Mus musculus L. (mouse) [MMU]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
B-family DNA polymerase


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MAPMHEEDCK LEASAVSDSG SFAASRARRE KKSKKGRQEA LERLKKAKAG EKYKYEVEDL
        70         80         90        100        110        120
TSVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI FDDDLEDDAL DTCGKGSDGK
       130        140        150        160        170        180
AHRKDRKDVK KPSVTKPNNI KAMFIASAGK KTTDKAVDLS KDDLLGDILQ DLNTETAQIT
       190        200        210        220        230        240
PPPVLIPKKK RSTGALLNPF SVHTPKAIPS GKPASPVLRN EPLLTPIPLK RAELAGELAQ
       250        260        270        280        290        300
PECPEDEQEL GVMEFEDGDF DESMDTEKVD EKPVTAKTWD QETEPVERVE HEADPERGTT
       310        320        330        340        350        360
SYLENFLPDV SCWDIDQDDE SIPQEVQVDS SNLPLVKGAD DEQVFQFYWL DAYEDPYNQP
       370        380        390        400        410        420
GVVFLFGKVW IESVKTHVSC CVMVKNIERT LYFLPREMKF DLNTGKETAI PVTMKDVYEE
       430        440        450        460        470        480
FDSKISAKYK IMKFKSKIVE KNYAFEIPDV PEKSEYLEVR YSAEVPQLPQ NLKGETFSHV
       490        500        510        520        530        540
FGTNTSSLEL FLMNRKIKGP CWLEVKNPQL LNQPISWCKF EVMALKPDLV NVIKDVSPPP
       550        560        570        580        590        600
LVVMSFSMKT MQNVQNHQHE IIAMAALVHH SFALDKAPPE PPFQTHFCVV SKPKDCIFPC
       610        620        630        640        650        660
DFKEVISKKN MKVEIAATER TLIGFFLAKV HKIDPDILVG HNICSFELEV LLQRINECKV
       670        680        690        700        710        720
PYWSKIGRLR RSNMPKLGSR SGFGERNATC GRMICDVEIS AKELIHCKSY HLSELVQQIL
       730        740        750        760        770        780
KTERIVIPTE NIRNMYSESS YLLYLLEHIW KDARFILQIM CELNVLPLAL QITNIAGNIM
       790        800        810        820        830        840
SRTLMGGRSE RNEFLLLHAF YENNYIVPDK QIFRKPQQKL GDEDEEIDGD TNKYKKGRKK
       850        860        870        880        890        900
ATYAGGLVLD PKVGFYDKFI LLLDFNSLYP SIIQEFNICF TTVQRVTSEV QKATEDEEQE
       910        920        930        940        950        960
QIPELPDPNL EMGILPREIR KLVERRKQVK QLMKQQDLNP DLVLQYDIRQ KALKLTANSM
       970        980        990       1000       1010       1020
YGCLGFSYSR FYAKPLAALV TYKGREILMH TKDMVQKMNL EVIYGDTDSI MINTNSTNLE
      1030       1040       1050       1060       1070       1080
EVFKLGNKVK SEVNKLYKLL EIDIDAVFKS LLLLKKKKYA ALVVEPTSDG NYITKQELKG
      1090       1100       1110       1120       1130       1140
LDIVRRDWCD LAKDTGNFVI GQILSDQSRD TIVENIQKRL IEIGENVLNG SVPVSQFEIN
      1150       1160       1170       1180       1190       1200
KALTKDPQDY PDRKSLPHVH VALWINSQGG RKVKAGDTVS YVICQDGSNL TATQRAYAPE
      1210       1220       1230       1240       1250       1260
QLQKLDNLAI DTQYYLAQQI HPVVARICEP IDGIDAVLIA LWLGLDSTQF RVHQYHKDEE
      1270       1280       1290       1300       1310       1320
NDALLGGPAQ LTDEEKYKDC EKFKCLCPSC GTENIYDNVF EGSGLDMEPS LYRCSNVDCK
      1330       1340       1350       1360       1370       1380
VSPLTFMVQL SNKLIMDIRR CIKKYYDGWL ICEEPTCCSR LRRLPLHFSR NGPLCPVCMK
      1390       1400       1410       1420       1430       1440
AVLRPEYSDK SLYTQLCFYR YIFDADCALE KLTEHEKDKL KKQFFPLRVL QDYRKVKNIA
      1450       1460
EQFLSWSGYS EVNLSKLFAN YAGKS   

