Mus musculus L. (mouse) [MMU]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
B-family DNA polymerase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MDCKRRQGPG PGVPPKRARG HLWDEDEPSP SQFEANLALL EEIEAENRLQ EAEEELQLPP
        70         80         90        100        110        120
EGTVGGQFST ADIDPRWRRP TLRALDPSTE PLIFQQLEID HYVGSAPPLP EGPLPSRNSV
       130        140        150        160        170        180
PILRAFGVTD EGFSVCCHIQ GFAPYFYTPA PPGFGAEHLS ELQQELNAAI SRDQRGGKEL
       190        200        210        220        230        240
SGPAVLAIEL CSRESMFGYH GHGPSPFLRI TLALPRLMAP ARRLLEQGVR VPGLGTPSFA
       250        260        270        280        290        300
PYEANVDFEI RFMVDADIVG CNWLELPAGK YVRRAEKKAT LCQLEVDVLW SDVISHPPEG
       310        320        330        340        350        360
QWQRIAPLRV LSFDIECAGR KGIFPEPERD PVIQICSLGL RWGEPEPFLR LALTLRPCAP
       370        380        390        400        410        420
ILGAKVQSYE REEDLLQAWA DFILAMDPDV ITGYNIQNFD LPYLISRAQA LKVDRFPFLG
       430        440        450        460        470        480
RVTGLRSNIR DSSFQSRQVG RRDSKVISMV GRVQMDMLQV LLREHKLRSY TLNAVSFHFL
       490        500        510        520        530        540
GEQKEDVQHS IITDLQNGNE QTRRRLAVYC LKDAFLPLRL LERLMVLVNN VEMARVTGVP
       550        560        570        580        590        600
LGYLLTRGQQ VKVVSQLLRQ AMRQGLLMPV VKTEGSEDYT GATVIEPLKG YYDVPIATLD
       610        620        630        640        650        660
FSSLYPSIMM AHNLCYTTLL RPGAAQKLGL KPDEFIKTPT GDEFVKSSVR KGLLPQILEN
       670        680        690        700        710        720
LLSARKRAKA ELAQETDPLR RQVLDGRQLA LKVSANSVYG FTGAQVGKLP CLEISQSVTG
       730        740        750        760        770        780
FGRQMIEKTK QLVESKYTVE NGYDANAKVV YGDTDSVMCR FGVSSVAEAM SLGREAANWV
       790        800        810        820        830        840
SSHFPSPIRL EFEKVYFPYL LISKKRYAGL LFSSRSDAHD KMDCKGLEAV RRDNCPLVAN
       850        860        870        880        890        900
LVTSSLRRIL VDRDPDGAVA HAKDVISDLL CNRIDISQLV ITKELTRAAA DYAGKQAHVE
       910        920        930        940        950        960
LAERMRKRDP GSAPSLGDRV PYVIIGAAKG VAAYMKSEDP LFVLEHSLPI DTQYYLEQQL
       970        980        990       1000       1010       1020
AKPLLRIFEP ILGEGRAESV LLRGDHTRCK TVLTSKVGGL LAFTKRRNCC IGCRSVIDHQ
      1030       1040       1050       1060       1070       1080
GAVCKFCQPR ESELYQKEVS HLNALEERFS RLWTQCQRCQ GSLHEDVICT SRDCPIFYMR
      1090       1100
KKVRKDLEDQ ERLLQRFGPP GPEAW   

