Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity).

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MDGKRKFNGT SNGHAKKPRN PDDDEEMGFE AELAAFENSE DMDQTLLMGD GPENQTTSER
        70         80         90        100        110        120
WSRPPPPELD PSKHNLEFQQ LDVENYLGQP LPGMPGAQIG PVPVVRMFGV TMEGNSVCCH
       130        140        150        160        170        180
VHGFCPYFYI EAPSQFEEHH CEKLQKALDQ KVIADIRNNK DNVQEAVLMV ELVEKLNIHG
       190        200        210        220        230        240
YNGDKKQRYI KISVTLPRFV AAASRLLKKE VIMSEIDFQD CRAFENNIDF DIRFMVDTDV
       250        260        270        280        290        300
VGCNWIELPM GHWRIRNSHS KPLPESRCQI EVDVAFDRFI SHEPEGEWSK VAPFRILSFD
       310        320        330        340        350        360
IECAGRKGIF PEAKIDPVIQ IANMVIRQGE REPFIRNVFT LNECAPIIGS QVLCHDKETQ
       370        380        390        400        410        420
MLDKWSAFVR EVDPDILTGY NINNFDFPYL LNRAAHLKVR NFEYLGRIKN IRSVIKEQML
       430        440        450        460        470        480
QSKQMGRREN QYVNFEGRVP FDLLFVLLRD YKLRSYTLNA VSYHFLQEQK EDVHHSIITD
       490        500        510        520        530        540
LQNGDEQTRR RLAMYCLKDA YLPLRLLEKL MAIVNYMEMA RVTGVPLESL LTRGQQIKVL
       550        560        570        580        590        600
SQLLRKAKTK GFIMPSYTSQ GSDEQYEGAT VIEPKRGYYA DPISTLDFAS LYPSIMMAHN
       610        620        630        640        650        660
LCYTTLVLGG TREKLRQQEN LQDDQVERTP ANNYFVKSEV RRGLLPEILE SLLAARKRAK
       670        680        690        700        710        720
NDLKVETDPF KRKVLDGRQL ALKISANSVY GFTGAQVGKL PCLEISGSVT AYGRTMIEMT
       730        740        750        760        770        780
KNEVESHYTQ ANGYENNAVV IYGDTDSVMV NFGVKTLERS MELGREAAEL VSSKFVHPIK
       790        800        810        820        830        840
LEFEKVYYPY LLINKKRYAG LYFTRPDTYD KMDCKGIETV RRDNSPLVAN LMNSCLQKLL
       850        860        870        880        890        900
IERDPDGAVA YVKQVIADLL CNRIDISHLV ITKELAKTDY AAKQAHVELA AKMKKRDPGT
       910        920        930        940        950        960
APKLGDRVPY VICAAAKNTP AYQKAEDPLY VLENSVPIDA TYYLEQQLSK PLLRIFEPIL
       970        980        990       1000       1010       1020
GDNAESILLK GEHTRTRTVV TSKVGGLAGF MTKKTSCLGC KSLMPKGYEQ ACLCPHCEPR
      1030       1040       1050       1060       1070       1080
MSELYQKEVG AKRELEETFS RLWTECQRCQ ESLHEEVICS NRDCPIFYMR QKVRMDLDNQ
      1090
EKRVLRFGLA EW    

