Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSSKDDILAQ AVENDSNYKE RLALIRSNDE IDAKLGFSRY TGLQEKKGFL INIQPSELVD
        70         80         90        100        110        120
EQTKVIISVV DYFFISDMDE RFKISYPFRP YFYIATLDGF EFQVSSYLSK KYGAQTAVEH
       130        140        150        160        170        180
MDREDLDLKD HLSGLKKTYI KLSFTSTVEL IKIRKELMPL VRKNTDRIKK ESAYADYLAR
       190        200        210        220        230        240
NLSGKGGDSK DQQLNGDILN QIVDIREYDV PFHMRVSIDE KIFVGLWYDV KGIGPNRVPT
       250        260        270        280        290        300
IKRKDLPLFH AKPKVLAFDI ETTKLPLKFP DRESDEIMMI SYMVDGRGFL IINREIVSAD
       310        320        330        340        350        360
INAFEYTPKA EYIGEFTVWN EKDEAALIRK FFDHFLQVRP NIVVTYNGDF FDWPFVEARA
       370        380        390        400        410        420
KIRGFNMERE IGFSKDSADE YKSRNCIHMD AFRWVKRDSY LPVGSQNLKA VTKAKLRYDP
       430        440        450        460        470        480
VEVEPELMCK MAREQPQQLA NYSVSDAVST YYLYMKYVHQ FIFALCTIIP LGADDVLRKG
       490        500        510        520        530        540
SGTLCEALLM VEAFHNNIVF PNKYTGPEET RFSKDGHRVE SETYVGGHVE ALEAGVFRAD
       550        560        570        580        590        600
IPAKFRLSVP ALEQLKSEIQ ETLRKELARE FEVTLDQVVD FDEQCAEVQD AFDGMINVPT
       610        620        630        640        650        660
RLENPRIYHL DVGAMYPNII LTNRLQPCAM VTEEICMGCS YNKPDAECKR TMAWEWRGEL
       670        680        690        700        710        720
TPATRGEYQQ IMQQLEAESF GKPPKHFHML ERSEREAIEM KRIKDYSRRV YGKTHLTRLE
       730        740        750        760        770        780
MRETTICQRE NHFYVETVKA FRDRRYEYKD MLKKAKGRFD QAQATNDLAT MTTSKLEMVL
       790        800        810        820        830        840
YESLQLAHKC ILNSFYGYVM RKGSRWFSME MAGIVCHTGA NIIREARKLV EQIGTPLELD
       850        860        870        880        890        900
TDGIWCLIPA SFPENVTFKL KNHKRSSVTV SYPGAMLNAL VYEGFTNHQY HTLEKDGSYS
       910        920        930        940        950        960
KSSENSIYFE VDGPYQCMIL PASKEEGKKL KKRYAVFNLD GSLAEMKGFE LKRRGELNII
       970        980        990       1000       1010       1020
KHFQGCVFKT FLNGKTLEET YKAVAADADH WLDILHSHGA DLTDEELFDL ISENRSMSRK
      1030       1040       1050       1060       1070       1080
LEDYGAQKST SISTAKRLAE FLGDDMVKDA GLACMFIISK HPIGAPVTER AIPVAIFKSD
      1090       1100       1110       1120       1130       1140
AKVRSHYIRK WTKQVDFNED TDIRDMLDWD YYLERFGSCI QKIITIPAAL QGISNPVPRV
      1150       1160       1170       1180       1190       1200
PHPDWLQNKI RNKFDAHRQP RINQIFAACQ KPSTSQMDNG KRRRTPDDDV ASEDAMDSQD
      1210       1220       1230       1240       1250       1260
DIIIDDDKEN GAKRQKNTKK VHTTEVVLEK KTLVEHGFDE WMGFLKKKWR VQRKERKTQL
      1270       1280       1290       1300       1310       1320
SSKDSDVVEA IVRGAREAEH DKEWHILSVE PTADASFFNV WLAVQGQMHK VIMKIGRRII
      1330       1340       1350       1360       1370       1380
VDSRAPRGDR DTIRRILPHH KTPGFLYEFR TDENQLTALM DKLYSETCSS TIDGIYESEV
      1390       1400       1410       1420       1430       1440
PTSFRAVLQL GSIVRPDHGI SLGGHQLTLE NLKPMEKAPY LPLDQKIRTI FLYKFSQDSR
      1450       1460       1470       1480       1490       1500
HVYSLIDSSG SAAYFYIVNT GDVQMPNMDS LYTSAYTKMM STERGQLCHT SESMPFTVKR
      1510       1520       1530       1540       1550       1560
FSSNTECERQ LGRALRVYRE VSSKTAIVLL LSDTDPFRLA RKLPNLGLFP NVQLHITEPS
      1570       1580       1590       1600       1610       1620
SLLNQIDWQK VVARRVLQHY FNSFFFLADY LEWARYLRVP IGNLPADHAL FGLDLLFARN
      1630       1640       1650       1660       1670       1680
LQKSGHALWA TRASRPDLGG KEMDDVRLSV DWNPLSIDDT VLLNRETFCE TACVELQLSA
      1690       1700       1710       1720       1730       1740
