Homo sapiens L. (human) [HSA]


STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSGFDDPGIF YSDSFGGDAQ ADEGQARKSQ LQRRFKEFLR QYRVGTDRTG FTFKYRDELK
        70         80         90        100        110        120
RHYNLGEYWI EVEMEDLASF DEDLADYLYK QPAEHLQLLE EAAKEVADEV TRPRPSGEEV
       130        140        150        160        170        180
LQDIQVMLKS DASPSSIRSL KSDMMSHLVK IPGIIIAASA VRAKATRISI QCRSCRNTLT
       190        200        210        220        230        240
NIAMRPGLEG YALPRKCNTD QAGRPKCPLD PYFIMPDKCK CVDFQTLKLQ ELPDAVPHGE
       250        260        270        280        290        300
MPRHMQLYCD RYLCDKVVPG NRVTIMGIYS IKKFGLTTSR GRDRVGVGIR SSYIRVLGIQ
       310        320        330        340        350        360
VDTDGSGRSF AGAVSPQEEE EFRRLAALPN VYEVISKSIA PSIFGGTDMK KAIACLLFGG
       370        380        390        400        410        420
SRKRLPDGLT RRGDINLLML GDPGTAKSQL LKFVEKCSPI GVYTSGKGSS AAGLTASVMR
       430        440        450        460        470        480
DPSSRNFIME GGAMVLADGG VVCIDEFDKM REDDRVAIHE AMEQQTISIA KAGITTTLNS
       490        500        510        520        530        540
RCSVLAAANS VFGRWDETKG EDNIDFMPTI LSRFDMIFIV KDEHNEERDV MLAKHVITLH
       550        560        570        580        590        600
VSALTQTQAV EGEIDLAKLK KFIAYCRVKC GPRLSAEAAE KLKNRYIIMR SGARQHERDS
       610        620        630        640        650        660
DRRSSIPITV RQLEAIVRIA EALSKMKLQP FATEADVEEA LRLFQVSTLD AALSGTLSGV
       670        680        690        700        710        720
EGFTSQEDQE MLSRIEKQLK RRFAIGSQVS EHSIIKDFTK QKYPEHAIHK VLQLMLRRGE
       730
IQHRMQRKVL YRLK    

