Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Replication factor C subunit 1


DESCRIPTION:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication.

STRUCTURE SIMILARITY:
Belongs to the activator 1 large subunit family.
Contains 1 BRCT domain.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSNSDIRSFF GGGNAQKKPK VSPTPTSPKP KRSLKKKRIV LSDDEDGTIE NSKVPASKSK
        70         80         90        100        110        120
VQKRNESEDI SHSLPSIVHE DDKLVGSDGV STTPDEYFEQ QSTRSRSKPR IISNKETTTS
       130        140        150        160        170        180
KDVVHPVKTE NFANDLDTTS DSKPVVHQTR ATRKPAQPKA EKSTTSKSKS HTTTATTHTS
       190        200        210        220        230        240
RSSKSKGLPR FSDEVSQALK NVPLIDVDSM GVMAPGTFYE RAATTQTPGS KPVPEGNSDC
       250        260        270        280        290        300
LSGISFVITG ILETLTRQEA TDLIKQYGGK VTGAPSVRTD FILLGENAGP RKVETIKQHK
       310        320        330        340        350        360
IPAINEDGLF YLITHLPASG GTGAAAQAAQ QKKEQEEKKI LETVARMDDS NKKESQPSQI
       370        380        390        400        410        420
WTSKYAPTSL KDICGNKGVV QKLQKWLQDY HKNRKSNFNK PGPDGLGLYK AVLLSGPPGI
       430        440        450        460        470        480
GKTTAAHLVA KLEGYDVLEL NASDTRSKRL LDEQLFGVTD SQSLAGYFGT KANPVDMAKS
       490        500        510        520        530        540
RLVLIMDEID GMSSGDRGGV GQLNMIIKKS MIPIICICND RAHPKLRPLD RTTFDLRFRR
       550        560        570        580        590        600
PDANSMRSRI MSIAYREGLK LSPQAVDQLV QGTQSDMRQI INLLSTYKLS CSEMTPQNSQ
       610        620        630        640        650        660
AVIKNSEKHI VMKPWDICSR YLHGGMFHPS SKSTINDKLE LYFNDHEFSY LMVQENYLNT
       670        680        690        700        710        720
TPDRIRQEPP KMSHLKHLEL ISSAANSFSD SDLVDSMIHG PQQHWSLMPT HALMSCVRPA
       730        740        750        760        770        780
SFVAGSGSRQ IRFTNWLGNN SKTNKLYRML REIQVHMRLK VSANKLDLRQ HYIPILYESL
       790        800        810        820        830        840
PVKLSTGHSD VVPEIIELMD EYYLNREDFD SITELVLPAD AGEKLMKTIP TAAKSAFTRK
       850        860        870        880        890        900
YNSSSHPIAF FGSSDVLPMK GSAQREVPDV EDAIEAEDEM LEEASDSEAA NEEDIDLSKD
       910        920        930
KFISVPKKPK KRTKAKAEAS SSSSTSRRSR KKTA  

