Mus musculus L. (mouse) [MMU]

FULL NAME: DNA ligase 1


DESCRIPTION:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MRKKEQERKG ETSAANMQRS IMSFFQPTKE GKAKKPEKET PSSIREKEPP PKVALKERNQ
        70         80         90        100        110        120
VVPESDSPVK RTGRKVAQVL SCEGEDEDEA PGTPKVQKPV SDSEQSSPPS PDTCPENSPV
       130        140        150        160        170        180
FNCSSPMDIS PSGFPKRRTA RKQLPKRTIQ DTLEEQNEDK TKTAKKRKKE EETPKESLAE
       190        200        210        220        230        240
AEDVKQKEEK EGDQLIVPSE PTKSPESVTL TKTENIPVCK AGVKLKPQEE EQSKPPARGA
       250        260        270        280        290        300
KTLSSFFTPR KPAVKTEVKQ EESGTLRKEE TKGTLDPANY NPSKNNYHPI EDACWKHGQK
       310        320        330        340        350        360
VPFLAVARTF EKIEEVSARL KMVETLSNLL RSVVALSPPD LLPVLYLSLN RLGPPQQGLE
       370        380        390        400        410        420
LGVGDGVLLK AVAQATGRQL ESIRAEVAEK GDVGLVAENS RSTQRLMLPP PPLTISGVFT
       430        440        450        460        470        480
KFCDIARLTG SASMAKKMDI IKGLFVACRH SEARYIARSL SGRLRLGLAE QSVLAALAQA
       490        500        510        520        530        540
VSLTPPGQEF PTAVVDAGKG KTAEARKMWL EEQGMILKQT FCEVPDLDRI IPVLLEHGLE
       550        560        570        580        590        600
RLPEHCKLSP GVPLKPMLAH PTRGVSEVLK RFEEVDFTCE YKYDGQRAQI HVLEGGEVKI
       610        620        630        640        650        660
FSRNQEDNTG KYPDIISRIP KIKHPSVTSF ILDTEAVAWD REKKQIQPFQ VLTTRKRKEV
       670        680        690        700        710        720
DASEIQVQVC LYAFDLIYLN GESLVRQPLS RRRQLLRENF VETEGEFVFT TSLDTKDTEQ
       730        740        750        760        770        780
IAEFLEQSVK DSCEGLMVKT LDVDATYEIA KRSHNWLKLK KDYLDGVGDT LDLVVIGAYL
       790        800        810        820        830        840
GRGKRAGRYG GFLLAAYDEE SEELQAICKL GTGFSDEELE EHHQSLQALV LPTPRPYVRI
       850        860        870        880        890        900
DGAVAPDHWL DPSIVWEVKC ADLSLSPIYP AARGLVDKEK GISLRFPRFI RVRKDKQPEQ
       910        920        930
ATTSNQVASL YRKQSQIQNQ QSSDLDSDVE DY  