Encoded by MCM5 gene

FULL NAME: minichromosome maintenance complex component 5


OTHER NAME(S):
CDC46
MGC5315
P1-CDC46


DESCRIPTION:
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgggat tcgacgatcc tggcattttc tacagcgaca gcttcggggg cgacgcccag
        70         80         90        100        110        120
gccgacgagg ggcaggcccg caaatcgcag ctgcagaggc gcttcaagga gttcctgcgg
       130        140        150        160        170        180
cagtaccgag tgggcaccga ccgcacgggc ttcaccttca aatacaggga tgaactcaag
       190        200        210        220        230        240
cggcattaca acctggggga gtactggatt gaggtggaga tggaggatct ggccagcttt
       250        260        270        280        290        300
gatgaggacc tggccgacta cttgtacaag cagccagccg agcacctgca gctgctggag
       310        320        330        340        350        360
gaagctgcca aggaggtagc tgatgaggtg acccggcccc ggccttctgg ggaggaggtg
       370        380        390        400        410        420
ctccaggaca tccaggtcat gctcaagtcg gacgccagcc cttccagcat tcgtagcctg
       430        440        450        460        470        480
aagtcggaca tgatgtcaca cctggtgaag atccctggca tcatcatcgc ggcctctgcg
       490        500        510        520        530        540
gtccgtgcca aggccacccg catctctatc cagtgccgca gctgccgcaa caccctcacc
       550        560        570        580        590        600
aacattgcca tgcgccctgg cctcgagggc tatgccctgc ccaggaagtg caacacagat
       610        620        630        640        650        660
caggctgggc gccccaaatg cccattggac ccgtacttca tcatgcccga caaatgcaaa
       670        680        690        700        710        720
tgcgtggact tccagaccct gaagctgcag gagctgcctg atgcagtccc ccacggggag
       730        740        750        760        770        780
atgcccagac acatgcagct ctactgcgac aggtacctgt gtgacaaggt cgtccctggg
       790        800        810        820        830        840
aacagggtta ccatcatggg catctactcc atcaagaagt ttggcctgac taccagcagg
       850        860        870        880        890        900
ggccgtgaca gggtgggcgt gggcatccga agctcctaca tccgtgtcct gggcatccag
       910        920        930        940        950        960
gtggacacag atggctctgg ccgcagcttt gctggggccg tgagccccca ggaggaggag
       970        980        990       1000       1010       1020
gagttccgtc gcctggctgc cctcccaaat gtctatgagg tcatctccaa gagcatcgcc
      1030       1040       1050       1060       1070       1080
ccctccatct ttgggggcac agacatgaag aaggccattg cctgcctgct ctttgggggc
      1090       1100       1110       1120       1130       1140
tcccgaaaga ggctccctga tggacttact cgccgaggag acatcaacct gctgatgcta
      1150       1160       1170       1180       1190       1200
ggggaccctg ggacagccaa gtcccagctt ctgaagtttg tggagaagtg ttctcccatt
      1210       1220       1230       1240       1250       1260
ggggtataca cgtctgggaa aggcagcagc gcagctggac tgacagcctc ggtgatgagg
      1270       1280       1290       1300       1310       1320
gacccttcgt cccggaattt catcatggag ggcggagcca tggtcctggc cgatggtggg
      1330       1340       1350       1360       1370       1380
gtcgtctgta ttgacgagtt tgacaagatg cgagaagatg accgtgtggc aatccacgaa
      1390       1400       1410       1420       1430       1440
gccatggagc agcagaccat ctctatcgcc aaggctggga tcaccaccac cctgaactcc
      1450       1460       1470       1480       1490       1500
cgctgctccg tcctggctgc tgccaactca gtgttcggcc gctgggatga gacgaagggg
      1510       1520       1530       1540       1550       1560
gaggacaaca ttgacttcat gcccaccatc ttgtcgcgct tcgacatgat cttcatcgtc
      1570       1580       1590       1600       1610       1620
aaggatgagc acaatgagga gagggatgtg atgctggcca agcatgtcat cactctgcac
      1630       1640       1650       1660       1670       1680
gtgagcgcac tgacacagac acaggctgtg gagggcgaga ttgacctggc caagctgaag
      1690       1700       1710       1720       1730       1740
aagtttattg cctactgccg agtgaagtgt ggcccccggc tgtcagcaga ggctgcagag
      1750       1760       1770       1780       1790       1800
aaactgaaga accgctacat catcatgcgg agcggggccc gtcagcacga gagggacagt
      1810       1820       1830       1840       1850       1860
gaccgccgct ccagcatccc catcactgtg cggcagctgg aggccattgt gcgcatcgcg
      1870       1880       1890       1900       1910       1920
gaagccctca gcaagatgaa gctgcagccc ttcgccacag aggcagatgt ggaggaggcc
      1930       1940       1950       1960       1970       1980
ctgcggctct tccaagtgtc cacgttggat gctgccttgt ccggtaccct gtcaggggtg
      1990       2000       2010       2020       2030       2040
gagggcttca ccagccagga ggaccaggag atgctgagcc gcatcgagaa gcagctcaag
      2050       2060       2070       2080       2090       2100
cgccgctttg ccattggctc ccaggtgtct gagcacagca tcatcaagga cttcaccaag
      2110       2120       2130       2140       2150       2160
cagaaatacc cggagcacgc catccacaag gtgctgcagc tcatgctgcg gcgcggcgag
      2170       2180       2190       2200
atccagcatc gcatgcagcg caaggttctc taccgcctca agtga 

Last modification date: Oct. 2, 2011