Mus musculus L. (mouse) [MMU]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
B-family DNA polymerase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MVLRNSGRRH PEPGADGEGS RDDGPSSSVS ALKRLERSQW TDKMDLRFGF ERLKEPGERT
        70         80         90        100        110        120
GWLINMHPTE ILDEDKRLVS AVDYYFIQDD GSRFKVALPY MPYFYIAARK GCDREVSSFL
       130        140        150        160        170        180
SKKFQGKIAK LENVPKEDLD LPNHLVGLKR SYIKLSFHTV EDLVKVRKEI SPAVKKNREQ
       190        200        210        220        230        240
DHASDEYTTM LSSILQGGSV ITDEDETSKK IADQLDNIVD MREYDVPYHI RLSIDLRIHV
       250        260        270        280        290        300
AHWYNVRFRG NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI
       310        320        330        340        350        360
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE VHLIQRWFEH IQETKPTIMV
       370        380        390        400        410        420
TYNGDFFDWP FVEARAAIHG LSMYQEIGFQ KDSQGEYKAP QCIHMDCLRW VKRDSYLPVG
       430        440        450        460        470        480
SHNLKAAAKA KLGYDPVELD PEDMCRMATE QPQTLATYSV SDAVATYYLY MKYVHPFIFA
       490        500        510        520        530        540
LCTIIPMEPD EVLRKGSGTL CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHMLDAETYV
       550        560        570        580        590        600
GGHVEALESG VFRSDIPCRF RMNPAAFDFL LQRVEKTMRH AIEEEEKVPV EQATNFQEVC
       610        620        630        640        650        660
EQIKTKLTSL KDVPNRIECP LIYHLDVGAM YPNIILTNRL QPSAIVDEAT CAACDFNKPG
       670        680        690        700        710        720
ASCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP EGPARAFHEL SREEQAKYEK
       730        740        750        760        770        780
RRLADYCRKA YKKIHVTKVE ERLTTICQRE NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS
       790        800        810        820        830        840
AAVEVGDASE VKRCKNMEIL YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA
       850        860        870        880        890        900
NIITQARELI EQIGRPLELD TDGIWCVLPN SFPENFVIKT TNAKKPKLTI SYPGAMLNIM
       910        920        930        940        950        960
VKEGFTNHQY QELTEPSSLT YVTHSENSIF FEVDGPYLAM ILPASKEEGK KLKKRYAVFN
       970        980        990       1000       1010       1020
EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE EVYGSVAKVA DYWLDVLYSK
      1030       1040       1050       1060       1070       1080
AANMPDSELF ELISENRSMS RKLEDYGEQK STSISTAKRL AEFLGDQMVK DAGLSCRYII
      1090       1100       1110       1120       1130       1140
SRKPEGSPVT ERAIPLAIFQ AEPTVRKHFL RKWLKSSSLQ DFDIRTILDW DYYIERLGSA
      1150       1160       1170       1180       1190       1200
IQKIITIPAA LQQVKNPVPR VKHPDWLHKK LLEKNDIYKQ KKISELFVLE GKRQIVMAQA
      1210       1220       1230       1240       1250       1260
SENSLSLCTP DMEDIGLTKP HHSTVPVATK RKRVWETQKE SQDIALTVPW QEVLGQPPSL
      1270       1280       1290       1300       1310       1320
GTTQEEWLVW LQFHKKKWQL QAQQRLALRK KQRLESAEDM PRLGPIREGP STGLGSFLRR
      1330       1340       1350       1360       1370       1380
TARSIMDLPW QIIQISETRQ AGLFRLWAII GNDLHCIKLS IPRVFYVNQR VAKAEDGPAY
      1390       1400       1410       1420       1430       1440
RKVNRALPRS NIVYNLYEYS VPEDMYQEHI NEINTELSVP DIEGVYETQV PLLFRALVQL
      1450       1460       1470       1480       1490       1500
