacaagatca agttgacggt accgaggatt
      4090       4100       4110       4120       4130       4140
ttctatgtaa atcagcgaag tgcagctcct ccagaggagg gtcaactttg gcgcaaggtc
      4150       4160       4170       4180       4190       4200
aatcgagttc tgccacgatc cagacctgtt ttcaatctct atcgatatag tgtgcccgaa
      4210       4220       4230       4240       4250       4260
cagctcttcc gggataactc gctgggcatg ctggcggatc tggcgacgcc cgacattgag
      4270       4280       4290       4300       4310       4320
ggcatatacg agacgcagat gacgttggaa tttcgcgccc tcatggacat gggctgcatt
      4330       4340       4350       4360       4370       4380
tgcggtgtcc agcgcgagga ggcacgtcgc ttggcccaat tggccaccaa ggatctggaa
      4390       4400       4410       4420       4430       4440
acatttagca tcgagcagct ggagcagcgg ccccagactc aggtcaaata tttggctagc
      4450       4460       4470       4480       4490       4500
gccaacaatc gattgcgcaa aatctacttg tatcagcata acacaccgac ggccaagaag
      4510       4520       4530       4540       4550       4560
gagatctggt cactgatcct aatgcccagc aagaaggcat ttgtttttgc cttggacaca
      4570       4580       4590       4600       4610       4620
gtgcgtgcca atcaaatgcc gaacatgagg caattgtata ccgccgagcg tttggccctg
      4630       4640       4650       4660       4670       4680
ctcaagaatc tgacggcaga ggagcaagat aaaattcctg tagaggatta cacatttgag
      4690       4700       4710       4720       4730       4740
gttctcattg aggtggatgt caaacaaatt taccggcaca tacagcgggc actgaccacc
      4750       4760       4770       4780       4790       4800
tacaaacagg agcatcaggg acccaccatt ctgtgccttc aaacggcgct gtcggcgcgt
      4810       4820       4830       4840       4850       4860
aaactcagcc tggccatgcc gatcctgctg gagtttcccc aggctgagat tcatatctcc
      4870       4880       4890       4900       4910       4920
gatgacgcta gtttgctttc tggccttgat tggcagcgac agggctccag ggcagtgata
      4930       4940       4950       4960       4970       4980
cgccactttc tgaatctgaa caatgttctt gatttgatgt tggatcagtg tcgctacttc
      4990       5000       5010       5020       5030       5040
catgtgccca ttggcaatat gccgccggat actgtgcttt tcggagcgga tcttttcttc
      5050       5060       5070       5080       5090       5100
gctcgcttgc tgcagcggca taactttgtg ctgtggtggt cggcgagtac cagaccagat
      5110       5120       5130       5140       5150       5160
ttgggtggcc gggaggcgga cgacagccgg ctgttggcgg aattcgagga gagcattagt
      5170       5180       5190       5200       5210       5220
gtggtgcaaa acaaggccgg tttctatccg gatgtttgcg tggagctggc tctggatagc
      5230       5240       5250       5260       5270       5280
ctggcggtga gtgccctgct ccaatcgact aggattcagg aaatggaagg cgcctcatct
      5290       5300       5310       5320       5330       5340
gccattacgt tcgatgtgat gccgcaggtc tcgctggagg agatgattgg cactgttccg
      5350       5360       5370       5380       5390       5400
gcggccacct tgccgagtta tgatgaaacg gccctctgtt ccgccgcctt ccgcgttatg
      5410       5420       5430       5440       5450       5460
cgctccatgg tgaatggttg gttgcgagag gtatccatca ataggaacat cttctcggac
      5470       5480       5490       5500       5510       5520
ttccagatcg tgcacttcta tcgatgggtg cgctccagta atgcactact ctatgatcct
      5530       5540       5550       5560       5570       5580
gctttgagaa gatctctgaa taatctgatg aggaagatgt tcttgcgcat tatagccgag
      5590       5600       5610       5620       5630       5640
ttcaagagat tgggcgccac cattatctat gcggacttta acaggattat ccttagttcg
      5650       5660       5670       5680       5690       5700
ggtaagaaaa ccgtttccga tgccctgggc tatgtggact acattgtgca aagcttgagg
      5710       5720       5730       5740       5750       5760
aacaaggaga tgttccactc catccaactg agcttcgagc aatgctggaa ctttatgctc
      5770       5780       5790       5800       5810       5820
tggatggacc aggcaaattt ctcgggaatt aggggaaagc taccaaaggg aatcgatgag
      5830       5840       5850       5860       5870       5880
acagtgtcgt caatagtttc cactaccatg atacgggatt ctgaacgcaa tcaagatgac
      5890       5900       5910       5920       5930       5940
gacgaggatg aagaagagga ttcggaaaac cgtgatccag tggagagcaa cgaggccgag
      5950       5960       5970       5980       5990       6000
caggatcaag aggatgagct gtccctggag ctcaactgga caattggcga acatctgccc
      6010       6020       6030       6040       6050       6060
gatgaaaacg agtgccgcga aaagtttgaa tccctgctga ccctcttcat gcaatctttg
      6070       6080       6090       6100       6110       6120
gctgaaaaga agaccaccga gcaggccatc aaggacatct cacactgtgc gttcgacttt
      6130       6140       6150       6160       6170       6180
atcctgaagc tgcacaagaa ctacggcaag ggcaagccga gcccgggcct agaacttatc
      6190       6200       6210       6220       6230       6240
cgcactctga tcaaggcgtt gagtgtggac aaaacgctgg cggagcagat caacgagttg
      6250       6260       6270       6280       6290       6300
cgccgaaata tgctgcgtct ggtggggatt ggtgagttct ccgacttggc tgagtgggag
      6310       6320       6330       6340       6350       6360
gatccctgcg acagtcacat catcaacgag gtcatctgca aagcgtgtaa tcactgcagg
      6370       6380       6390       6400       6410       6420
gacctggatc tctgcaagga caagcatcgc gccatgaaag atggagtacc cgtttggctg
      6430       6440       6450       6460       6470       6480
tgtgcccagt gctatgtggc ctatgataac gaggagatcg aaatgagaat gctggatgca
      6490       6500       6510       6520       6530       6540
ctgcagcgca agatgatgtc ctatgtgctg caggatctgc gctgttcgcg ctgcagcgag
      6550       6560       6570       6580       6590       6600
atcaagcgcg agaatctggc agagttctgc acttgcgctg gcaactttgt gcccctcatc
      6610       6620       6630       6640       6650       6660
agcgggaagg acatccagac actgctgggc acattcaaca aggtggctgc caaccacaag
      6670       6680       6690       6700       6710
atgcagttgc tccagcagac tgttcatcag gcgctgacca cgccacgcta g

Last modification date: Oct. 2, 2011