Homo sapiens L. (human) [HSA]

FULL NAME: 2-5A-dependent ribonuclease


DESCRIPTION:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA. turnover.

STRUCTURE SIMILARITY:
Contains 1 KEN domain.
Belongs to the protein kinase superfamily.
Contains 1 protein kinase domain.
Contains 9 ANK repeats.


CATALYTIC ACTIVITY:
Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.


ENZYME REGULATION:
After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family.


RELATED DISEASE(S):
prostate cancer


Amino acids sequence

        10         20         30         40         50         60
MESRDHNNPQ EGPTSSSGRR AAVEDNHLLI KAVQNEDVDL VQQLLEGGAN VNFQEEEGGW
        70         80         90        100        110        120
TPLHNAVQMS REDIVELLLR HGADPVLRKK NGATPFILAA IAGSVKLLKL FLSKGADVNE
       130        140        150        160        170        180
CDFYGFTAFM EAAVYGKVKA LKFLYKRGAN VNLRRKTKED QERLRKGGAT ALMDAAEKGH
       190        200        210        220        230        240
VEVLKILLDE MGADVNACDN MGRNALIHAL LSSDDSDVEA ITHLLLDHGA DVNVRGERGK
       250        260        270        280        290        300
TPLILAVEKK HLGLVQRLLE QEHIEINDTD SDGKTALLLA VELKLKKIAE LLCKRGASTD
       310        320        330        340        350        360
CGDLVMTARR NYDHSLVKVL LSHGAKEDFH PPAEDWKPQS SHWGAALKDL HRIYRPMIGK
       370        380        390        400        410        420
LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR AQREVSCLQS SRENSHLVTF
       430        440        450        460        470        480
YGSESHRGHL FVCVTLCEQT LEACLDVHRG EDVENEEDEF ARNVLSSIFK AVQELHLSCG
       490        500        510        520        530        540
YTHQDLQPQN ILIDSKKAAH LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE
       550        560        570        580        590        600
DLKAQSNEEV VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG
       610        620        630        640        650        660
NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK RGNFYQNTVG
       670        680        690        700        710        720
DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH
       730        740
SPNKPQCDGA GGASGLASPG C   

Encoded by RNASEL gene

FULL NAME: ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)