Encoded by Pold1 gene

FULL NAME: polymerase (DNA directed), delta 1, catalytic subunit


OTHER NAME(S):
125kDa


Nucleic acid sequence

        10         20         30         40         50         60
atggattgta agcggcgaca aggaccaggc cctggggtgc ccccaaagcg ggctcgaggg
        70         80         90        100        110        120
cacctctggg atgaggacga gccttcgccg tcgcagtttg aggcgaacct ggcactgctg
       130        140        150        160        170        180
gaggaaatag aggctgagaa ccggctgcag gaggcagagg aggagctgca gctgccccca
       190        200        210        220        230        240
gagggcaccg tgggtgggca gttttccact gcagacattg accctcggtg gcggcggccc
       250        260        270        280        290        300
accctacgtg ccctggaccc cagcacggag cccctcatct tccagcagct ggagattgac
       310        320        330        340        350        360
cactatgtgg gctcagcacc acccctgcca gaagggcccc tgccatcccg gaactcagtg
       370        380        390        400        410        420
cccatactga gggcctttgg ggtcaccgat gaaggcttct ccgtctgctg ccacatacag
       430        440        450        460        470        480
ggctttgccc cctacttcta cacccccgcg cctcctggtt ttggggccga gcacctgagt
       490        500        510        520        530        540
gagctgcagc aggagctgaa cgcagccatc agccgggacc agcgcggtgg gaaggagctc
       550        560        570        580        590        600
tcagggccgg cagtgctggc aatagagcta tgctcccgtg agagcatgtt tgggtaccac
       610        620        630        640        650        660
ggtcatggcc cttctccatt tctccgcatc accctggcac taccccgcct tatggcacca
       670        680        690        700        710        720
gcccgccgcc ttctggaaca gggtgtccga gtgccaggcc tgggcacccc gagcttcgca
       730        740        750        760        770        780
ccctacgaag ccaacgtgga ctttgagatc cggttcatgg tggatgctga cattgtggga
       790        800        810        820        830        840
tgcaactggt tggagctgcc agctggaaag tacgttcgga gggcggagaa gaaggccacc
       850        860        870        880        890        900
ctgtgtcagc tggaggtgga cgtgctgtgg tcagatgtga tcagtcaccc accggagggg
       910        920        930        940        950        960
cagtggcagc gcattgcacc cctgcgtgtg cttagcttcg acatcgagtg tgctggccga
       970        980        990       1000       1010       1020
aaaggcatct tccctgagcc tgagcgtgac cccgtgatcc agatctgttc tctggggctg
      1030       1040       1050       1060       1070       1080
cgctgggggg agccggagcc attcttgcgt ctggcactca cgctgcggcc ctgtgccccc
      1090       1100       1110       1120       1130       1140
atcctgggtg ccaaagtgca gagctatgag cgggaagaag acctgctcca ggcctgggcc
      1150       1160       1170       1180       1190       1200
gacttcatcc ttgccatgga ccctgacgtg atcaccggct acaacattca gaactttgac
      1210       1220       1230       1240       1250       1260
ctcccatacc tcatctctcg ggcacaggcc ctaaaggtgg accgcttccc tttcctgggc
      1270       1280       1290       1300       1310       1320
cgcgtgactg gtctccgctc caacatccgt gactcctcct tccaatcaag gcaggtcggc
      1330       1340       1350       1360       1370       1380
cggcgggaca gtaaggtgat cagcatggtg ggtcgcgttc agatggatat gctgcaggtg
      1390       1400       1410       1420       1430       1440
ctgcttcggg aacacaagct ccgctcctac acgctcaacg ctgtgagttt ccacttcctg
      1450       1460       1470       1480       1490       1500
ggcgagcaga aggaggacgt tcagcacagc atcatcaccg acctgcagaa tgggaacgaa
      1510       1520       1530       1540       1550       1560
cagacgcgcc gccgcctggc cgtgtactgc ctgaaggacg cctttctgcc actccgacta
      1570       1580       1590       1600       1610       1620
ctagagcgcc ttatggtgct ggtgaataat gtggagatgg cgcgtgtcac gggtgtaccc
      1630       1640       1650       1660       1670       1680
