Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. POL3 contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MSEKRSLPMV DVKIDDEDTP QLEKKIKRQS IDHGVGSEPV STIEIIPSDS FRKYNSQGFK
        70         80         90        100        110        120
AKDTDLMGTQ LESTFEQELS QMEHDMADQE EHDLSSFERK KLPTDFDPSL YDISFQQIDA
       130        140        150        160        170        180
EQSVLNGIKD ENTSTVVRFF GVTSEGHSVL CNVTGFKNYL YVPAPNSSDA NDQEQINKFV
       190        200        210        220        230        240
HYLNETFDHA IDSIEVVSKQ SIWGYSGDTK LPFWKIYVTY PHMVNKLRTA FERGHLSFNS
       250        260        270        280        290        300
WFSNGTTTYD NIAYTLRLMV DCGIVGMSWI TLPKGKYSMI EPNNRVSSCQ LEVSINYRNL
       310        320        330        340        350        360
IAHPAEGDWS HTAPLRIMSF DIECAGRIGV FPEPEYDPVI QIANVVSIAG AKKPFIRNVF
       370        380        390        400        410        420
TLNTCSPITG SMIFSHATEE EMLSNWRNFI IKVDPDVIIG YNTTNFDIPY LLNRAKALKV
       430        440        450        460        470        480
NDFPYFGRLK TVKQEIKESV FSSKAYGTRE TKNVNIDGRL QLDLLQFIQR EYKLRSYTLN
       490        500        510        520        530        540
AVSAHFLGEQ KEDVHYSIIS DLQNGDSETR RRLAVYCLKD AYLPLRLMEK LMALVNYTEM
       550        560        570        580        590        600
ARVTGVPFSY LLARGQQIKV VSQLFRKCLE IDTVIPNMQS QASDDQYEGA TVIEPIRGYY
       610        620        630        640        650        660
DVPIATLDFN SLYPSIMMAH NLCYTTLCNK ATVERLNLKI DEDYVITPNG DYFVTTKRRR
       670        680        690        700        710        720
GILPIILDEL ISARKRAKKD LRDEKDPFKR DVLNGRQLAL KISANSVYGF TGATVGKLPC
       730        740        750        760        770        780
LAISSSVTAY GRTMILKTKT AVQEKYCIKN GYKHDAVVVY GDTDSVMVKF GTTDLKEAMD
       790        800        810        820        830        840
LGTEAAKYVS TLFKHPINLE FEKAYFPYLL INKKRYAGLF WTNPDKFDKL DQKGLASVRR
       850        860        870        880        890        900
DSCSLVSIVM NKVLKKILIE RNVDGALAFV RETINDILHN RVDISKLIIS KTLAPNYTNP
       910        920        930        940        950        960
QPHAVLAERM KRREGVGPNV GDRVDYVIIG GNDKLYNRAE DPLFVLENNI QVDSRYYLTN
       970        980        990       1000       1010       1020
QLQNPIISIV APIIGDKQAN GMFVVKSIKI NTGSQKGGLM SFIKKVEACK SCKGPLRKGE
      1030       1040       1050       1060       1070       1080
GPLCSNCLAR SGELYIKALY DVRDLEEKYS RLWTQCQRCA GNLHSEVLCS NKNCDIFYMR
      1090
VKVKKELQEK VEQLSKW    