GCVCVVNKQL TRHLSGWEAE TFALEHLEMR SLAQFSYLEP GSIRHIYLYH HTQGHKALFG
      1510       1520       1530       1540       1550       1560
VFIPSQRRAS VFVLDTVRSN QMPGLSALYS SEHSLLLDKV DPKLLPPPKH TFEVRAETNL
      1570       1580       1590       1600       1610       1620
KTICRAIQRF LLAYKEERRG PTLIAVQSSW ELCRLTSEIP VLEEFPLVPI RVADKISYAV
      1630       1640       1650       1660       1670       1680
LDWQRHGARR MIRHYLNLDL CLSQAFEMSR YFHIPVGNLP EDISTFGSDL FFARHLQHHN
      1690       1700       1710       1720       1730       1740
HLLWLSPTSR PDLGGKEADD NRLVMEFDDR ATVEINSSGC YSTVCVELDI QNLAVNTILQ
      1750       1760       1770       1780       1790       1800
SHHVNDMEGA GSMGISFDVI QQASLEDMVT GNQAASALAN YDETALCSST FRILKSMVVG
      1810       1820       1830       1840       1850       1860
WVKEITQYHN IYADNQVMHF YRWLQSPCSL LHDPALHRTL HNMMKKLFLQ LIAEFKRLGS
      1870       1880       1890       1900       1910       1920
SVVYANFNRI ILCTKKRRIE DALAYVEYIT NSIHSKEIFH SLTISFSRCW EFLLWMDPSN
      1930       1940       1950       1960       1970       1980
YGGIKGKVPS SIHCGQVKEQ DSQAREETDE EEEDKEKDEE EEGMGESEVE DLLENNWNIL
      1990       2000       2010       2020       2030       2040
QFLPQAASCQ SYFLMIVSAY IVAVYQSMKE ELRHSAPGST PVKRKGASQF SQESEGATGS
      2050       2060       2070       2080       2090       2100
LPGMITFSQD YVANELTQSF FTITQKIQKK VTGSRNTTEP SEMFPVLPGS HLLLNNPALE
      2110       2120       2130       2140       2150       2160
FIKYVCKVLS LDTNITNQVN KLNRDLLRLV DVGEFSEEAQ FRDPCHSYVL PEVICHSCNF
      2170       2180       2190       2200       2210       2220
CRDLDLCKDS SFSQDGAILP QWLCSNCQAP YDSSAIESAL VEALQRKLMA FTLQDLVCLK
      2230       2240       2250       2260       2270       2280
CRGMKETHMP VYCSCAGDFT LTIRTEVFME QIRIFQNIAK YYSMSYLQET IEWLLQTSPV

SNC     

Encoded by Pole gene

FULL NAME: polymerase (DNA directed), epsilon


Nucleic acid sequence

        10         20         30         40         50         60
atggtcctga ggaacagtgg acggaggcac cccgagccgg gcgcggatgg cgaaggcagc
        70         80         90        100        110        120
cgggatgatg gtccctcttc ctcagtctca gcactcaagc gtctggaacg gagccagtgg
       130        140        150        160        170        180
acagacaaga tggacttacg gtttggtttc gaaaggctga aagagcctgg agaaaggact
       190        200        210        220        230        240
ggctggctga tcaacatgca ccctactgag atcttagatg aagacaaacg cttagtcagc
       250        260        270        280        290        300
gcggtggatt actacttcat tcaagatgat ggaagcagat ttaaggtggc cttgccctat
       310        320        330        340        350        360
atgccgtatt tctacattgc agcgagaaag ggttgtgatc gagaagtttc atcttttcta
       370        380        390        400        410        420
tccaagaagt ttcagggaaa aattgcaaag ttagagaatg tgcccaaaga agatctggac
       430        440        450        460        470        480
ttgccaaatc acttggtggg cttgaagcgg agttacatca agctgtcctt ccacactgtg
       490        500        510        520        530        540
gaggaccttg tcaaagtgag aaaggagatc tctcctgctg tgaagaagaa ccgagagcag
       550        560        570        580        590        600
gaccatgcta gtgatgagta tacaacaatg ctctccagta ttctgcaagg tggcagtgta
       610        620        630        640        650        660
attactgatg aggacgaaac ctctaagaag atagctgacc aattggacaa catagtggac
       670        680        690        700        710        720
