Mus musculus L. (mouse) [MMU]

FULL NAME: Replication factor C subunit 1


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction.

STRUCTURE SIMILARITY:
Belongs to the activator 1 large subunit family.
Contains 1 BRCT domain.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MDIRKFFGVI SSGKKPVNET VKNEKTKASE GTVKGKKGVK EAKVNNSGKE DASKPKQHSK
        70         80         90        100        110        120
KKRIINDSDS ESEETVQVKN AKKKSEKLSL SYKPGKVSQK DPVTYVSETD EDDDFVCKKA
       130        140        150        160        170        180
ASKSKENGVS TNSYLGTSNV KKNEENVKTK NKPLSPIKLT PTSVLDYFGT ESVQRSGKKM
       190        200        210        220        230        240
VTSKRKESSQ NTEDSRLNDE AIAKQLQLDE DAELERQLHE DEEFARTLAL LDEEPKIKKA
       250        260        270        280        290        300
RKDSEEGEES FSSVQDDLSK AEKQKSPNKA ELFSTARKTY SPAKHGKGRA SEDAKQPCKS
       310        320        330        340        350        360
AHRKEACSSP KASAKLALMK AKEESSYNET ELLAARRKES ATEPKGEKTT PKKTKVSPTK
       370        380        390        400        410        420
RESVSPEDSE KKRTNYQAYR SYLNREGPKA LGSKEIPKGA ENCLEGLTFV ITGVLESIER
       430        440        450        460        470        480
DEAKSLIERY GGKVTGNVSK KTNYLVMGRD SGQSKSDKAA ALGTKILDED GLLDLIRTMP
       490        500        510        520        530        540
GKRSKYEMAA EAEMKKEKSK LERTPQKNDQ GKRKISPAKK ESESKKCKLT LLKNSPMKAV
       550        560        570        580        590        600
KKEASTCPRG LDVKETHGNR SSNKEECLLW VDKYKPASLK NIIGQQGDQS CANKLLRWLR
       610        620        630        640        650        660
NWHKSSPEEK KHAAKFGKLA SKDDGSSFKA ALLSGPPGVG KTTTASLVCQ ELGYSYVELN
       670        680        690        700        710        720
ASDTRSKNSL KAVVAESLNN TSIKGFYTSG AAPSVSARHA LIMDEVDGMA GNEDRGGIQE
       730        740        750        760        770        780
LIGLIKHTKI PIICMCNDRN HPKIRSLVHY CFDLRFQRPR VEQIKSAMLS IAFKEGLKIP
       790        800        810        820        830        840
PPAMNEIILG ANQDVRQVLH NLSMWCAQSK ALTYDQAKAD SQRAKKDIRL GPFDVTRKVF
       850        860        870        880        890        900
AAGEETAHMS LMDKSDLFFH DYSIAPLFVQ ENYLHVKPVA AGGDMKKHLM LLSRAADSIC
       910        920        930        940        950        960
DGDLVDNQIR SKQNWSLLPT QAIYASVLPG ELMRGYMTQF PSFPSWLGKH SSTGKHDRIV
       970        980        990       1000       1010       1020
QDLSLHMSLR TYSSKRTVNM DYLSHIRDAL VRPLTSQGVE GAQHVIKLMD TYYLMKEDFE
      1030       1040       1050       1060       1070       1080
NIMEVSSWGG KPSAFSKLDP KVKAAFTRAY NKEAHLTPYS LQVVKTSRLS TGPALDSEYS
      1090       1100       1110       1120       1130
EEFQEDDTQS EKEQDAVETD AMIKKKTRSS KPSKSEREKE SKKGKGKNWK K