cttgggtacc tgctcacccg gggccagcag gtcaaggtcg tgtctcagct gctgcgccag
      1690       1700       1710       1720       1730       1740
gccatgcgcc aggggctgct gatgcctgtg gtgaagaccg agggcagtga ggactacacg
      1750       1760       1770       1780       1790       1800
ggagccacag tcattgagcc cctcaaaggg tactatgacg tccccattgc caccctggac
      1810       1820       1830       1840       1850       1860
ttctcctcct tgtacccatc catcatgatg gcccataatc tgtgctacac cacgctgctc
      1870       1880       1890       1900       1910       1920
cgacctgggg ctgcccagaa gctgggcctt aaaccagatg agttcatcaa gacacccact
      1930       1940       1950       1960       1970       1980
ggggatgagt ttgtgaagtc atctgtacgg aagggcctcc tgccccagat cctggagaat
      1990       2000       2010       2020       2030       2040
ctgctgagtg cccgcaagag ggccaaggct gagctggctc aggagacgga ccccctgcgg
      2050       2060       2070       2080       2090       2100
cgacaggtct tggacggccg gcaactggca ctaaaagtga gtgccaactc cgtatatggc
      2110       2120       2130       2140       2150       2160
ttcactggtg cccaggtggg caagctgcca tgtttggaga tctcccagag tgtcactggg
      2170       2180       2190       2200       2210       2220
ttcgggcggc agatgattga gaaaaccaag cagcttgtgg agtccaagta caccgtggaa
      2230       2240       2250       2260       2270       2280
aatggctacg atgccaacgc caaggtagtc tacggtgaca cggactctgt gatgtgccgg
      2290       2300       2310       2320       2330       2340
tttggcgtct cctctgtggc tgaagcaatg tctctggggc gggaggctgc aaactgggta
      2350       2360       2370       2380       2390       2400
tccagtcact tcccatcacc catccggctg gagttcgaga aggtttactt cccatacctg
      2410       2420       2430       2440       2450       2460
ctcatcagca agaagcgcta tgctggcctg ctcttctcct cccgctctga tgcccatgac
      2470       2480       2490       2500       2510       2520
aaaatggact gcaagggcct ggaggctgtg cgcagggaca actgtcccct ggtggccaac
      2530       2540       2550       2560       2570       2580
ctcgttacat cctctctgcg ccggatcctc gtggaccggg accctgatgg ggcagtagcc
      2590       2600       2610       2620       2630       2640
catgccaagg acgtcatctc ggacctgctg tgcaaccgca tagacatctc ccagctggtc
      2650       2660       2670       2680       2690       2700
atcaccaaag agttgacccg cgcagcagca gactatgctg gcaagcaggc tcacgtggag
      2710       2720       2730       2740       2750       2760
ctggctgaga ggatgaggaa gcgcgacccc ggcagtgcgc ccagcctggg tgaccgagtc
      2770       2780       2790       2800       2810       2820
ccctatgtga tcattggtgc tgctaagggt gtggccgcct acatgaagtc ggaggacccc
      2830       2840       2850       2860       2870       2880
ctgtttgtgc tggagcacag cctgcccatc gacactcagt actacctgga gcagcagctg
      2890       2900       2910       2920       2930       2940
gccaagccgc tcttgcgcat ctttgagccc atcctgggtg agggccgtgc agagtctgtg
      2950       2960       2970       2980       2990       3000
ctgctgcgcg gtgaccacac acgatgcaag actgtgctca ccagcaaggt gggcggcctc
      3010       3020       3030       3040       3050       3060
ttggccttca ccaagcgccg caactgttgc attggctgcc gctccgtaat cgaccatcaa
      3070       3080       3090       3100       3110       3120
ggagccgtgt gtaagttctg tcagccacgg gagtcggagc tctatcagaa ggaggtgtca
      3130       3140       3150       3160       3170       3180
cacctgaatg ccttggaaga acggttctct cgcctctgga cacagtgtca acgctgccag
      3190       3200       3210       3220       3230       3240
ggcagcttgc atgaggacgt catctgtacc agccgtgact gtcccatctt ctacatgcgc
      3250       3260       3270       3280       3290       3300
aagaaggtgc gcaaggacct ggaagaccag gaacggctgc tgcagcgctt tggaccgccc
      3310
ggccctgagg cctggtga    

Last modification date: Oct. 2, 2011