Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase epsilon catalytic subunit A


DESCRIPTION:
Participates in DNA repair and in chromosomal DNA replication.

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


PROTEIN TYPE(S):
B-family DNA polymerase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSLRSGGRRR ADPGADGEAS RDDGATSSVS ALKRLERSQW TDKMDLRFGF ERLKEPGEKT
        70         80         90        100        110        120
GWLINMHPTE ILDEDKRLGS AVDYYFIQDD GSRFKVALPY KPYFYIATRK GCEREVSSFL
       130        140        150        160        170        180
SKKFQGKIAK VETVPKEDLD LPNHLVGLKR NYIRLSFHTV EDLVKVRKEI SPAVKKNREQ
       190        200        210        220        230        240
DHASDAYTAL LSSVLQRGGV ITDEEETSKK IADQLDNIVD MREYDVPYHI RLSIDLKIHV
       250        260        270        280        290        300
AHWYNVRYRG NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI
       310        320        330        340        350        360
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE AHLIQRWFEH VQETKPTIMV
       370        380        390        400        410        420
TYNGDFFDWP FVEARAAVHG LSMQQEIGFQ KDSQGEYKAP QCIHMDCLRW VKRDSYLPVG
       430        440        450        460        470        480
SHNLKAAAKA KLGYDPVELD PEDMCRMATE QPQTLATYSV SDAVATYYLY MKYVHPFIFA
       490        500        510        520        530        540
LCTIIPMEPD EVLRKGSGTL CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHVLDSETYV
       550        560        570        580        590        600
GGHVEALESG VFRSDIPCRF RMNPAAFDFL LQRVEKTLRH ALEEEEKVPV EQVTNFEEVC
       610        620        630        640        650        660
DEIKSKLASL KDVPSRIECP LIYHLDVGAM YPNIILTNRL QPSAMVDEAT CAACDFNKPG
       670        680        690        700        710        720
ANCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP EGPARAFHEL SREEQAKYEK
       730        740        750        760        770        780
RRLADYCRKA YKKIHITKVE ERLTTICQRE NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS
       790        800        810        820        830        840
AAVEVGDAAE VKRCKNMEVL YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA
       850        860        870        880        890        900
NIITQARELI EQIGRPLELD TDGIWCVLPN SFPENFVFKT TNVKKPKVTI SYPGAMLNIM
       910        920        930        940        950        960
VKEGFTNDQY QELAEPSSLT YVTRSENSIF FEVDGPYLAM ILPASKEEGK KLKKRYAVFN
       970        980        990       1000       1010       1020
EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE EVYGSVAKVA DYWLDVLYSK
      1030       1040       1050       1060       1070       1080
AANMPDSELF ELISENRSMS RKLEDYGEQK STSISTAKRL AEFLGDQMVK DAGLSCRYII
      1090       1100       1110       1120       1130       1140
SRKPEGSPVT ERAIPLAIFQ AEPTVRKHFL RKWLKSSSLQ DFDIRAILDW DYYIERLGSA
      1150       1160       1170       1180       1190       1200
IQKIITIPAA LQQVKNPVPR VKHPDWLHKK LLEKNDVYKQ KKISELFTLE GRRQVTMAEA
      1210       1220       1230       1240       1250       1260
SEDSPRPSAP DMEDFGLVKL PHPAAPVTVK RKRVLWESQE ESQDLTPTVP WQEILGQPPA
      1270       1280       1290       1300       1310       1320
LGTSQEEWLV WLRFHKKKWQ LQARQRLARR KRQRLESAEG VLRPGAIRDG PATGLGSFLR
      1330       1340       1350       1360       1370       1380
RTARSILDLP WQIVQISETS QAGLFRLWAL VGSDLHCIRL SIPRVFYVNQ RVAKAEEGAS
      1390       1400       1410       1420       1430       1440
