Mus musculus L. (mouse) [MMU]

FULL NAME: DNA polymerase epsilon subunit 2


DESCRIPTION:
Participates in DNA repair and in chromosomal DNA replication.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase epsilon subunit B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAPERLRSRT VSAFKLRGLL LRSEATKYLT EALQSVTELE LEENLGKIID AVEKQPLSSN
        70         80         90        100        110        120
MIERSVVEAA VQECSQSMDE TIEHVFNIIG AFDIPRFIYN SERKKFLPLS MTNHAAPTLF
       130        140        150        160        170        180
GTARDKAELY LERYTILHQR THRHELFTPP VIGSHLEESG SKFQLKTIET LLGSTSKVGD
       190        200        210        220        230        240
VIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHANAF
       250        260        270        280        290        300
GFPPTEPSST TRAYYGNINF FGGPSNASVK TYTKLRQLED ENKDAMFVIV SDVWLDQVQV
       310        320        330        340        350        360
LEKFHVMFSG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKSLADIIC EYPSIHQSSR
       370        380        390        400        410        420
FVFVPGPEDP GFGSILPRPP LAESITQEFR QRVPFSVFTT NPCRIQYCTQ EIIIFREDLV
       430        440        450        460        470        480
NKMCRNCVRF PSSSLDIPTH FVKTILSQGH LAPLPLYVCP VHWAYDYTLR VYPVPDLLVI
       490        500        510        520
ADKYDPFTVT NTDCLCINPG SFPRSGFAFK VFYPSSKTVE DSKLQGF 

Encoded by Pole2 gene

FULL NAME: polymerase (DNA directed), epsilon 2 (p59 subunit)


Nucleic acid sequence

        10         20         30         40         50         60
atggcgccgg agcggctgcg gagccgcacg gtctcagctt tcaagctgcg gggcttgctg
        70         80         90        100        110        120
ctcaggagtg aagccaccaa gtatctgact gaagctctcc agtctgtcac tgaattggag
       130        140        150        160        170        180
ctagaggaga acctaggaaa gatcatcgat gcagttgaaa agcagccctt gtcctcgaac
       190        200        210        220        230        240
atgatcgaac gatctgtcgt ggaggcagct gtgcaagagt gcagtcagtc tatggatgag
       250        260        270        280        290        300
actatagagc acgttttcaa tatcattgga gcttttgata ttccacgttt tatatataat
       310        320        330        340        350        360
tcagaaagga aaaaatttct tcctctatcc atgactaatc atgctgcacc aaccttattt
       370        380        390        400        410        420
ggaacagcaa gagacaaagc cgagctgtat cttgaacgct ataccatttt acaccagagg
       430        440        450        460        470        480
acacacagac atgaattgtt cactcctccg gtgataggct cacaccttga agaaagtggg
       490        500        510        520        530        540
agcaagttcc agcttaaaac tatagaaacc ttactgggta gcacaagcaa agttggtgac
       550        560        570        580        590        600
gtgatcgtcc tggggatgat aacccagctg aaagagggga agtttttcct ggaagatcct
       610        620        630        640        650        660
actggaacag tacaactgga ccttagtaaa gctcagttcc acagtggctt atacaccgag
       670        680        690        700        710        720
gcctgcttcg tcctggcaga aggttggttt gaagatcaag tgtttcacgc caatgccttt
       730        740        750        760        770        780
ggatttcctc ccactgagcc ctccagcacc acaagggcgt actatggaaa tattaatttt
       790        800        810        820        830        840
tttggagggc cttctaatgc atcagtgaag acgtatacaa agctgagaca gctggaagat
       850        860        870        880        890        900
gagaacaagg acgccatgtt tgtgattgtg tctgatgttt ggttggacca agtgcaagtg
       910        920        930        940        950        960
ttggagaagt ttcatgtaat gttttctggt tactcgccag cacctccaac ctgctttatt
       970        980        990       1000       1010       1020
ctgtgtggta atttttcatc tgcaccatat ggaaaaaatc aagtccaggc tttgaaagat
      1030       1040       1050       1060       1070       1080
tccctaaaat ctttggcaga cataatttgt gaatatccaa gtatccacca aagtagccgt
      1090       1100       1110       1120       1130       1140
tttgtgtttg tgcctggccc agaggatcct ggatttggtt ccattttacc aaggccgcca
      1150       1160       1170       1180       1190       1200
ctcgctgaaa gcatcacaca ggaattcaga caaagggttc cgttttcagt tttcacgact
      1210       1220       1230       1240       1250       1260
aatccttgca gaattcagta ttgtacacaa gaaataatta tcttccgtga agacttagtg
      1270       1280       1290       1300       1310       1320
aataaaatgt gtagaaactg tgtccgtttt cctagcagca gtttggatat tcctactcac
      1330       1340       1350       1360       1370       1380
ttcgtaaaga ccatcttatc tcagggacat ctggctcctc tccctcttta cgtatgcccc
      1390       1400       1410       1420       1430       1440
gtccactggg catatgatta cacgttgaga gtgtacccgg tgcccgacct gctggtcatt
      1450       1460       1470       1480       1490       1500
gcagacaagt acgacccgtt caccgtgacc aacaccgatt gcctctgcat aaaccctggc
      1510       1520       1530       1540       1550       1560
tcctttccaa gaagtggatt tgcattcaaa gttttttacc cttccagtaa aacagtagaa
      1570       1580
gacagcaaac ttcagggctt ttga   

Last modification date: Oct. 2, 2011