Mus musculus L. (mouse) [MMU]

FULL NAME: Ribonuclease H2 subunit B


DESCRIPTION:
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

STRUCTURE SIMILARITY:
Belongs to the RNase H2 subunit B family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MAGGRDRGDL AARQLVFLLP EHLKDASKKK KKSSLLFVKL ANPHSGEGAT YLIDMCLQQL
        70         80         90        100        110        120
FEIKVFKEKH HSWFINQSVQ SGGLLHFATP MDPLFLLLHY LLKAGKEGKY QPLDQVVVDD
       130        140        150        160        170        180
TFPDCTLLLR FPELEKSLRH VTEEKEVNSK KYYKYSSEKT LKWLEKKVNQ TVVALKANNV
       190        200        210        220        230        240
NVGARVQSSA YFSGGQVSRD KEEDYVRYAH GLISDYIPKE LSDDLSKFLK LPEPPASLTN
       250        260        270        280        290        300
PPSKKLKLSD EPVEAKEDYT KFNTKDLKTG KKNSKMTAAQ KALAKVDKSG MKSIDAFFGA

KNKKTGKI     

Encoded by Rnaseh2b gene

FULL NAME: ribonuclease H2, subunit B


OTHER NAME(S):
1110019N06Rik
2610207P08Rik
Dleu8


Nucleic acid sequence

        10         20         30         40         50         60
atggccggag gtcgggaccg cggggacttg gcggccaggc agctagtgtt cctacttcca
        70         80         90        100        110        120
gaacatttaa aagatgcctc gaagaagaag aagaagagca gcctcctgtt cgtaaagctg
       130        140        150        160        170        180
gccaacccgc actcagggga aggagccaca tacttaattg atatgtgtct tcaacagctg
       190        200        210        220        230        240
tttgaaataa aagttttcaa ggaaaaacac cattcttggt ttataaatca atcagttcaa
       250        260        270        280        290        300
tcagggggcc ttctccactt tgccacaccc atggatccat tgttcctgct ccttcactat
       310        320        330        340        350        360
ctcctaaagg ctggcaaaga ggggaagtat cagcccttgg accaagtcgt ggtcgatgac
       370        380        390        400        410        420
acgtttccag attgcacctt gctgctgaga tttcctgagc ttgaaaagtc acttcggcat
       430        440        450        460        470        480
gtgacagagg aaaaagaagt gaacagcaag aagtactata agtacagctc agagaagaca
       490        500        510        520        530        540
ttgaagtggc tggagaagaa ggtcaaccaa actgtggtgg cactaaaagc taataatgtc
       550        560        570        580        590        600
aatgttggag cccgggttca gtcatctgca tatttctctg gtggtcaggt ttccagggac
       610        620        630        640        650        660
aaggaagagg attatgttcg ctatgcccat ggtctgatct ctgattacat ccctaaagaa
       670        680        690        700        710        720
ctgagtgatg atttatccaa gttcttgaag cttccagaac ctccagcttc attgaccaac
       730        740        750        760        770        780
cctccatcaa agaaactaaa gttatcagat gagcctgtag aagccaaaga agattacact
       790        800        810        820        830        840
aagtttaaca ctaaagactt gaagaccggc aagaaaaata gcaaaatgac tgcagctcag
       850        860        870        880        890        900
aaggctttgg ctaaagttga caaaagtgga atgaaaagta tcgatgcctt ttttggtgca
       910        920
aaaaataaaa aaactggaaa gatttga   

Last modification date: Oct. 2, 2011