Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Replication factor C subunit 3


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 3 binds ATP. Also involved in replication and DNA damage checkpoint controls, probably functioning as a checkpoint sensor.

STRUCTURE SIMILARITY:
Belongs to the activator 1 small subunits family.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSIEKGKGRA MDIDLPLGSE STLPWVEKYR PANLEDVVSH KDIISTLEKF ISSNRVPHML
        70         80         90        100        110        120
FYGPPGTGKT STILACARKI YGPNYRNQLM ELNASDDRGI DAVREQIKNF ASTRQIFAST
       130        140        150        160        170        180
FKMIILDEAD AMTLAAQNAL RRVIEKYTKN VRFCIICNYI NKISPAIQSR CTRFRFQPLP
       190        200        210        220        230        240
PKEIEKTVDH VIQSEHCNID PDAKMAVLRL SKGDMRKALN ILQACHAAYD HIDVSAIYNC
       250        260        270        280        290        300
VGHPHPSDID YFLKSIMNDE FVIAFNTISS IKQQKGLALQ DILTCIFEAL DELEIKPNAK
       310        320        330        340
IFILDQLATI EHRMSFGCSE KIQLSAMIAS IKTGVDLAAK VN 

Encoded by rfc3 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtctatcg aaaaaggtaa agggcgtgca atggacattg accttccttt gggaagtgag
        70         80         90        100        110        120
agtacgctcc catgggtgga aaagtaccga ccagctaatt tagaggatgt ggtttctcac
       130        140        150        160        170        180
aaagatatca tatctacgct tgaaaaattc attagttcaa atagagtccc tcatatgctg
       190        200        210        220        230        240
ttttatgggc cacctggcac aggcaaaacc tctacaattc ttgcgtgtgc tcgaaaaatt
       250        260        270        280        290        300
tatggaccaa attacagaaa tcagttgatg gagttaaatg caagcgatga tcgtggtatc
       310        320        330        340        350        360
gatgccgtga gggaacaaat caaaaatttt gccagcaccc ggcaaatctt tgcatctact
       370        380        390        400        410        420
ttcaaaatga ttatattaga tgaagccgat gccatgactt tggcggctca aaatgcttta
       430        440        450        460        470        480
cgaagagtaa ttgaaaaata tactaagaac gttcgttttt gcattatctg taactatatc
       490        500        510        520        530        540
aacaaaatat ctcctgctat tcaatctaga tgtaccaggt ttcgcttcca gcctttaccg
       550        560        570        580        590        600
cccaaagaga tagaaaaaac ggttgatcat gttattcaaa gcgaacattg taatattgac
       610        620        630        640        650        660
cctgatgcaa agatggccgt attaaggctt tccaaaggag atatgaggaa agcactgaat
       670        680        690        700        710        720
atactccagg cgtgccatgc tgcctacgat catattgatg tatctgctat ctataattgt
       730        740        750        760        770        780
gtaggccatc ctcacccttc cgatattgat tattttttga aatctatcat gaatgatgaa
       790        800        810        820        830        840
ttcgtaatcg ctttcaatac cattagctca atcaaacagc aaaagggttt ggccttgcaa
       850        860        870        880        890        900
gacattttga catgtatctt tgaagcacta gacgagcttg aaataaaacc aaatgctaaa
       910        920        930        940        950        960
atttttattc tggatcagct tgcaacgatt gaacatcgaa tgtcttttgg atgttctgaa
       970        980        990       1000       1010       1020
aaaatacagc tttcagcaat gatagcgagc attaaaactg gtgttgattt agcagcaaag

gtaaattga     

Last modification date: Oct. 2, 2011