YRKVNRVLPR SNMVYNLYEY SVPEDMYQEH INEINAELSA PDIEGVYETQ VPLLFRALVH
      1450       1460       1470       1480       1490       1500
LGCVCVVNKQ LVRHLSGWEA ETFALEHLEM RSLAQFSYLE PGSIRHIYLY HHAQAHKALF
      1510       1520       1530       1540       1550       1560
GIFIPSQRRA SVFVLDTVRS NQMPSLGALY SAEHGLLLEK VGPELLPPPK HTFEVRAETD
      1570       1580       1590       1600       1610       1620
LKTICRAIQR FLLAYKEERR GPTLIAVQSS WELKRLASEI PVLEEFPLVP ICVADKINYG
      1630       1640       1650       1660       1670       1680
VLDWQRHGAR RMIRHYLNLD TCLSQAFEMS RYFHIPIGNL PEDISTFGSD LFFARHLQRH
      1690       1700       1710       1720       1730       1740
NHLLWLSPTA RPDLGGKEAD DNCLVMEFDD QATVEINSSG CYSTVCVELD LQNLAVNTIL
      1750       1760       1770       1780       1790       1800
QSHHVNDMEG ADSMGISFDV IQQASLEDMI TGGQAASAPA SYDETALCSN TFRILKSMVV
      1810       1820       1830       1840       1850       1860
GWVKEITQYH NIYADNQVMH FYRWLRSPSS LLHDPALHRT LHNMMKKLFL QLIAEFKRLG
      1870       1880       1890       1900       1910       1920
SSVIYANFNR IILCTKKRRV EDAIAYVEYI TSSIHSKETF HSLTISFSRC WEFLLWMDPS
      1930       1940       1950       1960       1970       1980
NYGGIKGKVS SRIHCGLQDS QKAGGAEDEQ ENEDDEEERD GEEEEEAEES NVEDLLENNW
      1990       2000       2010       2020       2030       2040
NILQFLPQAA SCQNYFLMIV SAYIVAVYHC MKDGLRRSAP GSTPVRRRGA SQLSQEAEGA
      2050       2060       2070       2080       2090       2100
VGALPGMITF SQDYVANELT QSFFTITQKI QKKVTGSRNS TELSEMFPVL PGSHLLLNNP
      2110       2120       2130       2140       2150       2160
ALEFIKYVCK VLSLDTNITN QVNKLNRDLL RLVDVGEFSE EAQFRDPCRS YVLPEVICRS
      2170       2180       2190       2200       2210       2220
CNFCRDLDLC KDSSFSEDGA VLPQWLCSNC QAPYDSSAIE MTLVEVLQKK LMAFTLQDLV
      2230       2240       2250       2260       2270       2280
CLKCRGVKET SMPVYCSCAG DFALTIHTQV FMEQIGIFRN IAQHYGMSYL LETLEWLLQK

NPQLGH     

Encoded by POLE gene

FULL NAME: polymerase (DNA directed), epsilon


OTHER NAME(S):
DKFZp434F222
FLJ21434
POLE1


Nucleic acid sequence

        10         20         30         40         50         60
atgtctctga ggagcggcgg gcggcggcgc gcggacccag gcgcggatgg cgaggccagc
        70         80         90        100        110        120
agggatgatg gcgccacttc ctcagtttcg gcactcaagc gcctggaacg gagtcagtgg
       130        140        150        160        170        180
acggataaga tggatttgcg gtttggtttt gagcggctga aggagcctgg tgagaagaca
       190        200        210        220        230        240
ggctggctca ttaacatgca tcctaccgag attttagatg aagataagcg cttaggcagt
       250        260        270        280        290        300
gcagtggatt actactttat tcaagatgac ggaagcagat ttaaggtggc tttgccctat
       310        320        330        340        350        360
aaaccgtatt tctacattgc gaccagaaag ggttgtgagc gagaagtttc atcttttctc
       370        380        390        400        410        420
tccaagaagt ttcagggcaa aattgcaaaa gtggagactg tccccaaaga ggatctggac
       430        440        450        460        470        480
ttgccaaatc acttggtggg tttgaagcga aattacatca ggctgtcctt ccacactgtg
       490        500        510        520        530        540
gaggatcttg tcaaagtgag gaaggagatc tcccctgccg tgaagaagaa cagggagcag
       550        560        570        580        590        600
gatcacgcca gcgacgcgta cacagctctg ctttccagtg ttctgcagag gggcggtgtc
       610        620        630        640        650        660