VAVTALVQRS RVLEAEGADD VVTFDSMNTI AQQSVTGGAV NSIACYDEGA AVDATIKVLK
      1750       1760       1770       1780       1790       1800
QMLTECVRHI AHQGNARADE VVMTVSRWLN TRSALLFDAA LTRSVSVLES KLVLLLCAEC
      1810       1820       1830       1840       1850       1860
ERIGAKVIHA TAQKLVLNTG KSTSEEAKGF AEMLIQSLST NVVFAALHIT PVKFFDAMLW
      1870       1880       1890       1900       1910       1920
MDAHNHTGIR ISEKTESSPD VIADEEESSC TEFETTAIWK IAEEMPTEAN IQEEFLQMIG
      1930       1940       1950       1960       1970       1980
AYILEFLETN RKMHFDSESG ATFRSDCISQ KISHRLYRIV NKMVHNNADI AHCSVYLANA
      1990       2000       2010       2020       2030       2040
LCRALSCDQT SQLAVEGIRD NAKRLLHNSV VEADMTPLRS TTLFVSNVFC NSCSQASNVF
      2050       2060       2070       2080       2090       2100
LSSTDEILTC ATCQSKLNSD VIDMMICDRL NQLLTAYQIQ DHQCTKCKSV RHDTLSMYCE
      2110       2120       2130       2140
CCSQFIPQIT PAQLKHEAST VETVSIVRNF ALSSELATWV LKML 

Encoded by gid:173368 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgagctcca aggatgacat tcttgcacag gcggtcgaaa atgattcaaa ctacaaagag
        70         80         90        100        110        120
cggcttgccc tgatcagatc aaatgatgag attgatgcga agcttggttt ctctagatac
       130        140        150        160        170        180
acaggactac aggagaaaaa aggatttctg ataaacatcc aaccttcgga gcttgtcgac
       190        200        210        220        230        240
gagcaaacca aagttattat ttcggtcgtt gactatttct tcatcagtga tatggacgaa
       250        260        270        280        290        300
cgcttcaaaa tcagttaccc atttcgaccg tatttctata ttgccacgtt ggatggattt
       310        320        330        340        350        360
gaattccaag tatccagtta tctgtccaag aagtacggag cccagacagc agttgaacat
       370        380        390        400        410        420
atggatcggg aggatttaga tttgaaagat catctttctg ggttgaagaa gacatatatc
       430        440        450        460        470        480
aaactctcat tcaccagcac cgtggaattg ataaaaatcc gtaaggaatt aatgccgctg
       490        500        510        520        530        540
gtgcggaaaa acacagatcg catcaaaaaa gagtcggcgt acgctgacta tttggcgagg
       550        560        570        580        590        600
aatctgagtg gaaaaggagg agatagtaag gatcaacagt tgaatggtga catcttgaat
       610        620        630        640        650        660
caaattgttg atatcagaga atacgacgtg ccttttcaca tgagagtttc catcgatgaa
       670        680        690        700        710        720
aagatcttcg tcggattatg gtacgatgtg aaaggaattg gcccgaaccg tgttccaaca
       730        740        750        760        770        780
ataaagcgaa aagatttgcc cttgttccac gcaaagccga aagttctcgc ctttgacatt
       790        800        810        820        830        840
gaaacaacga aacttccgtt gaaatttccg gatcgtgaga gcgatgaaat tatgatgata
       850        860        870        880        890        900
tcatatatgg ttgatggacg tggatttttg attatcaacc gagaaatcgt gtcggctgat
       910        920        930        940        950        960
attaatgcgt tcgaatacac accgaaagcc gagtacatag gagaattcac agtctggaat
       970        980        990       1000       1010       1020
gagaaggacg aagctgctct gattcggaaa tttttcgatc attttttgca ggttcgtcca
      1030       1040       1050       1060       1070       1080
aatattgttg tcacctacaa tggagatttc ttcgattggc cattcgtaga agctcgtgcc
      1090       1100       1110       1120       1130       1140
aagatccgcg gattcaatat ggaaagggaa atcggatttt ctaaggattc cgccgatgag
      1150       1160       1170       1180       1190       1200
tacaaatcac gaaattgtat tcatatggac gctttccgat gggtcaaacg tgactcatat
      1210       1220       1230       1240       1250       1260
ctaccggttg gaagtcagaa tctgaaggca gtgacgaagg caaagctgag atatgatcca
      1270       1280       1290       1300       1310       1320
