Homo sapiens L. (human) [HSA]


STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSSPASTPSR RGSRRGRATP AQTPRSEDAR SSPSQRRRGE DSTSTGELQP MPTSPGVDLQ
        70         80         90        100        110        120
SPAAQDVLFS SPPQMHSSAI PLDFDVSSPL TYGTPSSRVE GTPRSGVRGT PVRQRPDLGS
       130        140        150        160        170        180
AQKGLQVDLQ SDGAAAEDIV ASEQSLGQKL VIWGTDVNVA ACKENFQRFL QRFIDPLAKE
       190        200        210        220        230        240
EENVGIDITE PLYMQRLGEI NVIGEPFLNV NCEHIKSFDK NLYRQLISYP QEVIPTFDMA
       250        260        270        280        290        300
VNEIFFDRYP DSILEHQIQV RPFNALKTKN MRNLNPEDID QLITISGMVI RTSQLIPEMQ
       310        320        330        340        350        360
EAFFQCQVCA HTTRVEMDRG RIAEPSVCGR CHTTHSMALI HNRSLFSDKQ MIKLQESPED
       370        380        390        400        410        420
MPAGQTPHTV ILFAHNDLVD KVQPGDRVNV TGIYRAVPIR VNPRVSNVKS VYKTHIDVIH
       430        440        450        460        470        480
YRKTDAKRLH GLDEEAEQKL FSEKRVELLK ELSRKPDIYE RLASALAPSI YEHEDIKKGI
       490        500        510        520        530        540
LLQLFGGTRK DFSHTGRGKF RAEINILLCG DPGTSKSQLL QYVYNLVPRG QYTSGKGSSA
       550        560        570        580        590        600
VGLTAYVMKD PETRQLVLQT GALVLSDNGI CCIDEFDKMN ESTRSVLHEV MEQQTLSIAK
       610        620        630        640        650        660
AGIICQLNAR TSVLAAANPI ESQWNPKKTT IENIQLPHTL LSRFDLIFLL LDPQDEAYDR
       670        680        690        700        710        720
RLAHHLVALY YQSEEQAEEE LLDMAVLKDY IAYAHSTIMP RLSEEASQAL IEAYVDMRKI
       730        740        750        760        770        780
GSSRGMVSAY PRQLESLIRL AEAHAKVRLS NKVEAIDVEE AKRLHREALK QSATDPRTGI
       790        800        810        820        830        840
VDISILTTGM SATSRKRKEE LAEALKKLIL SKGKTPALKY QQLFEDIRGQ SDIAITKDMF
       850        860
EEALRALADD DFLTVTGKTV RLL   