attactgatg aagaggaaac ctctaagaag atagctgacc agttggacaa cattgtggac
       670        680        690        700        710        720
atgcgcgagt acgatgttcc ctaccacatc cgcctctcca ttgacctgaa gatccacgtg
       730        740        750        760        770        780
gctcattggt acaatgtcag ataccgagga aatgcttttc cggtagaaat cacccgccga
       790        800        810        820        830        840
gatgaccttg ttgaacgacc tgaccctgtg gttttggcat ttgacattga gacgaccaaa
       850        860        870        880        890        900
ctgcccctca agtttcctga tgctgagaca gaccagatta tgatgatttc ctacatgatc
       910        920        930        940        950        960
gatggccagg gctacctcat caccaacagg gagattgttt cagaagatat tgaagatttt
       970        980        990       1000       1010       1020
gagttcaccc ccaagccaga atatgaaggc cccttttgtg tcttcaatga acccgatgag
      1030       1040       1050       1060       1070       1080
gctcatctga tccaaaggtg gtttgaacac gtccaggaga ccaaacccac catcatggtc
      1090       1100       1110       1120       1130       1140
acctacaacg gggacttttt tgactggcca tttgtggagg cccgggcagc agtccacggt
      1150       1160       1170       1180       1190       1200
ctgagcatgc agcaggagat aggcttccag aaggacagcc agggggagta caaggcgccc
      1210       1220       1230       1240       1250       1260
cagtgcatcc acatggactg cctcaggtgg gtgaagaggg acagttacct tcctgtgggc
      1270       1280       1290       1300       1310       1320
agtcataatc tcaaggcggc cgccaaggcc aagctaggct atgatcccgt ggagctagac
      1330       1340       1350       1360       1370       1380
ccggaggaca tgtgccggat ggccacggag cagccccaga ctctggccac gtattctgtg
      1390       1400       1410       1420       1430       1440
tcagatgctg tcgccactta ctacctgtac atgaagtacg tccacccatt catctttgct
      1450       1460       1470       1480       1490       1500
ctgtgcacca ttattcccat ggagcccgac gaggtgctgc ggaagggctc tggcactctg
      1510       1520       1530       1540       1550       1560
tgtgaggcct tgctgatggt gcaggccttc cacgccaaca tcatcttccc caacaagcaa
      1570       1580       1590       1600       1610       1620
gagcaggagt tcaataagct gacggacgac ggacacgtgc tggactctga gacctacgtc
      1630       1640       1650       1660       1670       1680
gggggccacg tggaggccct cgagtctggg gttttccgca gcgatatccc ttgccggttt
      1690       1700       1710       1720       1730       1740
aggatgaatc ctgccgcctt tgacttcctg ctgcagcggg ttgagaagac cttgcgccac
      1750       1760       1770       1780       1790       1800
gcccttgagg aagaggagaa agtgcctgtg gagcaagtca ccaactttga agaggtgtgt
      1810       1820       1830       1840       1850       1860
gatgagatta agagcaagct tgcctccctg aaggacgttc ccagccgcat cgagtgtcca
      1870       1880       1890       1900       1910       1920
ctcatctacc acctggacgt gggggccatg taccccaaca tcatcctgac caaccgcctg
      1930       1940       1950       1960       1970       1980
cagccctctg ccatggtgga cgaagccacc tgtgctgcct gtgacttcaa taagcctgga
      1990       2000       2010       2020       2030       2040
gcaaactgcc agcggaagat ggcctggcag tggaggggcg agttcatgcc agccagtcgc
      2050       2060       2070       2080       2090       2100
agcgaatacc atcggatcca gcaccagctg gagtcagaga agttcccccc cttgttccca
      2110       2120       2130       2140       2150       2160
gaggggccag ctcgggcctt tcatgaactg tcccgcgagg aacaggcgaa atacgagaag
      2170       2180       2190       2200       2210       2220
