Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA ligase 1


DESCRIPTION:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).

STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MFFSKAGKAA VEWAKGSKVP YKEFALTLEK IEELSGKKKV DELAQFFTKV LDFSPDDLTA
        70         80         90        100        110        120
CVYMSVNQLG PSYEGLELGV AENSLIKAVA KATGRTEGKI KEDLRAKGDL GTVAQQSRSN
       130        140        150        160        170        180
QKMLAVPKAL TVPTVFNKLT EIAKLSGTSA MNKKVDAISA LLIACQGIEA RFLVRMLAGK
       190        200        210        220        230        240
MRIGLGEQSV LSALGHAFTL SKITDQKVRG DKLDSLKDAN VKRVKTAYCE CPNYNRLIEV
       250        260        270        280        290        300
ALTEGVEALV EKCKLSPGIP LKPMLAHPTK GIDEIMRRFR NQTMTCEWKY DGERGQIHKR
       310        320        330        340        350        360
EDGQIFIYSR NQENNTTKYP DIIEKISSCI GDGVTSFIVD AEVVAIDEAG LILPFQVLST
       370        380        390        400        410        420
RKRKNATDDN GVKVVVFLFD LLYFNGEPLV RKPLRKRREL LRTNFKKIDG SFYFATSVDT
       430        440        450        460        470        480
NDTDEINSFF DEAVQNKCEG LMIKTLDTEA TYEISRRSHS WLKMKKDYVD GVGDTLDLVV
       490        500        510        520        530        540
MGAYSGVGKR TGVYGGYLLG CYNPTTEEYE SVCKIGTGFT DEDLAEQYKI LQDKKIDKSP
       550        560        570        580        590        600
SYYQFDHTLK PDDTFSPYLV FEVKCADITI SPRHKAASGL TDDGKGISLR FPRFLRIRDD
       610        620        630        640        650        660
KNSDDATSSE QVLEMYKNQE AFANQKIEKA DAVDEDDEFE EKEDEEEELN MTNVSEGSSK
       670        680        690        700        710        720
ENPVKEEIKK ETPKSVSPKK FEKKPPVKSS PVNKSPVKSS PIKKEAEKKK GPVASIFSSS
       730        740        750        760        770
TKKNEKDVKV ESPSPIRKKK LPSDSDESDE ETSTNKKQPA KKRSRVAIDS DSD

