Mus musculus L. (mouse) [MMU]

FULL NAME: DNA polymerase epsilon subunit 4


DESCRIPTION:
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAAAAAAGSG TPREEEAPGG EAAASQAQAP TSAPGGVRLS RLPLARVKAL VKADPDVTLA
        70         80         90        100        110
GQEAIFILAR AAELFVETIA KDAYCCAQQG KRKTLQRRDL DNAIEAVDEF AFLEGTLD

Encoded by Pole4 gene

FULL NAME: polymerase (DNA-directed), epsilon 4 (p12 subunit)


OTHER NAME(S):
2400007P05Rik
5830430F06Rik


Nucleic acid sequence

        10         20         30         40         50         60
atggcggcag cggcggctgc tgggagcggg acgcccagag aggaagaggc tcccggaggg
        70         80         90        100        110        120
gaggcagcgg cttcgcaggc ccaagccccg acgagtgcac ccgggggagt tcgcctctcg
       130        140        150        160        170        180
aggctgcctc tggcgagagt aaaggccttg gtgaaggcag accctgacgt aacgctggcg
       190        200        210        220        230        240
ggacaggaag ccatctttat cctggcgcgt gccgcggaac tgttcgtgga gactatcgca
       250        260        270        280        290        300
aaagatgcct actgctgtgc tcaacaagga aagaggaaaa ctctccagag gagagatttg
       310        320        330        340        350
gataatgcaa tagaagctgt ggatgaattc gcttttctag aaggcacttt ggattaa

Last modification date: Oct. 2, 2011