atgcgagagt atgatgttcc ctaccacatt cgcctctcca ttgacctcag aatccatgtg
       730        740        750        760        770        780
gcccactggt acaatgttag atttcgagga aatgcttttc ctgtggaaat cacccgacga
       790        800        810        820        830        840
gatgatcttg ttgaacgacc tgaccctgtg gttttggcat ttgacatcga gacgaccaaa
       850        860        870        880        890        900
ctgcctctca aattccctga tgctgagacc gatcagatca tgatgatctc ctatatgatt
       910        920        930        940        950        960
gatggccagg gctacctcat cactaacagg gagattgttt cagaagatat tgaagatttt
       970        980        990       1000       1010       1020
gagttcaccc ctaagccaga atatgaaggg cccttttgtg tcttcaatga acccgacgag
      1030       1040       1050       1060       1070       1080
gtccatctga tccagagatg gtttgagcat atccaggaaa ccaaacctac cattatggtc
      1090       1100       1110       1120       1130       1140
acctacaatg gggatttttt tgactggcca tttgtggagg ctagggcagc aattcatggc
      1150       1160       1170       1180       1190       1200
ctcagcatgt accaggagat aggcttccag aaggatagcc agggggaata taaggcacca
      1210       1220       1230       1240       1250       1260
cagtgcatcc acatggactg cctcaggtgg gtgaagaggg acagttacct tcctgtgggc
      1270       1280       1290       1300       1310       1320
agtcataatc tcaaggcagc tgccaaggcc aaacttggct atgaccctgt agagctggac
      1330       1340       1350       1360       1370       1380
cctgaggaca tgtgtcgtat ggccactgaa cagccccaga ctctggccac ttactcagtg
      1390       1400       1410       1420       1430       1440
tcagatgctg tggctactta ctacctgtac atgaaatacg tccacccctt catattcgcc
      1450       1460       1470       1480       1490       1500
ctgtgcacca ttattcccat ggaacctgat gaggtgctgc ggaagggctc cgggacactg
      1510       1520       1530       1540       1550       1560
tgtgaagcct tgctgatggt gcaagctttc catgccaaca ttatcttccc caataagcaa
      1570       1580       1590       1600       1610       1620
gagcaggagt tcaacaagct gacagatgat ggccacatgc tagatgctga gacctacgtc
      1630       1640       1650       1660       1670       1680
gggggccacg tggaggcact agagtctggt gtcttcagaa gtgatatccc ctgccggttt
      1690       1700       1710       1720       1730       1740
aggatgaatc ctgcagcctt tgatttcctg ctgcaacgag tcgagaagac tatgcgccac
      1750       1760       1770       1780       1790       1800
gccattgaag aagaagagaa ggtgcctgtg gaacaagcca ccaactttca agaggtgtgt
      1810       1820       1830       1840       1850       1860
gagcagatta agaccaagct cacctcccta aaagatgttc ctaacagaat tgaatgtcct
      1870       1880       1890       1900       1910       1920
ctaatctacc atctagatgt gggggccatg tatcctaaca taattcttac caaccgccta
      1930       1940       1950       1960       1970       1980
cagccttctg ccatagtgga tgaggccacc tgtgctgcct gtgacttcaa taagcctgga
      1990       2000       2010       2020       2030       2040
gcaagttgtc agaggaagat ggcctggcag tggaggggag aattcatgcc agccagtcgc
      2050       2060       2070       2080       2090       2100
agtgaatacc atcggattca gcatcagctg gagtcggaga agtttccccc tttgtttcca
      2110       2120       2130       2140       2150       2160
gaggggccag cacgggcctt tcacgagctg tcccgtgaag aacaggctaa atacgagaag
      2170       2180       2190       2200       2210       2220
aggaggctgg cagattattg ccggaaagcc tataagaaga tccatgtgac caaggtagaa
