Mus musculus L. (mouse) [MMU]

FULL NAME: Ribonuclease H2 subunit A


DESCRIPTION:
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

STRUCTURE SIMILARITY:
Belongs to the RNase HII family. Eukaryotic subfamily.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDLSELERDN TGRCRLSSPV PAVCLKEPCV LGVDEAGRGP VLGPMVYAIC YCPLSRLADL
        70         80         90        100        110        120
EALKVADSKT LTENERERLF AKMEEDGDFV GWALDVLSPN LISTSMLGRV KYNLNSLSHD
       130        140        150        160        170        180
TAAGLIQYAL DQNVNVTQVF VDTVGMPETY QARLQQHFPG IEVTVKAKAD SLFPVVSAAS
       190        200        210        220        230        240
IFAKVARDKA VKNWQFVENL QDLDSDYGSG YPNDPKTKAW LRKHVDPVFG FPQFVRFSWS
       250        260        270        280        290        300
TAQAILEKEA EDVIWEDSEA EEDPERPGKI TSYFSQGPQT CRPQAPHRYF QERGLEAASS

L     

Encoded by Rnaseh2a gene

FULL NAME: ribonuclease H2, large subunit


OTHER NAME(S):
2400006P09Rik
RNASEHI
RNHIA
RNHL


Nucleic acid sequence

        10         20         30         40         50         60
atggatctca gcgagctgga gagggacaat acgggtcgtt gtcgtctgag ttctcctgta
        70         80         90        100        110        120
cctgctgtgt gtctcaagga gccgtgcgtt ctgggcgtgg atgaagcggg ccgaggccct
       130        140        150        160        170        180
gtgcttggtc ccatggtcta cgccatctgt tactgccccc tgtctcgctt ggcagatctg
       190        200        210        220        230        240
gaggccctga aagtggcaga ctctaagacc ttgacagaga acgagcggga gaggctcttt
       250        260        270        280        290        300
gcgaaaatgg aggaggatgg agactttgtg ggttgggctt tggacgtcct gtctccaaac
       310        320        330        340        350        360
ctgatctcta ccagcatgct tgggcgagtc aagtacaacc tcaactccct gtcacacgat
       370        380        390        400        410        420
acagctgcgg ggctgataca gtacgcactg gaccagaatg tgaatgtcac tcaggtattt
       430        440        450        460        470        480
gtggacactg taggaatgcc agagacatac caggctcgat tacaacagca ctttcccggg
       490        500        510        520        530        540
atagaggtga cagtcaaggc caaagctgac tccctgttcc ctgtggtcag tgctgccagc
       550        560        570        580        590        600
atctttgcca aggtggcccg agacaaggct gtgaagaact ggcagtttgt ggaaaattta
       610        620        630        640        650        660
caggatctgg actccgatta tggctcaggc tatcccaatg atcccaagac caaagcctgg
       670        680        690        700        710        720
ctgaggaaac atgtggaccc tgtgtttggc tttccccagt ttgtacggtt cagttggagc
       730        740        750        760        770        780
acagcccagg ccatcctgga gaaggaggca gaagatgtca tttgggagga ctcagaagct
       790        800        810        820        830        840
gaggaggatc ctgaaagacc gggaaaaatc acctcctact tcagccaggg cccgcagacc
       850        860        870        880        890        900
tgccgccctc aggcccccca cagatacttc caggagcgag gcctggaggc agccagcagc

ctctag     

Last modification date: Oct. 2, 2011