agaaggctgg cggattactg ccggaaagcc tacaagaaga tccacatcac caaggtggaa
      2230       2240       2250       2260       2270       2280
gagcgtctca ccaccatctg ccagcgggaa aactccttct acgtggacac cgtgcgtgcc
      2290       2300       2310       2320       2330       2340
ttccgggaca ggcgttacga gttcaaaggg ctccacaagg tgtggaaaaa gaagctctcg
      2350       2360       2370       2380       2390       2400
gcggccgtgg aggtgggcga cgcggctgag gtgaagcgct gcaagaacat ggaggtgctg
      2410       2420       2430       2440       2450       2460
tatgactcgc tgcagctggc ccacaagtgc atcctgaact ccttctatgg ctatgtcatg
      2470       2480       2490       2500       2510       2520
cgcaaggggg ctcgctggta ctccatggag atggctggca tcgtctgctt cacaggggcc
      2530       2540       2550       2560       2570       2580
aacatcatca cccaggcacg ggagctgatc gagcagattg ggaggccctt agagctggac
      2590       2600       2610       2620       2630       2640
acagatggta tatggtgcgt cctgcccaac agcttcccag aaaattttgt cttcaagacg
      2650       2660       2670       2680       2690       2700
accaatgtga agaagcccaa agtgaccatc tcctacccag gcgccatgtt gaacatcatg
      2710       2720       2730       2740       2750       2760
gtcaaggaag gcttcaccaa tgaccagtac caggagctgg ctgagccgtc ctcactcacc
      2770       2780       2790       2800       2810       2820
tacgtcaccc gctcagagaa cagcatcttt tttgaggttg atgggcccta ccttgccatg
      2830       2840       2850       2860       2870       2880
attcttccag cctccaagga agaaggcaag aaattgaaga agaggtatgc tgtgttcaat
      2890       2900       2910       2920       2930       2940
gaagacggtt ctctggctga gctcaagggc tttgaggtca aacgccgcgg ggaactgcag
      2950       2960       2970       2980       2990       3000
ctgattaaga tcttccaatc ctcggtgttt gaggccttcc tcaagggcag cacgctggaa
      3010       3020       3030       3040       3050       3060
gaggtgtatg gctctgtagc caaggtggct gactactggc tggacgtgct gtacagcaag
      3070       3080       3090       3100       3110       3120
gcagccaaca tgcctgactc tgagctattc gagctcatct ctgagaaccg ttccatgtct
      3130       3140       3150       3160       3170       3180
cggaagctgg aagattacgg ggagcagaag tctacgtcca tcagcacagc aaagcgcctg
      3190       3200       3210       3220       3230       3240
gccgagttcc tgggagacca gatggtcaag gatgcagggc tgagttgccg ctacatcatc
      3250       3260       3270       3280       3290       3300
tcccgcaagc ccgagggctc ccctgtcacg gagagggcca tcccacttgc cattttccaa
      3310       3320       3330       3340       3350       3360
gcagagccca cggtgaggaa gcactttctc cggaaatggc tcaagagctc ttcccttcaa
      3370       3380       3390       3400       3410       3420
gactttgata ttcgagcaat tctggattgg gactactaca ttgagcggct gggaagcgcc
      3430       3440       3450       3460       3470       3480
atccagaaga tcatcaccat ccctgcggcc ctgcagcagg taaagaaccc agtgccacgt
      3490       3500       3510       3520       3530       3540
gtcaaacacc ccgactggct gcacaaaaaa ctgctggaga agaatgatgt ctacaagcag
      3550       3560       3570       3580       3590       3600
aagaagatca gtgagctctt caccctggag ggcaggagac aggtcacgat ggccgaggcc
      3610       3620       3630       3640       3650       3660
tcagaagaca gtccgaggcc aagtgctcct gacatggagg acttcggcct cgtaaagctg
      3670       3680       3690       3700       3710       3720
cctcacccag cagcccctgt cactgtgaag aggaagcgag ttctttggga gagccaggag
      3730       3740       3750       3760       3770       3780