Encoded by Lig1 gene

FULL NAME: ligase I, DNA, ATP-dependent


OTHER NAME(S):
AL033288
LigI


Nucleic acid sequence

        10         20         30         40         50         60
atgagaaaaa aagagcaaga gaggaaagga gagacttctg ctgccaacat gcagagaagt
        70         80         90        100        110        120
attatgtcat tttttcaacc cacaaaagaa ggtaaagcga agaagccaga gaaggagaca
       130        140        150        160        170        180
cccagcagca tcagagagaa ggaaccccct ccaaaggtgg cgctgaagga gaggaatcaa
       190        200        210        220        230        240
gtggtgcccg agagtgattc tccagtgaag aggacaggaa ggaaggtagc ccaggttctg
       250        260        270        280        290        300
agctgtgaag gggaggacga agatgaagcc cctggcaccc ccaaagtcca gaagcctgtg
       310        320        330        340        350        360
tcagactctg aacagagctc tcctcccagc cctgacacat gtcctgagaa cagtcctgtc
       370        380        390        400        410        420
ttcaactgca gctcccccat ggacatctcc ccatcaggat tcccaaagcg tcgaactgcg
       430        440        450        460        470        480
cggaagcagc tccccaaacg gacaattcaa gacactcttg aggagcagaa tgaggacaaa
       490        500        510        520        530        540
accaaaacag ctaagaaaag gaagaaagaa gaagagaccc caaaagaaag cctcgcagag
       550        560        570        580        590        600
gctgaagacg taaaacagaa ggaagaaaag gagggggacc agctcatagt cccctctgag
       610        620        630        640        650        660
cccacaaagt cccctgagtc agtaaccctg acaaagacag agaacattcc agtgtgtaag
       670        680        690        700        710        720
gcaggagtga aactgaagcc tcaggaagag gaacagagca aacctcctgc tagaggtgcc
       730        740        750        760        770        780
aagacactga gcagtttctt cacaccccga aaaccagcag tgaaaactga agtcaaacaa
       790        800        810        820        830        840
gaagagtcag gcactctaag gaaggaagag accaagggaa ccctggatcc agcaaattat
       850        860        870        880        890        900
aatccttcca agaataacta tcatcccatt gaagatgcct gctggaaaca tggccagaag
       910        920        930        940        950        960
gtcccttttc tcgccgtggc ccggacattt gagaagattg aggaggtttc tgctaggctc
       970        980        990       1000       1010       1020
aagatggtgg agacattgag caacctgctg cgctccgtgg tggccctgtc ccctccagac
      1030       1040       1050       1060       1070       1080
ttgctccctg ttctctatct cagcctcaac cgcctcgggc cacctcagca gggactagag
      1090       1100       1110       1120       1130       1140
ctgggtgttg gtgatggtgt cctcctcaag gccgttgccc aggccacagg tcgtcagctg
      1150       1160       1170       1180       1190       1200
gagtccatcc gggctgaggt agctgagaag ggggatgtgg ggctggtggc cgagaacagc
      1210       1220       1230       1240       1250       1260
cgcagcactc agagactcat gctgcctcca cctccactta ctatttctgg agtcttcacc
      1270       1280       1290       1300       1310       1320
aaattctgtg acattgcccg gctcactggc agtgcttcca tggccaagaa gatggacatt
      1330       1340       1350       1360       1370       1380
atcaagggcc tttttgttgc ctgccgccac tcagaagcca ggtacattgc caggtcccta
      1390       1400       1410       1420       1430       1440
agcgggcggc tgcgccttgg cctagctgag cagtcggtac tggctgctct tgcccaggct
      1450       1460       1470       1480       1490       1500
gtgagcctca caccccctgg ccaagaattt cccacggcgg tggtggatgc tgggaagggc
      1510       1520       1530       1540       1550       1560
aagacagcag aggccagaaa gatgtggttg gaagaacaag gcatgatctt gaagcagacc
      1570       1580       1590       1600       1610       1620
ttctgtgagg ttcctgacct ggatcgaatc atccctgtgc tgctggaaca tggcctggaa
      1630       1640       1650       1660       1670       1680
cgtctcccag agcactgcaa gctgagccca ggggtccctc ttaaaccaat gctggctcat
      1690       1700       1710       1720       1730       1740
cccactcggg gtgtcagtga ggtcctaaaa cgctttgagg aggtcgactt cacctgtgaa
      1750       1760       1770       1780       1790       1800
tataaatacg atgggcagcg agcacagata catgttctgg aaggtggaga agtgaagatc
      1810       1820       1830       1840       1850       1860
ttcagcagga accaggaaga caacacagga aagtatcctg acattatcag ccgcatcccc
      1870       1880       1890       1900       1910       1920
aagattaaac acccctcagt cacatctttc attctggaca ctgaggctgt ggcctgggac
      1930       1940       1950       1960       1970       1980
cgggaaaaga agcagatcca accattccaa gtactcacca cgcgcaagcg caaggaggtt
      1990       2000       2010       2020       2030       2040
gatgcatcgg agatacaggt gcaagtgtgt ctgtatgctt ttgacctcat ctacctcaac
      2050       2060       2070       2080       2090       2100
ggagagtccc tggttcgcca gcccctgtct cgacgccggc agctgctccg tgagaacttc
      2110       2120       2130       2140       2150       2160
gtggagacag agggtgagtt tgtcttcacc acctctttgg acaccaagga caccgagcag
      2170       2180       2190       2200       2210       2220
attgctgagt tcttggagca gtcagtgaag gactcctgtg agggcctgat ggtgaagacc
      2230       2240       2250       2260       2270       2280
ttggatgttg atgccactta tgagattgcc aagaggtcac acaactggct caagctgaag
      2290       2300       2310       2320       2330       2340
aaggactacc ttgacggtgt gggtgacact ctggaccttg tggtgattgg tgcctacctg
      2350       2360       2370       2380       2390       2400
ggccggggga agcgggctgg ccggtatgga ggcttcctgt tggctgccta cgatgaggag
      2410       2420       2430       2440       2450       2460
agtgaagagc ttcaggctat atgcaagctg ggaactggat tcagcgatga ggagctggag
      2470       2480       2490       2500       2510       2520
gaacaccacc agagcctgca ggccctggta ttgcctaccc cacgccccta tgtgaggatt
      2530       2540       2550       2560       2570       2580
gatggggcag tggccccaga ccattggctg gacccaagca ttgtgtggga ggtgaagtgt
      2590       2600       2610       2620       2630       2640
gctgatcttt ccctgtcccc catctaccct gctgcacggg gcctggtgga caaagaaaaa
      2650       2660       2670       2680       2690       2700
gggatctctc ttcgttttcc tcggttcatt cgtgtccgta aagacaagca gccagagcag
      2710       2720       2730       2740       2750       2760
gccactacca gtaaccaggt tgcctctttg taccggaagc agagtcagat tcagaaccaa
      2770       2780       2790
caaagctcag acttggactc cgacgttgaa gactattaa  

Last modification date: Oct. 2, 2011