Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase epsilon subunit 4


DESCRIPTION:
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAAAAAAGSG TPREEEGPAG EAAASQPQAP TSVPGARLSR LPLARVKALV KADPDVTLAG
        70         80         90        100        110
QEAIFILARA AELFVETIAK DAYCCAQQGK RKTLQRRDLD NAIEAVDEFA FLEGTLD

Encoded by POLE4 gene

FULL NAME: polymerase (DNA-directed), epsilon 4 (p12 subunit)


OTHER NAME(S):
YHHQ1
p12


DESCRIPTION:
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggcgg cggcggcggc aggaagcggg acgccccgag aggaggaggg acctgctggg
        70         80         90        100        110        120
gaggcagcgg cctcgcagcc ccaggcccca acgagtgtgc ctggggctcg tctctcgagg
       130        140        150        160        170        180
ttgcctctgg cgcgagtgaa ggccttggtg aaggcagatc ccgacgtgac gctagcggga
       190        200        210        220        230        240
caggaagcca tcttcattct ggcacgagcc gcggaactgt ttgtggagac cattgcaaaa
       250        260        270        280        290        300
gatgcctact gttgcgctca gcagggaaaa aggaaaaccc ttcagaggag agacttggat
       310        320        330        340        350
aatgcaatag aagctgtgga tgaatttgct tttctggaag gtactttaga ttga

Last modification date: Oct. 2, 2011