gttgaggtgg agccggaact gatgtgcaaa atggctcgag agcagcctca acagctggcc
      1330       1340       1350       1360       1370       1380
aattactcgg tttcggatgc agtgtccact tattatctct acatgaagta tgttcatcaa
      1390       1400       1410       1420       1430       1440
tttatcttcg ctttgtgcac aattatccca ctaggagcag atgacgtgtt gagaaaagga
      1450       1460       1470       1480       1490       1500
tctggaacac tttgtgaagc tcttctgatg gttgaagcat tccataacaa tattgtgttc
      1510       1520       1530       1540       1550       1560
ccgaacaagt acactggacc agaggagaca agattcagta aagatggaca tcgtgttgag
      1570       1580       1590       1600       1610       1620
agcgagacct atgtcggagg acacgtggaa gctctggagg ccggcgtatt cagagcggat
      1630       1640       1650       1660       1670       1680
attccagcaa aattccggct ttccgttcct gctcttgagc aattaaaatc cgagattcaa
      1690       1700       1710       1720       1730       1740
gagacccttc gcaaggagct ggctcgagag tttgaggtca ctcttgacca ggtcgttgac
      1750       1760       1770       1780       1790       1800
tttgatgagc agtgcgctga agttcaagat gcatttgatg gaatgataaa tgtgccaaca
      1810       1820       1830       1840       1850       1860
cgcctcgaga atccacgtat ctaccatttg gacgtcgggg ccatgtaccc caacatcatt
      1870       1880       1890       1900       1910       1920
ttgactaatc gattgcagcc atgtgcgatg gtcaccgagg agatttgcat gggatgctcc
      1930       1940       1950       1960       1970       1980
tacaacaaac cagacgcaga atgcaagagg acgatggctt gggaatggag gggagagctg
      1990       2000       2010       2020       2030       2040
acaccagcca ctcgaggaga ataccagcaa attatgcagc aactcgaagc agaatcgttt
      2050       2060       2070       2080       2090       2100
ggaaaaccac cgaaacactt tcatatgctc gagagatcgg agcgagaagc catcgaaatg
      2110       2120       2130       2140       2150       2160
aagcgtatca aagattacag caggcgtgtc tacggaaaga ctcatttgac aagattagaa
      2170       2180       2190       2200       2210       2220
atgagagaaa ctacaatttg tcaacgggag aatcatttct acgtggaaac tgtaaaagcg
      2230       2240       2250       2260       2270       2280
ttccgtgata gaagatacga gtacaaggat atgttgaaaa aggcgaaagg acgattcgat
      2290       2300       2310       2320       2330       2340
caagcccagg cgacaaatga tcttgcaact atgactacat ctaagttgga aatggtgctc
      2350       2360       2370       2380       2390       2400
tacgaatcac tgcagctggc tcacaagtgc attctcaact ctttctacgg atatgtgatg
      2410       2420       2430       2440       2450       2460
cgtaaaggat ccagatggtt ttcaatggag atggctggaa ttgtgtgcca tactggtgca
      2470       2480       2490       2500       2510       2520
aatatcatcc gagaagcacg caaacttgtt gaacagattg gaacaccgtt ggagcttgac
      2530       2540       2550       2560       2570       2580
actgatggaa tttggtgcct gatccctgct tcgttccctg aaaatgtcac tttcaagctg
      2590       2600       2610       2620       2630       2640
aaaaatcaca aaagaagttc tgttacagtg tcgtatccgg gtgcaatgct gaatgcgttg
      2650       2660       2670       2680       2690       2700
gtgtatgaag gattcaccaa tcatcagtac cacactctgg aaaaagatgg gtcttactca
      2710       2720       2730       2740       2750       2760
aaatcgtcgg agaattcgat ttatttcgaa gtagatggtc catatcaatg tatgattctg
      2770       2780       2790       2800       2810       2820
cctgcatcaa aggaagaggg aaagaaattg aagaaacgat acgccgtgtt caatttagat
      2830       2840       2850       2860       2870       2880
ggatcactgg cggaaatgaa gggattcgag ttgaagagac gtggagagtt gaatattatc
      2890       2900       2910       2920       2930       2940
aaacattttc agggatgcgt attcaaaacc ttcctcaacg gaaaaactct tgaggagacg
      2950       2960       2970       2980       2990       3000
tacaaagcag tggcagctga tgcggatcac tggctggata ttcttcactc ccatggcgcc
