Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA replication licensing factor mcm-5


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSNLDNPGIY YQERFFANDG VPDTGRELIA EYRQLITQFR NFIRDFSTGG FGMIYRDQLK
        70         80         90        100        110        120
RNYFSHEYRL EINLNHLKNF DEDIEMKLRK FPGKVLPALE EAAKIVADEI TTPRPKGEEK
       130        140        150        160        170        180
LHDIQVTLTL DEYPTSLRQV KSAQVSQVVK ISGIIVAAAQ VRSKATKVTL QCRQCKHTIP
       190        200        210        220        230        240
DVSIKPGLEG FALPRTCAAP QQGQMQRCPI DPYIMLPDKC ECVDYQTLKL QENPEDVPHG
       250        260        270        280        290        300
EMPRHLQLFT ERYLTDKVVP GNRVTIVGVY SIKKLIQKKG GDKSLQGIRT PYLRVLGIHM
       310        320        330        340        350        360
ETSGPGRTNF TTFTPEEERM FKTLAQRKDA YELIAKSIAP SIYGSADIKK SIACLLFGGA
       370        380        390        400        410        420
RKKLPDGITR RGDINVLLLG DPGTAKSQLL KFVEQVSPIG VYTSGKGSSA AGLTASVIRD
       430        440        450        460        470        480
PQSRSFIMEG GAMVLADGGV VCIDEFDKMR EDDRVAIHEA MEQQTISIAK AGITTTLNSR
       490        500        510        520        530        540
CSVLAAANSV YGRWDESRGD DNIDFMPTIL SRFDMIYIVK DTHDVLKDAT LAKHVIEVHV
       550        560        570        580        590        600
NASAAKERDI AGVPKTATTD SDGVMTMFDT DGFLTIEFLK KFVTYARLNC GPRLTPQASE
       610        620        630        640        650        660
KLVNHYVKMR NPVVNADAFK SGKKAHNSAI PITVRQLEAI VRIAESIAKM ELQQFATDKH
       670        680        690        700        710        720
VEEALRLFRV STIEAAATGN LAGVEGFTST ADQEALNRIE VQMKKRFAIG THVSEHLIVQ
       730        740        750
DFVARQHYRE SLVKKVIDNL VRRGDLQQKM QRKMLYRVR  

