Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication ATP-dependent helicase dna2


DESCRIPTION:
Required for DNA replication; has 3' to 5' ATP-dependent DNA helicase activity specific for forked substrates. Has a direct role coordinating the multienzyme process of Okazaki fragment elongation and maturation.

STRUCTURE SIMILARITY:
Belongs to the DNA2/NAM7 helicase family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MFNDQSKTTS SVKGICATTD NNHGNLKKTN STPFRKNYLL NGRTKLKLEN FAYNASTEIS
        70         80         90        100        110        120
SPKISEKKHS SLPIKRKNTF NESSTSFSPF TKAHKEITDD LKPDKSFTRK SDLNSQDMPE
       130        140        150        160        170        180
VCFQETSKDL CRSSSTQHLL DHQTTDSTII DMKPVSTNSK SDVFTLYTDE TVLLRRCASD
       190        200        210        220        230        240
NKPLINNNLS SSNVSENQSR SFGSYDEVKN QGNNLHKVPS LVSIIRNARS SEQSRIAANS
       250        260        270        280        290        300
SCLLKGSDTE IDEDDFALEA EDLAALDSLE RQYSQLPNST VTASAKDIEK TAKVNHVGGD
       310        320        330        340        350        360
LQSYCSATKA SDATINEEPV NLALDKACNS LPDINSDFID DWDDSCDGCT PGELCEFSSE
       370        380        390        400        410        420
YTVLEVHEDF IFHEGNHFRQ LKLILEANDI LHQLFLRGDW TETSIFVGDS IRVEATFDKD
       430        440        450        460        470        480
NTAIVDNDKG LIIIHPKILM SATAVASSFP CLRKAVISDR VGIYGPPTKA MVTGNILHDF
       490        500        510        520        530        540
FQHALYRGID ALENVDINLE TSIKTYISDI YFADLSLDEI REELDARLPL LKSIVERYLI
       550        560        570        580        590        600
SKKNDNNNES IHISRLLDIE ESIWSPRFGL KGNIDATVEV VLTEKPESSS TLTLPLELKT
       610        620        630        640        650        660
GRYVDNISHF AQSLLYTLLI SDRYGINTNQ ALLCYLENST IKNLVASNSQ LRGLIMTRNS
       670        680        690        700        710        720
LAQHNFRRSL PEMISNRKIC DHCSLVSECL FFQKMSDKGV ANSNGLTESW NEWMREVKDE
       730        740        750        760        770        780
DLEFYKKWEK LLNQEERLLL LKRGDVLTFD TEELEAYGKT LYPLYITKED IVCLEIDDRV
       790        800        810        820        830        840
FHYKFAFLND NGYPRNFLHS GFSVGERVFI SDEHGHWSLA KGHIVHIQDS CIEVRTRHRL
       850        860        870        880        890        900
HIPWLKMPNF DFKKNQVFFG NYEDSKLSFI GSNHTRYRID KDEFSSGIAS IRGTLMSSVL
       910        920        930        940        950        960
PDAPLIIRDM IIRLKPPKFC NSALIDPEFL KCLNEDQITA LKKCHAAEHY SLILGMPGTG
       970        980        990       1000       1010       1020
KTTTISSLIR SLLAKKKKIL LTSFTHLAVD NILIKLKGCD STIVRLGSPH KIHPLVKEFC
      1030       1040       1050       1060       1070       1080
LTEGTTFDDL ASLKHFYEDP QIVACSSLGV YHSIFNKRKF DYCIIDEASQ IPLPICLGPL
      1090       1100       1110       1120       1130       1140
QLAEKFVLVG DHYQLPPLVK NSRTSKDGLS LSLFKLLSEK HPEAVTTLRL QYRMNEDINS
      1150       1160       1170       1180       1190       1200
LSSELIYGGN LVCGSKTISQ KKLILPKAHL SDGLPDSSSS LHWVNKLINP SHSVIFFNTD
      1210       1220       1230       1240       1250       1260
DILGVESKTN NILENHTEAF LIEQAVSSFL ERGVKQSSIG IISIYKSQVE LLSKNLKSFT
      1270       1280       1290       1300       1310       1320
EIEINTVDRY QGRDKDIILI SFVRSNSKNL VGELLRDWHR LNVALSRAKV KCIMFGSLST
      1330       1340       1350       1360       1370       1380
LSSSNIVSHL LKLLEKNKWI FTLNENDIAT KFDENSSPIK DCSQVATTNN AKVIIRKNQR
      1390
FFNSDNLCEK AILPQLEF    

Encoded by dna2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgttcaacg accagtcgaa aacaacttca tctgtgaaag gtatatgtgc cactactgac
        70         80         90        100        110        120
aacaatcatg gtaatttaaa aaaaactaat tcaactcctt tcaggaaaaa ctatttgcta
       130        140        150        160        170        180
aatgggagaa ctaaattgaa gctggaaaat tttgcgtaca atgcatctac agaaattagt
       190        200        210        220        230        240
tcacctaaaa tctctgaaaa aaagcattct tcattaccaa ttaaacgaaa gaatactttt
       250        260        270        280        290        300
aatgaatcct caacatcttt ttccccattt actaaagctc ataaagaaat tactgacgat
       310        320        330        340        350        360
ttaaagcctg acaaatcttt cacgcggaaa tctgacttga atagccaaga catgccagaa