Encoded by POL3 gene


OTHER NAME(S):
CDC2
HPR6
TEX1


Nucleic acid sequence

        10         20         30         40         50         60
atgagtgaaa aaagatccct tcccatggtt gatgtgaaga tcgatgacga ggatactccc
        70         80         90        100        110        120
cagttggaaa agaaaatcaa acggcaatca atagatcatg gtgttggaag tgaacctgtt
       130        140        150        160        170        180
tcaacaatag agattattcc gagtgattct tttcgaaaat ataatagtca aggcttcaaa
       190        200        210        220        230        240
gcaaaggata cagatttaat gggtacgcaa ttagagtcta cttttgaaca agacgtatcg
       250        260        270        280        290        300
caaatggaac atgatatggc cgaccaagaa gagcatgacc tgtcatcatt cgagcgtaag
       310        320        330        340        350        360
aaacttccaa ccgattttga cccaagtttg tatgatattt ctttccaaca aattgatgcg
       370        380        390        400        410        420
gaacagagcg tactgaatgg tatcaaagat gaaaatacat ctaccgtggt aaggtttttt
       430        440        450        460        470        480
ggtgtcacta gtgaaggaca ctctgtactt tgtaatgtta cagggttcaa gaactatctt
       490        500        510        520        530        540
tacgtcccag cgcccaattc ttccgacgct aacgatcagg agcaaatcaa caagtttgtg
       550        560        570        580        590        600
cactatttaa acgaaacatt tgaccacgct attgattcga ttgaagttgt atctaaacag
       610        620        630        640        650        660
tctatctggg gttattccgg agataccaaa ttaccattct ggaaaatata cgtcacctat
       670        680        690        700        710        720
ccgcatatgg tcaacaaact gcgtactgcg tttgaaagag gtcatctttc attcaactcg
       730        740        750        760        770        780
tggttttcta acggcacgac tacttatgat aacattgcct acactttaag gttaatggta
       790        800        810        820        830        840
gattgtggaa ttgtcggtat gtcctggata acattaccaa aaggaaagta ttcgatgatt
       850        860        870        880        890        900
gagcctaata acagagtttc ctcttgtcag ttggaagttt caattaatta tcgtaaccta
       910        920        930        940        950        960
atagcacatc ctgctgaggg tgattggtct catacagctc cattgcgtat catgtccttt
       970        980        990       1000       1010       1020
gatatcgagt gtgctggtag gattggcgtc tttccggaac ctgaatacga tcccgtcatc
      1030       1040       1050       1060       1070       1080
caaattgcca acgttgtgag tattgctggc gctaagaaac cattcattcg taatgtgttt
      1090       1100       1110       1120       1130       1140
actctgaata catgctcacc cataacaggt tcaatgattt tttcccacgc cactgaagag
      1150       1160       1170       1180       1190       1200
gaaatgttga gcaattggcg taactttatc atcaaagttg atcctgatgt tatcattggt
      1210       1220       1230       1240       1250       1260
tataatacta caaattttga tatcccttat cttttaaacc gtgcaaaggc gctaaaggtg
      1270       1280       1290       1300       1310       1320
aatgatttcc catattttgg aaggttaaaa accgttaagc aagaaattaa agagtctgtg
      1330       1340       1350       1360       1370       1380
ttctcttcga aggcttatgg tacaagagaa accaaaaatg tcaatattga cggccgatta
      1390       1400       1410       1420       1430       1440
cagttggatc ttttgcaatt tattcagcgt gagtataaac taagatccta cacgttgaat
      1450       1460       1470       1480       1490       1500
gcagtctctg cgcacttttt aggtgaacag aaggaggatg tacattatag catcatttct
      1510       1520       1530       1540       1550       1560
gatctacaaa atggcgatag tgaaacaaga agaaggttgg ccgtttactg tttgaaagac
      1570       1580       1590       1600       1610       1620
gcctacctgc ctttaaggct tatggaaaaa ctaatggcgt tagttaacta tacagaaatg
      1630       1640       1650       1660       1670       1680
gctcgtgtta caggtgtgcc attttcatat ttactagctc gtggtcaaca aattaaagtt
      1690       1700       1710       1720       1730       1740
gtttctcaac tatttcgaaa gtgcctggag attgatactg tgatacctaa catgcaatct
      1750       1760       1770       1780       1790       1800
caggcctctg atgaccaata tgagggtgcc actgttattg agcctattcg tggttattac
      1810       1820       1830       1840       1850       1860
gatgtaccga ttgcaacttt ggatttcaat tctttatatc caagtattat gatggcgcac
      1870       1880       1890       1900       1910       1920
aacctatgtt atacaacact ttgtaacaaa gctactgtag agagattgaa tcttaaaatt
      1930       1940       1950       1960       1970       1980
gacgaagact acgtcataac acctaatgga gattattttg ttaccacaaa aagaaggcgt
      1990       2000       2010       2020       2030       2040
ggtatattac caattattct ggatgaatta ataagtgcta gaaaacgcgc taaaaaagat
      2050       2060       2070       2080       2090       2100
ctgagagatg agaaggatcc attcaaaaga gatgttttaa atggtagaca attggctttg
      2110       2120       2130       2140       2150       2160
aagatttcag ctaactctgt ctatggtttt acaggagcga cggtgggtaa attgccatgt
      2170       2180       2190       2200       2210       2220
ttagccattt cttcatctgt tactgcttat ggtcgtacca tgattttaaa aactaaaacc
      2230       2240       2250       2260       2270       2280
gcagtccaag aaaaatattg tataaagaat ggttataagc acgatgccgt tgtggtttac
      2290       2300       2310       2320       2330       2340
ggtgacactg attccgttat ggtaaagttt ggtacaacag atttaaagga agctatggat
      2350       2360       2370       2380       2390       2400
cttggtaccg aagctgccaa atatgtctcc actctattca aacatccgat taacttagaa
      2410       2420       2430       2440       2450       2460
tttgaaaaag catacttccc ttaccttttg ataaataaaa agcgttatgc aggtttattc
      2470       2480       2490       2500       2510       2520
tggactaatc ctgacaagtt tgacaagttg gaccaaaaag gccttgcttc tgtccgtcgt
      2530       2540       2550       2560       2570       2580
gattcctgtt ccttggtttc tattgttatg aataaagttt taaagaaaat tttaattgaa
      2590       2600       2610       2620       2630       2640
agaaatgtag atggtgcttt agcttttgtc agagaaacta tcaatgatat tctgcataat
      2650       2660       2670       2680       2690       2700
agagtagata tttcaaagtt gattatatca aagacgttag ccccaaatta cacaaatcca
      2710       2720       2730       2740       2750       2760
cagccgcacg ccgttttggc tgaacgtatg aagaggagag agggcgttgg tccaaatgtt
      2770       2780       2790       2800       2810       2820
ggtgatcgtg tggactatgt cattatcggt ggtaatgata aactttacaa tagagcagaa
      2830       2840       2850       2860       2870       2880
gatccattat ttgtactaga aaacaatatt caagtggatt cgcgctatta tttaactaat
      2890       2900       2910       2920       2930       2940
caattacaaa atccaatcat tagtattgtt gcacctatta ttggcgacaa acaggcgaac
      2950       2960       2970       2980       2990       3000
ggtatgttcg ttgtgaaatc cattaaaatt aacacaggct ctcaaaaagg aggcttgatg
      3010       3020       3030       3040       3050       3060
agctttatta aaaaagttga ggcttgtaaa agttgtaaag gtccgttgag gaaaggtgaa
      3070       3080       3090       3100       3110       3120
ggccctcttt gttcaaactg tctagcaagg tctggagaat tatacataaa ggcattatac
      3130       3140       3150       3160       3170       3180
gatgtcagag atttagagga aaaatactca agattatgga cacaatgcca aaggtgcgct
      3190       3200       3210       3220       3230       3240
ggtaacttac atagtgaagt tttgtgttca aataagaact gtgacatttt ttatatgcgg
      3250       3260       3270       3280       3290
gttaaggtta aaaaagagct gcaggagaaa gtagaacaat taagcaaatg gtaa

Last modification date: Oct. 2, 2011