Encoded by Pola1 gene

FULL NAME: polymerase (DNA directed), alpha 1


OTHER NAME(S):
AW321876
Pola


Nucleic acid sequence

        10         20         30         40         50         60
atggcgccca tgcacgaaga ggactgtaaa ctggaggcaa gcgctgtgtc agattcaggg
        70         80         90        100        110        120
agttttgcag cttcccgagc tcggcgagaa aagaaatcaa agaaaggacg tcaagaagct
       130        140        150        160        170        180
ttagagagac tgaaaaaggc taaagctggg gagaagtata aatacgaagt tgaggacctc
       190        200        210        220        230        240
acaagtgttt atgaagaagt tgatgaagag cagtattcga aactggttca ggcccgtcag
       250        260        270        280        290        300
gatgatgact ggattgtgga tgacgatggg ataggctatg tggaagatgg cagagagatt
       310        320        330        340        350        360
tttgatgatg accttgagga tgatgcactt gacacctgtg gaaaaggaag tgatggcaaa
       370        380        390        400        410        420
gcacacagaa aggacaggaa ggatgtaaag aaaccttcag tgacaaaacc aaacaatatc
       430        440        450        460        470        480
aaggcaatgt tcattgctag tgccgggaag aaaactacag ataaagcagt agacttgtcc
       490        500        510        520        530        540
aaggatgatc tgctaggtga cattctacag gatctaaaca ctgagacagc tcaaataact
       550        560        570        580        590        600
ccaccacctg tattgatacc aaagaaaaaa agatctactg gggctttgct caaccctttt
       610        620        630        640        650        660
tcagtgcaca cccctaaggc aattccttca ggaaaacctg cttcccctgt cctcaggaat
       670        680        690        700        710        720
gagcctctgt taactcccat tcctcttaaa cgtgctgaac ttgctggaga gctggctcag
       730        740        750        760        770        780
ccagaatgtc cagaagatga gcaggagcta ggggtaatgg agtttgaaga cggtgacttt
       790        800        810        820        830        840
gatgagtcca tggacacaga gaaggtagat gagaagcctg tgactgctaa gacttgggac
       850        860        870        880        890        900
caagagactg agccagtaga aagggtggaa catgaggcag atcctgagag gggaaccaca
       910        920        930        940        950        960
tcttacttag aaaattttct gccagatgtc tcttgttggg acattgatca ggatgatgaa
       970        980        990       1000       1010       1020
agcatacctc aggaagttca agtggattcc agtaatctcc cattggtaaa aggggcagat
      1030       1040       1050       1060       1070       1080
gatgaacaag tgtttcagtt ttattggctg gatgcttatg aagatccata caaccaacca
      1090       1100       1110       1120       1130       1140
ggtgtggttt ttctgtttgg caaagtgtgg attgaatcag tcaaaaccca tgtgagctgt
      1150       1160       1170       1180       1190       1200
tgtgttatgg tgaaaaatat tgagcgaaca ctctacttcc ttccccgtga aatgaaattt
      1210       1220       1230       1240       1250       1260
gacctaaaca cagggaaaga aacagcaatt ccagttacaa tgaaggatgt ttatgaagaa
      1270       1280       1290       1300       1310       1320
tttgattcaa aaatttcagc aaaatataaa ataatgaagt tcaagtccaa gatagtggaa
      1330       1340       1350       1360       1370       1380
aagaactatg cttttgagat acctgatgtt ccagaaaaat ctgagtacct ggaagttaga
      1390       1400       1410       1420       1430       1440
tactcggcag aagtgccaca gcttccacag aatttaaaag gagaaacatt ttctcatgtg
