Mus musculus L. (mouse) [MMU]

FULL NAME: DNA replication licensing factor MCM6


DESCRIPTION:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDLAAAAEPG AGSQHPEVRD EVAEKCQKLF LDFLEEFQGS DGEIKYLQFA EELIRPERNT
        70         80         90        100        110        120
LVVSFADLEQ FNQQLSTTIQ EEFYRVYPYL CRALKTFVKD RKEIPFAKDF YVAFQDLPTR
       130        140        150        160        170        180
HKIRELTSSR IGLLTRISGQ VVRTHPVHPE LVSGTFLCLD CQTVIKDVEQ QFKYTQPNIC
       190        200        210        220        230        240
RNPVCANRKR FLLDTNKSRF VDFQKVRIQE TQAELPRGSI PRSLEVILRA EAVESAQAGD
       250        260        270        280        290        300
RCDFTGALIV VPDVSKLSTP GARAETNSRV SGADGYETEG IRGLRALGVR DLSYRLVFLA
       310        320        330        340        350        360
CHVAPTNPRF GGKELRDEEQ TAESIKNQMT VKEWEKVFEM SQDKNLYHNL CTSLFPTIHG
       370        380        390        400        410        420
NDEVKRGVLL MLFGGVPKTT GEGTSLRGDI NVCIVGDPST AKSQFLKHVD EFSPRAVYTS
       430        440        450        460        470        480
GKASSAAGLT AAVVRDEESH EFVIEAGALM LADNGVCCID EFDKMDMRDQ VAIHEAMEQQ
       490        500        510        520        530        540
TISITKAGVK ATLNARTSIL AAANPVSGHY DRSKSLKQNI NLSAPIMSRF DLFFILVDEC
       550        560        570        580        590        600
NEVTDYAIAR RIVDLHSRIE ESIDRVYSLD DIRRYLLFAR QFKPKISKES EDFIVEQYKR
       610        620        630        640        650        660
LRQRDGSGVT KSSWRITVRQ LESMIRLSES MARMHCCDEV QPKHVKEAFR LLNKSIIRVE
       670        680        690        700        710        720
TPDVNLDQEE EIQMETDEGQ GGVNGHADSP APVNRFNGSS EDASQETVSK PSLRLGFAEY
       730        740        750        760        770        780
CRISNLIVLH LRKMEEEEDE SALKRSELVN WYLKEIESEI DSEEELINKK TIIEKVVHRL
       790        800        810        820
THYDHVLIEL TQAGLKGSSE GSESYEEDPY LVVNPNYLLE D 

Encoded by Mcm6 gene

FULL NAME: minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)