Encoded by Rfc1 gene

FULL NAME: replication factor C (activator 1) 1


OTHER NAME(S):
140kDa
Alp145
MGC96526
RFC140
Recc1


Nucleic acid sequence

        10         20         30         40         50         60
atggacattc ggaaattctt tggggttata tcaagtggaa aaaagcctgt aaacgagaca
        70         80         90        100        110        120
gtaaagaatg agaagacaaa agcttcggag ggaactgtca aaggaaaaaa gggagtcaag
       130        140        150        160        170        180
gaggccaagg tcaataactc cggtaaagag gacgcctcca aaccaaagca gcacagcaag
       190        200        210        220        230        240
aagaagagga tcatcaatga ctcagactca gagtcagagg agacagtaca ggtaaaaaat
       250        260        270        280        290        300
gctaaaaaga aatcagaaaa attgtcactg tcttataaac ctggtaaagt ctctcagaag
       310        320        330        340        350        360
gatcctgtca cctacgtctc tgagacagat gaagatgatg actttgtatg taaaaaggca
       370        380        390        400        410        420
gcctccaaat caaaagagaa tggagtatct acaaatagtt accttggaac atcaaacgtg
       430        440        450        460        470        480
aaaaaaaatg aagaaaacgt taagactaag aacaagccgt tatctccaat aaaactcaca
       490        500        510        520        530        540
ccaacgtcag tgctcgacta ttttggaact gaaagtgtcc agagatctgg gaagaagatg
       550        560        570        580        590        600
gtgacaagca aaaggaaaga atcttctcaa aacacagagg attccagatt aaatgatgag
       610        620        630        640        650        660
gccatcgcca agcagctgca gctggatgaa gatgcagagc tggagaggca gttgcatgaa
       670        680        690        700        710        720
gatgaagaat ttgcaagaac actggcctta ttggatgaag aacccaagat caaaaaggcc
       730        740        750        760        770        780
cgaaaggatt ctgaagaggg agaagaatca ttttcatctg tccaagatga tttaagcaaa
       790        800        810        820        830        840
gcagaaaagc agaaaagccc taataaagcc gagcttttct caactgcaag aaagacctac
       850        860        870        880        890        900
agtcctgcta agcatggcaa ggggagggct tcagaagatg ctaagcagcc ttgcaaatca
       910        920        930        940        950        960
gctcaccgga aggaagcctg ttcctcaccc aaggccagtg ccaaactggc gcttatgaaa
       970        980        990       1000       1010       1020
gcaaaagaag aaagttctta caacgaaaca gagctgctgg ctgcaagaag aaaagaaagc
      1030       1040       1050       1060       1070       1080
gccactgaac ccaaaggaga gaaaacaact cctaagaaaa cgaaagtttc tccaactaag
      1090       1100       1110       1120       1130       1140
agagagtctg taagcccaga agactctgaa aagaagcgca ctaattatca agcttatcga
      1150       1160       1170       1180       1190       1200
agctacttga accgagaagg tcccaaagct ctgggctcca aagaaatacc caagggagct
      1210       1220       1230       1240       1250       1260
gaaaattgct tggaaggcct gacgtttgtg atcacaggag tgctggagtc cattgaacga
      1270       1280       1290       1300       1310       1320
gacgaagcca agtctctaat tgaacgttat ggggggaaag taacaggaaa cgtgagcaag
      1330       1340       1350       1360       1370       1380
aaaaccaact acctcgtcat gggccgcgac agtgggcagt ccaagagtga caaggcagca
      1390       1400       1410       1420       1430       1440
gctctgggaa caaaaatcct cgatgaagac ggcctgttgg atctgattcg aactatgcca
      1450       1460       1470       1480       1490       1500
ggcaagagat ccaagtatga gatggctgct gaggctgaga tgaagaaaga aaagtccaaa
      1510       1520       1530       1540       1550       1560
ttggagcgaa caccccaaaa aaatgatcaa ggaaaaagaa aaattagtcc agccaagaag
      1570       1580       1590       1600       1610       1620
gagtcagagt ctaaaaagtg caagctgact ctcctaaaga acagtcctat gaaggcagtg
      1630       1640       1650       1660       1670       1680
aagaaggagg caagcacgtg cccaaggggc ctggatgtca aggagacaca tggcaaccgc