      1450       1460       1470       1480       1490       1500
tttggaacta acacgtctag cttggaactg ttcttgatga ataggaagat caaaggacct
      1510       1520       1530       1540       1550       1560
tgttggcttg aagtaaaaaa tccacaactc ttgaatcagc caatcagttg gtgtaaattt
      1570       1580       1590       1600       1610       1620
gaggtaatgg ctttgaaacc agacctggtg aatgtaatta aggatgtcag tcctcctcca
      1630       1640       1650       1660       1670       1680
cttgtggtga tgtctttcag catgaagaca atgcagaatg tacagaacca tcaacatgag
      1690       1700       1710       1720       1730       1740
attattgcta tggcggcttt ggttcatcac agttttgcat tagataaagc acctccagag
      1750       1760       1770       1780       1790       1800
cctccctttc agacacattt ctgtgttgtg tctaaaccaa aggactgtat tttcccatgt
      1810       1820       1830       1840       1850       1860
gatttcaaag aagtgatttc gaaaaagaat atgaaggttg agatcgctgc aacagaaaga
      1870       1880       1890       1900       1910       1920
accttgatag gatttttcct tgcaaaagtt cacaaaattg accctgacat tcttgtgggt
      1930       1940       1950       1960       1970       1980
cataatattt gtagttttga actggaagtg ctgctgcaaa gaattaatga gtgcaaggtt
      1990       2000       2010       2020       2030       2040
ccttactggt ccaagatagg tcggctgagg agatccaaca tgccaaaact tgggagccgg
      2050       2060       2070       2080       2090       2100
agtggatttg gtgaaagaaa tgctacctgt ggccgaatga tatgtgatgt ggaaatttca
      2110       2120       2130       2140       2150       2160
gcaaaagaat tgattcattg taaaagctac catttgtctg aacttgttca gcagattctg
      2170       2180       2190       2200       2210       2220
aaaactgaga ggattgtaat tccaacagaa aatatacgaa acatgtatag tgaatcttct
      2230       2240       2250       2260       2270       2280
tatctgttgt acctgttgga acatatctgg aaagatgcca gattcatttt gcagatcatg
      2290       2300       2310       2320       2330       2340
tgtgagctaa atgttcttcc attagcattg cagatcacta acatcgctgg gaacattatg
      2350       2360       2370       2380       2390       2400
tctaggacac tgatgggtgg acgatctgag cgaaatgagt ttttgttgct tcatgcattt
      2410       2420       2430       2440       2450       2460
tatgaaaaca actatattgt gcctgacaag cagattttca gaaaacctca gcaaaaactg
      2470       2480       2490       2500       2510       2520
ggagatgaag atgaggaaat tgatggggac accaataaat acaagaaagg gcgtaagaaa
      2530       2540       2550       2560       2570       2580
gcaacttacg ctggaggctt ggttttggac cccaaagttg gtttttatga caagttcatt
      2590       2600       2610       2620       2630       2640
ttgctcctgg atttcaacag tttatatcct tccatcattc aggaatttaa catttgtttt
      2650       2660       2670       2680       2690       2700
acaacagtgc aaagagttac ttcagaggtg cagaaagcta cagaggatga ggaacaagaa
      2710       2720       2730       2740       2750       2760
cagatccctg agttgccaga tccaaactta gagatgggca ttttgcccag agagattcgg
      2770       2780       2790       2800       2810       2820
aaactggtag agcggagaaa acaagtcaaa cagctaatga aacagcaaga tttaaatcca
      2830       2840       2850       2860       2870       2880
gaccttgttc ttcagtatga catccgacag aaggctttga agctcacagc aaacagtatg
      2890       2900       2910       2920       2930       2940
