Mus musculus L. (mouse) [MMU]

FULL NAME: DNA replication licensing factor MCM3


DESCRIPTION:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQNKVRELI SDNQYRLIVS VNDLRRKNEK
        70         80         90        100        110        120
RANRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYI GLEGSFGSKH VSPRTLTSCF
       130        140        150        160        170        180
LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA TKKTIERRYS DLTTLVAFPS SSVYPTKDEE
       190        200        210        220        230        240
NNPLETEYGL SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKVK PGDRIQVVGT
       250        260        270        280        290        300
YRCLPGKKGC YTSGTFRTVL IACNVKQMSK DIQPAFSADD IAKIKKFSKT RSKDVFEQLA
       310        320        330        340        350        360
RSLAPSIHGH DYVKKAILCL LLGGVERELE NGSHIRGDIN ILLIGDPSVA KSQLLRYVLC
       370        380        390        400        410        420
TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL ADRGVVCIDE FDKMSDMDRT
       430        440        450        460        470        480
AIHEVMEQGR VTIAKAGIHA RLNARCSVLA AANPVYGRYD QYKTPMENIG LQDSLLSRFD
       490        500        510        520        530        540
LLFIMLDQMD PEQDREISDH VLRMHQYRAP GEQDGDALPL GSSVDILATD DPDFTQDDQQ
       550        560        570        580        590        600
DTRIYEKHDS LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP TLTQESAAYI AEEYSRLRSQ
       610        620        630        640        650        660
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ YAYFKKVLEK
       670        680        690        700        710        720
EKKRKKASED ESDLEDEEEK SQEDTEQKRK RRKTHAKDGE SYDPYDFSEA ETQMPQVHTP
       730        740        750        760        770        780
KTDDSQEKTD DSQETQDSQK VELSEPRLKA FKAALLEVFQ EAHEQSVGML HLTESINRNR
       790        800        810
EEPFSSEEIQ ACLSRMQDDN QVMVSEGIVF LI  

Encoded by Mcm3 gene

FULL NAME: minichromosome maintenance deficient 3 (S. cerevisiae)


