Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA ligase 3


STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MPPKKRMKNG SSLKSTSKKG EKSRNIITIQ DLFSKREAQL TDTPNKLLTD HDQSASDYAY
        70         80         90        100        110        120
ALKLQQLFDS ENQATAPEKL PKDVIIPEEE YHTDTFNVVK ESNDKPKENL VTSEECKASF
       130        140        150        160        170        180
FSTDSVNKDS TIDYDALQKD PLTYVKSCRA RFVSKDTKSF SYSSLANTFS LISSTKSRIR
       190        200        210        220        230        240
IVTLLTNFLL TLLYADPDSL IATVWLCTNS IAPNFYGKNL GVGPAMYSKA LKEVCGITAS
       250        260        270        280        290        300
ALKNLWNKYG DPGDVAFEAK VSVRTLSRPE PLTIKKVYST LLKIADSNGN GAQNRKLELT
       310        320        330        340        350        360
KFLLISSNAE EVRYIGRSIM QNLRIGAVQN TMLASLSKAF FIFDNQNEIF NFNSDSLQQQ
       370        380        390        400        410        420
FRQGEEIVKQ SFFQVPDYNI LVATLLREGI ENLKDNMSIR PGIPVKPMLG SITKNLQHML
       430        440        450        460        470        480
ERLTDHNFSC EFKYDGQRAQ IHCDRLGNIK IFSRHLEEIT GRFPDVIEVA QLALKHSCDF
       490        500        510        520        530        540
IIEGELVAID KSNGQILDFQ KLSTRERKKV TVADITIDVC VFVFDIMFCD GKSCLQMPLI
       550        560        570        580        590        600
ERRRMFFEHF NLIPNRFQFV SSLETNEEQS IQEFFSLAIT NKCEGLMVKV LNGTNSKFPS
       610        620        630        640        650        660
TYEPDKRGEG WIKVKQDYDD EFESLDLVPI GAWYGNGRKA GWFSPILLAV YNPDTGAYEA
       670        680        690        700        710        720
VCKCMSGFSD QFYKELTQKY SLESGNSSLK PIYNFCETGK VTPQIYFAPQ EVWEIKGAQI
       730        740        750        760        770
TSSPAYKAAL GLIQDDRGLS IRFPRFIRVR SDKGPEDAST NSILADMYMK QLNT