      3010       3020       3030       3040       3050       3060
gatcttaccg atgaagaact attcgacttg atttcagaga acagaagtat gtcgagaaag
      3070       3080       3090       3100       3110       3120
ctggaagact atggagcaca aaagagcaca tcaatcagta ctgcaaaacg gctagctgaa
      3130       3140       3150       3160       3170       3180
ttcctcggag atgatatggt caaagatgct ggactagcct gcatgttcat catctcgaag
      3190       3200       3210       3220       3230       3240
catccgattg gtgcaccggt tacggaaaga gctattccag ttgcaatctt caagtcagat
      3250       3260       3270       3280       3290       3300
gctaaagttc gcagtcatta catcaggaag tggacgaaac aagtggattt caatgaggat
      3310       3320       3330       3340       3350       3360
accgatattc gggatatgtt ggattgggat tactatttgg aacgatttgg cagttgtatt
      3370       3380       3390       3400       3410       3420
cagaagatta tcacaattcc agccgcactt caaggcatat caaatccagt gccacgtgta
      3430       3440       3450       3460       3470       3480
ccacatccag attggttgca gaacaagata cggaataaat tcgacgctca caggcagcca
      3490       3500       3510       3520       3530       3540
cgtatcaatc agattttcgc cgcctgccaa aaaccttcaa cttcacaaat ggacaatgga
      3550       3560       3570       3580       3590       3600
aaacgtcgta gaacacctga tgatgacgtg gcatctgaag atgctatgga ttcacaagat
      3610       3620       3630       3640       3650       3660
gacatcataa tcgacgatga taaggagaat ggagcgaagc ggcagaagaa caccaagaag
      3670       3680       3690       3700       3710       3720
gtacatacaa ctgaggtagt cctcgagaag aagacgttgg tggaacacgg tttcgatgaa
      3730       3740       3750       3760       3770       3780
tggatgggat ttctgaaaaa gaagtggaga gtgcagagaa aggagagaaa aactcagcta
      3790       3800       3810       3820       3830       3840
tcatcgaaag attcagatgt agtggaggcg attgttcgtg gtgcgagaga agccgagcat
      3850       3860       3870       3880       3890       3900
gacaaggaat ggcatatttt gagtgtggag ccgactgcgg acgcctcatt tttcaatgtt
      3910       3920       3930       3940       3950       3960
tggctagcag ttcagggaca aatgcacaaa gtgattatga agattggtag acggatcatc
      3970       3980       3990       4000       4010       4020
gtcgattctc gtgctccacg cggcgatcgt gatacaattc gacgaatttt accacatcac
      4030       4040       4050       4060       4070       4080
aagacacctg gtttccttta cgaattccgt acagatgaga atcagctgac agcactcatg
      4090       4100       4110       4120       4130       4140
gataagctgt attcggagac gtgtagttcg acgattgatg gaatctacga gtcagaagtt
      4150       4160       4170       4180       4190       4200
cccacaagct tccgtgctgt actccaactt ggctcaatcg ttcgaccgga tcatggaatc
      4210       4220       4230       4240       4250       4260
tcgctgggtg gacatcaact gacactggaa aatttaaaac ctatggagaa ggcaccgtat
      4270       4280       4290       4300       4310       4320
ctaccactag atcagaagat tcggactatc ttcttgtata agttctcaca ggattctcgg
      4330       4340       4350       4360       4370       4380
catgtctatt cgcttattga ttcgtctggc tccgcagctt acttctacat tgttaatact
      4390       4400       4410       4420       4430       4440
ggagatgttc agatgcctaa tatggactcc ctctacacat ccgcatacac taaaatgatg
      4450       4460       4470       4480       4490       4500
tcaactgaac gtggtcagct ctgtcacact tctgaaagca tgccgttcac agtgaagcga
      4510       4520       4530       4540       4550       4560
ttctcatcaa atacagaatg cgaacgtcaa ttgggaagag cattgcgtgt atatcgagag
      4570       4580       4590       4600       4610       4620
gtttcgtcca aaactgcgat tgttcttttg ctcagtgaca cggatccatt ccgattggca
      4630       4640       4650       4660       4670       4680
cgaaaacttc cgaatctcgg attattccca aatgtgcagc ttcatatcac tgaaccatcg
      4690       4700       4710       4720       4730       4740
tcacttctca atcagataga ctggcaaaaa gtcgtggctc gtcgagtact gcaacactat
