Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Ribonuclease H2 subunit A


DESCRIPTION:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication.

STRUCTURE SIMILARITY:
Belongs to the RNase HII family. Eukaryotic subfamily.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MKDDHDAWEP EELVSDNNSS ENELQEDQNS SITFLPPSVN KSNPAKSNYY HSTVTDDISK
        70         80         90        100        110        120
SQPYRLGVDE AGRGPVLGPM VYAVAYCPVD FDLTNYGFAD SKTLASLKRE ELLKLICNKS
       130        140        150        160        170        180
NELGKNVGWS TMSISARELA AGMLRYRNKY NLNLQAHDTT IDLIKKVYES GINVTEIYVD
       190        200        210        220        230        240
TVGPPISYQE KLQAHFPQAK VTVTKKADSL FPIVSLASIC AKVTRDIQLE CARESIRTEN
       250        260        270        280        290        300
WGSGYSSDAR TTEWLKVNVD KIFGWKGDIV RYSWKTAKDL LELPSKSQSS IEIDWHEDDD
       310        320
TPTLNFTQKK KPNPASRSWF GSEFYF   

Encoded by rnh201 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgaaagatg atcacgatgc atgggaacca gaagaactag tcagtgacaa taactcttca
        70         80         90        100        110        120
gaaaatgagc tacaagaaga ccaaaattct tcaataactt ttttaccacc ttcagttaat
       130        140        150        160        170        180
aaatcgaatc ccgcaaaatc gaattactat cattcaacag tcactgatga tatttccaag
       190        200        210        220        230        240
agtcagccat atcgattagg agtagatgaa gctggtagag gccctgtctt aggacctatg
       250        260        270        280        290        300
gtatatgctg tcgcttactg tccagtcgat ttcgatttga ccaactatgg gtttgctgac
       310        320        330        340        350        360
agtaaaactt tggcctcctt aaagcgagag gaacttctga aattaatttg caacaaatct
       370        380        390        400        410        420
aacgagctag gaaaaaacgt tggatggtct actatgtcta tttccgcaag agaattagct
       430        440        450        460        470        480
gcaggaatgc tgaggtaccg gaacaagtat aatttaaatc ttcaagcaca tgatacgaca
       490        500        510        520        530        540
attgacttaa taaaaaaagt ttatgaatca ggaataaatg ttacagagat ttacgtggat
       550        560        570        580        590        600
acagtaggac ctccaatatc ataccaggaa aaattacaag ctcattttcc tcaagcgaaa
       610        620        630        640        650        660
gtcactgtca ctaaaaaagc agattccctt tttcccatcg tgagtttagc ttctatctgt
       670        680        690        700        710        720
gctaaagtta ctagagatat tcaactggaa tgcgctcgtg aaagtattcg aactgagaac
       730        740        750        760        770        780
tggggttctg gatattcttc tgacgctcga actaccgagt ggttaaaagt aaatgtcgat
       790        800        810        820        830        840
aaaattttcg gatggaaggg agacatagtt agatattcat ggaaaaccgc taaggattta
       850        860        870        880        890        900
ctagaattac cttccaaatc acagtcttcg attgaaatag attggcacga agatgacgat
       910        920        930        940        950        960
actcctactt tgaactttac acagaaaaag aaaccgaatc cggcttctcg ttcgtggttt
       970        980
ggatcagagt tttattttta g   

Last modification date: Oct. 2, 2011