Encoded by mcm-5 gene

FULL NAME: yeast MCM (licensing factor) related


Nucleic acid sequence

        10         20         30         40         50         60
atgtctaacc tcgacaaccc cggaatctac tatcaggaac gattctttgc gaatgacgga
        70         80         90        100        110        120
gttccagata ctggaagaga gttgatcgct gaatatcgtc agcttatcac tcaattccgc
       130        140        150        160        170        180
aattttatcc gtgatttttc cactggaggc ttcggaatga tttacagaga tcagctgaag
       190        200        210        220        230        240
cgcaactact tcagccatga atatcgcctt gaaattaacc tgaatcatct gaaaaatttc
       250        260        270        280        290        300
gacgaggaca ttgagatgaa gctgagaaaa ttcccaggaa aagtgctccc agctctcgag
       310        320        330        340        350        360
gaagccgcca aaattgtcgc tgatgagatt accacgccaa gaccaaaggg agaggagaag
       370        380        390        400        410        420
cttcatgata ttcaagtgac actgacgctt gacgagtatc caacctcact tcgacaggtt
       430        440        450        460        470        480
aaatctgctc aggtctccca ggttgtcaag atttccggaa ttattgtggc tgctgctcag
       490        500        510        520        530        540
gttcgctcta aagccactaa agtaaccctc caatgtcgtc agtgcaagca cacaattcca
       550        560        570        580        590        600
gatgtttcga tcaagccagg acttgaagga tttgctcttc caagaacttg tgcagcacca
       610        620        630        640        650        660
caacaaggac aaatgcagcg atgcccaata gatccatata ttatgctgcc cgacaagtgt
       670        680        690        700        710        720
gaatgtgtcg attatcagac tttgaagctt caggagaatc cagaagacgt tccacatgga
       730        740        750        760        770        780
gaaatgccac gtcatcttca gcttttcacg gagagatatt tgactgataa agtggttcct
       790        800        810        820        830        840
ggaaatcgag tcacaattgt tggagtttat tcgattaaaa agttgattca aaaaaagggt
       850        860        870        880        890        900
ggtgacaaat ctcttcaagg aattcgtaca ccatatctca gagttcttgg aatccacatg
       910        920        930        940        950        960
gaaacatctg gacctggaag aaccaatttc acaacgttta cacctgaaga agagagaatg
       970        980        990       1000       1010       1020
ttcaagactt tggctcagag gaaagatgct tatgaactta tcgctaaatc gattgctcca
      1030       1040       1050       1060       1070       1080
tcaatctatg gatccgctga tatcaagaaa tcgattgctt gtttgttgtt cggaggtgct
      1090       1100       1110       1120       1130       1140
cgtaagaagc ttccagatgg aattacacga cgtggagaca tcaatgttct cttgctcgga
      1150       1160       1170       1180       1190       1200
gatccaggaa cagcaaaatc tcagttgttg aagttcgttg agcaagtgtc tccaattgga
      1210       1220       1230       1240       1250       1260
gtgtacacat ctggaaaagg atcatcggct gctggtctca ctgcatcagt tattcgtgat
      1270       1280       1290       1300       1310       1320
ccacaatcac gctcgttcat catggaaggt ggtgcaatgg ttctggctga tggtggagtc
      1330       1340       1350       1360       1370       1380
gtttgtattg atgaattcga taaaatgcgt gaagatgatc gagttgcaat tcacgaagca
      1390       1400       1410       1420       1430       1440
atggaacaac agaccatttc tattgcaaag gctggaatta caactacttt gaattctcgt
      1450       1460       1470       1480       1490       1500
tgctcggttc tggcggccgc taattcggtt tacggaagat gggatgagtc gagaggagat
      1510       1520       1530       1540       1550       1560
gataatatcg attttatgcc aactattctg tctcgtttcg atatgatcta cattgtgaag
      1570       1580       1590       1600       1610       1620
gatactcatg atgttctcaa agatgctacc ctcgcgaagc acgtcatcga agttcatgtg
      1630       1640       1650       1660       1670       1680
aatgcatctg ctgctaaaga acgtgatatt gcaggagtcc caaaaacagc cacaactgat
      1690       1700       1710       1720       1730       1740
tcagatggtg tgatgacaat gttcgatacg gatggtttct tgactatcga gttcctcaag
      1750       1760       1770       1780       1790       1800
aaattcgtca catatgctcg tttgaactgt ggaccacgtc ttactccgca agcttctgag
      1810       1820       1830       1840       1850       1860
aagctcgtta atcactacgt taagatgaga aatccagttg tcaatgctga tgcttttaaa
      1870       1880       1890       1900       1910       1920
tcaggaaaga aggctcataa ttcggcaatt ccgattaccg ttcgtcaact cgaagccatt
      1930       1940       1950       1960       1970       1980
gttcgtattg ctgaaagtat tgcaaagatg gagcttcagc agtttgccac tgacaagcac
      1990       2000       2010       2020       2030       2040
gtcgaggaag cgctccgtct gttccgtgtt tcaacaattg aagcggcggc aactggaaat
      2050       2060       2070       2080       2090       2100
ttggcaggag tcgaaggatt tacttcaaca gctgatcaag aagcattgaa tcgtatcgaa
      2110       2120       2130       2140       2150       2160
gtgcaaatga agaagagatt cgcaatcggt acacacgttt ctgagcattt gattgttcaa
      2170       2180       2190       2200       2210       2220
gactttgttg ctcgtcaaca ttatagagag tctcttgtca agaaggttat cgataatttg
      2230       2240       2250       2260       2270       2280
gtccgtcgtg gagacttgca acaaaagatg caacgcaaga tgctctaccg tgttcgataa

Last modification date: Oct. 2, 2011