Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA replication licensing factor mcm-6


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDNIIGGQAQ QVEDTDGTRV QNEFSKFLKS FKDQKNEFIY KSAMKELVQP EKNTIFINMQ
        70         80         90        100        110        120
HLYKFSNNLA TTIELQYYRV YPFMCEALHL ATLDACDESE RQQMFKKQLY VSLFNLDAKT
       130        140        150        160        170        180
KVRELSADKV GGLVRIAGQI VRTHPVHPEL SRACFVCEDC GVTTRDVQQQ FRYTQPTKCA
       190        200        210        220        230        240
NPQCMNRTRF SLDVNSSTFV DFQKIRIQET QAELPRGSIP RTVDVIVRGE MVETVQPGDK
       250        260        270        280        290        300
CDIVGTLIVI PDIAQLSTPG LRAETSNQNR GRATDKSEGI TGLKALGVRD LTYKMAFLAC
       310        320        330        340        350        360
HIQQTESLVG GDASGAVEET DYLDLWSKMS TEDRATLKKM SDDKKIEKNI VDSLFPNIYG
       370        380        390        400        410        420
NHEVKLGVLL MLLGGVAKKS RDEGTSLRGD INVCLVGDPS TAKSQVLKAV EEFSPRAIYT
       430        440        450        460        470        480
SGKASSAAGL TAAVVKDEES FEFVIEAGAL MLADNGVCCI DEFDKMDLKD QVAIHEAMEQ
       490        500        510        520        530        540
QTISITKAGV KATLNARASI LAAANPVNGR YDRSRPLKYN VQMSAPIMSR FDLFFVLVDE
       550        560        570        580        590        600
CNEVTDYAIA RRILDNHRAI SEHTERDSVY KIDDIKKYIA FARCFKPKIS DKAAETLVRE
       610        620        630        640        650        660
YKKLRMSDSN NAATSSWRIT VRQLESLVRL SEALARLHCG KEVLVEHVEK AAELLNKSIV
       670        680        690        700        710        720
RVEQPDIALD DDDFDNNIMV VEADKENQRG DDSMDHDGEK ENAPKIDIAK LKISFKEYKQ
       730        740        750        760        770        780
LSDVLVLHMR SDEDNQGEDE YDGVKQSALV EWYLSTIEAD LETEEDFNVQ KTICERVIHR
       790        800        810
LIHQDHVLLE VEQGEDPTLC VHPNYVIADE   