      4750       4760       4770       4780       4790       4800
ttcaacagct tcttcttcct cgccgactat cttgaatggg ctcgctatct tcgtgttcca
      4810       4820       4830       4840       4850       4860
atcggtaatc tgcctgctga tcatgcgctc ttcggattgg atcttctctt cgccagaaac
      4870       4880       4890       4900       4910       4920
ctccagaaat caggtcacgc tctgtgggca actcgtgcga gccgtccgga cttgggagga
      4930       4940       4950       4960       4970       4980
aaggaaatgg atgatgttcg tctttcagtt gattggaatc cgttatcaat agatgatacg
      4990       5000       5010       5020       5030       5040
gttctgttga atcgggagac gttctgtgaa actgcctgtg ttgaacttca actcagcgct
      5050       5060       5070       5080       5090       5100
gttgccgtga cggctttagt tcaacgaagt cgtgttttgg aggcagaagg ggccgacgat
      5110       5120       5130       5140       5150       5160
gtagtcacat ttgactcgat gaatacaatt gcacaacagt cagtgacagg aggagctgta
      5170       5180       5190       5200       5210       5220
aactcaatcg cctgctatga tgaaggagcc gcggtggatg caacgataaa agtgctcaaa
      5230       5240       5250       5260       5270       5280
caaatgctca cagaatgcgt tcgccatatt gcccatcaag gaaatgcacg tgccgatgaa
      5290       5300       5310       5320       5330       5340
gttgtgatga ccgtatccag atggctcaac actcgatctg ctctactctt tgacgctgcc
      5350       5360       5370       5380       5390       5400
ctcaccagga gtgtttcggt gctggagagt aagttggtgc tactattgtg tgcggaatgt
      5410       5420       5430       5440       5450       5460
gaacgaattg gagcaaaagt tattcacgca actgctcaaa agctggtgtt gaatacagga
      5470       5480       5490       5500       5510       5520
aaatcgacaa gcgaggaggc caaggggttt gcggagatgc tcattcagtc gttgagcaca
      5530       5540       5550       5560       5570       5580
aatgttgttt ttgcggctct tcatatcact cctgtgaagt ttttcgatgc gatgctctgg
      5590       5600       5610       5620       5630       5640
atggacgcac acaatcatac tggaattcga atttccgaaa agaccgaatc gtccccagat
      5650       5660       5670       5680       5690       5700
gtgatagctg atgaagaaga aagtagctgc accgagttcg agacaactgc tatttggaag
      5710       5720       5730       5740       5750       5760
atcgcagaag aaatgccaac agaggcgaat attcaggagg aattcctcca aatgattggc
      5770       5780       5790       5800       5810       5820
gcctacattc ttgaattcct tgaaaccaat cgaaaaatgc actttgactc ggagtccggt
      5830       5840       5850       5860       5870       5880
gcaactttcc ggtcagactg catctcacaa aagatctcac atcgtctcta tcgaattgtg
      5890       5900       5910       5920       5930       5940
aacaagatgg tgcataacaa tgcggatatt gcacattgtt ctgtgtattt ggcgaatgcg
      5950       5960       5970       5980       5990       6000
ctctgtcgag ctctatcctg tgatcagacc tcccagttgg cagtcgaagg aattcgggat
      6010       6020       6030       6040       6050       6060
aatgcgaagc gtcttctgca caattctgtt gtggaagccg acatgacacc actgcgttca
      6070       6080       6090       6100       6110       6120
acgactctct tcgtctcaaa tgtcttctgc aattcgtgtt ctcaggcctc gaacgtattc
      6130       6140       6150       6160       6170       6180
ctttcctcca ctgatgagat tctcacatgt gccacgtgtc agagtaagct caactctgac
      6190       6200       6210       6220       6230       6240
gtcattgata tgatgatttg cgatcgattg aaccagctgc tcactgccta ccagattcag
      6250       6260       6270       6280       6290       6300
gatcatcagt gcacgaaatg caaatcggtt cgtcacgaca cactatcaat gtactgcgaa
      6310       6320       6330       6340       6350       6360
tgctgttccc agttcattcc acaaatcaca cctgcacagc tgaagcacga ggcttccacc
      6370       6380       6390       6400       6410       6420
gtcgagactg tctccatcgt ccgcaatttc gcgttgagct ccgaactcgc cacatgggtc
      6430
ttgaaaatgt tgtga    

Last modification date: Oct. 2, 2011