OTHER NAME(S):
DKFZp781D08126
MGC104972
MGC133329
PRCA1
RNS4


DESCRIPTION:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggagagca gggatcataa caacccccag gagggaccca cgtcctccag cggtagaagg
        70         80         90        100        110        120
gctgcagtgg aagacaatca cttgctgatt aaagctgttc aaaacgaaga tgttgacctg
       130        140        150        160        170        180
gtccagcaat tgctggaagg tggagccaat gttaatttcc aggaagagga agggggctgg
       190        200        210        220        230        240
acacctctgc ataacgcagt acaaatgagc agggaggaca ttgtggaact tctgcttcgt
       250        260        270        280        290        300
catggtgctg accctgttct gaggaagaag aatggggcca cgccttttat cctcgcagcg
       310        320        330        340        350        360
attgcgggga gcgtgaagct gctgaaactt ttcctttcta aaggagcaga tgtcaatgag
       370        380        390        400        410        420
tgtgattttt atggcttcac agccttcatg gaagccgctg tgtatggtaa ggtcaaagcc
       430        440        450        460        470        480
ctaaaattcc tttataagag aggagcaaat gtgaatttga ggcgaaagac aaaggaggat
       490        500        510        520        530        540
caagagcggc tgaggaaagg aggggccaca gctctcatgg acgctgctga aaaaggacac
       550        560        570        580        590        600
gtagaggtct tgaagattct ccttgatgag atgggggcag atgtaaacgc ctgtgacaat
       610        620        630        640        650        660
atgggcagaa atgccttgat ccatgctctc ctgagctctg acgatagtga tgtggaggct
       670        680        690        700        710        720
attacgcatc tgctgctgga ccatggggct gatgtcaatg tgaggggaga aagagggaag
       730        740        750        760        770        780
actcccctga tcctggcagt ggagaagaag cacttgggtt tggtgcagag gcttctggag
       790        800        810        820        830        840
caagagcaca tagagattaa tgacacagac agtgatggca aaacagcact gctgcttgct
       850        860        870        880        890        900
gttgaactca aactgaagaa aatcgccgag ttgctgtgca aacgtggagc cagtacagat
       910        920        930        940        950        960
tgtggggatc ttgttatgac agcgaggcgg aattatgacc attcccttgt gaaggttctt
       970        980        990       1000       1010       1020
ctctctcatg gagccaaaga agattttcac cctcctgctg aagactggaa gcctcagagc
      1030       1040       1050       1060       1070       1080
tcacactggg gggcagccct gaaggatctc cacagaatat accgccctat gattggcaaa
      1090       1100       1110       1120       1130       1140
ctcaagttct ttattgatga aaaatacaaa attgctgata cttcagaagg aggcatctac
      1150       1160       1170       1180       1190       1200
ctggggttct atgagaagca agaagtagct gtgaagacgt tctgtgaggg cagcccacgt
      1210       1220       1230       1240       1250       1260
gcacagcggg aagtctcttg tctgcaaagc agccgagaga acagtcactt ggtgacattc
      1270       1280       1290       1300       1310       1320
tatgggagtg agagccacag gggccacttg tttgtgtgtg tcaccctctg tgagcagact
      1330       1340       1350       1360       1370       1380
ctggaagcgt gtttggatgt gcacagaggg gaagatgtgg aaaatgagga agatgaattt
      1390       1400       1410       1420       1430       1440
gcccgaaatg tcctgtcatc tatatttaag gctgttcaag aactacactt gtcctgtgga
      1450       1460       1470       1480       1490       1500
tacacccacc aggatctgca accacaaaac atcttaatag attctaagaa agctgctcac
      1510       1520       1530       1540       1550       1560
ctggcagatt ttgataagag catcaagtgg gctggagatc cacaggaagt caagagagat
      1570       1580       1590       1600       1610       1620
ctagaggacc ttggacggct ggtcctctat gtggtaaaga agggaagcat ctcatttgag
      1630       1640       1650       1660       1670       1680
gatctgaaag ctcaaagtaa tgaagaggtg gttcaacttt ctccagatga ggaaactaag
      1690       1700       1710       1720       1730       1740
gacctcattc atcgtctctt ccatcctggg gaacatgtga gggactgtct gagtgacctg
      1750       1760       1770       1780       1790       1800
ctgggtcatc ccttcttttg gacttgggag agccgctata ggacgcttcg gaatgtggga
      1810       1820       1830       1840       1850       1860
aatgaatccg acatcaaaac acgaaaatct gaaagtgaga tcctcagact actgcaacct
      1870       1880       1890       1900       1910       1920
gggccttctg aacattccaa aagttttgac aagtggacga ctaagattaa tgaatgtgtt
      1930       1940       1950       1960       1970       1980
atgaaaaaaa tgaataagtt ttatgaaaaa agaggcaatt tctaccagaa cactgtgggt
      1990       2000       2010       2020       2030       2040
gatctgctaa agttcatccg gaatttggga gaacacattg atgaagaaaa gcataaaaag
      2050       2060       2070       2080       2090       2100
atgaaattaa aaattggaga cccttccctg tattttcaga agacatttcc agatctggtg
      2110       2120       2130       2140       2150       2160
atctatgtct acacaaaact acagaacaca gaatatagaa agcatttccc ccaaacccac
      2170       2180       2190       2200       2210       2220
agtccaaaca agcctcagtg tgatggagct ggtggggcca gtgggttggc cagccctggg

tgctga     

Last modification date: Oct. 2, 2011