Mus musculus L. (mouse) [MMU]

FULL NAME: DNA replication licensing factor MCM4


DESCRIPTION:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSSPASTPSR RSSRRGRVTP TQSLRSEESR SSPNRRRRGE DSSTGELLPM PTSPGADLQS
        70         80         90        100        110        120
PPAQNALFSS PPQMHSLAIP LDFDVSSPLT YGTPSSRVEG TPRSGVRGTP VRQRPDLGSA
       130        140        150        160        170        180
RKGLQVDLQS DGAAAEDIVP SEQSLGQKLV IWGTDVNVAT CKENFQRFLQ CFTDPLAKEE
       190        200        210        220        230        240
ENVGIDITQP LYMQQLGEIN ITGEPFLNVN CEHIKSFSKN LYRQLISYPQ EVIPTFDMAV
       250        260        270        280        290        300
NEIFFDRYPD SILEHQIQVR PFNALKTKSM RNLNPEDIDQ LITISGMVIR TSQLIPEMQE
       310        320        330        340        350        360
AFFQCQVCAH TTRVEIDRGR IAEPCSCVHC HTTHSMALIH NRSFFSDKQM IKLQESPEDM
       370        380        390        400        410        420
PAGQTPHTIV LFAHNDLVDK VQPGDRVNVT GIYRAVPIRV NPRVSNVKSV YKTHIDVIHY
       430        440        450        460        470        480
RKTDAKRLHG LDEEAEQKLF SEKRVKLLKE LSRKPDIYER LASALAPSIY EHEDIKKGIL
       490        500        510        520        530        540
LQLFGGTRKD FSHTGRGKFR AEINILLCGD PGTSKSQLLQ YVYNLVPRGQ YTSGKGSSAV
       550        560        570        580        590        600
GLTAYVMKDP ETRQLVLQTG ALVLSDNGIC CIDEFDKMNE STRSVLHEVM EQQTLSIAKA
       610        620        630        640        650        660
GIICQLNART SVLAAANPIE SQWNPKKTTI ENIQLPHTLL SRFDLIFLML DPQDEAYDRR
       670        680        690        700        710        720
LAHHLVSLYY QSEEQVEEEF LDMAVLKDYI AYAHSTIMPR LSEEASQALI EAYVNMRKIG
       730        740        750        760        770        780
SSRGMVSAYP RQLESLIRLA EAHAKVRFSN KVEAIDVEEA KRLHREALKQ SATDPRTGIV
       790        800        810        820        830        840
DISILTTGMS ATSRKRKEEL AEALRKLILS KGKTPALKYQ QLFEDIRGQS DTAITKDMFE
       850        860
EALRALADDD FLTVTGKTVR LL   

Encoded by Mcm4 gene

FULL NAME: minichromosome maintenance deficient 4 homolog (S. cerevisiae)


