Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA ligase 1


DESCRIPTION:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).

STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MRTVFSQIPR FKQVNQYIRM STRQSDISNF FISSASHKSE HVEVSQSSSD SKNVDGRSTS
        70         80         90        100        110        120
EKRKVESVKL VDESKHNNHD DTGTQNVERE NNIVSEAKKQ KTLGSSSSSS DAVSSNNDSG
       130        140        150        160        170        180
ASTPIPLPIK EPPLESNARN DKLKGHATFA EMVKAFTKIE NTSKRLEIID IMGTYFFGIL
       190        200        210        220        230        240
RDHPSDLLAC VYLSINKLGP DYSGLELGIG ESIIMKAIGE STGQTLQQIK LSFHKVGDLG
       250        260        270        280        290        300
LVAQTSRQNQ PTMFKPAALT IPFLFDSLKK IAQMSGNQSQ NRKIGVIKRL LSSCEGAEPK
       310        320        330        340        350        360
YLIRALEGKL RLQLAEKTIL VALANATAQY HADKNGEKLS QQDRIEGEQI LRDVYCQLPS
       370        380        390        400        410        420
YDLIVPHLIE HGLGTLRETC KLTPGIPTKP MLAKPTKQIS EVLNTFDQAA FTCEYKYDGE
       430        440        450        460        470        480
RAQVHFTEDG KFYVFSRNSE NMSVRYPDIS VSVSKWKKPD ARSFILDCEA VGWDRDENKI
       490        500        510        520        530        540
LPFQKLATRK RKDVKIGDIK VRACLFAFDI LYLNGQPLLE TPLNERRKLL YSMFQPSTGD
       550        560        570        580        590        600
FTFAKHSDQK SIESIEEFLE ESVKDSCEGL MVKMLEGPDS HYEPSKRSRH WLKVKKDYLS
       610        620        630        640        650        660
GVGDSLDLIV IGAYYGKGKR TSVYGAFLLG CYDPDTETVQ SICKLGTGFS EEHLETFYNQ
       670        680        690        700        710        720
LKDIVISKKK DFYAHSDVPA HQPDVWFEPK YLWEVLAADL SLSPVYKAAI GYVQEDKGIS
       730        740        750        760
LRFPRFIRIR EDKSWEDATT SEQVSEFYRS QVAYSQKEKE GSPAAEDY 