gagtcccagg acctcacgcc gactgtgccc tggcaggaaa tcttggggca gcctcccgcc
      3790       3800       3810       3820       3830       3840
ctgggaacca gccaggagga atggcttgtc tggctccggt tccacaagaa gaagtggcag
      3850       3860       3870       3880       3890       3900
ctgcaggccc ggcagcgcct cgcccgcagg aagaggcagc gtctggagtc ggcagagggt
      3910       3920       3930       3940       3950       3960
gtgctcaggc ccggggccat ccgggatggt cctgccacgg ggctggggag cttcttgcga
      3970       3980       3990       4000       4010       4020
agaactgccc gcagcatcct ggaccttccg tggcagattg tgcagatcag cgagaccagc
      4030       4040       4050       4060       4070       4080
caggccggcc tgttcaggct gtgggcgctc gttggcagtg acttgcactg catcaggctg
      4090       4100       4110       4120       4130       4140
agcatccccc gtgtgttcta cgtgaaccag cgagtcgcta aagcggagga gggtgcttcg
      4150       4160       4170       4180       4190       4200
tatcgcaagg taaatcgggt ccttcctcgc tccaacatgg tctacaatct ctatgagtat
      4210       4220       4230       4240       4250       4260
tcagtgccag aggacatgta ccaggaacac atcaacgaga tcaacgctga gctgtcagcg
      4270       4280       4290       4300       4310       4320
ccagacatcg agggcgtata tgagactcag gttccgttac tgttccgggc cctggtgcac
      4330       4340       4350       4360       4370       4380
ctgggctgtg tgtgtgtggt caataaacag ctggtgaggc acctttcagg ctgggaagca
      4390       4400       4410       4420       4430       4440
gagacctttg ctcttgagca cctggagatg cgctctctgg cccagttcag ctacctggaa
      4450       4460       4470       4480       4490       4500
ccagggagta tccgccatat ctacctgtac caccacgcac aggcccacaa agcgctcttc
      4510       4520       4530       4540       4550       4560
gggatcttca tcccctcaca gcgcagggca tccgtctttg tgctggacac tgtgcgcagc
      4570       4580       4590       4600       4610       4620
aaccagatgc ccagccttgg cgccctgtac tcagcagagc acggcctcct cctggagaag
      4630       4640       4650       4660       4670       4680
gtgggccctg agctcctgcc accccccaaa cacaccttcg aagttcgggc agaaactgac
      4690       4700       4710       4720       4730       4740
ctgaagacca tctgcagagc catccagcga ttcctgctcg cctacaagga ggagcgccgg
      4750       4760       4770       4780       4790       4800
gggcccacac tcatcgctgt tcagtccagc tgggagctga agaggctggc cagtgaaatt
      4810       4820       4830       4840       4850       4860
cctgtcttgg aggaattccc actggtgcct atctgtgtgg ctgacaagat caactatggg
      4870       4880       4890       4900       4910       4920
gtcctggact ggcagcgcca tggagcccgg cgcatgatcc gtcactacct caacctggac
      4930       4940       4950       4960       4970       4980
acctgcctgt cgcaggcctt cgagatgagc aggtactttc acattcccat tgggaaccta
      4990       5000       5010       5020       5030       5040
ccagaggaca tctccacatt cggctccgac ctcttctttg cccgccacct ccagcgccac
      5050       5060       5070       5080       5090       5100
aaccacctgc tctggctgtc ccctacagcc cgccctgacc tgggtggaaa ggaggctgat
      5110       5120       5130       5140       5150       5160
gacaactgtc ttgtcatgga gttcgatgac caagccactg ttgagatcaa cagttcaggc
      5170       5180       5190       5200       5210       5220
tgttactcca cagtgtgtgt ggagctggac cttcagaacc tggccgtcaa caccattctc
      5230       5240       5250       5260       5270       5280
cagtctcacc atgtcaacga catggagggg gccgacagca tggggatcag cttcgacgtg
      5290       5300       5310       5320       5330       5340