Encoded by rfc1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgagtaatt ctgacattcg aagcttcttt ggaggaggga acgctcaaaa aaagccaaaa
        70         80         90        100        110        120
gtctcaccga ctcctacttc cccaaaacca aaaaggagtt tgaagaaaaa aagaatcgtt
       130        140        150        160        170        180
ttatcagatg atgaagatgg tacaatagag aattcaaaag ttcctgcatc caaaagcaaa
       190        200        210        220        230        240
gtgcaaaaac gtaatgagtc ggaagatatt tcccattctt tgccatccat tgttcatgaa
       250        260        270        280        290        300
gacgataaac ttgtcggttc agatggagtt tcaactacac ctgatgagta ctttgaacaa
       310        320        330        340        350        360
cagtctactc ggtcacgttc taaaccgcgg attatctcca ataaagaaac tactacttcc
       370        380        390        400        410        420
aaagatgtcg tacatcctgt aaaaacagaa aattttgcca atgacttgga taccacttca
       430        440        450        460        470        480
gacagtaagc cagttgtcca tcaaactaga gctacacgta aacctgctca acctaaagca
       490        500        510        520        530        540
gaaaaatcga caacttcaaa gtcaaaatct cataccacaa ctgcgacaac tcacacaagt
       550        560        570        580        590        600
cgttctagca agtcgaaagg cttacctagg ttctcagacg aagtttccca agccctcaaa
       610        620        630        640        650        660
aatgttcctt taattgacgt agactctatg ggtgtgatgg ctccaggtac tttctatgaa
       670        680        690        700        710        720
cgggcggcta caacacaaac tccaggctca aaacccgtcc ctgaaggcaa tagcgattgt
       730        740        750        760        770        780
ctctcgggaa ttagctttgt tattacagga attctagaga ctttaactag acaagaggct
       790        800        810        820        830        840
acagacctga tcaaacaata tggtggaaaa gtgacaggtg caccttctgt tagaacagac
       850        860        870        880        890        900
tttattctct taggtgagaa tgctggtcca agaaaagtgg aaacaattaa acaacacaag
       910        920        930        940        950        960
attcctgcta ttaacgagga tggactcttc tatcttataa ctcatcttcc tgcttcagga
       970        980        990       1000       1010       1020
ggaacgggtg ctgcggctca ggctgctcaa cagaaaaagg aacaagaaga aaagaaaatc
      1030       1040       1050       1060       1070       1080
cttgaaactg ttgcgagaat ggacgatagt aataaaaagg aatcacaacc ttcacagata
      1090       1100       1110       1120       1130       1140
tggacttcaa aatatgcgcc aacttcttta aaggatattt gtggtaataa gggtgtcgtt
      1150       1160       1170       1180       1190       1200
caaaaacttc aaaagtggct acaggattac cacaaaaaca ggaagtccaa ctttaataaa
      1210       1220       1230       1240       1250       1260
cctggacctg atggtctggg tctatacaaa gccgtattac tctctggtcc tccaggtatt
      1270       1280       1290       1300       1310       1320
ggcaagacga ctgctgctca tttggtagca aaattagaag gttacgatgt tttggaactg
      1330       1340       1350       1360       1370       1380
aacgctagtg acactagaag caagcgcttg ctagatgagc agctgttcgg tgtgacagat
      1390       1400       1410       1420       1430       1440
agtcaatcac ttgccggcta ctttggcaca aaagctaacc ccgttgacat ggcaaagtcc
      1450       1460       1470       1480       1490       1500
cgacttgtac tcattatgga cgaaatcgat ggcatgtcat cgggtgatcg tggaggcgtt
      1510       1520       1530       1540       1550       1560
ggtcagttga atatgattat taaaaaaagc atgataccaa ttatttgtat ttgcaatgac
      1570       1580       1590       1600       1610       1620
cgtgctcatc caaagctgcg gccccttgac cgtactacgt ttgacctccg tttccgtcgg
      1630       1640       1650       1660       1670       1680
ccagatgcta attcaatgcg atcccgaata atgtctatag cgtatcgtga aggtctcaaa
      1690       1700       1710       1720       1730       1740
ttgtcaccac aagcagtcga tcaactggtt caggggacgc agtccgatat gcgccaaatt
      1750       1760       1770       1780       1790       1800
attaatttgc tatccactta caagttaagc tgttcagaaa tgacacctca aaatagccaa
      1810       1820       1830       1840       1850       1860
gctgttatta aaaattctga aaagcatatc gttatgaaac catgggatat ctgtagtcgt
      1870       1880       1890       1900       1910       1920
tacttacatg gaggaatgtt tcatccatca agcaagtcca ccattaatga taaattagag
      1930       1940       1950       1960       1970       1980
ctgtatttta atgatcacga attttcttat cttatggttc aagaaaacta ccttaatact
      1990       2000       2010       2020       2030       2040
acaccagata gaattcgtca agaaccaccg aaaatgtcac atttgaagca tttagaatta
      2050       2060       2070       2080       2090       2100
atatctagtg ctgctaactc cttttccgac tctgatcttg ttgattcaat gattcatggt
      2110       2120       2130       2140       2150       2160
cctcaacaac actggtcact tatgccaacc catgctctta tgtcttgcgt gcgacctgct
      2170       2180       2190       2200       2210       2220
tctttcgtgg ctggttccgg ttccaggcag attcgcttta ctaattggtt gggtaataac
      2230       2240       2250       2260       2270       2280
tcgaagacaa ataaattata tcgtatgctt cgtgagatac aagtacacat gcgtttaaaa
      2290       2300       2310       2320       2330       2340
gtatccgcta ataaattgga cttgcggcag cattatattc caatattgta tgagtctctg
      2350       2360       2370       2380       2390       2400
cctgtaaagc tatcaacagg ccattcagac gtcgttccag aaatcattga attgatggat
      2410       2420       2430       2440       2450       2460
gaatattatc taaatcgtga agattttgat tcaataacgg aattagttct tcctgcagat
      2470       2480       2490       2500       2510       2520
gcaggtgaga aactcatgaa aaccataccg actgctgcaa aatctgcatt cacaagaaaa
      2530       2540       2550       2560       2570       2580
tacaattctt cgagtcaccc catcgccttc tttggaagta gtgatgtttt acctatgaag
      2590       2600       2610       2620       2630       2640
ggctctgctc agcgcgaagt gccggatgtc gaagatgcaa ttgaagccga agatgagatg
      2650       2660       2670       2680       2690       2700
ttagaagaag ctagtgactc agaggctgct aatgaagagg acatagattt aagcaaagac
      2710       2720       2730       2740       2750       2760
aaatttattt cggtaccaaa gaaacctaaa aaaaggacta aggcaaaggc tgaagcgtcc
      2770       2780       2790       2800
tcttctagct caaccagtcg ccgatccaga aaaaagacag cttaa 

Last modification date: Oct. 2, 2011