Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase epsilon subunit 2


DESCRIPTION:
Participates in DNA repair and in chromosomal DNA replication.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase epsilon subunit B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN AVEKQPLSSN
        70         80         90        100        110        120
MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF
       130        140        150        160        170        180
GTPRDKAEMF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTTKIGD
       190        200        210        220        230        240
AIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF
       250        260        270        280        290        300
GFPPTEPSST TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV
       310        320        330        340        350        360
LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC EYPDIHQSSR
       370        380        390        400        410        420
FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT NPCRIQYCTQ EITVFREDLV
       430        440        450        460        470        480
NKMCRNCVRF PSSNLAIPNH FVKTILSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI
       490        500        510        520
ADKYDPFTTT NTECLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGF 

Encoded by POLE2 gene

FULL NAME: polymerase (DNA directed), epsilon 2 (p59 subunit)


OTHER NAME(S):
DPE2


Nucleic acid sequence

        10         20         30         40         50         60
atggcgccgg agcggctgcg gagccgggcg ctctccgcct tcaagttgcg gggcttgctg
        70         80         90        100        110        120
ctccgtggtg aagctattaa gtacctcaca gaagctcttc agtctatcag tgaattagag
       130        140        150        160        170        180
cttgaagata aactggaaaa gataattaat gcagttgaga agcaaccctt gtcatcaaac
       190        200        210        220        230        240
atgattgaac gatctgtggt ggaagcagca gtccaggaat gcagtcagtc tgttgatgaa
       250        260        270        280        290        300
actatagagc acgttttcaa tatcatagga gcatttgata ttccacgctt tgtgtacaat
       310        320        330        340        350        360
tcagaaagaa aaaaatttct tcctctgtta atgaccaacc accctgcacc aaatttattt
       370        380        390        400        410        420
ggaacaccaa gagataaagc agagatgttt cgtgagcgat ataccatttt gcaccagagg
       430        440        450        460        470        480
acccacaggc atgaattatt tactcctccg gtgataggtt ctcaccctga tgaaagcgga
       490        500        510        520        530        540
agcaaattcc agcttaaaac aatagaaacc ttattgggta gtacaaccaa aatcggagat
       550        560        570        580        590        600
gcgattgttc ttggaatgat aacgcagtta aaagagggaa aattttttct ggaagatcct
       610        620        630        640        650        660
actggaacag tccaactaga ccttagtaaa gctcagttcc atagtggttt atacacagag
       670        680        690        700        710        720
gcatgctttg tcttagcaga aggttggttt gaagatcaag tgtttcatgt caatgccttt
       730        740        750        760        770        780
ggatttccac ccactgagcc ctctagtact actagggcat actatggaaa tattaatttt
       790        800        810        820        830        840
tttggaggtc cttctaatac atctgtgaag acttctgcaa aactaaaaca gctagaagag
       850        860        870        880        890        900
gagaataaag atgctatgtt tgtgttttta tctgatgttt ggttggacca ggtggaagta
       910        920        930        940        950        960
ttggaaaaac ttcgcataat gtttgctggt tattcaccag cacctccaac ctgctttatt
       970        980        990       1000       1010       1020
ctgtgtggta atttttcatc tgcaccatat ggaaaaaatc aagttcaagc tttgaaagat
      1030       1040       1050       1060       1070       1080
tccctaaaaa ctttggcaga tataatatgt gaatacccag atattcacca aagtagtcgt
      1090       1100       1110       1120       1130       1140
tttgtgtttg tacctggtcc agaggatcct ggatttggtt ccatcttacc aaggccacca
      1150       1160       1170       1180       1190       1200
cttgctgaaa gcatcactaa tgaattcaga caaagggtac cattttcagt ttttactact
      1210       1220       1230       1240       1250       1260
aatccttgca gaattcagta ctgtacacag gaaattactg tcttccgtga agacttagta
      1270       1280       1290       1300       1310       1320
aataaaatgt gcagaaactg cgtccgtttt cctagcagca atttggctat tcctaatcac
      1330       1340       1350       1360       1370       1380
tttgtaaaga ctatcttatc ccaaggacat ctgactcccc tacctcttta tgtctgccca
      1390       1400       1410       1420       1430       1440
gtgtattggg catatgacta tgctttgaga gtgtatcctg tgcccgatct acttgtcatt
      1450       1460       1470       1480       1490       1500
gcagacaaat atgatccttt cactacgaca aataccgaat gcctctgcat aaaccctggc
      1510       1520       1530       1540       1550       1560
tcttttccaa gaagtggatt ttcattcaaa gttttttatc cttctaataa gacagtagaa
      1570       1580
gatagcaaac ttcaaggctt ttga   

Last modification date: Oct. 2, 2011