atccagcagg cctccctgga ggacatgatc acgggtggtc aggctgccag tgccccggcc
      5350       5360       5370       5380       5390       5400
agctacgatg agacagccct gtgctctaac accttcagga tcctgaagag catggtcgtg
      5410       5420       5430       5440       5450       5460
ggctgggtga aggagatcac ccagtaccac aacatctatg cagacaacca ggtgatgcac
      5470       5480       5490       5500       5510       5520
ttctaccgct ggcttcggtc gccatcctct ctgcttcatg accctgccct gcaccgcaca
      5530       5540       5550       5560       5570       5580
ctccacaaca tgatgaagaa gctcttcctg cagctcatcg ctgagttcaa gcgcctgggg
      5590       5600       5610       5620       5630       5640
tcatcagtca tctacgccaa cttcaaccgc atcatcctct gtacaaagaa gcgccgtgtg
      5650       5660       5670       5680       5690       5700
gaagatgcca tcgcttacgt ggagtacatc accagcagca tccattcaaa ggagaccttc
      5710       5720       5730       5740       5750       5760
cattctctga caatttcttt ctctcgatgc tgggaatttc ttctctggat ggatccatct
      5770       5780       5790       5800       5810       5820
aactatggcg gaatcaaagg aaaagtttca tctcgtattc actgtggact gcaagactcc
      5830       5840       5850       5860       5870       5880
cagaaagcag ggggagcaga ggatgagcag gaaaatgagg acgatgagga ggaaagagat
      5890       5900       5910       5920       5930       5940
ggggaggagg aggaagaggc ggaggaatcc aacgtggagg atttactgga aaacaactgg
      5950       5960       5970       5980       5990       6000
aacattttgc agtttttgcc acaggcagcc tcctgccaga actacttcct catgattgtt
      6010       6020       6030       6040       6050       6060
tcagcgtaca tcgtggccgt gtaccactgc atgaaggacg ggctgaggcg cagtgctcca
      6070       6080       6090       6100       6110       6120
gggagcaccc ccgtgaggag gaggggggcc agccagctct cccaggaggc cgagggggcg
      6130       6140       6150       6160       6170       6180
gtcggagccc ttcccggaat gatcaccttc tctcaggatt atgtcgcaaa tgagctcact
      6190       6200       6210       6220       6230       6240
cagagcttct tcaccatcac tcagaagatt cagaagaaag tcacaggctc tcggaactcc
      6250       6260       6270       6280       6290       6300
actgagctct cagagatgtt tcctgtcctc cccggttccc acttgctgct caataaccct
      6310       6320       6330       6340       6350       6360
gccctggagt tcatcaaata cgtgtgcaag gtgctgtccc tggacaccaa catcacaaac
      6370       6380       6390       6400       6410       6420
caggtgaata agctgaaccg agacctgctt cgcctggtgg atgtcggcga gttctccgag
      6430       6440       6450       6460       6470       6480
gaggcccagt tccgagaccc ctgccgctcc tacgtgcttc ctgaggtcat ctgccgcagc
      6490       6500       6510       6520       6530       6540
tgtaacttct gccgcgacct ggacctgtgt aaagactctt ccttctcaga ggatggggcg
      6550       6560       6570       6580       6590       6600
gtcctgcctc agtggctctg ctccaactgt caggcgccct acgactcctc tgccatcgag
      6610       6620       6630       6640       6650       6660
atgacgctgg tggaagttct acagaagaag ctgatggcct tcaccctgca ggacctggtc
      6670       6680       6690       6700       6710       6720
tgcctgaagt gccgcggggt gaaggagacc agcatgcctg tgtactgcag ctgcgcggga
      6730       6740       6750       6760       6770       6780
gacttcgccc tcaccatcca cacccaggtc ttcatggaac agatcggaat attccggaac
      6790       6800       6810       6820       6830       6840
attgcccagc actacggcat gtcgtacctc ctggagaccc tggagtggct gctgcagaag
      6850       6860
aacccacagc tgggccatta g   

Last modification date: Oct. 2, 2011