Homo sapiens L. (human) [HSA]

FULL NAME: Protein phosphatase 1D


DESCRIPTION:
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.

STRUCTURE SIMILARITY:
Belongs to the PP2C family.
Contains 1 PP2C-like domain.


CATALYTIC ACTIVITY:
A phosphoprotein + H(2)O = a protein + phosphate.


RELATED DISEASE(S):
breast cancer (BC)


Amino acids sequence

        10         20         30         40         50         60
MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG
        70         80         90        100        110        120
GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL
       130        140        150        160        170        180
WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII
       190        200        210        220        230        240
RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG
       250        260        270        280        290        300
VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT
       310        320        330        340        350        360
LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ
       370        380        390        400        410        420
RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK
       430        440        450        460        470        480
SLEEDPWPRV NSKDHIPALV RSNAFSENFL EVSAEIAREN VQGVVIPSKD PEPLEENCAK
       490        500        510        520        530        540
ALTLRIHDSL NNSLPIGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE
       550        560        570        580        590        600
SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK

TVCVC     

Encoded by PPM1D gene

FULL NAME: protein phosphatase, Mg2+/Mn2+ dependent, 1D


OTHER NAME(S):
PP2C-DELTA
WIP1


DESCRIPTION:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggggc tgtactcgct gggagtgagc gtcttctccg accagggcgg gaggaagtac
        70         80         90        100        110        120
atggaggacg ttactcaaat cgttgtggag cccgaaccga cggctgaaga aaagccctcg
       130        140        150        160        170        180
ccgcggcggt cgctgtctca gccgttgcct ccgcggccgt cgccggccgc ccttcccggc
       190        200        210        220        230        240
ggcgaagtct cggggaaagg cccagcggtg gcagcccgag aggctcgcga ccctctcccg
       250        260        270        280        290        300
gacgccgggg cctcgccggc acctagccgc tgctgccgcc gccgttcctc cgtggccttt
       310        320        330        340        350        360
ttcgccgtgt gcgacgggca cggcgggcgg gaggcggcac agtttgcccg ggagcacttg
       370        380        390        400        410        420
tggggtttca tcaagaagca gaagggtttc acctcgtccg agccggctaa ggtttgcgct
       430        440        450        460        470        480
gccatccgca aaggctttct cgcttgtcac cttgccatgt ggaagaaact ggcggaatgg
       490        500        510        520        530        540
ccaaagacta tgacgggtct tcctagcaca tcagggacaa ctgccagtgt ggtcatcatt
       550        560        570        580        590        600
cggggcatga agatgtatgt agctcacgta ggtgactcag gggtggttct tggaattcag
       610        620        630        640        650        660
gatgacccga aggatgactt tgtcagagct gtggaggtga cacaggacca taagccagaa
       670        680        690        700        710        720
cttcccaagg aaagagaacg aatcgaagga cttggtggga gtgtaatgaa caagtctggg
       730        740        750        760        770        780
gtgaatcgtg tagtttggaa acgacctcga ctcactcaca atggacctgt tagaaggagc
       790        800        810        820        830        840
acagttattg accagattcc ttttctggca gtagcaagag cacttggtga tttgtggagc
       850        860        870        880        890        900
tatgatttct tcagtggtga atttgtggtg tcacctgaac cagacacaag tgtccacact
       910        920        930        940        950        960
cttgaccctc agaagcacaa gtatattata ttggggagtg atggactttg gaatatgatt
       970        980        990       1000       1010       1020
ccaccacaag atgccatctc aatgtgccag gaccaagagg agaaaaaata cctgatgggt
      1030       1040       1050       1060       1070       1080
gagcatggac aatcttgtgc caaaatgctt gtgaatcgag cattgggccg ctggaggcag
      1090       1100       1110       1120       1130       1140
cgtatgctcc gagcagataa cactagtgcc atagtaatct gcatctctcc agaagtggac
      1150       1160       1170       1180       1190       1200
aatcagggaa actttaccaa tgaagatgag ttatacctga acctgactga cagcccttcc
      1210       1220       1230       1240       1250       1260
tataatagtc aagaaacctg tgtgatgact ccttccccat gttctacacc accagtcaag
      1270       1280       1290       1300       1310       1320
tcactggagg aggatccatg gccaagggtg aattctaagg accatatacc tgccctggtt
      1330       1340       1350       1360       1370       1380
cgtagcaatg ccttctcaga gaatttttta gaggtttcag ctgagatagc tcgagagaat
      1390       1400       1410       1420       1430       1440
gtccaaggtg tagtcatacc ctcaaaagat ccagaaccac ttgaagaaaa ttgcgctaaa
      1450       1460       1470       1480       1490       1500
gccctgactt taaggataca tgattctttg aataatagcc ttccaattgg ccttgtgcct
      1510       1520       1530       1540       1550       1560
actaattcaa caaacactgt catggaccaa aaaaatttga agatgtcaac tcctggccaa
      1570       1580       1590       1600       1610       1620
atgaaagccc aagaaattga aagaacccct ccaacaaact ttaaaaggac attagaagag
      1630       1640       1650       1660       1670       1680
tccaattctg gccccctgat gaagaagcat agacgaaatg gcttaagtcg aagtagtggt
      1690       1700       1710       1720       1730       1740
gctcagcctg caagtctccc cacaacctca cagcgaaaga actctgttaa actcaccatg
      1750       1760       1770       1780       1790       1800
cgacgcagac ttaggggcca gaagaaaatt ggaaatcctt tacttcatca acacaggaaa
      1810
actgtttgtg tttgctga    

Last modification date: Oct. 2, 2011