OTHER NAME(S):
19G
AI325074
AU045576
Cdc21
KIAA4003
Mcmd4
mKIAA4003
mcdc21


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgtccc cggcatccac cccgagccgc cgcagcagcc gacgcggacg agtcacccca
        70         80         90        100        110        120
acccagtccc ttcgaagtga ggaaagcagg tcgtcaccca atcggagacg tagaggcgaa
       130        140        150        160        170        180
gattcttcca ccggagagct actgccaatg cccacctcac caggagccga cctgcagagc
       190        200        210        220        230        240
ccacctgcac agaatgcctt gttttccagc cctcctcaga tgcattcttt agctattcct
       250        260        270        280        290        300
ttggactttg atgttagttc accattgaca tatggcactc ccagctcgcg agtggaagga
       310        320        330        340        350        360
accccaagaa gtggggtgag aggcacacct gtaaggcaga ggccagatct gggctcagca
       370        380        390        400        410        420
cgaaagggtt tgcaggtgga tctgcagtct gatggcgcag cagcagaaga catcgtacca
       430        440        450        460        470        480
agtgaacagt ctctaggcca aaagcttgtg atttggggaa cagatgtgaa tgtggcaaca
       490        500        510        520        530        540
tgtaaagaga attttcagag attccttcag tgttttactg atcctctggc caaagaagaa
       550        560        570        580        590        600
gaaaatgttg gcatagatat tactcaacct ttgtacatgc aacaacttgg agagattaat
       610        620        630        640        650        660
attacaggag agccattttt aaatgtgaac tgcgaacaca taaaatcatt tagcaaaaat
       670        680        690        700        710        720
ctgtatagac agctcatctc ctacccacag gaggttatac caacctttga catggctgtc
       730        740        750        760        770        780
aatgagatct tctttgaccg ttatcctgac tccatcttag aacatcagat tcaagtcaga
       790        800        810        820        830        840
ccttttaatg cgttgaagac aaagagtatg agaaacttga atccagaaga cattgatcag
       850        860        870        880        890        900
ctcatcacca tcagtggcat ggtcatcaga acatcacagc tgattccgga gatgcaggag
       910        920        930        940        950        960
gcctttttcc aatgccaagt ctgtgcccac accacccggg tggagataga tcgaggcaga
       970        980        990       1000       1010       1020
attgctgagc cctgcagttg tgtgcactgc cacactaccc acagcatggc actgatccac
      1030       1040       1050       1060       1070       1080
aaccgatcat tcttctctga caagcaaatg atcaaacttc aagagtctcc tgaagacatg
      1090       1100       1110       1120       1130       1140
cctgctgggc agacacctca cactattgtc ctttttgccc acaatgacct tgttgacaag
      1150       1160       1170       1180       1190       1200
gttcaaccag gggacagagt gaacgtcaca ggcatatatc gagcagtacc aattcgagtt
      1210       1220       1230       1240       1250       1260
aatccaagag tgagcaacgt gaagtctgtc tataaaaccc acattgatgt cattcattat
      1270       1280       1290       1300       1310       1320
cggaaaacgg atgcaaaacg tctgcatggc cttgatgaag aagcagaaca gaaacttttt
      1330       1340       1350       1360       1370       1380
tcagagaaac gtgtgaaatt gcttaaggaa ctttccagga agccagatat ttatgagcgg
      1390       1400       1410       1420       1430       1440
cttgcttcag ccttggctcc cagcatttat gaacatgaag atatcaaaaa gggaatctta
      1450       1460       1470       1480       1490       1500
cttcagctct ttggtggaac aaggaaggat ttcagtcaca ctgggagggg taaattccgt
      1510       1520       1530       1540       1550       1560
gctgagatca acatccttct gtgtggggac cctggcacca gcaagtccca gctgctacag
      1570       1580       1590       1600       1610       1620
tatgtgtaca acctggtccc cagaggccag tacacgtctg gaaaaggctc cagtgcggtc
      1630       1640       1650       1660       1670       1680
ggcctcaccg cctatgtgat gaaagaccct gagaccaggc agcttgtcct ccagacaggt
      1690       1700       1710       1720       1730       1740
gccctcgtcc tgagtgacaa tgggatatgc tgcatcgatg agtttgacaa aatgaatgaa
      1750       1760       1770       1780       1790       1800
agcacaaggt ctgtgctgca tgaggtcatg gaacagcaga ctctgtccat tgcaaaggct
      1810       1820       1830       1840       1850       1860
gggatcatct gtcagctcaa tgcgcgcacc tctgtcctgg cagcagcaaa tcctattgag
      1870       1880       1890       1900       1910       1920
tctcagtgga atcctaaaaa aacaaccatt gaaaatatcc aactaccgca cacattgttg
      1930       1940       1950       1960       1970       1980
tcaaggtttg atctcatttt cctcatgcta gaccctcagg atgaggcata tgaccggcgt
      1990       2000       2010       2020       2030       2040
ctagctcatc acctggtttc attgtactac caaagtgagg agcaagtgga ggaggagttc
      2050       2060       2070       2080       2090       2100
ctggacatgg ccgtgctgaa agactacatt gcatatgccc atagtaccat catgccccga
      2110       2120       2130       2140       2150       2160
ctgagtgagg aggccagcca ggctctcatt gaggcttatg taaacatgag gaagattggg
      2170       2180       2190       2200       2210       2220
agtagccggg ggatggtttc tgcttaccct cgacagctag agtcattaat tcgcttagca
      2230       2240       2250       2260       2270       2280
gaagcccatg ctaaagtaag attttcaaac aaagttgaag caattgatgt ggaagaggca
      2290       2300       2310       2320       2330       2340
aaacgcctcc accgggaggc tctgaagcag tctgcaactg accctcgtac tggcattgtg
      2350       2360       2370       2380       2390       2400
gatatttcta ttcttactac aggaatgagt gccacttctc gtaaacggaa agaagaatta
      2410       2420       2430       2440       2450       2460
gctgaagcat tgagaaaact tattttatct aagggtaaaa caccagcctt aaagtaccaa
      2470       2480       2490       2500       2510       2520
cagctgtttg aggatattcg gggacagtct gacacagcaa ttaccaagga catgtttgaa
      2530       2540       2550       2560       2570       2580
gaagccctgc gagctttggc tgatgatgat ttcctaacag tgactgggaa gactgtccgc

ctgctctga     

Last modification date: Oct. 2, 2011