Encoded by DNApol-delta gene

FULL NAME: DNA-polymerase-delta


OTHER NAME(S):
5949
CAA61369
CG5949
Dm Poldelta
Dmel\CG5949
DNA Pol Delta


Nucleic acid sequence

        10         20         30         40         50         60
atggatggca agcgcaagtt taatggaacc tccaatggac atgccaagaa gcccaggaat
        70         80         90        100        110        120
cctgatgacg atgaggaaat gggctttgag gcggagctgg ccgccttcga gaactccgag
       130        140        150        160        170        180
gacatggacc agactctgct aatgggcgat ggacccgaga accaaacgac cagtgagcgt
       190        200        210        220        230        240
tggtcccgtc cgccgccccc agaactagat ccctccaagc acaacttgga gtttcagcag
       250        260        270        280        290        300
ctggacgtgg aaaactattt gggacagccg ttgccgggaa tgccaggtgc ccaaatagga
       310        320        330        340        350        360
cccgtgccgg tggtccgaat gtttggtgtc accatggagg gtaactctgt gtgctgccat
       370        380        390        400        410        420
gtgcatggtt tctgtccata cttctacata gaggcgccca gtcaattcga ggagcaccat
       430        440        450        460        470        480
tgcgagaaac tacaaaaagc cttggatcaa aaggttattg ccgatattcg caacaacaaa
       490        500        510        520        530        540
gataatgtcc aggaggctgt gcttatggtg gaactggtgg agaagctgaa catccatgga
       550        560        570        580        590        600
tacaatggag acaagaagca gaggtacatc aaaatatcgg ttacgctgcc cagatttgtg
       610        620        630        640        650        660
gctgcggctt cacgtctcct caaaaaggaa gtgatcatgt cggagattga cttccaggac
       670        680        690        700        710        720
tgtcgcgcct ttgagaataa catagacttt gacattcgct tcatggtgga cactgatgtg
       730        740        750        760        770        780
gtaggttgca attggataga gcttcccatg ggtcactggc gaataaggaa cagtcacagc
       790        800        810        820        830        840
aagccgttgc ctgaatcccg ctgccagatt gaagtagacg tggccttcga cagatttata
       850        860        870        880        890        900
tcccacgagc ccgaaggtga atggtccaag gtggctccct tccggatcct ctcctttgat
       910        920        930        940        950        960
attgaatgcg ctggtcgcaa aggaatattt ccggaagcca aaatagatcc agtcatccag
       970        980        990       1000       1010       1020
atagccaata tggtgataag gcagggagaa cgagaacctt tcattaggaa tgtctttacc
      1030       1040       1050       1060       1070       1080
ctaaatgaat gcgctccaat cataggcagc caggtgttgt gccacgacaa ggagacccag
      1090       1100       1110       1120       1130       1140
atgctggaca agtggtctgc ctttgtccgg gaagttgacc cggatatttt gaccggatat
      1150       1160       1170       1180       1190       1200
aatatcaaca actttgactt cccctatttg cttaaccgag cagctcactt gaaggtcagg
      1210       1220       1230       1240       1250       1260
aactttgagt atttgggcag gattaagaac attcgttcgg tgatcaagga acagatgttg
      1270       1280       1290       1300       1310       1320
cagtcgaagc agatgggtcg cagggaaaac cagtacgtta attttgaggg tagagttccc
      1330       1340       1350       1360       1370       1380
ttcgatctcc tctttgtcct gctgcgcgac tacaaactac gctcgtacac tctcaacgct
      1390       1400       1410       1420       1430       1440
gtgagctatc actttctgca ggagcaaaag gaggatgtgc atcatagcat tatcacagat
      1450       1460       1470       1480       1490       1500
cttcagaatg gagacgagca gacacgtcga cgtttggcca tgtactgcct aaaggatgcc
      1510       1520       1530       1540       1550       1560
tacttaccgc ttagattgct ggaaaagtta atggccattg ttaactacat ggagatggcc
      1570       1580       1590       1600       1610       1620
agggtgacgg gtgtgccact ggagtccttg ctcacccgcg gacaacagat aaaggtttta
