Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA primase small subunit


DESCRIPTION:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

MISCELLANEOUS:
The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).


STRUCTURE SIMILARITY:
Belongs to the eukaryotic-type primase small subunit family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MPEQVTDQEN QAPQQQTTAV HAYNPEVLQD MLPVYYRRLF PHLPFYRWLS YGSSEDAIFS
        70         80         90        100        110        120
NREISFTLQD DIYIRYLCFD TQAELEKEIC SRNPIKIDIG PVMHSKPKNH RSIPGGLTPV
       130        140        150        160        170        180
QRELVFDIDM TDYDEVRTCC SGAGVCLKCW KFMVLAARVL DVALREDFGF EHIIWIFSGR
       190        200        210        220        230        240
RGIHCWVCDY QARHLDGRGR YAVAEYLNII TYASFAGGNS PRCSMGDRPH HSLKRALKIV
       250        260        270        280        290        300
EPMFEEIVLE DQNLFGTPKG VTKLLNMVHD DAARGELESY MQKNLEDGAH SRLVWESFIK
       310        320        330        340        350        360
YANSMRTSTT SAWSRKLKNI VAEIQLGLLY PRLDINVTRG FNHLLKAPFC IHPATGKVCV
       370        380        390        400        410        420
PFSVSAVAKF DPTTVPTITQ LLHEINAFDD KSKSYMEAPE DKSRIKDHKK TSMFKGVVVF
       430
EEFLRKLERS QKSASLQF    

Encoded by DNApol-alpha50 gene

FULL NAME: DNA polymerase alpha 50kD


OTHER NAME(S):
anon-WO0140519.257
CG7108
Dmel\CG7108
Dmpol alpha
DNA polalpha
DNApol-alpha
DNApolalpha
DNApolalpha50
Dpri50
Pol
pol alpha
POLA
polalpha
Polalpha
polalpha50
PRI1


Nucleic acid sequence

        10         20         30         40         50         60
atgcccgaac aagtcacaga tcaggagaac caggctccac agcagcagac tactgctgtg
        70         80         90        100        110        120
catgcctaca atcccgaagt cctgcaggat atgttgcccg tgtattacag gcgcctcttt
       130        140        150        160        170        180
ccccacctgc ccttctaccg ttggctatcg tatggatcat ccgaggatgc tatcttttcc
       190        200        210        220        230        240
aatcgtgaaa tttcctttac actgcaggac gatatctaca tacgttacct ctgctttgat
       250        260        270        280        290        300
acccaagctg aattggaaaa ggagatctgc tcgaggaatc ctattaagat tgacatagga
       310        320        330        340        350        360
ccagtaatgc attccaaacc caaaaaccat cgttcaattc ctggcggctt aacgcccgta
       370        380        390        400        410        420
caacgtgaac tcgtttttga tatagatatg acggattacg acgaggtgcg tacctgttgc
       430        440        450        460        470        480
tctggagcag gggtatgcct gaaatgctgg aagtttatgg tgctggctgc cagggttttg
       490        500        510        520        530        540
gatgtcgctt tgcgcgagga tttcggtttc gagcacataa tctggatttt ctcaggtaga
       550        560        570        580        590        600
cgaggtatcc attgctgggt ttgcgactac caagcccgtc acttggacgg acgtggtcgc
       610        620        630        640        650        660
tatgctgtgg cggaatacct taacattatt acctatgcca gtttcgcggg cggcaattca
       670        680        690        700        710        720
cccagatgtt caatgggaga ccgaccgcat catagcctaa agagagcctt aaagatagtg
       730        740        750        760        770        780
gagcccatgt tcgaggagat tgtactagag gatcagaatc tttttggaac tcccaaggga
       790        800        810        820        830        840
gttaccaaac ttcttaacat ggtccacgat gacgctgcgc gtggcgaact agaatcttat
       850        860        870        880        890        900
atgcaaaaga atttggagga tggagcacac tcgcgactcg tttgggagag cttcattaag
       910        920        930        940        950        960
tacgccaact ctatgagaac atccacgaca agtgcctgga gtcgcaagct gaagaacatt
       970        980        990       1000       1010       1020
gtagccgaaa tccagcttgg actgctctat cctcgtttgg acatcaatgt cactagggga
      1030       1040       1050       1060       1070       1080
ttcaatcatt tgctaaaggc accgttttgc attcatccag ccactggaaa agtgtgcgtt
      1090       1100       1110       1120       1130       1140
ccgtttagtg tgagtgctgt ggccaagttt gatcccacca cagtgccgac gatcacccag
      1150       1160       1170       1180       1190       1200
ttgcttcacg agatcaacgc tttcgatgat aagagcaaga gctacatgga ggcgccggag
      1210       1220       1230       1240       1250       1260
gataagagcc gcatcaagga tcacaagaag actagcatgt tcaagggtgt cgtggttttc
      1270       1280       1290       1300       1310
gaggagttcc tgcgaaaact ggagcgcagc cagaaatctg ccagcttgca gttttga

Last modification date: Oct. 2, 2011