tatggttgcc tgggattttc gtacagcaga ttttatgcta aaccactggc tgccttggtg
      2950       2960       2970       2980       2990       3000
acatacaaag gaagggagat tttgatgcat acgaaagaca tggtacagaa gatgaatctt
      3010       3020       3030       3040       3050       3060
gaagttattt atggagacac agattcaatt atgataaata ccaatagcac caacctggaa
      3070       3080       3090       3100       3110       3120
gaagtattta agttgggaaa caaggtaaaa agtgaagtga ataaattgta caaactgctt
      3130       3140       3150       3160       3170       3180
gaaatagaca ttgatgctgt tttcaagtct ctgctgttgc tgaagaaaaa gaaatatgct
      3190       3200       3210       3220       3230       3240
gctctagttg ttgaaccaac atcagatggg aattacatta ccaagcagga gctgaaagga
      3250       3260       3270       3280       3290       3300
ttagatatag ttagaagaga ctggtgtgat cttgccaagg acactggaaa ctttgtcatt
      3310       3320       3330       3340       3350       3360
ggccagattc tttctgatca aagccgggac accattgtgg aaaacattca gaagaggtta
      3370       3380       3390       3400       3410       3420
atagaaattg gagaaaatgt gctaaatggc agtgtcccag tgagccagtt tgaaattaac
      3430       3440       3450       3460       3470       3480
aaggcattga caaaggatcc ccaggattac cctgatagaa aaagcttacc tcatgtacat
      3490       3500       3510       3520       3530       3540
gttgcactgt ggataaattc tcaaggaggc aggaaggtga aagctggtga tacggtgtcc
      3550       3560       3570       3580       3590       3600
tatgttattt gtcaggatgg gtcaaacctc actgcaactc agagggccta tgccccagaa
      3610       3620       3630       3640       3650       3660
caattgcaga aacttgacaa tttagccatc gacacccaat actacttggc ccagcagatc
      3670       3680       3690       3700       3710       3720
caccctgttg tggctcggat ctgtgagcca atagatggaa ttgatgctgt actcattgca
      3730       3740       3750       3760       3770       3780
ttatggctag gacttgactc cactcaattt agagttcatc agtatcacaa agatgaagag
      3790       3800       3810       3820       3830       3840
aatgatgccc tccttggtgg tccagcacag ctaactgatg aagagaaata caaggattgt
      3850       3860       3870       3880       3890       3900
gaaaaattca aatgcctttg tccttcatgt ggaactgaaa atatttatga taatgtcttt
      3910       3920       3930       3940       3950       3960
gaaggctcgg gactggatat ggaacccagt ttgtatcgtt gcagtaatgt tgattgtaag
      3970       3980       3990       4000       4010       4020
gtttcaccgt tgaccttcat ggtacagctg agcaacaaat tgatcatgga cattagacgg
      4030       4040       4050       4060       4070       4080
tgcattaaaa agtactatga tggctggttg atatgtgaag agccaacttg ttgcagtcgc
      4090       4100       4110       4120       4130       4140
cttcgacgtc ttccccttca tttctcccga aatgggcctc tgtgtccagt ctgcatgaaa
      4150       4160       4170       4180       4190       4200
gctgtgctta gaccagagta ttctgacaag tccttgtaca cccagctgtg cttttaccgg
      4210       4220       4230       4240       4250       4260
tacatttttg atgcggactg tgcactggaa aaacttactg aacatgagaa agataaattg
      4270       4280       4290       4300       4310       4320
aagaagcagt ttttccctct ccgagttctt caggactaca gaaaagtcaa gaacatagca
      4330       4340       4350       4360       4370       4380
gagcagttct tgtcctggag tggctactct gaagtgaacc tcagcaagct cttcgccaat
      4390
tacgctggga agtcctga    

Last modification date: Oct. 2, 2011