      1690       1700       1710       1720       1730       1740
agtagcaaca aagaggaatg tctgctctgg gtggataagt acaagcccgc ctcactcaag
      1750       1760       1770       1780       1790       1800
aacataatcg gacagcaggg tgaccagagc tgtgccaaca aattactacg ttggctcaga
      1810       1820       1830       1840       1850       1860
aactggcaca agagttctcc tgaagagaaa aaacatgcag caaagtttgg caaacttgcc
      1870       1880       1890       1900       1910       1920
agcaaagatg atggctccag tttcaaggca gctctgctgt ctggccctcc aggtgttggc
      1930       1940       1950       1960       1970       1980
aaaaccacta cagcttctct tgtgtgtcag gaattgggct acagttatgt ggaactaaat
      1990       2000       2010       2020       2030       2040
gcaagtgata ctcggagtaa gaacagtttg aaagcagttg ttgctgaatc cttgaacaac
      2050       2060       2070       2080       2090       2100
accagcatca aaggctttta tacaagtgga gcggctcctt ccgtgagtgc gaggcacgcc
      2110       2120       2130       2140       2150       2160
ctcatcatgg atgaggtcga tggcatggca ggcaatgaag acaggggtgg aattcaggag
      2170       2180       2190       2200       2210       2220
ctaataggcc tgataaagca tactaaaatt cccatcattt gtatgtgcaa tgatagaaac
      2230       2240       2250       2260       2270       2280
caccccaaaa ttcgctcatt ggttcattat tgttttgatc ttcgtttcca aagacctcga
      2290       2300       2310       2320       2330       2340
gttgaacaga ttaagagtgc aatgctgtct attgcattta aagagggttt aaaaatcccc
      2350       2360       2370       2380       2390       2400
cctccagcta tgaatgaaat aattttggga gctaatcaag atgtcagaca ggttttacac
      2410       2420       2430       2440       2450       2460
aatctcagta tgtggtgtgc acaaagtaag gccctgacct atgaccaagc caaggctgat
      2470       2480       2490       2500       2510       2520
tctcagaggg ctaagaagga tatcagactg ggcccatttg atgtcactcg gaaagtgttt
      2530       2540       2550       2560       2570       2580
gcagctggag aggagactgc acacatgtca ctgatggaca agtcagatct cttcttccat
      2590       2600       2610       2620       2630       2640
gactattcca tagcacccct ctttgtccag gagaactacc tgcatgtaaa gcctgtggct
      2650       2660       2670       2680       2690       2700
gcaggaggtg acatgaaaaa gcacttgatg cttttaagcc gggcagcaga tagcatatgt
      2710       2720       2730       2740       2750       2760
gacggtgact tagtggacaa tcagatccgg agtaagcaaa actggagtct tctgcccacc
      2770       2780       2790       2800       2810       2820
caggccatct atgccagtgt tcttcctgga gagttgatgc ggggctacat gactcagttt
      2830       2840       2850       2860       2870       2880
ccgagcttcc cgagctggct ggggaagcac tcgtctacgg gcaaacatga tcggattgtt
      2890       2900       2910       2920       2930       2940
caggacctat ccttgcacat gagtcttaga acttactcca gcaaaaggac agtgaacatg
      2950       2960       2970       2980       2990       3000
gattacctgt cacacatcag agacgcactt gtacgaccct tgacctcaca aggggtagaa
      3010       3020       3030       3040       3050       3060
ggggctcagc atgtcatcaa acttatggac acatactatc tgatgaaaga agattttgag
      3070       3080       3090       3100       3110       3120
aacatcatgg aagttagcag ctgggggggc aagcccagtg ccttttccaa gctggatccc
      3130       3140       3150       3160       3170       3180
aaggtgaaag cggccttcac aagagcctac aataaggagg cccacctgac cccatactca
      3190       3200       3210       3220       3230       3240
cttcaggtag taaagacatc gaggctcagc acgggtccag cactggattc tgagtacagt
      3250       3260       3270       3280       3290       3300
gaggagttcc aggaagatga cactcagtct gagaaagagc aggatgcagt ggagactgac
      3310       3320       3330       3340       3350       3360
gccatgatca agaaaaagac aagatcttca aaaccttcaa agtcagaaag agagaaggag
      3370       3380       3390
tccaaaaaag gaaaaggaaa gaattggaag aaatga  

Last modification date: Oct. 2, 2011