       370        380        390        400        410        420
gtatgttttc aagaaacttc gaaggatttg tgtcgtagct cttctactca acatttgctg
       430        440        450        460        470        480
gatcatcaaa cgacggactc aacgattata gatatgaaac cagtgtcaac gaactcaaaa
       490        500        510        520        530        540
tctgatgtgt ttacattata tacggatgaa actgtcctat tacgacgatg tgcttcagat
       550        560        570        580        590        600
aataagccac tgataaacaa taatttgtcg agttcaaatg tttcggaaaa ccagagtaga
       610        620        630        640        650        660
agcttcggat cgtatgatga agtaaaaaac caaggaaata acctgcataa agtccctagc
       670        680        690        700        710        720
ttggtgtcta taattcgtaa tgcaagatca tctgagcaat caagaattgc tgcaaattcc
       730        740        750        760        770        780
agttgtcttc tcaaaggatc agataccgaa attgacgagg atgattttgc cttagaagct
       790        800        810        820        830        840
gaagatctgg cagcattaga ttcccttgaa cgccaatact cacaattacc taattctaca
       850        860        870        880        890        900
gtaactgctt ctgcaaagga catagaaaag acagctaagg tcaaccatgt gggaggtgat
       910        920        930        940        950        960
ttgcaatctt attgttcagc aacaaaagca tctgatgcta caataaatga agaacctgtg
       970        980        990       1000       1010       1020
aaccttgctc ttgataaagc ttgtaattca ttgccggata tcaatagcga ctttatcgat
      1030       1040       1050       1060       1070       1080
gattgggatg attcgtgtga tggatgcact cctggtgaat tgtgcgagtt ttcctccgaa
      1090       1100       1110       1120       1130       1140
tacacagtat tagaagttca cgaagacttc atttttcatg aagggaatca ctttcgacaa
      1150       1160       1170       1180       1190       1200
ttaaagttga ttttggaagc aaatgatata ctgcatcagt tatttttacg cggtgattgg
      1210       1220       1230       1240       1250       1260
actgagacta gtatttttgt aggggattct atccgtgttg aagctacatt tgacaaagat
      1270       1280       1290       1300       1310       1320
aataccgcta tcgttgacaa cgataaagga cttattatca tacatccgaa aattttaatg
      1330       1340       1350       1360       1370       1380
tctgctacgg cagtggccag ctcttttcct tgtttgagga aagccgtaat atctgacagg
      1390       1400       1410       1420       1430       1440
gttggcattt atggacctcc tacaaaagct atggtaactg gaaacatttt acatgatttt
      1450       1460       1470       1480       1490       1500
tttcaacacg cattatacag aggtattgat gcccttgaaa atgttgatat caaccttgaa
      1510       1520       1530       1540       1550       1560
acatcaataa aaacatacat ctctgatatc tattttgctg atttgtcgct cgatgaaatt
      1570       1580       1590       1600       1610       1620
cgagaggaac ttgatgcgag gcttcccctt cttaaatcta ttgttgaaag atatttaata
      1630       1640       1650       1660       1670       1680
agtaaaaaaa atgacaacaa caatgaaagt attcacattt caaggcttct cgatattgag
      1690       1700       1710       1720       1730       1740
gaatccatat ggtcacccag atttggatta aaaggtaata tcgatgctac agttgaggtg
      1750       1760       1770       1780       1790       1800
gttttaactg aaaaacctga gtcttcgtca accctcacac ttccgttaga gcttaaaact
      1810       1820       1830       1840       1850       1860
ggccgatatg tcgacaatat tagccatttt gctcaaagtt tgctttatac attactcatt
      1870       1880       1890       1900       1910       1920
tcagatcgtt atggtatcaa tactaatcag gcattattat gctatttgga aaatagtact
      1930       1940       1950       1960       1970       1980
atcaagaatt tggttgcaag taactcccaa cttcgagggt tgatcatgac aagaaattct
      1990       2000       2010       2020       2030       2040
cttgcacagc ataactttag gcgcagcctt cctgaaatga tttcgaaccg aaaaatttgc
      2050       2060       2070       2080       2090       2100
gatcactgca gtttagtttc tgaatgtttg ttctttcaaa agatgagtga taaaggagta
      2110       2120       2130       2140       2150       2160
gctaatagta acggcttgac tgagtcatgg aatgaatgga tgcgcgaagt aaaagatgag
      2170       2180       2190       2200       2210       2220
gatcttgaat tttataagaa gtgggagaag ttattaaatc aagaggaacg actcttacta
      2230       2240       2250       2260       2270       2280
ctaaaaagag gcgatgtgtt gacttttgat acagaagagc tagaagctta tggaaaaact