      2230       2240       2250       2260       2270       2280
gaacgtctaa ctaccatctg ccagcgggaa aactcatttt atgtggacac agtgcgggcc
      2290       2300       2310       2320       2330       2340
ttcagagaca ggcgctatga gttcaaagga ctgcacaagg tgtggaagaa gaagctctcg
      2350       2360       2370       2380       2390       2400
gcagctgtag aggtgggcga tgcatcagag gtgaagcgct gcaagaacat ggagatcctt
      2410       2420       2430       2440       2450       2460
tacgattcac tgcagctggc tcacaagtgc atcctgaact ccttctacgg ctatgtcatg
      2470       2480       2490       2500       2510       2520
cgcaaaggag ctcgctggta ttccatggag atggctggta tcgtctgctt tacaggagcc
      2530       2540       2550       2560       2570       2580
aacatcatca cccaagcaag agaactgatt gagcagatcg ggaggccttt agaattggac
      2590       2600       2610       2620       2630       2640
acggacggaa tatggtgcgt cctacccaat agctttcctg aaaattttgt catcaagaca
      2650       2660       2670       2680       2690       2700
accaatgcga agaaacccaa actgaccatc tcctatcctg gtgccatgtt gaacatcatg
      2710       2720       2730       2740       2750       2760
gtcaaggaag gctttaccaa ccaccagtac caggaactaa cagagccttc gtctctcacc
      2770       2780       2790       2800       2810       2820
tatgtcaccc actctgagaa tagtatcttt tttgaagtcg atggaccata ccttgctatg
      2830       2840       2850       2860       2870       2880
atccttccag cctccaagga agaaggcaag aagctgaaga aaagatatgc tgtgttcaat
      2890       2900       2910       2920       2930       2940
gaagatggtt ccttggctga actgaaaggt tttgaggtga aacgccgagg ggagttgcag
      2950       2960       2970       2980       2990       3000
ctgattaaaa tattccagtc ctcagttttt gaggccttcc tcaagggcag cacactggag
      3010       3020       3030       3040       3050       3060
gaagtgtatg gctcggtggc caaagtggct gactactggc tagatgtgct ctatagcaag
      3070       3080       3090       3100       3110       3120
gctgctaata tgcccgattc tgaattgttt gagctgattt ctgagaaccg ctccatgtct
      3130       3140       3150       3160       3170       3180
cggaagctgg aagattacgg ggagcagaag tctacatcca tcagcacagc aaagcgcctg
      3190       3200       3210       3220       3230       3240
gctgagttcc tgggagacca gatggtcaaa gatgctggac tgagctgccg ctatatcatc
      3250       3260       3270       3280       3290       3300
tcccgaaagc cagaggggtc tcctgtcact gagagggcca ttccacttgc cattttccaa
      3310       3320       3330       3340       3350       3360
gcagagccta cagtgaggaa acattttctc cggaaatggc taaagagttc atcacttcaa
      3370       3380       3390       3400       3410       3420
gactttgata ttcggacaat tctggactgg gactactaca tagagaggct ggggagtgcc
      3430       3440       3450       3460       3470       3480
atccagaaaa tcatcaccat ccccgcagct ctgcagcagg tgaagaaccc agttccacgt
      3490       3500       3510       3520       3530       3540
gtcaaacatc cagactggct acacaaaaaa ctactagaga agaatgatat ctacaaacag
      3550       3560       3570       3580       3590       3600
aagaagatca gtgagctctt tgtgcttgaa ggaaagagac agattgtgat ggcccaggct
      3610       3620       3630       3640       3650       3660
tcagaaaaca gtctgagtct ctgcactcca gacatggagg acattggact cacaaagcca
      3670       3680       3690       3700       3710       3720
caccactcta cagtcccagt tgctactaag aggaagcgag tctgggagac ccaaaaggag
      3730       3740       3750       3760       3770       3780
tctcaggata ttgcactaac tgtgccctgg caagaggtct tagggcagcc tccctccctt
