Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Probable DNA polymerase epsilon subunit 2


DESCRIPTION:
Participates in DNA repair and in chromosomal DNA replication (By similarity).

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase epsilon subunit B family.


SUBUNIT STRUCTURE:
Consists of four subunits (By similarity).


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MDTTAEENAL RREIVKTFQI HAFELKKEAV KLCVKLFLDH DKETRKKWTN KMIELLKKQT
        70         80         90        100        110        120
LQSSLISEEL IRDTFRQCKS KGTQDAGKLL NVFDAFSLQP YDFDADLRKM VLRKEKTSLA
       130        140        150        160        170        180
ADSSSFSHAA RQRFFIVKQR AMRCASLKNF KFTTCEILGS STKHLQSVVV LGMLTQQKAD
       190        200        210        220        230        240
CYHIEDLSGS VEVEFKEDTK FHHALFHEHS IAIFEGTFEN SVLTVNEVAM VPVESAEVTR
       250        260        270        280        290        300
KELSSNENWF GGDDKIAFRC SDRLRSALAK QEDTSLVFLS DVFLDDKKVM KAVFKLLQGY
       310        320        330        340        350        360
KDQPPVAIVF CGNFCSRPRQ TDTIDLLDRG FRWLANQLTP LRKDYEKTQF IFVPGPDDPF
       370        380        390        400        410        420
VDTVLPRPHL PSLLFKHISP IISCTFASNP CRIQFASQEI VVFRSDLIKK TCRHSINSIT
       430        440        450        460        470        480
VESIPSRYAR SVLSQAHLCP LPQHITPVLP DFSHSLSLHP LPDLLITADR FETFTEKVVG
       490        500        510        520        530
ADTIVSNPGS FSRSNYTFHV YYPCQNRVEA SQIPVSELDD HSNIKNVIIF FFLF

Encoded by gid:177673 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggacacaa ctgccgagga gaatgcgctg cgccgagaaa ttgtcaaaac ctttcagata
        70         80         90        100        110        120
cacgcatttg agctcaaaaa agaagcggtc aaattatgtg tgaagctatt cctagaccat
       130        140        150        160        170        180
gacaaagaaa ctcgaaagaa atggacgaat aaaatgattg aattactcaa aaagcagaca
       190        200        210        220        230        240
ctgcaatcat ccctaatcag tgaagaactc atcagagata cattccgtca atgtaaatca
       250        260        270        280        290        300
aaaggaaccc aagatgcagg aaaactgctc aatgtattcg acgcattctc cctccagccg
       310        320        330        340        350        360
tatgattttg atgcggatct tcggaaaatg gttctaagaa aagaaaaaac tagtctggct
       370        380        390        400        410        420
gctgattcgt cgtcattctc acatgctgca cgacaacgat tttttattgt taagcagcgt
       430        440        450        460        470        480
gcaatgcgat gtgcttcact gaaaaacttc aaattcacca catgcgaaat tttgggaagt
       490        500        510        520        530        540
tccacaaaac atcttcaatc agttgtagtt ctcggtatgc ttactcagca aaaggccgac
       550        560        570        580        590        600
tgctatcata tcgaagatct aagcggttca gttgaagtag aatttaaaga agacacgaaa
       610        620        630        640        650        660
tttcatcatg cgttattcca tgagcattca attgcaattt ttgaaggaac ttttgagaat
       670        680        690        700        710        720
agtgttttaa cagtgaatga agttgcaatg gtacctgtag aatcagcaga agttacgaga
       730        740        750        760        770        780
aaagagttga gttcgaatga gaattggttt ggaggagatg ataagatcgc attccggtgc
       790        800        810        820        830        840
agtgatcgcc tacgatcagc tctggctaag caggaagata cttcccttgt cttcctttcc
       850        860        870        880        890        900
gatgtttttt tggatgataa aaaggttatg aaagcagtat tcaaattgct acaaggatac
       910        920        930        940        950        960
aaagatcaac ctccagttgc aattgttttt tgtggaaatt tttgctcaag acccagacaa
       970        980        990       1000       1010       1020
actgatacaa ttgatttact ggatcgtgga ttcaggtggt tggctaatca attgacacca
      1030       1040       1050       1060       1070       1080
ctcagaaagg attatgaaaa aacacagttt atctttgtac caggacctga tgatccattt
      1090       1100       1110       1120       1130       1140
gttgacacgg tacttcctcg tccacatctt ccatctcttc tcttcaagca tatttcccca
      1150       1160       1170       1180       1190       1200
attatctcgt gtacatttgc ttcgaatccg tgtcgaattc aattcgcaag ccaggagatt
      1210       1220       1230       1240       1250       1260
gttgtcttcc gaagtgattt gatcaaaaaa acgtgcagac attcaatcaa tagtatcact
      1270       1280       1290       1300       1310       1320
gtcgaatcca tcccatcgag atatgcaaga agtgtgttga gccaggcgca tttgtgtcca
      1330       1340       1350       1360       1370       1380
cttcctcaac atattacacc agttttaccg gatttctctc attccttgtc acttcatcca
      1390       1400       1410       1420       1430       1440
cttcccgatc ttctgatcac tgctgatcgt ttcgagactt tcaccgaaaa agtcgttgga
      1450       1460       1470       1480       1490       1500
gctgacacaa ttgtctcaaa tcctggttca ttctctcgaa gcaactacac tttccacgtc
      1510       1520       1530       1540       1550       1560
tattatccct gtcagaatcg cgtggaagct tcacaaatcc cagtttccga acttgatgat
      1570       1580       1590       1600
cactctaaca tcaaaaatgt aatcatattc ttcttccttt tctga 

Last modification date: Jan. 7, 2012