Mus musculus L. (mouse) [MMU]

FULL NAME: Ribonuclease H1


DESCRIPTION:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).

STRUCTURE SIMILARITY:
Contains 1 RNase H domain.
Belongs to the RNase H family.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


ENZYME REGULATION:
In the presence of magnesium, manganese is inhibitory (By similarity).


PROTEIN TYPE(S):
RNase


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MRWLLPLSRT VTLAVVRLRR GICGLGMFYA VRRGRRTGVF LSWSECKAQV DRFPAARFKK
        70         80         90        100        110        120
FATEDEAWAF VRSSSSPDGS KGQESAHEQK SQAKTSKRPR EPLGEGEELP EPGPKHTRQD
       130        140        150        160        170        180
TEPSAVVSKD AFSYMGESVV VYTDGCCSSN GRKRARAGIG VYWGPGHPLN VGIRLPGRQT
       190        200        210        220        230        240
NQRAEIHAAC KAIMQAKAQN ISKLVLYTDS MFTINGITNW VQGWKKNGWR TSTGKDVINK
       250        260        270        280
EDFMELDELT QGMDIQWMHI PGHSGFVGNE EADRLAREGA KQSED 

Encoded by Rnaseh1 gene

FULL NAME: ribonuclease H1


Nucleic acid sequence

        10         20         30         40         50         60
atgcgctggc tgctgccgct gtcccgcaca gtgacactgg ccgtcgtacg cctgaggcga
        70         80         90        100        110        120
ggcatttgcg ggctcgggat gttctatgcg gtgaggagag gccgcaggac cggagtcttc
       130        140        150        160        170        180
ctgagttgga gtgagtgcaa agcccaggtg gaccggtttc ctgctgccag gtttaagaaa
       190        200        210        220        230        240
tttgccacag aagatgaggc ctgggccttt gtcaggagct cttcaagccc ggatggttca
       250        260        270        280        290        300
aaagggcagg aaagtgcaca tgagcagaag tcacaggcga agaccagcaa gcggcctcgg
       310        320        330        340        350        360
gagcccctgg gtgaagggga agaacttcca gagccagggc cgaagcacac acgacaggac
       370        380        390        400        410        420
accgagccct cggctgtagt gagcaaggac gcattttctt atatgggaga gtcagtcgtt
       430        440        450        460        470        480
gtctacacgg atggctgttg ctccagtaat ggacggaagc gggcacgagc aggaattggc
       490        500        510        520        530        540
gtttactggg gcccaggcca ccccttaaat gtaggtataa ggcttcctgg gcgacagaca
       550        560        570        580        590        600
aaccagaggg ccgagatcca tgcagcctgc aaggccatca tgcaagccaa ggctcagaac
       610        620        630        640        650        660
atcagcaagc tggttctgta cacagacagc atgttcacca tcaatgggat aactaactgg
       670        680        690        700        710        720
gttcagggct ggaagaagaa tggctggaga acaagtacag ggaaagatgt gatcaacaag
       730        740        750        760        770        780
gaggacttca tggagctgga cgagctcact cagggcatgg acatccagtg gatgcacatt
       790        800        810        820        830        840
cctggtcact caggatttgt gggcaatgaa gaggccgaca gactggcacg ggaaggagcg
       850
aagcagtctg aggactga    

Last modification date: Oct. 2, 2011