Encoded by mcm-6 gene

FULL NAME: yeast MCM (licensing factor) related


Nucleic acid sequence

        10         20         30         40         50         60
atggacaaca ttatcggcgg tcaagcccag caagtggagg acaccgacgg aactcgtgtg
        70         80         90        100        110        120
cagaacgagt tttccaagtt tttgaagagc ttcaaagacc agaaaaatga gtttatctac
       130        140        150        160        170        180
aaatctgcga tgaaggagct cgtgcaacca gaaaagaata ccattttcat taacatgcaa
       190        200        210        220        230        240
catctctaca agttcagtaa caatctcgca acaactatcg agctgcaata ctacagggtc
       250        260        270        280        290        300
tatccattca tgtgcgaagc tctacacttg gccactttag atgcttgtga tgaaagtgag
       310        320        330        340        350        360
agacagcaaa tgttcaagaa gcaattgtac gtttcgctgt tcaatctcga tgcgaaaacg
       370        380        390        400        410        420
aaagttcgtg agctttctgc ggacaaagtc ggaggcctcg tgcgcattgc cggtcagatt
       430        440        450        460        470        480
gtccgaactc acccagtgca tccagaactt tcacgggctt gtttcgtgtg tgaggattgc
       490        500        510        520        530        540
ggtgttacca cacgtgatgt tcaacagcag ttcagataca ctcagccaac taaatgtgct
       550        560        570        580        590        600
aatcctcaat gcatgaatcg taccagattc agtctcgatg tcaactcatc tactttcgtc
       610        620        630        640        650        660
gacttccaga agattagaat tcaggagact caagcagagt tgcctcgtgg atcaattcca
       670        680        690        700        710        720
cgtactgtcg atgtgattgt tcgaggagaa atggttgaaa ctgtccaacc aggagataaa
       730        740        750        760        770        780
tgtgacattg ttggaactct tatcgtcatt ccagatattg ctcaattgag cactcctgga
       790        800        810        820        830        840
cttcgtgctg agacttcaaa tcagaacaga ggcagagcga ccgataaaag cgaaggaatc
       850        860        870        880        890        900
actggattga aagctcttgg agtccgtgat cttacctata aaatggcatt cttggcttgt
       910        920        930        940        950        960
catattcaac aaaccgagag tcttgttggt ggagatgctt cgggagctgt tgaggagact
       970        980        990       1000       1010       1020
gattatcttg atttatggtc gaaaatgtca acagaagatc gtgcaacact gaagaaaatg
      1030       1040       1050       1060       1070       1080
agtgacgata agaaaatcga gaagaacatt gtcgattcac ttttcccgaa catttatgga
      1090       1100       1110       1120       1130       1140
aaccacgaag ttaagcttgg agttcttctg atgcttcttg gaggtgtcgc gaagaagagc
      1150       1160       1170       1180       1190       1200
agggacgaag gaacttcact gagaggtgat atcaacgttt gtcttgttgg agatccatca
      1210       1220       1230       1240       1250       1260
actgccaagt cgcaagttct gaaagctgtg gaagagttca gtccaagagc tatttacact
      1270       1280       1290       1300       1310       1320
tctggaaaag catcttcagc tgctggtctg actgctgctg ttgtaaaaga cgaggaatcg
      1330       1340       1350       1360       1370       1380
ttcgagtttg tcattgaagc tggagctctc atgcttgccg acaatggagt ttgttgtatt
      1390       1400       1410       1420       1430       1440
gatgagttcg acaaaatgga cctcaaggat caggttgcca ttcacgaggc aatggaacaa
      1450       1460       1470       1480       1490       1500
caaaccattt ccatcaccaa agctggagtc aaagcaacat tgaatgcccg tgcatcaatt
      1510       1520       1530       1540       1550       1560
cttgccgctg caaatccagt taatggacgt tatgatagaa gtcgtccgtt gaagtataat
      1570       1580       1590       1600       1610       1620
gtccagatgt cagctccgat tatgtcacgt ttcgatcttt tctttgtgtt ggtcgatgag
      1630       1640       1650       1660       1670       1680
tgcaatgaag ttactgatta cgctattgcc cgtcggatcc ttgataatca tcgtgcgatc
      1690       1700       1710       1720       1730       1740
agtgagcata ctgaacgtga cagtgtttac aaaattgatg atatcaagaa gtatatcgcg
      1750       1760       1770       1780       1790       1800
tttgctcgtt gcttcaagcc gaagatttcg gataaagctg ctgaaactct tgttcgagag
      1810       1820       1830       1840       1850       1860
tacaagaaac ttcgtatgtc tgacagcaac aatgcagcca cgtcatcatg gagaatcact
      1870       1880       1890       1900       1910       1920
gttcgtcaat tggagtctct cgttcgtctg tctgaggctc ttgctcgtct tcactgtgga
      1930       1940       1950       1960       1970       1980
aaggaagtac tggtggaaca tgtcgaaaag gctgccgaac ttctcaacaa gtctatcgtc
      1990       2000       2010       2020       2030       2040
agagttgagc aaccagacat tgctttggat gatgacgact ttgacaacaa tatcatggtt
      2050       2060       2070       2080       2090       2100
gttgaagcag acaaagagaa tcaaagagga gatgatagta tggatcatga tggagagaag
      2110       2120       2130       2140       2150       2160
gaaaatgctc cgaagattga tatagcaaag ctcaaaatct cattcaagga atacaagcaa
      2170       2180       2190       2200       2210       2220
ttgtctgatg ttctcgtttt acatatgcga tccgatgaag acaatcaagg agaagacgag
      2230       2240       2250       2260       2270       2280
tatgatggtg tcaagcagag tgcacttgtt gaatggtact tgtcgacaat cgaagcagat
      2290       2300       2310       2320       2330       2340
ttggagacgg aggaagactt caacgtacaa aagactattt gcgagcgtgt aattcatcgt
      2350       2360       2370       2380       2390       2400
ctcattcacc aggatcacgt tcttcttgaa gttgagcaag gagaagatcc aactctctgt
      2410       2420       2430
gttcatccga actatgttat tgccgacgaa taa  

Last modification date: Oct. 2, 2011