Encoded by lig-1 gene

FULL NAME: LIGase


Nucleic acid sequence

        10         20         30         40         50         60
atgtttttct caaaagctgg caaagccgct gttgaatggg caaagggttc aaaagtccct
        70         80         90        100        110        120
tacaaggagt ttgctctcac ccttgagaaa atcgaagagt tatcgggaaa aaagaaagtg
       130        140        150        160        170        180
gatgaattgg ctcaattttt caccaaagtt ctggactttt cacccgacga tttaacagcg
       190        200        210        220        230        240
tgcgtgtaca tgtcagttaa tcagctcggg ccatcgtatg aagggctcga gcttggagtt
       250        260        270        280        290        300
gctgaaaatt cgctgatcaa ggctgttgct aaagcgaccg gacgtacaga gggaaaaatt
       310        320        330        340        350        360
aaagaagatc ttcgcgcgaa aggagatctt gggactgtcg cacaacagtc aagatccaat
       370        380        390        400        410        420
cagaaaatgc ttgctgttcc aaaagcatta actgttccaa ctgttttcaa caagttaacc
       430        440        450        460        470        480
gaaattgcaa agctcagtgg cacttcagct atgaacaaga aagttgatgc cattagtgca
       490        500        510        520        530        540
ctcctcattg catgtcaagg aattgaggct cgattcctcg tccgaatgct cgccggcaaa
       550        560        570        580        590        600
atgagaatcg gtctcggtga acaaagtgtt ctatcagcac ttggacatgc attcactctt
       610        620        630        640        650        660
tcgaaaataa ctgatcaaaa ggttcgtggt gacaaactcg attctctgaa agatgcaaat
       670        680        690        700        710        720
gttaagcgag taaagaccgc ctattgcgaa tgccctaact acaatcgtct gatcgaagtt
       730        740        750        760        770        780
gcactgactg aaggtgtgga agctcttgtc gaaaaatgta aactttcacc cggaattcca
       790        800        810        820        830        840
ctgaaaccta tgctggctca ccctacaaag ggaattgatg aaattatgcg acgattcaga
       850        860        870        880        890        900
aatcagacaa tgacctgtga atggaaatat gacggagaac gcggccagat tcataaacga
       910        920        930        940        950        960
gaagacgggc aaattttcat ctacagtcga aaccaagaga acaacactac caagtacccc
       970        980        990       1000       1010       1020
gatattatcg aaaaaatttc atcctgcatc ggggatgggg taacttcatt tattgtcgat
      1030       1040       1050       1060       1070       1080
gctgaagttg tagctatcga tgaggctggc ttaattcttc cgttccaagt tttgtcgact
      1090       1100       1110       1120       1130       1140
cgtaaaagga aaaatgcaac tgatgataac ggagtcaagg ttgtagtttt tcttttcgat
      1150       1160       1170       1180       1190       1200
cttctctact tcaatgggga gcctctcgtg agaaaaccac tccgaaaaag aagagaactt
      1210       1220       1230       1240       1250       1260
cttcgaacaa acttcaaaaa gattgatgga agcttctatt ttgcaacttc cgtagataca
      1270       1280       1290       1300       1310       1320
aatgatactg atgaaatcaa ctctttcttc gatgaagccg ttcaaaataa atgcgaagga
      1330       1340       1350       1360       1370       1380
ctcatgatca aaactctcga cactgaagct acttatgaga tttcaagacg ttcccacagc
      1390       1400       1410       1420       1430       1440
tggttgaaaa tgaagaaaga ttacgttgat ggagtaggag atacgttgga tcttgtcgtc
      1450       1460       1470       1480       1490       1500
atgggtgctt attctggagt tggaaagaga actggagtgt atggaggata tcttctcgga
      1510       1520       1530       1540       1550       1560
tgttacaatc ctactacaga agagtacgaa agtgtatgca agattggaac tggtttcact
      1570       1580       1590       1600       1610       1620
gatgaagatt tggccgagca atacaagatc ctacaagaca agaaaattga caaatctcct
      1630       1640       1650       1660       1670       1680
tcttattatc aatttgatca cactcttaaa ccagatgaca ctttttctcc gtatcttgtt
      1690       1700       1710       1720       1730       1740
ttcgaagtca aatgtgccga tattactata tctccgcgtc acaaagctgc aagtggattg
      1750       1760       1770       1780       1790       1800
acggatgatg gaaaaggaat ctctttgaga tttcctcgtt tcctgcgtat tcgggacgat
      1810       1820       1830       1840       1850       1860
aaaaattccg acgatgcaac atcttcggag caagttcttg aaatgtacaa aaaccaagaa
      1870       1880       1890       1900       1910       1920
gcttttgcca accagaagat cgaaaaggcg gatgcagttg atgaggatga cgaatttgaa
      1930       1940       1950       1960       1970       1980
gaaaaagaag atgaagagga ggagttgaac atgaccaatg tatctgaagg aagttctaaa
      1990       2000       2010       2020       2030       2040
gaaaatccag tgaaagagga gatcaagaaa gagactccta aatcagtatc cccgaaaaaa
      2050       2060       2070       2080       2090       2100
ttcgaaaaga aaccgcctgt aaaatcttca ccagttaaca aatcgcccgt gaaaagttca
      2110       2120       2130       2140       2150       2160
ccaataaaga aagaagcaga gaaaaagaaa ggaccagttg ctagcatctt ttcatcatcg
      2170       2180       2190       2200       2210       2220
acaaagaaga atgaaaaaga cgttaaagtg gaatctccat ctccgatcag aaagaagaag
      2230       2240       2250       2260       2270       2280
ctgccttctg attctgacga gtctgatgaa gaaacctcaa ctaataagaa acagccagca
      2290       2300       2310       2320
aagaagaggt ctcgcgttgc aattgattcc gattccgact aa 

Last modification date: Oct. 2, 2011