Mus musculus L. (mouse) [MMU]

FULL NAME: DNA2-like helicase


DESCRIPTION:
May function in chromosomal DNA replication (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA2/NAM7 helicase family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MEPLDELDLL LLEEDGGAEA VPRVELLRKK ADALFPETVL SRGVDNRYLV LAVETSQNER
        70         80         90        100        110        120
GAEEKRLHVT ASQDREHEVL CILRNGWSSV PVEPGDIVHL EGDCTSEPWI IDDDFGYFIL
       130        140        150        160        170        180
YPDMMISGTS VASSIRCLRR AVLSETFRGS DPATRQMLIG TILHEVFQKA ISESFAPERL
       190        200        210        220        230        240
QELALQTLRE VRHLKEMYRL NLSQDEILCE VEEYLPSFSK WAEDFMRKGP SSEFPQMQLS
       250        260        270        280        290        300
LPSDGSNRSS PCNIEVVKSL DIEESIWSPR FGLKGKIDVT VGVKIHRDCK MKYKVMPLEL
       310        320        330        340        350        360
KTGKESNSIE HRSQVVLYTL LSQERREDPE AGWLLYLKTG QMYPVPANHL DKRELLKLRN
       370        380        390        400        410        420
WLAASLLHRV SRAAPGEEAR LSALPQIIEE EKTCKYCSQI GNCALYSRAV EEQGDDASIP
       430        440        450        460        470        480
EAMLSKIQEE TRHLQLAHLK YFSLWCLMLT LESQSKDNRK THQSIWLTPA SELEESGNCV
       490        500        510        520        530        540
GNLVRTEPVS RVCDGQYLHN FQRKNGPMPA TNLMAGDRII LSGEERKLFA LSKGYVKKMN
       550        560        570        580        590        600
KAAVTCLLDR NLSTLPATTV FRLDREERHG DISTPLGNLS KLMESTDPSK RLRELIIDFR
       610        620        630        640        650        660
EPQFIAYLSS VLPHDAKDTV ANILKGLNKP QRQAMKRVLL SKDYTLIVGM PGTGKTTTIC
       670        680        690        700        710        720
ALVRILSACG FSVLLTSYTH SAVDNILLKL AKFKVGFLRL GQSHKVHPDI QKFTEEEICR
       730        740        750        760        770        780
SRSIASLAHL EELYNSHPIV ATTCMGINHP IFSRKTFDFC IVDEASQISQ PVCLGPLFFS
       790        800        810        820        830        840
RRFVLVGDHQ QLPPLVVNRE ARALGMSESL FKRLERNESA VVQLTVQYRM NRKIMSLSNK
       850        860        870        880        890        900
LTYAGKLECG SDRVANAVLA LPNLKDARLS LQLYADYSDS PWLAGVLEPD NPVCFLNTDK
       910        920        930        940        950        960
VPAPEQVENG GVSNVTEARL IVFLTSTFIK AGCSPSDIGV IAPYRQQLRI ISDLLARSSV
       970        980        990       1000       1010       1020
GMVEVNTVDK YQGRDKSLIL VSFVRSNEDG TLGELLKDWR RLNVALTRAK HKLILLGSVS
      1030       1040       1050       1060
SLKRFPPLGT LFDHLNAEQL ILDLPSREHE SLSHILGDCQ RD 

Encoded by Dna2 gene

FULL NAME: DNA replication helicase 2 homolog (yeast)