      3790       3800       3810       3820       3830       3840
ggaaccacac aggaagagtg gttggtctgg ctccagttcc acaagaaaaa gtggcagctg
      3850       3860       3870       3880       3890       3900
caggcccaac agcgcctagc cctcaggaag aagcaacgct tagagtcagc agaagatatg
      3910       3920       3930       3940       3950       3960
ccaaggcttg ggcctatccg agaggggcct tccacaggac tggggagctt tttgcgaagg
      3970       3980       3990       4000       4010       4020
actgcccgca gcatcatgga ccttccatgg cagataatac agatcagtga gaccagacag
      4030       4040       4050       4060       4070       4080
gctggtctgt tccggctgtg ggctatcatt ggcaatgact tgcactgcat caagctgagt
      4090       4100       4110       4120       4130       4140
atccctcgag tattctatgt aaaccagcgg gttgccaaag cagaggatgg acctgcatat
      4150       4160       4170       4180       4190       4200
cggaaggtga atcgggctct tcctcgttcc aacattgtct acaatctcta tgagtattca
      4210       4220       4230       4240       4250       4260
gtaccagagg acatgtacca agaacacatc aacgagatca acactgagtt gtcagtacca
      4270       4280       4290       4300       4310       4320
gacattgagg gcgtgtatga gacacaggtc ccattgttat tccgggccct cgtgcagctg
      4330       4340       4350       4360       4370       4380
ggctgtgtgt gtgtggtcaa caagcagctg acaaggcacc tttcgggctg ggaagctgaa
      4390       4400       4410       4420       4430       4440
acttttgccc tcgagcacct tgaaatgcgt tctctggccc agttcagcta cttggaacca
      4450       4460       4470       4480       4490       4500
gggagtatcc gccatatcta cctgtaccat cacactcagg gccacaaggc actctttggg
      4510       4520       4530       4540       4550       4560
gtctttatcc cctcacagcg aagagcatct gtgtttgtgt tggatactgt acgaagcaac
      4570       4580       4590       4600       4610       4620
caaatgccag ggctcagtgc cctgtactca tcagaacaca gcctgctgct ggacaaggtg
      4630       4640       4650       4660       4670       4680
gaccccaagc tcctgcctcc cccaaaacac acctttgaag ttcgtgctga aaccaacctg
      4690       4700       4710       4720       4730       4740
aagactatct gcagagccat ccagcgcttc ctgcttgcct acaaggaaga gcgccgaggg
      4750       4760       4770       4780       4790       4800
cccacactca tcgctgtcca gtctagctgg gagctgtgta ggctgaccag tgagattcca
      4810       4820       4830       4840       4850       4860
gtcttagaag agttcccact agtgcctatc cgagtggctg acaagatcag ctatgcagtc
      4870       4880       4890       4900       4910       4920
ctggactggc agcgccatgg agctcgccga atgatccggc actacctcaa tttagacttg
      4930       4940       4950       4960       4970       4980
tgcctgtcgc aggcctttga gatgagcagg tacttccaca tccctgttgg aaacctgccg
      4990       5000       5010       5020       5030       5040
gaagacatct ccacctttgg ctcagacctc ttttttgcac gccacctcca gcaccataac
      5050       5060       5070       5080       5090       5100
cacctgcttt ggctatcccc tacctctcgg cctgacctgg gtgggaagga agctgatgac
      5110       5120       5130       5140       5150       5160
aaccgccttg tcatggagtt tgatgaccga gccactgtgg agatcaatag ttctggctgt
      5170       5180       5190       5200       5210       5220
tactctactg tgtgcgtgga actggacatt caaaatctgg cagtcaacac catcctccag
      5230       5240       5250       5260       5270       5280
tcccatcatg tcaatgacat ggagggggct ggcagcatgg gcatcagctt cgatgtgatc
      5290       5300       5310       5320       5330       5340