OTHER NAME(S):
ASP-l1
D1Wsu22e
Mcmd6


Nucleic acid sequence

        10         20         30         40         50         60
atggacctcg cagcggccgc ggagcccggc gccggaagcc agcacccgga ggtgcgcgac
        70         80         90        100        110        120
gaggtggccg agaaatgcca gaagctgttc ctagacttcc tggaagagtt ccagggtagt
       130        140        150        160        170        180
gatggagaaa ttaaatactt gcagtttgca gaggagctaa ttcgtcctga gagaaacacg
       190        200        210        220        230        240
ctggttgtga gttttgcaga cctggaacaa tttaaccaac aactttctac caccattcag
       250        260        270        280        290        300
gaagagttct atagagtcta cccttacctg tgtcgagcct tgaagacctt tgtcaaagac
       310        320        330        340        350        360
cgaaaggaga tcccttttgc taaggatttt tatgttgcat tccaagacct acctactaga
       370        380        390        400        410        420
cacaagattc gtgagctcac ttcatccagg attgggctgc tcacccgaat cagtggccag
       430        440        450        460        470        480
gtggtgcgca ctcacccagt tcaccctgag cttgtgagtg gaactttcct gtgccttgac
       490        500        510        520        530        540
tgtcaaacag tgattaagga cgtagagcag cagttcaaat acacacagcc gaatatctgc
       550        560        570        580        590        600
cgaaatccag tgtgtgccaa caggaagagg ttccttctag acactaataa atcaagattt
       610        620        630        640        650        660
gttgattttc aaaaggttcg cattcaagag actcaagcgg aacttccccg gggaagtatt
       670        680        690        700        710        720
ccccggagtt tagaggttat cctgagagct gaagctgtgg agtcagccca agctggtgac
       730        740        750        760        770        780
agatgtgatt tcacaggggc actgattgtt gtgcctgatg tctccaagct tagcacacca
       790        800        810        820        830        840
ggagcacgtg cagagactaa ctcccgagtc agtggagctg atgggtatga gacagaaggc
       850        860        870        880        890        900
attcgagggc tccgggccct tggtgtcaga gatctgtcat acaggctggt cttccttgcc
       910        920        930        940        950        960
tgccatgttg caccaaccaa cccaaggttt ggagggaaag aactcagaga tgaggaacag
       970        980        990       1000       1010       1020
accgctgaga gcattaagaa ccaaatgacg gtgaaggaat gggaaaaggt gtttgaaatg
      1030       1040       1050       1060       1070       1080
agtcaggaca aaaacctgta ccacaatctc tgcacgagcc tcttccctac tatacatggc
      1090       1100       1110       1120       1130       1140
aatgatgaag taaaacgcgg tgtcttactg atgttgttcg gtggtgttcc taagacaaca
      1150       1160       1170       1180       1190       1200
ggggaaggaa cctctcttcg tggggatata aatgtttgca ttgttggtga tccaagtaca
      1210       1220       1230       1240       1250       1260
gctaagagcc aatttctcaa gcacgtggac gagttcagtc ccagagctgt ctataccagt
      1270       1280       1290       1300       1310       1320
ggcaaagcct ccagcgctgc cggcttaaca gcagctgtgg tgagagatga agaatctcac
      1330       1340       1350       1360       1370       1380
gaatttgtca ttgaggctgg agcgttgatg ctggctgata atggtgtctg ttgtattgat
      1390       1400       1410       1420       1430       1440
gaatttgata agatggacat gcgggaccaa gttgctattc acgaagctat ggagcagcag
      1450       1460       1470       1480       1490       1500
accatctcta tcacgaaagc aggagtgaag gcaactctga atgccaggac atccatttta
      1510       1520       1530       1540       1550       1560
gctgcagcaa accctgtcag cggacactat gacagatcaa aatctttgaa acagaacatc
      1570       1580       1590       1600       1610       1620
aatctgtcag cgcccatcat gtcccgcttt gatctcttct tcattctggt ggatgaatgc
      1630       1640       1650       1660       1670       1680
aatgaggtga cagattatgc tattgccagg cgcatagtag acttgcattc aagaattgaa
      1690       1700       1710       1720       1730       1740
gaatcgatcg atcgagttta ttcccttgat gatataagaa ggtaccttct ctttgcccga
      1750       1760       1770       1780       1790       1800
cagtttaaac ccaagatttc caaagagtca gaagacttca ttgtggagca gtacaaacgt
      1810       1820       1830       1840       1850       1860
ctccgccaga gggatggctc tggggtcacc aagtcctcgt ggagaatcac cgtgcgacag
      1870       1880       1890       1900       1910       1920
cttgagagca tgatccgact ctcagaatca atggcccgca tgcactgctg tgacgaggtt
      1930       1940       1950       1960       1970       1980
cagcctaaac atgtgaagga agcttttcga ttactgaata aatcaatcat ccgtgtagag
      1990       2000       2010       2020       2030       2040
acgcctgatg tcaatctaga tcaagaggaa gagatccaga tggagacgga tgagggacaa
      2050       2060       2070       2080       2090       2100
ggaggcgtca atggtcatgc cgacagccct gcccctgtga ataggttcaa cggctccagt
      2110       2120       2130       2140       2150       2160
gaagatgcca gccaggagac tgtttccaag ccctccctga ggctgggctt tgctgaatac
      2170       2180       2190       2200       2210       2220
tgccgaatct cgaacctcat cgtgctccac ctcaggaaaa tggaagaaga ggaggacgag
      2230       2240       2250       2260       2270       2280
tcggcactaa agagaagcga gcttgtcaac tggtacctga aggaaatcga atcagagata
      2290       2300       2310       2320       2330       2340
gactctgaag aagagctcat aaataaaaag acgatcattg agaaggttgt tcatcgtctc
      2350       2360       2370       2380       2390       2400
acacactacg atcacgttct gattgagctc acccaggctg ggctgaaagg ctccagtgaa
      2410       2420       2430       2440       2450       2460
ggaagcgaga gctatgagga agacccctac ctggtagtca accctaacta cttgcttgaa

gattga     

Last modification date: Oct. 2, 2011