Encoded by MCM4 gene

FULL NAME: minichromosome maintenance complex component 4


OTHER NAME(S):
CDC21
CDC54
MGC33310
P1-CDC21
hCdc21


DESCRIPTION:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgtccc cggcgtcgac cccgagccgc cgcggcagcc ggcgtggaag ggccaccccc
        70         80         90        100        110        120
gcccagacgc ctcggagtga ggatgccagg tcatctccct ctcagagacg tagaggcgag
       130        140        150        160        170        180
gattccacct ccacggggga gttgcagccg atgccaacct cgcctggagt ggacctgcag
       190        200        210        220        230        240
agccctgctg cgcaggacgt gctgttttcc agccctcccc aaatgcattc ttcagctatc
       250        260        270        280        290        300
cctcttgact ttgatgttag ttcaccactg acatacggca ctcccagctc tcgggtagag
       310        320        330        340        350        360
ggaaccccaa gaagtggtgt taggggcaca cctgtgagac agaggcctga cctgggctct
       370        380        390        400        410        420
gcacagaagg gcctgcaagt ggatctgcag tctgacgggg cagcagcaga agatatagtg
       430        440        450        460        470        480
gcaagtgagc agtctctagg ccaaaaactt gtgatctggg gaacagatgt aaatgtggca
       490        500        510        520        530        540
gcatgcaaag aaaactttca gagatttctt cagcgtttta ttgaccctct ggctaaagaa
       550        560        570        580        590        600
gaagaaaatg ttggcataga tattactgaa cctctataca tgcaacgact tggggagatt
       610        620        630        640        650        660
aatgttattg gtgagccatt tttaaatgtg aactgtgaac acatcaaatc atttgacaaa
       670        680        690        700        710        720
aatttgtaca gacaactcat ctcttaccca caggaagtta ttccaacttt tgacatggct
       730        740        750        760        770        780
gtcaatgaaa tcttctttga ccgttaccct gactcaatct tagaacatca gattcaagta
       790        800        810        820        830        840
agaccattca acgcattgaa gactaagaat atgagaaacc tgaatccaga agacattgac
       850        860        870        880        890        900
cagctcatca ccatcagcgg catggtgatc aggacatccc agctgattcc cgagatgcag
       910        920        930        940        950        960
gaggccttct tccagtgcca agtgtgtgcc cacacgaccc gggtggagat ggaccgcggc
       970        980        990       1000       1010       1020
cgcattgcag agcccagtgt gtgcgggcgc tgccacacca cccacagcat ggcactcatc
      1030       1040       1050       1060       1070       1080
cacaaccgct ccctcttctc tgacaagcag atgatcaagc ttcaggagtc tccggaagac
      1090       1100       1110       1120       1130       1140
atgcctgcag ggcagacacc acacacagtt atcctgtttg ctcacaatga tctcgttgac
      1150       1160       1170       1180       1190       1200
aaggtccagc ctggggacag agtgaatgtt acaggcatct atcgagctgt gcctattcga
      1210       1220       1230       1240       1250       1260
gtcaatccaa gagtgagtaa tgtgaagtct gtctacaaaa cccacattga tgtcattcat
      1270       1280       1290       1300       1310       1320
tatcggaaaa cggatgcaaa acgtctgcat ggccttgatg aagaagcaga acagaaactt
      1330       1340       1350       1360       1370       1380
ttttcagaga aacgtgtgga attgcttaag gaactttcca ggaaaccaga catttatgag
      1390       1400       1410       1420       1430       1440
aggcttgctt cagccttggc tccaagcatt tatgaacatg aagatataaa gaagggaatt
      1450       1460       1470       1480       1490       1500
ttgcttcagc tctttggcgg gacaaggaag gattttagtc acactggaag gggcaaattt
      1510       1520       1530       1540       1550       1560
cgggctgaga tcaacatctt gctgtgtggc gaccctggta ccagcaagtc ccagctgctg
      1570       1580       1590       1600       1610       1620
cagtacgtgt acaacctcgt ccccaggggc cagtacacgt ctgggaaggg ctccagtgca
      1630       1640       1650       1660       1670       1680
gttggcctca ctgcgtacgt aatgaaagac cctgagacaa ggcagctggt cctgcagaca
      1690       1700       1710       1720       1730       1740
ggtgctcttg tcctgagtga caacggcatc tgctgtatcg atgagttcga caagatgaat
      1750       1760       1770       1780       1790       1800
gaaagtacaa gatcggtatt gcatgaagtc atggaacagc agactctgtc cattgcaaag
      1810       1820       1830       1840       1850       1860
gctgggatca tctgtcagct caatgcgcgc acctctgtcc tggcagcagc aaatcccatt
      1870       1880       1890       1900       1910       1920
gagtctcagt ggaatcctaa aaaaacaacc attgaaaaca tccagctgcc tcatacttta
      1930       1940       1950       1960       1970       1980
ttatcaaggt ttgatttgat cttcctcttg ctggaccctc aggacgaagc ctatgacagg
      1990       2000       2010       2020       2030       2040
cgtctggctc accacctggt cgcactgtac taccagagcg aggagcaggc agaggaggag
      2050       2060       2070       2080       2090       2100
ctcctggaca tggcggtgct aaaggactac attgcctacg cgcacagcac catcatgccg
      2110       2120       2130       2140       2150       2160
cggctaagtg aggaagccag ccaggctctc atcgaggctt atgtagacat gaggaagatt
      2170       2180       2190       2200       2210       2220
ggcagtagcc ggggaatggt ttctgcatac cctcgacagc tagagtcatt aatccgctta
      2230       2240       2250       2260       2270       2280
gcagaagccc atgctaaagt aagattgtct aacaaagttg aagccattga tgtggaagag
      2290       2300       2310       2320       2330       2340
gccaaacgcc tccatcggga agctctgaag cagtctgcaa ctgatccccg gactggcatc
      2350       2360       2370       2380       2390       2400
gtggacatat ctattcttac tacggggatg agtgccacct ctcgtaaacg gaaagaagaa
      2410       2420       2430       2440       2450       2460
ttagctgaag cattgaaaaa gcttatttta tctaagggca aaacaccagc tctaaaatac
      2470       2480       2490       2500       2510       2520
cagcaacttt ttgaagatat tcggggacaa tctgacatag caattactaa agatatgttt
      2530       2540       2550       2560       2570       2580
gaagaagcac tgcgtgccct ggcagatgat gatttcctga cagtgactgg gaagaccgtg
      2590
cgcttgctct ga    

Last modification date: Oct. 2, 2011