      2290       2300       2310       2320       2330       2340
ctgtatcctt tatacattac taaagaggat atcgtttgtt tagaaattga tgacagggtt
      2350       2360       2370       2380       2390       2400
tttcattaca aattcgcttt tttaaatgac aatggttatc ctcgaaattt cttgcactca
      2410       2420       2430       2440       2450       2460
ggcttcagcg ttggtgaacg agtatttatt tctgatgaac atggacactg gtcactagct
      2470       2480       2490       2500       2510       2520
aaaggacaca tagtccatat tcaagattca tgtattgaag tacgaactcg tcatcgactt
      2530       2540       2550       2560       2570       2580
catattccat ggctaaagat gcctaacttt gatttcaaaa aaaaccaggt attttttggt
      2590       2600       2610       2620       2630       2640
aactatgaag attccaaatt gtcatttatc ggaagtaacc atacgaggta cagaattgat
      2650       2660       2670       2680       2690       2700
aaggacgaat tttcgagcgg aattgcatca ataagaggta ccttgatgtc ttctgtatta
      2710       2720       2730       2740       2750       2760
ccagatgctc ccttaattat aagggacatg attatccgtt tgaagcctcc aaaattttgt
      2770       2780       2790       2800       2810       2820
aatagtgcat taatcgatcc tgaatttttg aaatgtttaa acgaagatca aattacagct
      2830       2840       2850       2860       2870       2880
ttaaagaaat gccacgctgc agaacattat agtttgatac tcggaatgcc tggaacgggg
      2890       2900       2910       2920       2930       2940
aaaaccacta caatttctag cttaatcaga tcattgcttg ccaaaaagaa gaaaatactt
      2950       2960       2970       2980       2990       3000
cttacttctt ttacgcattt agcagttgat aacattttaa ttaaactgaa gggttgtgat
      3010       3020       3030       3040       3050       3060
agcacaatcg tccgcttagg atctcctcat aaaatccatc ccctagtaaa agaattttgt
      3070       3080       3090       3100       3110       3120
ttgactgaag gaacgacgtt tgacgactta gcgtcattaa aacattttta cgaagacccc
      3130       3140       3150       3160       3170       3180
caaatagttg catgctcttc tctaggggta tatcattcca ttttcaataa aagaaaattc
      3190       3200       3210       3220       3230       3240
gattattgta taattgatga ggcatcccaa atacctctac caatttgctt aggccctttg
      3250       3260       3270       3280       3290       3300
cagcttgctg aaaaatttgt tttagttggt gatcattatc aacttcctcc tttagtaaaa
      3310       3320       3330       3340       3350       3360
aattcaagaa catctaagga tggtttgtcg ctcagtctat ttaaattact atcagaaaag
      3370       3380       3390       3400       3410       3420
catcctgaag ccgttaccac tttaagacta caatatcgta tgaatgaaga cattaattca
      3430       3440       3450       3460       3470       3480
ttatctagtg aacttattta tggcggcaat ttggtgtgtg ggtccaagac gatatcccaa
      3490       3500       3510       3520       3530       3540
aaaaaattaa ttttgccaaa agctcatcta agtgatggtt tacccgattc gtcgtctagc
      3550       3560       3570       3580       3590       3600
ctacattggg tcaacaagtt aatcaatcct agtcattcag tcatattttt taataccgat
      3610       3620       3630       3640       3650       3660
gatattctgg gagttgaatc aaaaactaat aatattctag aaaatcatac tgaagctttt
      3670       3680       3690       3700       3710       3720
ttgatagaac aagcagtttc ctccttcttg gaacgaggcg ttaagcaaag ttctatcggg
      3730       3740       3750       3760       3770       3780
ataatttcaa tttacaaaag tcaggtggag ttgctttcta agaatcttaa atcattcact
      3790       3800       3810       3820       3830       3840
gaaatagaaa ttaacactgt cgatcgttat caaggaagag acaaggacat cattttaata
      3850       3860       3870       3880       3890       3900
tcttttgtga gatccaacag taaaaactta gttggagaat tgctacgcga ttggcatcgt
      3910       3920       3930       3940       3950       3960
ttgaacgttg ctttaagcag ggcgaaagtg aaatgtatta tgtttggctc gttatctact
      3970       3980       3990       4000       4010       4020
ctttcgtctt caaatatagt ttctcattta ttgaaattat tagaaaaaaa caaatggatt
      4030       4040       4050       4060       4070       4080
ttcacgttaa atgagaatga tatagcaacg aaatttgacg agaatagctc tccaattaag
      4090       4100       4110       4120       4130       4140
gattgttctc aggttgcaac gacaaataat gctaaagtta ttattagaaa gaaccaaagg
      4150       4160       4170       4180       4190
ttttttaata gtgacaattt atgtgaaaaa gctattttac ctcaactgga attttga

Last modification date: Oct. 2, 2011