Encoded by cdc17 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcgaacag tattttcgca aattcctcgt tttaaacaag tcaatcagta catacggatg
        70         80         90        100        110        120
tcgacaaggc agtcagacat tagcaacttc ttcatttctt ctgcttcgca caaaagcgag
       130        140        150        160        170        180
cacgtggagg tttctcaatc gtcttctgat tccaaaaatg ttgatgggag aagcacaagc
       190        200        210        220        230        240
gaaaagagaa aggtcgaatc agtgaaatta gtcgacgagt cgaaacacaa caaccacgac
       250        260        270        280        290        300
gacactggaa ctcaaaatgt tgagcgtgaa aataatattg tgtctgaggc aaaaaagcaa
       310        320        330        340        350        360
aagactttag gttcatcctc ctcttcttca gatgccgtat ctagtaacaa cgattctggg
       370        380        390        400        410        420
gcatctactc caataccttt gccaatcaaa gaaccaccgt tagagtccaa tgctcgcaat
       430        440        450        460        470        480
gataagttaa aaggtcatgc aacatttgct gaaatggtaa aagcattcac aaaaatagag
       490        500        510        520        530        540
aatactagca aacggttgga aatcattgat ataatgggga cttacttttt tggaattctt
       550        560        570        580        590        600
cgcgaccatc ccagcgattt actggcctgt gtgtatttaa gtatcaataa gttgggccca
       610        620        630        640        650        660
gattactcgg gactagagct aggaattggc gaaagcatta taatgaaggc tattggagag
       670        680        690        700        710        720
tctacagggc aaacgcttca acagattaaa ctatcgtttc acaaagttgg tgatcttggt
       730        740        750        760        770        780
cttgtagctc aaacatcccg tcaaaatcaa cccactatgt ttaaacctgc agcgctgaca
       790        800        810        820        830        840
attccatttt tatttgactc attaaaaaaa attgctcaaa tgagcggaaa ccaatcccaa
       850        860        870        880        890        900
aatagaaaaa ttggagtgat caagcggcta ttgagttcct gtgaaggtgc agaacctaaa
       910        920        930        940        950        960
tatttgattc gagctttgga aggcaagcta cgcctccaac ttgccgaaaa aaccatttta
       970        980        990       1000       1010       1020
gtagcattag caaatgccac cgctcaatat catgctgata agaatggaga aaaactttcg
      1030       1040       1050       1060       1070       1080
caacaagaca ggattgaagg agagcagatt cttcgagatg tttactgtca actgccttca
      1090       1100       1110       1120       1130       1140
tacgacctta tcgttcctca cttgattgag catggacttg gtactttgcg tgaaacttgt
      1150       1160       1170       1180       1190       1200
aaattaacac ctggaatccc aacaaaaccc atgctggcta agccgacgaa acaaatttca
      1210       1220       1230       1240       1250       1260
gaagttttga atacgtttga tcaagccgca tttacatgtg aatacaaata cgatggcgag
      1270       1280       1290       1300       1310       1320
cgcgcccaag ttcattttac cgaagatggg aagttttatg tattttctag gaattctgaa
      1330       1340       1350       1360       1370       1380
aacatgtctg ttcgctatcc ggacatctct gtttctgtat cgaagtggaa aaaaccagat
      1390       1400       1410       1420       1430       1440
gctcgttctt ttattctcga ttgcgaagct gtcggttggg accgtgatga aaacaaaatt
      1450       1460       1470       1480       1490       1500
ttaccttttc aaaaacttgc aacaagaaag aggaaagatg tgaaaattgg ggacattaag
      1510       1520       1530       1540       1550       1560
gtccgagcat gccttttcgc ttttgacatt ttatacctaa atgggcaacc tcttttggaa
      1570       1580       1590       1600       1610       1620
accccactca acgagcgtcg aaaactactt tactcaatgt ttcaaccaag tactggagac
      1630       1640       1650       1660       1670       1680
tttacttttg ctaaacatag cgatcaaaag tctattgaat ccattgaaga attccttgaa
      1690       1700       1710       1720       1730       1740
gaatctgtca aagattcttg tgagggttta atggtcaaaa tgcttgaagg cccggattct
      1750       1760       1770       1780       1790       1800
cattatgaac cgtcaaaacg ttccaggcat tggctaaaag ttaaaaaaga ctatctttct
      1810       1820       1830       1840       1850       1860
ggtgttggag attctctgga tttgattgta attggcgcat actacggaaa gggtaaacgt
      1870       1880       1890       1900       1910       1920
acttctgttt atggtgcctt tcttttgggc tgctacgatc cagataccga aacagttcaa
      1930       1940       1950       1960       1970       1980
tcgatttgca aactcgggac tggtttttca gaggagcatt tagaaacttt ttacaatcaa
      1990       2000       2010       2020       2030       2040
cttaaagaca ttgttatatc taaaaagaaa gatttttatg ctcatagcga tgtacctgcg
      2050       2060       2070       2080       2090       2100
catcagcctg acgtctggtt tgagcctaag tacttgtggg aagtcttagc tgccgattta
      2110       2120       2130       2140       2150       2160
tctttgtctc cggtttacaa agctgcaatt ggatatgttc aagaggacaa aggaatcagt
      2170       2180       2190       2200       2210       2220
ttacgttttc caagattcat tcgtattcgg gaagacaaga gctgggagga tgctacaaca
      2230       2240       2250       2260       2270       2280
agtgaacagg tttcagaatt ctatcgttcg caggtggctt acagtcaaaa ggaaaaagaa
      2290       2300
gggtccccag ctgccgaaga ttattaa   

Last modification date: Oct. 2, 2011