OTHER NAME(S):
Dna2l
E130315B21Rik
KIAA0083


Nucleic acid sequence

        10         20         30         40         50         60
atggagccgc tggacgagct ggacctgctg ctgctggaag aggacggcgg agcggaggcc
        70         80         90        100        110        120
gtgccgcggg tggagctact tcggaagaag gcggacgctt tgtttccaga gacagttctg
       130        140        150        160        170        180
agccgaggag tggataaccg gtacctggtg ctagctgttg agacctcgca gaatgaaaga
       190        200        210        220        230        240
ggagccgagg agaagcgctt gcacgtcacg gcgtcccagg accgagagca cgaagttctg
       250        260        270        280        290        300
tgcatcctga ggaatggctg gagctcagta ccagttgagc caggggacat cgttcactta
       310        320        330        340        350        360
gagggagact gcacatctga gccgtggata atagacgatg actttggata ttttattctg
       370        380        390        400        410        420
tacccggaca tgatgatctc cggcacaagc gtcgctagca gcattcggtg tctgagaaga
       430        440        450        460        470        480
gctgtcctga gcgagacctt caggggctct gatccagcca ctcgccagat gctgatcggt
       490        500        510        520        530        540
acaattctcc acgaagtctt tcagaaagcg ataagtgaga gctttgctcc agaaaggcta
       550        560        570        580        590        600
caagagcttg ctcttcagac cctccgagaa gtgaggcatt tgaaggaaat gtatcgcttg
       610        620        630        640        650        660
aatctgagcc aagatgaaat actctgtgaa gttgaggagt atctcccttc tttctctaag
       670        680        690        700        710        720
tgggcggagg acttcatgcg taagggccct tcgtctgaat tccctcaaat gcagctctct
       730        740        750        760        770        780
ctgccaagcg atggcagtaa cagaagttca ccttgtaaca ttgaagtagt caagtcactg
       790        800        810        820        830        840
gatatcgaag aaagcatctg gtcccctagg tttggactga agggcaaaat agacgtcaca
       850        860        870        880        890        900
gtcggggtca aaatacatcg agattgtaaa atgaaataca aggtaatgcc actggagctg
       910        920        930        940        950        960
aagaccggca aagagtccaa ctccatcgag caccggagtc aggtggtcct gtacacgctg
       970        980        990       1000       1010       1020
ctaagccagg agaggcgaga ggaccccgag gctggctggc ttctctacct caagaccggg
      1030       1040       1050       1060       1070       1080
cagatgtacc ctgtgcccgc caaccatctg gacaaaagag aactgctgaa gctcaggaac
      1090       1100       1110       1120       1130       1140
tggctggccg cctcgctgct gcaccgtgtg agccgagcag ctccggggga ggaagctcgg
      1150       1160       1170       1180       1190       1200
ctctctgcct tgccacagat aatcgaggaa gagaaaactt gtaaatactg ttcgcagata
      1210       1220       1230       1240       1250       1260
ggcaactgtg ctctttatag cagagcagtt gaagagcagg gagatgacgc atccatccca
      1270       1280       1290       1300       1310       1320
gaagccatgc tgtccaaaat ccaggaagaa acacggcacc tgcagctggc gcacttgaag
      1330       1340       1350       1360       1370       1380
tatttcagcc tgtggtgtct catgttaacg ctggagtcgc aatctaaaga caaccggaag
      1390       1400       1410       1420       1430       1440
actcaccaga gtatctggtt aacgcctgcc tctgaactgg aggagagtgg caactgtgtt
      1450       1460       1470       1480       1490       1500
ggaaacctgg tcaggacgga gcctgtatca agagtttgtg atggacagta tttacataat
      1510       1520       1530       1540       1550       1560
tttcagcgga aaaatggtcc catgccagcc accaatctga tggcaggtga caggattatt
      1570       1580       1590       1600       1610       1620
ttaagtggag aagagagaaa actatttgct ttgtccaaag gctacgtgaa gaagatgaac
      1630       1640       1650       1660       1670       1680
aaggcagccg ttacctgctt gctagacagg aacttgtcga cactcccagc aacaacggtg
      1690       1700       1710       1720       1730       1740
tttcgattag accgggaaga aagacatggc gacataagta ctccactagg aaatctgtct
      1750       1760       1770       1780       1790       1800
aaattgatgg aaagcacaga tcccagcaaa agacttcgag aattaatcat cgatttcagg
      1810       1820       1830       1840       1850       1860
gaacctcagt tcatcgccta cctcagctcc gtccttccac acgatgcgaa ggatacggtg
      1870       1880       1890       1900       1910       1920
gccaacattc taaagggttt gaataaaccc cagagacaag caatgaagag agtccttctt
      1930       1940       1950       1960       1970       1980
tcgaaagact acacgctcat tgttgggatg ccagggacag gaaagacaac caccatctgt
      1990       2000       2010       2020       2030       2040
gccctggtga ggatcctctc tgcctgtggg ttcagcgttc tgctgaccag ctacacgcac
      2050       2060       2070       2080       2090       2100
tccgccgttg acaatattct cctgaagtta gccaagttta aagtcggatt tttgcgcttg
      2110       2120       2130       2140       2150       2160
ggtcagtctc ataaggtcca tccagacatc cagaagttta cagaggagga gatttgcaga
      2170       2180       2190       2200       2210       2220
tcgaggtcca ttgcgtcttt agcccatcta gaagaactct ataacagtca ccctattgtt
      2230       2240       2250       2260       2270       2280
gcaacaacct gcatgggaat aaatcaccca atattttccc gaaaaacctt tgatttctgt
      2290       2300       2310       2320       2330       2340
attgtggatg aagcatctca aatcagccag cccgtctgcc tgggcccact gttcttttcg
      2350       2360       2370       2380       2390       2400
cggaggtttg tgctggtggg ggaccatcag cagctgcctc ccctggttgt aaaccgagag
      2410       2420       2430       2440       2450       2460
gcaagagctc tgggcatgag cgagagcttg ttcaagaggc tggagcggaa cgagagcgct
      2470       2480       2490       2500       2510       2520
gtggtgcagc tgaccgtgca ataccgaatg aacaggaaga ttatgtccct gagcaacaag
      2530       2540       2550       2560       2570       2580
ctcacatacg cagggaaact ggagtgtggg tcagaccgag tggccaacgc agtgctagcc
      2590       2600       2610       2620       2630       2640
ctgcccaacc tcaaggacgc aaggctgagc ctccagcttt atgccgacta ctctgacagc
      2650       2660       2670       2680       2690       2700
ccctggctgg ctggagtgtt agagccagac aatcccgtgt gtttccttaa cacagacaag
      2710       2720       2730       2740       2750       2760
gtcccagctc cagagcaagt tgaaaatggt ggtgttagca atgtcacaga agccagactc
      2770       2780       2790       2800       2810       2820
attgtcttcc taacctcaac ttttataaag gcaggctgca gcccctcaga cattggcgtc
      2830       2840       2850       2860       2870       2880
atcgccccgt accgacagca gctgcggatc atcagcgact tactggcccg gtcttctgtt
      2890       2900       2910       2920       2930       2940
gggatggttg aggttaacac agtagacaaa taccaaggaa gggacaagag tctcatcctg
      2950       2960       2970       2980       2990       3000
gtgtcctttg ttaggagtaa tgaggatgga actctcggcg agctcctgaa agattggcgg
      3010       3020       3030       3040       3050       3060
agactcaacg tggcactcac cagagccaag cataaactga tcctgctggg cagcgtgtcc
      3070       3080       3090       3100       3110       3120
tcgctgaagc gcttcccgcc tctggggacg ctctttgacc atctgaatgc agagcagtta
      3130       3140       3150       3160       3170       3180
atcctggacc ttccttccag agagcatgag agcctcagcc acatcctggg cgattgtcag

cgagactga     

Last modification date: Oct. 2, 2011