Encoded by adl1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcctccca aaaagcgcat gaaaaatggc tcttctttaa aatctacgtc taaaaagggt
        70         80         90        100        110        120
gagaaaagcc gaaatattat tacaattcaa gatttgtttt caaaacgaga agcacagctt
       130        140        150        160        170        180
acagatacac caaacaaatt gctcaccgat cacgatcaaa gcgccagcga ttatgcttat
       190        200        210        220        230        240
gcattaaagc ttcaacagct ttttgattct gagaaccaag ctactgctcc ggaaaagctt
       250        260        270        280        290        300
cctaaagatg taattatacc tgaagaagag tatcatactg acacatttaa tgttgtaaaa
       310        320        330        340        350        360
gaaagcaatg ataaacctaa ggagaattta gttacaagcg aagaatgcaa agcttctttt
       370        380        390        400        410        420
ttctcaactg atagcgtgaa caaagattcc acaattgatt acgatgcttt acagaaagat
       430        440        450        460        470        480
cctttgactt acgtgaaaag ttgtcgagcc cgatttgttt caaaagatac aaaaagcttc
       490        500        510        520        530        540
agttactcat cacttgctaa caccttttcc ttaattagtt ctaccaaatc caggatacgc
       550        560        570        580        590        600
attgtcacat tattaaccaa tttccttctc acacttctgt atgcagatcc tgattcctta
       610        620        630        640        650        660
attgcaacag tttggttatg taccaattct attgccccca acttttatgg aaaaaacctt
       670        680        690        700        710        720
ggtgtcggac ctgcaatgta ctctaaagct ttgaaagaag tttgtggcat tacagcaagt
       730        740        750        760        770        780
gctttgaaaa atttatggaa caaatatggc gatccaggag atgtagcgtt cgaagctaaa
       790        800        810        820        830        840
gtgtctgtgc gcacgttaag cagaccagaa cctttgacta ttaagaaggt ttattctact
       850        860        870        880        890        900
ttactaaaga ttgctgacag taacggtaat ggtgcccaga accgtaaatt agagttaact
       910        920        930        940        950        960
aaatttttat tgataagttc taatgctgag gaggttcgat atatagggag gagtataatg
       970        980        990       1000       1010       1020
caaaatctaa gaataggggc tgttcaaaac accatgttag cttcactaag caaagctttt
      1030       1040       1050       1060       1070       1080
tttatttttg acaatcaaaa cgaaatattt aattttaatt ctgactcact tcaacaacaa
      1090       1100       1110       1120       1130       1140
tttcgtcaag gagaagagat tgttaaacaa agtttctttc aggtccctga ttataacatt
      1150       1160       1170       1180       1190       1200
ttggttgcaa cccttcttcg agaggggata gaaaacttaa aagacaatat gtctattcgc
      1210       1220       1230       1240       1250       1260
cctggaatcc cagtaaaacc tatgcttggt tctatcacaa agaatttgca gcatatgtta
      1270       1280       1290       1300       1310       1320
gaaagattga ctgatcataa cttctcttgt gagttcaagt acgatggaca aagagcacaa
      1330       1340       1350       1360       1370       1380
attcattgcg atagacttgg aaacattaag atatttagcc gccatttgga ggaaattaca
      1390       1400       1410       1420       1430       1440
ggaagatttc cggatgtcat tgaagttgct caattagcat tgaaacattc atgtgatttt
      1450       1460       1470       1480       1490       1500
attatagaag gcgaattggt ggctattgac aaaagtaatg gtcagatact ggattttcaa
      1510       1520       1530       1540       1550       1560
aaactttcaa ctagagaaag aaaaaaagtt acagtggctg atattacaat agacgtgtgt
      1570       1580       1590       1600       1610       1620
gtttttgttt ttgatattat gttttgtgat gggaaatctt gcttacaaat gcctttaatt
      1630       1640       1650       1660       1670       1680
gaaagaagaa gaatgttttt tgagcatttt aatttaattc caaatcgctt tcagttcgtg
      1690       1700       1710       1720       1730       1740
tcttctttgg aaacaaatga ggagcaatcc attcaagaat tttttagtct tgcaattact
      1750       1760       1770       1780       1790       1800
aataaatgcg aaggattaat ggtgaaggta ctgaatggaa caaactcaaa gtttccttca
      1810       1820       1830       1840       1850       1860
acgtatgaac ctgataaaag aggtgaggga tggattaaag tcaaacagga ttatgatgat
      1870       1880       1890       1900       1910       1920
gaatttgagt cattggatct tgttcccata ggcgcttggt acggtaatgg aagaaaagcc
      1930       1940       1950       1960       1970       1980
ggatggttca gtccaatttt gcttgctgtt tacaatccag acactggcgc gtatgaagca
      1990       2000       2010       2020       2030       2040
gtctgtaaat gcatgtccgg ttttagtgac caattttata aggaattaac acaaaagtat
      2050       2060       2070       2080       2090       2100
tccttagaat ctggcaatag cagtcttaaa cccatatata atttttgcga aacaggtaag
      2110       2120       2130       2140       2150       2160
gtaactccac aaatatactt tgcccctcaa gaagtttggg aaattaaggg tgctcaaata
      2170       2180       2190       2200       2210       2220
acatcctcac ctgcatacaa ggcggctttg ggattaattc aggatgatcg cggtttatca
      2230       2240       2250       2260       2270       2280
attcgattcc cacgcttcat tagagttcgg tcagacaaag gaccagagga cgcatccacg
      2290       2300       2310       2320
aattcaatat tggctgacat gtatatgaaa caacttaata cttga 

Last modification date: Oct. 2, 2011