      1630       1640       1650       1660       1670       1680
agtcaattgc tgcgcaaggc caaaaccaag ggattcatca tgccctcgta cacctctcag
      1690       1700       1710       1720       1730       1740
ggatcggatg aacagtatga aggagcgact gtgattgaac caaaacgtgg ctactatgcg
      1750       1760       1770       1780       1790       1800
gaccccatct ccacgctgga tttcgcctcc ctgtatccaa gtataatgat ggcgcataat
      1810       1820       1830       1840       1850       1860
ttgtgctaca ccaccttggt tttgggtgga actcgtgaga agctgcggca gcaggagaac
      1870       1880       1890       1900       1910       1920
ctgcaggacg atcaagtgga acgtacgcct gcaaacaact actttgtgaa gtctgaggtg
      1930       1940       1950       1960       1970       1980
cgtcgtggtc tgctccctga gattctggaa tctcttttgg cggccagaaa gcgtgccaaa
      1990       2000       2010       2020       2030       2040
aatgacctaa aagtggaaac agatccgttt aaaagaaagg tcctggatgg cagacagctg
      2050       2060       2070       2080       2090       2100
gcgctgaaga tttcggctaa ttccgtgtac ggatttactg gcgcacaggt tggaaagttg
      2110       2120       2130       2140       2150       2160
ccatgcttag agatctcggg cagcgtcacc gcctacggtc gtaccatgat cgagatgacg
      2170       2180       2190       2200       2210       2220
aaaaacgaag tggaatccca ttacacacag gccaatggct acgagaacaa tgcagtggtc
      2230       2240       2250       2260       2270       2280
atctacggcg acactgattc tgtgatggtt aatttcggag taaaaactct ggagcgcagc
      2290       2300       2310       2320       2330       2340
atggagctgg gacgcgaggc tgccgaactg gtcagttcca agttcgtgca tcctattaaa
      2350       2360       2370       2380       2390       2400
ttggaattcg agaaagttta ctatccttac ctgctgatta acaagaaacg ctatgcggga
      2410       2420       2430       2440       2450       2460
ttatacttta cgcgcccaga tacctacgat aaaatggatt gcaagggcat agaaaccgtg
      2470       2480       2490       2500       2510       2520
aggagagata actctccgct ggtggccaac ctgatgaact cctgcctgca gaaactactc
      2530       2540       2550       2560       2570       2580
atcgaaaggg atcccgatgg tgcagttgcc tatgtgaaac aggtgatagc cgatctcctc
      2590       2600       2610       2620       2630       2640
tgcaatcgca tcgacatctc gcacttggtc ataaccaagg agttggccaa aacggattac
      2650       2660       2670       2680       2690       2700
gcagccaaac aggcacacgt tgagctggcc gccaagatga agaaaagaga tcccggtacg
      2710       2720       2730       2740       2750       2760
gcgcccaaac tgggggatcg agttccctat gtgatctgtg cggcagccaa aaacacaccc
      2770       2780       2790       2800       2810       2820
gcttaccaga aggccgagga tccgctgtat gtgctggaaa acagcgtgcc catcgatgcc
      2830       2840       2850       2860       2870       2880
acttactacc tggaacagca gctgtctaag ccgctgctaa ggatctttga acctattttg
      2890       2900       2910       2920       2930       2940
ggcgacaatg ccgagtcaat tttgttaaaa ggagaacaca cgcgcacacg aactgtggta
      2950       2960       2970       2980       2990       3000
acatccaaag tgggtggact tgctggattt atgaccaaga aaacgtcgtg tttgggctgt
      3010       3020       3030       3040       3050       3060
aaatccctga tgcccaaggg ctacgaacag gcctgtctgt gtccacactg cgagccacga
      3070       3080       3090       3100       3110       3120
atgagtgagc tgtatcagaa ggaggtgggt gcgaagaggg aactggagga gaccttctct
      3130       3140       3150       3160       3170       3180
cgcctatgga ccgagtgcca gcgatgccag gaatccttgc acgaggaggt catctgctcc
      3190       3200       3210       3220       3230       3240
aacagagatt gtcccatctt ctacatgcga cagaaggttc gcatggatct ggacaatcag
      3250       3260       3270
gagaagcggg tgttgcgatt cggcctggcc gagtggtaa  

Last modification date: Oct. 2, 2011