OTHER NAME(S):
AL033361
C80350
Mcmd
P1
p1.m


Nucleic acid sequence

        10         20         30         40         50         60
atggcgggca cagtagtgct ggatgatgtg gagctgcggg aagcgcagag agactacttg
        70         80         90        100        110        120
gacttcctgg atgacgagga ggaccaaggc atttaccaga acaaggttcg ggaactgatc
       130        140        150        160        170        180
agtgacaatc agtatcggct gattgtcagc gtgaatgacc tgcgcaggaa gaatgaaaag
       190        200        210        220        230        240
agggctaacc gcctcctgaa caatgcgttt gaggagctgg ttgccttcca gcgggccttg
       250        260        270        280        290        300
aaggatttcg tggcctccat tgacgccacc tacgccaagc agtatgagga gttctacata
       310        320        330        340        350        360
ggattggaag gcagctttgg ctcaaagcac gtctctcccc ggactctcac ttcctgcttc
       370        380        390        400        410        420
ctcagctgtg tggtctgtgt ggaaggcatt gttactaaat gctctctggt tcgccccaaa
       430        440        450        460        470        480
gtcgttcgca gtgttcacta ctgtcctgct actaagaaga ccatagagcg acgctactct
       490        500        510        520        530        540
gacctcacca ccctagtggc tttcccatcc agttctgttt atcccacaaa ggatgaggag
       550        560        570        580        590        600
aacaaccccc tggagacaga gtatggcctg tctgtctaca aggaccatca gaccatcacc
       610        620        630        640        650        660
atccaggaga tgccagagaa ggcccctgct ggtcagctcc ctcgctctgt ggatgtcatt
       670        680        690        700        710        720
ctagacgatg acctggtgga taaagtgaag cctggtgaca gaatacaggt ggtggggacc
       730        740        750        760        770        780
taccgctgcc ttccagggaa gaagggctgc tacacctcgg ggaccttcag gaccgtcctg
       790        800        810        820        830        840
attgcctgta atgtgaagca gatgagtaag gatattcagc ctgcattctc tgcggacgat
       850        860        870        880        890        900
atagccaaga tcaagaagtt cagcaaaact cgttccaagg atgtctttga gcagctggcc
       910        920        930        940        950        960
cggtcgttag ccccgagcat ccatgggcat gactatgtca agaaggcaat cctctgcttg
       970        980        990       1000       1010       1020
ctcctgggag gggtggagcg ggaacttgaa aacggcagcc acatccgtgg agacatcaat
      1030       1040       1050       1060       1070       1080
attcttctaa taggtgaccc ctccgttgcc aagtcccagc ttctgcggta cgtgctttgc
      1090       1100       1110       1120       1130       1140
acggcgccca gggccattcc caccacggga cggggctcct ctggagtggg tctcacagct
      1150       1160       1170       1180       1190       1200
gctgtcacta cagaccagga aacaggggag cgccgcctgg aagctggtgc tatggtcctg
      1210       1220       1230       1240       1250       1260
gctgaccgtg gagtggtttg cattgatgag tttgacaaga tgtctgacat ggaccgcaca
      1270       1280       1290       1300       1310       1320
gccatccacg aggtgatgga gcagggtcga gtgaccattg caaaggctgg catccatgcc
      1330       1340       1350       1360       1370       1380
cggctcaatg cccgctgcag tgttttggca gctgccaatc cagtctatgg caggtatgat
      1390       1400       1410       1420       1430       1440
cagtataaga cgcccatgga gaacattggg ctgcaggact cactgctgtc tagatttgac
      1450       1460       1470       1480       1490       1500
ctgctcttca tcatgctgga tcagatggat cctgaacagg atcgggagat ctcagaccac
      1510       1520       1530       1540       1550       1560
gtcctgagga tgcaccaata cagggccccg ggggagcagg acggtgatgc tttgccattg
      1570       1580       1590       1600       1610       1620
ggtagttcag tggatatcct ggccacagac gatcctgact ttacccagga tgaccagcaa
      1630       1640       1650       1660       1670       1680
gatacccgca tttatgagaa gcatgacagc cttctacatg ggaccaagaa gaaaaaggag
      1690       1700       1710       1720       1730       1740
aagatggtga gcgcagcttt tatgaagaag tacattcacg tggccaaaat tatcaagccc
      1750       1760       1770       1780       1790       1800
accctgacac aggagtcagc agcctacatt gcagaagaat actcacgcct gcgcagccag
      1810       1820       1830       1840       1850       1860
gacagtatga gctcagacac tgcccggaca tctccagtta cagcacggac actggaaact
      1870       1880       1890       1900       1910       1920
ctgattcgac tggccacggc ccatgcgaag gcccggatga gcaagactgt ggacctgcag
      1930       1940       1950       1960       1970       1980
gatgcagagg aagccgtgga gctggttcag tatgcttatt tcaagaaggt tctggagaag
      1990       2000       2010       2020       2030       2040
gagaagaaac gtaagaaggc aagtgaggat gaatcagacc tagaagatga agaggaaaag
      2050       2060       2070       2080       2090       2100
agccaggaag acactgagca gaagcggaaa aggaggaaga ctcatgccaa ggatggagag
      2110       2120       2130       2140       2150       2160
tcctatgacc cttacgactt cagtgaagca gagacgcaga tgcctcaagt gcacacccca
      2170       2180       2190       2200       2210       2220
aagactgacg attcccaaga gaagaccgat gattctcagg agacccagga ctcccagaaa
      2230       2240       2250       2260       2270       2280
gtggaactca gtgagcccag gctgaaggct tttaaggcgg ccctcttaga agtgttccag
      2290       2300       2310       2320       2330       2340
gaagctcatg agcagtctgt gggcatgctc cacctcacag aatccatcaa ccggaataga
      2350       2360       2370       2380       2390       2400
gaagagccgt tctcctcaga ggaaatccag gcttgcctga gccggatgca ggatgataac
      2410       2420       2430
caggtcatgg tgtctgaggg catcgtcttc cttatctga  

Last modification date: Oct. 2, 2011