cagcaggcct ccctagagga catggtaaca ggcaatcaag ctgccagtgc cctggccaac
      5350       5360       5370       5380       5390       5400
tacgatgaga cagccctctg ctctagtacc ttcaggatcc tgaagagcat ggtggttggc
      5410       5420       5430       5440       5450       5460
tgggtaaagg aaatcacaca gtaccacaac atctatgctg acaaccaggt aatgcacttc
      5470       5480       5490       5500       5510       5520
taccgctggc tccagtcacc gtgctctctg ctccacgacc cagcccttca ccggacgctg
      5530       5540       5550       5560       5570       5580
cacaacatga tgaagaagct cttcctgcag ctcattgctg agttcaagcg cctggggtca
      5590       5600       5610       5620       5630       5640
tcagtcgtct atgccaactt caatcgcatc attctctgta caaagaagcg ccgaatagag
      5650       5660       5670       5680       5690       5700
gatgcccttg cctatgtgga atatattacc aacagcatcc attctaaaga gatcttccat
      5710       5720       5730       5740       5750       5760
tccctgacca tctctttctc tcgatgctgg gaattccttc tctggatgga tccatccaac
      5770       5780       5790       5800       5810       5820
tatggtggaa tcaaaggaaa agttccatct agtattcact gtggacaggt aaaagagcaa
      5830       5840       5850       5860       5870       5880
gactcccagg caagagagga aactgatgaa gaggaggagg acaaggaaaa ggacgaggag
      5890       5900       5910       5920       5930       5940
gaagagggca tgggagagtc cgaggttgag gacttactgg agaacaactg gaacattcta
      5950       5960       5970       5980       5990       6000
cagttcttgc cccaggcagc ctcttgccag agctacttcc tcatgattgt ttcagcatac
      6010       6020       6030       6040       6050       6060
atcgtagctg tgtaccaaag catgaaggag gagttgagac acagtgcccc gggcagtacc
      6070       6080       6090       6100       6110       6120
cctgtgaaga ggaagggggc cagccagttc tcccaggagt ctgaaggggc aactggatct
      6130       6140       6150       6160       6170       6180
cttcctggaa tgatcacttt ctctcaagat tatgtggcaa atgagctcac tcagagcttc
      6190       6200       6210       6220       6230       6240
ttcaccatta ctcagaaaat tcagaagaaa gtcacaggtt ctcggaacac cactgagccc
      6250       6260       6270       6280       6290       6300
tcagagatgt tccccgtcct ccctggttca cacttgctgc tcaataatcc tgctctggag
      6310       6320       6330       6340       6350       6360
ttcatcaaat atgtgtgcaa ggtactatct ctggatacaa acatcacaaa tcaggtgaat
      6370       6380       6390       6400       6410       6420
aagctgaaca gagaccttct tcgcctggta gacgttggtg aattctctga ggaggcccag
      6430       6440       6450       6460       6470       6480
ttcagagacc cctgccactc ctacgtgctc cctgaggtaa tctgccacag ctgtaatttc
      6490       6500       6510       6520       6530       6540
tgccgagacc tggacctgtg caaagattcc tctttctctc aggatggagc catcctgcct
      6550       6560       6570       6580       6590       6600
cagtggctct gctccaattg tcaagccccc tatgactcct ctgccattga gtcagccttg
      6610       6620       6630       6640       6650       6660
gtggaagccc tgcagaggaa actgatggcc ttcacacttc aggacctggt atgcctcaag
      6670       6680       6690       6700       6710       6720
tgccgtggta tgaaagagac ccatatgcct gtgtactgca gctgcgcagg ggactttact
      6730       6740       6750       6760       6770       6780
ctcaccatcc gcactgaggt cttcatggaa cagattagaa tcttccagaa cattgccaag
      6790       6800       6810       6820       6830       6840
tactacagca tgtcatatct ccaggagacc atagaatggc tgttacagac aagccctgta
      6850
tcaaactgtt ag    

Last modification date: Oct. 2, 2011